Li X, Qiao S, Zhao Y, Gu M, Gao R, Liu K, Ge Z, Ma. G1-like PB2 gene improves virus replication and competitive advantage of H9N2 virus. Virus Genes. 2021 Sep 14. Abstract
submitted by kickingbird at Sep, 15, 2021 from Virus Genes. 2021 Sep 14 (via https://link.springer.com/article/10.1007%2Fs11262-021-01870)
H9N2 subtype avian influenza virus has dramatically evolved and undergone extensive reassortment since its emergence in early 1990s in China. The genotype S (G57), emerging in 2007 with the substitution ... Borkenhagen LK, Allen MW, Runstadler JA. Influenza Virus Genotype to Phenotype Predictions Through Machine Learning: A Systematic Review. Emerg Microbes Infect. 2021 Sep 9:1-58.. Abstract
submitted by kickingbird at Sep, 14, 2021 from Emerg Microbes Infect. 2021 Sep 9:1-58. (via https://www.tandfonline.com/doi/full/10.1080/22221751.2021.1)
Background: There is great interest in understanding the viral genomic predictors of phenotypic traits that allow influenza A viruses to adapt to or become more virulent in different hosts. Machine learning ... Rüdiger D, Pelz L, Hein MD, Kupke SY, Reichl U.. Multiscale model of defective interfering particle replication for influenza A virus infection in animal cell culture. PLoS Comput Biol. 2021 Sep 7;17(9):e1009357. Abstract
submitted by kickingbird at Sep, 8, 2021 from PLoS Comput Biol. 2021 Sep 7;17(9):e1009357 (via https://journals.plos.org/ploscompbiol/article?id=10.1371/jo)
Cell culture-derived defective interfering particles (DIPs) are considered for antiviral therapy due to their ability to inhibit influenza A virus (IAV) production. DIPs contain a large internal deletion ... Zhang Z, Guo F, Roy A, Yang J, Luo W, Shen X, Irwi. Evolutionary perspectives and adaptation dynamics of human seasonal influenza viruses from 2009 to 2019: An insight from codon usage. Infect Genet Evol. 2021 Sep 3:105067. Abstract
submitted by kickingbird at Sep, 7, 2021 from Infect Genet Evol. 2021 Sep 3:105067 (via https://www.sciencedirect.com/science/article/abs/pii/S15671)
The annually recurrent seasonal influenza viruses, namely, influenza A viruses (H1N1/pdm2009 and H3N2) and influenza B viruses, contribute substantially to human disease burden. Elucidation of host adaptation, ... Nacken W, Schreiber A, Masemann D, Ludwig S. The Effector Domain of the Influenza A Virus Nonstructural Protein NS1 Triggers Host Shutoff by Mediating Inhibition and Global Deregulation of Host Transcription When Associated with Specific Structu. mBio. 2021 Sep 7:e0219621. Abstract
submitted by kickingbird at Sep, 7, 2021 from mBio. 2021 Sep 7:e0219621 (via https://journals.asm.org/doi/10.1128/mBio.02196-21)
Host shutoff in influenza A virus (IAV) infection is a key process contributing to viral takeover of the cellular machinery and resulting in the downregulation of host gene expression. Analysis of nascently ... Allen JD, Ross TM. Evaluation of Next-Generation H3 Influenza Vaccines in Ferrets Pre-Immune to Historical H3N2 Viruses. Front Immunol. 2021 Aug 12;12:707339. Abstract
submitted by kickingbird at Sep, 7, 2021 from Front Immunol. 2021 Aug 12;12:707339 (via https://www.frontiersin.org/articles/10.3389/fimmu.2021.7073)
Each person has a unique immune history to past influenza virus infections. Exposure to influenza viruses early in life establishes memory B cell populations that influence future immune responses to influenza ... Freyn AW, Pine M, Rosado VC, Benz M, Muramatsu H,. Antigen modifications improve nucleoside-modified mRNA-based influenza virus vaccines in mice. Mol Ther Methods Clin Dev. 2021 Jun 12;22:84-95. Abstract
submitted by kickingbird at Sep, 7, 2021 from Mol Ther Methods Clin Dev. 2021 Jun 12;22:84-95 (via https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8390451/)
Nucleoside-modified, lipid nanoparticle-encapsulated mRNAs have recently emerged as suitable vaccines for influenza viruses and other pathogens in part because the platform allows delivery of multiple ... Ganti K, Han J, Manicassamy B, Lowen AC. Rab11a mediates cell-cell spread and reassortment of influenza A virus genomes via tunneling nanotubes. PLoS Pathog. 2021 Sep 2;17(9):e1009321. Abstract
submitted by kickingbird at Sep, 3, 2021 from PLoS Pathog. 2021 Sep 2;17(9):e1009321 (via https://journals.plos.org/plospathogens/article?id=10.1371/j)
Influenza A virus [IAV] genomes comprise eight negative strand RNAs packaged into virions in the form of viral ribonucleoproteins [vRNPs]. Rab11a plays a crucial role in the transport of vRNPs from the ... Abraham M, Beavis AC, Xiao P, Villinger FJ, Li Z,. Evaluation of a new viral vaccine vector in mice and rhesus macaques: J paramyxovirus (JPV)-expressing HA of influenza A virus H5N1. J Virol. 2021 Sep 1:JVI0132121. Abstract
submitted by kickingbird at Sep, 2, 2021 from J Virol. 2021 Sep 1:JVI0132121 (via https://journals.asm.org/doi/10.1128/JVI.01321-21)
H5N1, an avian influenza virus, is known to circulate in many Asian countries like Bangladesh, China, Cambodia, Indonesia, and Vietnam. The current FDA-approved H5N1 vaccine has a moderate level of efficacy. ... Horio Y, Shichiri M, Isegawa Y. Development of a method for evaluating the mRNA transcription activity of influenza virus RNA-dependent RNA polymerase through real-time reverse transcription polymerase chain reaction. Virol J. 2021 Aug 28;18(1):177. Abstract
submitted by kickingbird at Aug, 30, 2021 from Virol J. 2021 Aug 28;18(1):177 (via https://virologyj.biomedcentral.com/articles/10.1186/s12985-)
Background: The development of an influenza RNA-dependent RNA polymerase (RdRp) inhibitor is required; therefore, a method for evaluating the activity of influenza RdRp needs to be developed. The current ... Namba T, Tsuge M, Yashiro M, Saito Y, Liu K, Nishi. Anti-high mobility group box 1 monoclonal antibody suppressed hyper-permeability and cytokine production in human pulmonary endothelial cells infected with influenza A virus. Inflamm Res. 2021 Aug 29. Abstract
submitted by kickingbird at Aug, 30, 2021 from Inflamm Res. 2021 Aug 29 (via https://link.springer.com/article/10.1007%2Fs00011-021-01496)
Objective: High mobility group box-1 (HMGB1) has been reported to be involved in influenza A virus-induced acute respiratory distress syndrome (ARDS). We studied the efficacy of an anti-HMGB1 mAb using ... Jerry C, Stallknecht DE, Leyson C, Berghaus R, Jor. Age-Associated Changes in Recombinant H5 Highly Pathogenic and Low Pathogenic Avian Influenza Hemagglutinin Tissue Binding in Domestic Poultry Species. Animals (Basel). 2021 Jul 28;11(8):2223. Abstract
submitted by kickingbird at Aug, 30, 2021 from Animals (Basel). 2021 Jul 28;11(8):2223 (via https://www.mdpi.com/2076-2615/11/8/2223)
The 2014 outbreak of clade 2.3.4.4A highly pathogenic avian influenza (HPAI) led to the culling of millions of commercial chickens and turkeys and death of various wild bird species. In this outbreak, ... Tarek M, Naguib MM, Arafa AS, Tantawy LA, Selim KM. Epidemiology, Genetic Characterization, and Pathogenesis of Avian Influenza H5N8 Viruses Circulating in Northern and Southern Parts of Egypt, 2017-2019. Animals (Basel). 2021 Jul 26;11(8):2208. Abstract
submitted by kickingbird at Aug, 30, 2021 from Animals (Basel). 2021 Jul 26;11(8):2208 (via https://www.mdpi.com/2076-2615/11/8/2208)
Highly pathogenic avian influenza (HPAI) viruses of subtype H5N8 continue to circulate, causing huge economic losses and serious impact on poultry production worldwide. Recently, HPAIV H5N8 has been spreading ... Yeo SJ, Hoang VT, Duong TB, Nguyen NM, Tuong HT, A. Emergence of a Novel Reassortant H5N3 Avian Influenza Virus in Korean Mallard Ducks in 2018. Intervirology. 2021 Aug 26:1-16. Abstract
submitted by kickingbird at Aug, 30, 2021 from Intervirology. 2021 Aug 26:1-16 (via https://www.karger.com/Article/FullText/517057)
Introduction: The avian influenza (AI) virus causes a highly contagious disease which is common in wild and domestic birds and sporadic in humans. Mutations and genetic reassortments among the 8 negative-sense ... Jones JE, Le Sage V, Padovani GH, Calderon M, Wrig. Parallel evolution between genomic segments of seasonal human influenza viruses reveals RNA-RNA relationships. Elife. 2021 Aug 27;10:e66525. Abstract
submitted by kickingbird at Aug, 30, 2021 from Elife. 2021 Aug 27;10:e66525 (via https://elifesciences.org/articles/66525)
The influenza A virus (IAV) genome consists of eight negative-sense viral RNA (vRNA) segments that are selectively assembled into progeny virus particles through RNA-RNA interactions. To explore putative ... Ali M, Yaqub T, Shahid MF, Wong FY, Mukhtar N, Nae. Genetic Characterization of Highly Pathogenic Avian Influenza A(H5N8) Virus in Pakistani Live Bird Markets Reveals Rapid Diversification of Clade 2.3.4.4b Viruses. Viruses. 2021 Aug 18;13(8):1633. Abstract
submitted by kickingbird at Aug, 29, 2021 from Viruses. 2021 Aug 18;13(8):1633 (via https://www.mdpi.com/1999-4915/13/8/1633)
The highly pathogenic (HPAI) avian influenza A(H5N1) viruses have undergone reassortment with multiple non-N1-subtype neuraminidase genes since 2008, leading to the emergence of H5Nx viruses. H5Nx viruses ... Zhang X, Bo Z, Meng C, Chen Y, Zhang C, Cao Y, Wu. Generation and Evaluation of Recombinant Thermostable Newcastle Disease Virus Expressing the HA of H9N2 Avian Influenza Virus. Viruses. 2021 Aug 13;13(8):1606. Abstract
submitted by kickingbird at Aug, 29, 2021 from Viruses. 2021 Aug 13;13(8):1606 (via https://www.mdpi.com/1999-4915/13/8/1606)
H9N2 avian influenza virus (AIV) has become endemic in many countries, causing great economic losses when co-infected with other pathogens. So far, several live vaccines based on Newcastle disease virus ... Treshchalina A, Postnikova Y, Boravleva E, Gambary. Substitution Arg140Gly in Hemagglutinin Reduced the Virulence of Highly Pathogenic Avian Influenza Virus H7N1. Viruses. 2021 Aug 11;13(8):1584. Abstract
submitted by kickingbird at Aug, 29, 2021 from Viruses. 2021 Aug 11;13(8):1584 (via https://www.mdpi.com/1999-4915/13/8/1584)
The H7 subtype of avian influenza viruses (AIV) stands out among other AIV. The H7 viruses circulate in ducks, poultry and equines and have repeatedly caused outbreaks of disease in humans. The laboratory ... Amer F, Li R, Rabie N, El-Husseiny MH, Yehia N, Ha. Temporal Dynamics of Influenza A(H5N1) Subtype before and after the Emergence of H5N8. Viruses. 2021 Aug 7;13(8):1565. Abstract
submitted by kickingbird at Aug, 29, 2021 from Viruses. 2021 Aug 7;13(8):1565 (via https://www.mdpi.com/1999-4915/13/8/1565)
Highly pathogenic avian influenza (HPAI) viruses continue to circulate worldwide, causing numerous outbreaks among bird species and severe public health concerns. H5N1 and H5N8 are the two most fundamental ... Steinberg J, Wadenpohl T, Jung S. The Endogenous RIG-I Ligand Is Generated in Influenza A-Virus Infected Cells. Viruses. 2021 Aug 7;13(8):1564. Abstract
submitted by kickingbird at Aug, 29, 2021 from Viruses. 2021 Aug 7;13(8):1564 (via https://www.mdpi.com/1999-4915/13/8/1564)
As a result of a viral infection, viral genomes are not only recognized by RIG-I, but also lead to the activation of RNase L, which cleaves cellular RNA to generate the endogenous RIG-I ligand (eRL). The ... 6896 items, 20/Page, Page[137/345][|<<] [|<] [131] [132] [133] [134] [135] [136] [137] [138] [139] [140] [>|] [>>|] |
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