Sun, X., Lisboa, C., Carney, P.J. et al. Hemagglutinin E190D substitution in clade 2.3.4.4b A(H5N1) influenza virus reduces receptor binding and viral fitness. npj Viruses (2026). Abstract
submitted by kickingbird at 2 hours ago from npj Viruses (2026) (via https://www.nature.com/articles/s44298-026-00197-2)
The detection of a clade 2.3.4.4b influenza A(H5N1) virus bearing an HA-E190D substitution in an infected human raises concern about mammalian adaptation. We evaluated the impact of the naturally occurring ... Phung Nguyen The Nguyen, Nguyen Thanh Hung, Ngo Ng. Central Nervous System Involvement by Novel Clade 2.3.2.1e H5N1 Avian Influenza Virus in a Paediatric Patient. Open Forum Infectious Diseases, 2026;, ofag283. Abstract
submitted by kickingbird at 21 hours ago from Open Forum Infectious Diseases, 2026;, ofag283 (via https://academic.oup.com/ofid/advance-article/doi/10.1093/of)
Novel clade 2.3.2.1e A(H5N1) virus was detected in cerebrospinal fluid but not in respiratory, rectal-swab and blood samples of an eight-year-old boy presenting with meningoencephalitis without respiratory ... Jun Jiao, etc.,al. [preprint]G4 Eurasian avian-like H1N1 swine influenza viruses exhibit enhanced pathogenicity potential in mice and pigs. https://doi.org/10.64898/2026.05.12.724537. Abstract
submitted by kickingbird at 2 days ago from https://doi.org/10.64898/2026.05.12.724537 (via https://www.biorxiv.org/content/10.64898/2026.05.12.724537v1)
Currently circulating swine influenza viruses (SIVs) mainly include H1N1, H1N2, and H3N2 subtypes. In this study, two G4 genotype Eurasian avian-like (EA) H1N1 SIVs were isolated from 556 samples collected ... Alejandra Garcia-Glaessner, etc.,al. [preprint]Outbreak of H9N2 avian influenza viruses in lesser rhea in Peru, June-July 2025. https://doi.org/10.64898/2026.05.08.723762. Abstract
submitted by kickingbird at 2 days ago from https://doi.org/10.64898/2026.05.08.723762 (via https://www.biorxiv.org/content/10.64898/2026.05.08.723762v1)
Avian influenza viruses (AIVs) are endemic in the Americas and responsible for outbreaks in both domestic and wild birds that occasionally spill over into humans. We report the first known outbreak of ... Nathaniel Jackson, etc.,al. [preprint]A single PA-X mutation in bovine-origin H5N1 influenza virus reduces pathogenicity in mice. https://doi.org/10.64898/2026.05.09.724031. Abstract
submitted by kickingbird at 2 days ago from https://doi.org/10.64898/2026.05.09.724031 (via https://www.biorxiv.org/content/10.64898/2026.05.09.724031v1)
Dairy cows have emerged as a reservoir for human infection with highly pathogenic avian influenza (HPAI) H5N1. At the bovine–human interface, H5N1 strains may acquire adaptive mutations that influence ... Ort, J.T., Sobel Leonard, A., Li, S.H. et al. Cross-reactive human antibody responses to H5N1 influenza virus neuraminidase are shaped by immune history. Nat Commun (2026). Abstract
submitted by kickingbird at 2 days ago from Nat Commun (2026) (via https://link.springer.com/article/10.1038/s41467-026-72941-4)
H5N1 highly pathogenic avian influenza viruses have spread globally and pose a pandemic risk. Prior studies suggest that early life exposures to group 1 influenza viruses (H1N1 and H2N2) prime antibodies ... Huang, J., Ma, K., Ding, S., Wang, Y., Xiong, J.,. A CRISPR activation screen identifies CH25H as a restriction factor against influenza viruses by targeting accessible cholesterol. Emerging Microbes & Infections. Abstract
submitted by kickingbird at 2 days ago from Emerging Microbes & Infections (via https://www.tandfonline.com/doi/full/10.1080/22221751.2026.2)
Influenza A viruses (IAVs) cause severe outbreaks with high mortality in birds and humans. A deeper understanding of cell-intrinsic defense mechanisms against influenza viruses is therefore crucial for ... Steiner J, Mwanga M, et al. Concurrent Detection of Swine-Origin Influenza A(H1N1) Virus in Pigs and Farmer, Switzerland. Emerg Infect Dis. 2026 Jun. Abstract
submitted by kickingbird at 2 days ago from Emerg Infect Dis. 2026 Jun (via https://wwwnc.cdc.gov/eid/article/32/6/25-1487_article)
We report zoonotic transmission of Eurasian avian-like swine influenza A(H1N1) virus from pigs to a farmer. The pigs and farmer experienced influenza-like illness. Whole-genome sequencing revealed >99.9% ... Eszter Kovács, etc.,al. H5N1 2.3.4.4b HA E190D and Q226H mutations, picked up as minority variants in a patient, result in an inability to bind sialic acid. Virology. Abstract
submitted by kickingbird at 3 days ago from Virology (via https://www.sciencedirect.com/science/article/abs/pii/S00426)
A human infection with clade 2.3.4.4b H5N1 influenza A virus in Canada revealed minority variants E190D and Q226H in the hemagglutinin (HA) receptor-binding site (RBS). Because mutations at positions 190 ... Zhiyuan Liu, etc.,al. Gga-miR-449c suppresses H9N2 influenza virus replication via targeting the viral genome and suppressor of cytokine signaling 3. International Journal of Biological Macromolecules. Abstract
submitted by kickingbird at 3 days ago from International Journal of Biological Macromolecules (via https://www.sciencedirect.com/science/article/abs/pii/S01418)
Avian influenza virus is a globally prevalent pathogen in poultry populations, causing severe economic losses to the poultry industry worldwide. In the present study, we demonstrate that miR-449c generates ... Chen X, Zheng X, Zhang L, Cai X, Hong X, Hou S, Ma. Long noncoding RNA#61 synergizes with viral PA-X to augment pyroptosis and attenuate the virulence of highly pathogenic H5N1 influenza virus in mice. J Virol 0:e02214-25. Abstract
submitted by kickingbird at 3 days ago from J Virol 0:e02214-25 (via https://journals.asm.org/doi/10.1128/jvi.02214-25)
Long non-coding RNAs (LncRNAs) play pivotal regulatory roles in various biological processes, notably in immune regulation and viral infection. We previously identified the broad anti-influenza activity ... Giacinti JA, Signore A, Torchetti M, Enrique Valde. North American perspective on the highly pathogenic avian influenza H5Nx clade 2.3.4.4b outbreak (November 2021 - March 2025). Can J Microbiol. 2026 May 11. Abstract
submitted by kickingbird at 4 days ago from Can J Microbiol. 2026 May 11 (via https://cdnsciencepub.com/doi/10.1139/cjm-2025-0275)
Influenza A (H5Nx) highly pathogenic avian influenza viruses of clade 2.3.4.4b were first detected in North America in late 2021, initiating a multi-year outbreak unprecedented in geographic extent, duration, ... Michelle Wille, etc.,al. [preprint]Migratory bird and marine mammal surveillance fails to find evidence for an HPAI H5N1 2.3.4.4b incursion into Australia in 2025. https://doi.org/10.64898/2026.05.07.722556. Abstract
submitted by kickingbird at 5 days ago from https://doi.org/10.64898/2026.05.07.722556 (via https://www.biorxiv.org/content/10.64898/2026.05.07.722556v1)
The panzootic caused by high pathogenicity avian influenza (HPAI) H5N1 clade 2.3.4.4b has been devastating for animals, globally. Despite global spread, the virus remains absent in Oceania. Herein we report ... Grace E. Quirk, etc.,al. [preprint]Variable transmission efficiency of mammalian origin HPAI D1.1 H5N1 strains in ferrets. https://doi.org/10.64898/2026.05.07.722809. Abstract
submitted by kickingbird at 5 days ago from https://doi.org/10.64898/2026.05.07.722809 (via https://www.biorxiv.org/content/10.64898/2026.05.07.722809v1)
Highly pathogenic avian influenza H5N1 2.3.4.4b genotype D1.1 lineage continues to predominate in the United States wild bird population and has spilled over into dairy cattle three independent times. ... Zhao, Y., Liu, C., Li, Y. et al. Genetic and biological characterization of H9N2 avian influenza viruses isolated from swine in China. BMC Vet Res (2026). Abstract
submitted by kickingbird at 7 days ago from BMC Vet Res (2026) (via https://link.springer.com/article/10.1186/s12917-026-05501-z)
Background: H9N2 avian influenza virus (AIV) has been circulating in poultry in China for decades and are undergoing adaptation to mammals, posing potential pandemic risks. To investigate the prevalence ... Richard J Sugrue, Richard Sutejo, Boon Huan Tan. [preprint]Evaluating the use of siRNA to silence the expression of the H5N2 virus polymerase genes as strategy to block the transmission of the avian H5N2 virus in mammalian cells. https://doi.org/10.64898/2026.05.04.722578. Abstract
submitted by kickingbird at 7 days ago from https://doi.org/10.64898/2026.05.04.722578 (via https://www.biorxiv.org/content/10.64898/2026.05.04.722578v1)
We prepared siRNA libraries against the H5N2 virus NP gene, and the PA, PB1 and PB2 genes that express the proteins that form the virus polymerase complex. The antiviral activity of the siRNA libraries ... Josephine von Kempis, etc.,al. [preprint]Opposing cell type preferences for binding and replication shape influenza A virus infection in human airways. https://doi.org/10.64898/2026.05.04.722582. Abstract
submitted by kickingbird at 7 days ago from https://doi.org/10.64898/2026.05.04.722582 (via https://www.biorxiv.org/content/10.64898/2026.05.04.722582v1)
Influenza A viruses (IAVs) pose a persistent threat to human health through seasonal epidemics and zoonotic spillover from avian reservoirs. As respiratory pathogens, they primarily target the airway epithelium. ... Tamiru N. Alkie et al. Mammary and respiratory infection of sheep with H5Nx clade 2.3.4.4b viruses with milk-mediated transmission to lambs. Sci. Adv.12,eaed1287(2026). Abstract
submitted by kickingbird at 7 days ago from Sci. Adv.12,eaed1287(2026) (via https://www.science.org/doi/10.1126/sciadv.aed1287)
H5Nx clade 2.3.4.4b viruses are evolving rapidly, expanding host ranges and threatening animal and public health. In the US, genotype B3.13 dominates dairy outbreaks, while D1.1 is linked to fewer cases. ... Kieran TJ, Maines TR, Belser JA. Limited ´heft´ of weight-based outcomes in predicting influenza A virus disease severity in ferrets. PLoS Comput Biol. 2026 May 8;22(5):e1014210. Abstract
submitted by kickingbird at 7 days ago from PLoS Comput Biol. 2026 May 8;22(5):e1014210 (via https://journals.plos.org/ploscompbiol/article?id=10.1371/jo)
Studies evaluating viral pathogenicity in small mammalian models often quantify disease severity using the magnitudes of temperature rise and weight loss post-challenge. However, no rigorous assessment ... Mengdan Fei, etc.,al. Migration of Brown-headed Gulls on the Qinghai-Tibet Plateau: Potential transmission routes for highly pathogenic H5Nx virus. Avian Research. Abstract
submitted by kickingbird at 7 days ago from Avian Research (via https://www.sciencedirect.com/science/article/pii/S205371662)
The Qinghai-Tibet Plateau serves as a critical hub along the Central Asian Flyway (CAF) and a recognized hotspot for the emergence of highly pathogenic avian influenza (HPAI) viruses. Despite recurrent ... 6833 items, 20/Page, Page[1/342][|<<] [|<] [1] [2] [3] [4] [5] [6] [7] [8] [9] [10] [>|] [>>|] |
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