Hu J, Peng P, Li J, Zhang Q, Li R, Wang X, Gu M, H. Single Dose of Bivalent H5 and H7 Influenza Virus-Like Particle Protects Chickens Against Highly Pathogenic H5N1 and H7N9 Avian Influenza Viruses. Front Vet Sci. 2021 Nov 11;8:774630. Abstract
submitted by kickingbird at 20 hours ago from Front Vet Sci. 2021 Nov 11;8:774630 (via https://www.frontiersin.org/articles/10.3389/fvets.2021.7746)
Both H5N1 and H7N9 subtype avian influenza viruses cause enormous economic losses and pose considerable threats to public health. Bivalent vaccines against both two subtypes are more effective in control ...
Kuroda Y, Okada A, Shimoda H, Miwa Y, Watamori A,. Influenza A virus infection in domestic ferrets. Jpn J Infect Dis. 2021 Nov 30. Abstract
submitted by kickingbird at 2 days ago from Jpn J Infect Dis. 2021 Nov 30 (via https://www.jstage.jst.go.jp/article/yoken/advpub/0/advpub_J)
Ferrets are animals that are known to be susceptible to influenza A virus (IAV) infection. To evaluate the risk of IAV transmission from diseased ferrets to humans, we performed a serosurvey to detect ...
Luo S, Xie Z, Li M, Li D, Xie L, Huang J, Zhang M,. Survey of low pathogenic avian influenza viruses in live poultry markets in Guangxi Province, Southern China, 2016-2019. Sci Rep. 2021 Dec 1;11(1):23223. Abstract
submitted by kickingbird at 2 days ago from Sci Rep. 2021 Dec 1;11(1):23223 (via https://www.nature.com/articles/s41598-021-02639-8)
Low pathogenic avian influenza viruses (LPAIVs) have been widespread in poultry and wild birds throughout the world for many decades. LPAIV infections are usually asymptomatic or cause subclinical symptoms. ...
Wu XX, Tang SJ, Yao SH, Zhou YQ, Xiao LL, Cheng LF. The viral distribution and pathological characteristics of BALB/c mice infected with highly pathogenic Influenza H7N9 virus. Virol J. 2021 Nov 29;18(1):237. Abstract
submitted by kickingbird at 3 days ago from Virol J. 2021 Nov 29;18(1):237 (via https://virologyj.biomedcentral.com/articles/10.1186/s12985-)
Background: The highly pathogenic Influenza H7N9 virus is believed to cause multiple organ infections. However, there have been few systematic animal experiments demonstrating the virus distribution after ...
Zheng J, Chen F, Wu K, Wang J, Li F, Huang S, Lu J. Clinical and virological impact of single and dual infections with influenza A (H1N1) and SARS-CoV-2 in adult inpatients. PLoS Negl Trop Dis. 2021 Nov 29;15(11):e0009997. Abstract
submitted by kickingbird at 5 days ago from PLoS Negl Trop Dis. 2021 Nov 29;15(11):e0009997 (via https://journals.plos.org/plosntds/article?id=10.1371/journa)
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) mimics the influenza A (H1N1) virus in terms of clinical presentation, transmission mechanism, and seasonal coincidence. Comprehensive data ...
Xu L, Zhao L, Che J, Zhang Q, Cao R, Li X. Identification of novel influenza polymerase PB2 inhibitors using virtual screening approach and molecular dynamics simulation analysis of active compounds. Bioorg Med Chem. 2021 Nov 11;52:116515. Abstract
submitted by kickingbird at 5 days ago from Bioorg Med Chem. 2021 Nov 11;52:116515 (via https://www.sciencedirect.com/science/article/abs/pii/S09680)
Hierarchical virtual screening combined with ADME prediction and cluster analysis methods were used to identify influenza virus PB2 inhibitors with high activity, good druggability properties, and diverse ...
Zhou B, Wang L, Liang Y, Li J, Pan X. Arctiin suppresses H9N2 avian influenza virus-mediated inflammation via activation of Nrf2/HO-1 signaling. BMC Complement Med Ther. 2021 Nov 26;21(1):289. Abstract
submitted by kickingbird at 5 days ago from BMC Complement Med Ther. 2021 Nov 26;21(1):289 (via https://bmccomplementmedtherapies.biomedcentral.com/articles)
Background: H9N2 avian influenza viruses (AIVs) infect avian and mammalian hosts and provide internal genes for new emerging highly pathogenic avian viruses that cause severe pneumonia with high mortality, ...
Lamotte LA, Tafforeau L. How Influenza A Virus NS1 Deals with the Ubiquitin System to Evade Innate Immunity. Viruses. 2021 Nov 19;13(11):2309. Abstract
submitted by kickingbird at 5 days ago from Viruses. 2021 Nov 19;13(11):2309 (via https://www.mdpi.com/1999-4915/13/11/2309)
Ubiquitination is a post-translational modification regulating critical cellular processes such as protein degradation, trafficking and signaling pathways, including activation of the innate immune response. ...
Li Y, Zhang X, Liu Y, Feng Y, Wang T, Ge Y, Kong Y. Characterization of Canine Influenza Virus A (H3N2) Circulating in Dogs in China from 2016 to 2018. Viruses. 2021 Nov 15;13(11):2279.. Abstract
submitted by kickingbird at 5 days ago from Viruses. 2021 Nov 15;13(11):2279. (via https://www.mdpi.com/1999-4915/13/11/2279)
Avian H3N2 influenza virus follows cross-host transmission and has spread among dogs in Asia since 2005. After 2015-2016, a new H3N2 subtype canine influenza epidemic occurred in dogs in North America ...
Lee YN, Lee DH, Kwon JH, Shin JI, Hong SY, Cha RM,. Genetic Characterization of Novel H7Nx Low Pathogenic Avian Influenza Viruses from Wild Birds in South Korea during the Winter of 2020-2021. Viruses. 2021 Nov 13;13(11):2274. Abstract
submitted by kickingbird at 5 days ago from Viruses. 2021 Nov 13;13(11):2274 (via https://www.mdpi.com/1999-4915/13/11/2274)
Zoonotic infection with avian influenza viruses (AIVs) of subtype H7, such as H7N9 and H7N4, has raised concerns worldwide. During the winter of 2020-2021, five novel H7 low pathogenic AIVs (LPAIVs) containing ...
Duong BT, Bal J, Sung HW, Yeo SJ, Park H. Molecular Analysis of the Avian H7 Influenza Viruses Circulating in South Korea during 2018-2019: Evolutionary Significance and Associated Zoonotic Threats. Viruses. 2021 Nov 11;13(11):2260. Abstract
submitted by kickingbird at 5 days ago from Viruses. 2021 Nov 11;13(11):2260 (via https://www.mdpi.com/1999-4915/13/11/2260)
Avian influenza virus (AIV) subtypes H5 and H7, possessing the ability to mutate spontaneously from low pathogenic (LP) to highly pathogenic (HP) variants, are major concerns for enormous socio-economic ...
Ren Y, Long S, Cao S. Molecular Docking and Virtual Screening of an Influenza Virus Inhibitor That Disrupts Protein-Protein Interactions. Viruses. 2021 Nov 5;13(11):2229. Abstract
submitted by kickingbird at 5 days ago from Viruses. 2021 Nov 5;13(11):2229 (via https://www.mdpi.com/1999-4915/13/11/2229)
Influenza is an acute respiratory infection caused by the influenza virus, but few drugs are available for its treatment. Consequently, researchers have been engaged in efforts to discover new antiviral ...
Nguyen ATV, Hoang VT, Sung HW, Yeo SJ, Park H. Genetic Characterization and Pathogenesis of Three Novel Reassortant H5N2 Viruses in South Korea, 2018. Viruses. 2021 Oct 30;13(11):2192. Abstract
submitted by kickingbird at 5 days ago from Viruses. 2021 Oct 30;13(11):2192 (via https://www.mdpi.com/1999-4915/13/11/2192)
The outbreaks of H5N2 avian influenza viruses have occasionally caused the death of thousands of birds in poultry farms. Surveillance during the 2018 winter season in South Korea revealed three H5N2 isolates ...
Bougon J, Deblanc C, Renson P, Quéguiner S, Gorin. Successive Inoculations of Pigs with Porcine Reproductive and Respiratory Syndrome Virus 1 (PRRSV-1) and Swine H1N2 Influenza Virus Suggest a Mutual Interference between the Two Viral Infections. Viruses. 2021 Oct 27;13(11):2169. Abstract
submitted by kickingbird at 5 days ago from Viruses. 2021 Oct 27;13(11):2169 (via https://www.mdpi.com/1999-4915/13/11/2169)
Porcine reproductive and respiratory syndrome virus (PRRSV) and swine influenza A virus (swIAV) are major pathogens of the porcine respiratory disease complex, but little is known on their interaction ...
Ishida H, Murakami S, Kamiki H, Matsugo H, Katayam. Construction of an Influenza D Virus with an Eight-Segmented Genome. Viruses. 2021 Oct 27;13(11):2166. Abstract
submitted by kickingbird at 5 days ago from Viruses. 2021 Oct 27;13(11):2166 (via https://www.mdpi.com/1999-4915/13/11/2166)
Influenza D virus (IDV) may cause the bovine respiratory disease complex, which is the most common and costly disease affecting the cattle industry. Previously, we revealed that eight segments could be ...
Nu?ez IA, Huang Y, Ross TM. Next-Generation Computationally Designed Influenza Hemagglutinin Vaccines Protect against H5Nx Virus Infections. Pathogens. 2021 Oct 20;10(11):1352. Abstract
submitted by kickingbird at 5 days ago from Pathogens. 2021 Oct 20;10(11):1352 (via https://www.mdpi.com/2076-0817/10/11/1352)
H5N1 COBRA hemagglutinin (HA) sequences, termed human COBRA-2 HA, were constructed through layering of HA sequences from viruses isolated from humans collected between 2004-2007 using only clade 2 strains. ...
Wang Y, Sun W, Wang Z, Zhao M, Zhang X, Kong Y, Wa. Amino acid sites related to the PB2 subunits of IDV affect polymerase activity. Virol J. 2021 Nov 22;18(1):230. Abstract
submitted by kickingbird at 11 days ago from Virol J. 2021 Nov 22;18(1):230 (via https://virologyj.biomedcentral.com/articles/10.1186/s12985-)
Background: In 2011, a new influenza virus, named Influenza D Virus (IDV), was isolated from pigs, and then cattle, presenting influenza-like symptoms. IDV is one of the causative agents of Bovine Respiratory ...
Alnaji FG, Reiser WK, Rivera-Cardona J, Te Velthui. Influenza A Virus Defective Viral Genomes Are Inefficiently Packaged into Virions Relative to Wild-Type Genomic RNAs. mBio. 2021 Nov 23:e0295921. Abstract
submitted by kickingbird at 11 days ago from mBio. 2021 Nov 23:e0295921 (via https://journals.asm.org/doi/10.1128/mBio.02959-21)
Deletion-containing viral genomes (DelVGs) are commonly produced during influenza A virus infection and have been implicated in influencing clinical infection outcomes. Despite their ubiquity, the specific ...
Gravel C, Muralidharan A, Duran A, Zetner A, Pfeif. Synthetic vaccine affords full protection to mice against lethal challenge of influenza B virus of both genetic lineages. iScience. 2021 Oct 21;24(11):103328.. Abstract
submitted by kickingbird at 11 days ago from iScience. 2021 Oct 21;24(11):103328. (via https://www.cell.com/iscience/fulltext/S2589-0042(21)01297-9)
A quarter of all seasonal influenza cases are caused by type B influenza virus (IBV) that also dominates periodically. Here, we investigated a recombinant adenovirus vaccine carrying a synthetic HA2 representing ...
Vinh DN, Nhat NTD, de Bruin E, Vy NHT, Thao TTN, P. Age-seroprevalence curves for the multi-strain structure of influenza A virus. Nat Commun. 2021 Nov 18;12(1):6680. Abstract
submitted by kickingbird at 14 days ago from Nat Commun. 2021 Nov 18;12(1):6680 (via https://www.nature.com/articles/s41467-021-26948-8)
The relationship between age and seroprevalence can be used to estimate the annual attack rate of an infectious disease. For pathogens with multiple serologically distinct strains, there is a need to describe ...
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