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2018-7-21 21:16:12
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Sant S, etc.,al. Single-Cell Approach to Influenza-Specific CD8+ T Cell Receptor Repertoires Across Different Age Groups, Tissues, and Following Influenza Virus Infection. Front Immunol. 2018 Jun 27;9:1453.  Abstract  
submitted by kickingbird at 5 days ago from Front Immunol. 2018 Jun 27;9:1453 (via https://www.ncbi.nlm.nih.gov/pubmed/29997621)
CD8+ T cells recognizing antigenic peptides derived from conserved internal viral proteins confer broad protection against distinct influenza viruses. As memory CD8+ T cells change throughout the human ...

Ng YP, Yip TF, Peiris JSM, Ip NY, Lee SMY. Avian influenza A H7N9 virus infects human astrocytes and neuronal cells and induces inflammatory immune responses. J Neurovirol. 2018 Jul 9.  Abstract  
submitted by kickingbird at 5 days ago from J Neurovirol. 2018 Jul 9 (via https://www.ncbi.nlm.nih.gov/pubmed/29987581)
Seasonal, pandemic, and avian influenza virus infections may be associated with central nervous system pathology, albeit with varying frequency and different mechanisms. Here, we demonstrate that differentiated ...

Schr?der T. etc.,al. The clinically approved MEK inhibitor Trametinib efficiently blocks influenza A virus propagation and cytokine expression. Antiviral Res. 2018 Jul 7;157:80-92.  Abstract  
submitted by kickingbird at 5 days ago from Antiviral Res. 2018 Jul 7;157:80-92 (via https://www.ncbi.nlm.nih.gov/pubmed/29990517)
Influenza A virus (IAV) infections are still a major global threat for humans, especially for the risk groups of young children and the elderly. Annual epidemics and sporadically occurring pandemics highlight ...

Bangaru S, etc.,al. A multifunctional human monoclonal neutralizing antibody that targets a unique conserved epitope on influenza HA. Nat Commun. 2018 Jul 10;9(1):2669.  Abstract  
submitted by kickingbird at 5 days ago from Nat Commun. 2018 Jul 10;9(1):2669 (via https://www.ncbi.nlm.nih.gov/pubmed/29991715)
The high rate of antigenic drift in seasonal influenza viruses necessitates frequent changes in vaccine composition. Recent seasonal H3 vaccines do not protect against swine-origin H3N2 variant (H3N2v) ...

Gao Z, etc.,al. The PA-interacting host protein nucleolin acts as an antiviral factor during highly pathogenic H5N1 avian influenza virus infection. Arch Virol. 2018 Jul 5.  Abstract  
submitted by kickingbird at 12 days ago from Arch Virol. 2018 Jul 5 (via https://www.ncbi.nlm.nih.gov/pubmed/29974255)
Polymerase acidic (PA) protein is a multifunctional regulator of influenza A virus (IAV) replication and pathogenesis. In a previous study, we reported that nucleolin (NCL) is a novel PA-interacting host ...

Keating R, Morris MY, etc.,al. Potential killers exposed: tracking endogenous influenza-specific CD8+ T cells. Immunol Cell Biol. 2018 Jul 4..  Abstract  
submitted by kickingbird at 12 days ago from Immunol Cell Biol. 2018 Jul 4. (via https://www.ncbi.nlm.nih.gov/pubmed/29972699)
Current influenza A virus (IAV) vaccines stimulate antibody responses that are directed against variable regions of the virus, and are therefore ineffective against divergent strains. As CD8+ T cells target ...

Hu J, Ma C, Liu X. PA-X: a key regulator of influenza A virus pathogenicity and host immune responses. Med Microbiol Immunol. 2018 Jul 4..  Abstract  
submitted by kickingbird at 12 days ago from Med Microbiol Immunol. 2018 Jul 4. (via https://www.ncbi.nlm.nih.gov/pubmed/29974232)
PA-X, a fusion protein belonging to influenza A viruses (IAVs), integrating the N-terminal 191 amino acids of PA gene and the ribosomal frame-shifting product that lengthens out to 41 or 61 amino acids. ...

Thulin NK, Wang TT. The Role of Fc Gamma Receptors in Broad Protection against Influenza Viruses. Vaccines (Basel). 2018 Jun 29;6(3).  Abstract  
submitted by kickingbird at 12 days ago from Vaccines (Basel). 2018 Jun 29;6(3) (via https://www.ncbi.nlm.nih.gov/pubmed/29966222)
Recent studies have revealed multiple roles for Fc gamma receptors (FcγRs) in broad immunity against influenza viruses. Activating FcγR pathways can be harnessed to confer protection mediated ...

Qiang X, Kou Z, Fang G, Wang Y. Scoring Amino Acid Mutations to Predict Avian-to-Human Transmission of Avian Influenza Viruses. Molecules. 2018 Jun 29;23(7).  Abstract  
submitted by kickingbird at 12 days ago from Molecules. 2018 Jun 29;23(7) (via https://www.ncbi.nlm.nih.gov/pubmed/29966263)
Avian influenza virus (AIV) can directly cross species barriers and infect humans with high fatality. Using machine learning methods, the present paper scores the amino acid mutations and predicts interspecies ...

Zhu R, etc.,al. Genetic and biological characterization of H9N2 avian influenza viruses isolated in China from 2011 to 2014.. PLoS One. 2018 Jul 3;13(7):e0199260..  Abstract  
submitted by kickingbird at 12 days ago from PLoS One. 2018 Jul 3;13(7):e0199260. (via https://www.ncbi.nlm.nih.gov/pubmed/29969454)
The genotypes of the H9N2 avian influenza viruses have changed since 2013 when almost all H9N2 viruses circulating in chickens in China were genotype 57 (G57) with the fittest lineage of each gene. To ...

Smith BL, etc.,al. Avian Influenza Virus PB1 Gene in H3N2 Viruses Evolved in Humans To Reduce Interferon Inhibition by Skewing Codon Usage toward Interferon-Altered tRNA Pools. MBio. 2018 Jul 3;9(4)..  Abstract  
submitted by kickingbird at 12 days ago from MBio. 2018 Jul 3;9(4). (via https://www.ncbi.nlm.nih.gov/pubmed/29970470)
Influenza A viruses cause an annual contagious respiratory disease in humans and are responsible for periodic high-mortality human pandemics. Pandemic influenza A viruses usually result from the reassortment ...

Obul M, etc.,al. Structural modification on rupestonic acid leads to highly potent inhibitors against influenza virus. Mol Divers. 2018 Jul 3..  Abstract  
submitted by kickingbird at 12 days ago from Mol Divers. 2018 Jul 3. (via https://www.ncbi.nlm.nih.gov/pubmed/29971616)
Influenza viruses are responsible for seasonal epidemics and occasional pandemics, which cause significant morbidity and mortality. Although several drugs (adamantanes and neuraminidase inhibitors) are ...

García-Pérez CA, etc.,al. Proteome-wide analysis of human motif-domain interactions mapped on influenza a virus. BMC Bioinformatics. 2018 Jun 25.  Abstract  
submitted by kickingbird at Jul, 3, 2018 from BMC Bioinformatics. 2018 Jun 25 (via https://www.ncbi.nlm.nih.gov/pubmed/29940841)
BACKGROUND: The influenza A virus (IAV) is a constant threat for humans worldwide. The understanding of motif-domain protein participation is essential to combat the pathogen.RESULTS: In this study, a ...

Makarkov AI, Patel AR, Bainov V, Ward BJ, et al. A novel serological assay for influenza based on DiD fluorescence dequenching that is free from observer bias and potentially automatable - A proof of concept study. Vaccine 2018;36:4485-4493.  Abstract  
submitted by kickingbird at Jul, 3, 2018 from Vaccine 2018;36:4485-4493 (via https://www.ncbi.nlm.nih.gov/m/pubmed/29929824/)
BACKGROUND: Serum hemagglutination inhibition (HAI) and microneutralization (MN) antibodies are often used as a correlate of protection for influenza. However, these manual assays are labor-intensive and ...

Ping X, Hu W, Xiong R, Zhang X, et a. Generation of a broadly reactive influenza H1 antigen using a consensus HA sequence. Vaccine 2018 Jun 27..  Abstract  
submitted by kickingbird at Jul, 3, 2018 from Vaccine 2018 Jun 27. (via https://www.ncbi.nlm.nih.gov/m/pubmed/29960799/)
H1N1, one of the most prevalent influenza A virus subtypes affecting the human population, can cause infections varying from mild respiratory syndrome to severe pneumonia. The current H1N1 vaccine needs ...

Liu F, Tzeng WP, Horner L, Kamal RP, et al.. Both Immune Priming and Egg-adaptation in the Vaccine Influence Antibody Responses to Circulating A(H1N1)pdm09 Viruses Following Influenza Vaccination in Adults. Infect Dis 2018 Jun 21.  Abstract  
submitted by kickingbird at Jul, 3, 2018 from Infect Dis 2018 Jun 21 (via https://www.ncbi.nlm.nih.gov/m/pubmed/29931203/)
Background: Although ferret antisera used in influenza surveillance did not detect antigenic drift of A(H1N1)pdm09 viruses during 2015-16 season, low vaccine effectiveness was reported in adults. We investigated ...

Root JJ, Bosco-Lauth AM, Marlenee NL, Bowen RA, et. Cottontail rabbits shed clade 2.3.4.4 H5 highly pathogenic avian influenza A viruses. Arch Virol 2018 Jun 13..  Abstract  
submitted by kickingbird at Jul, 3, 2018 from Arch Virol 2018 Jun 13. (via https://www.ncbi.nlm.nih.gov/m/pubmed/29948379/)
During 2014-2015, clade 2.3.4.4 H5Nx highly pathogenic (HP) avian influenza A viruses (IAV) were first detected in North America and subsequently caused one of the largest agricultural emergencies in U.S.HISTORY: ...

Prabhu SS, Chakraborty TT, Kumar N, Banerjee I. Association between IFITM3 rs12252 polymorphism and influenza susceptibility and severity: A meta-analysis. Gene. 2018 Jun 22.  Abstract  
submitted by kickingbird at Jun, 28, 2018 from Gene. 2018 Jun 22 (via https://www.ncbi.nlm.nih.gov/pubmed/29940276)
Intrinsic host susceptibility to viral infections plays a major role in determining infection severity in different individuals. In human influenza virus infections, multiple genetic association studies ...

Rim A, Nacira L, Abdeljelil G.. Viral interference between Low Pathogenic Avian Influenza H9N2 and avian infectious bronchitis viruses in vitro and in ovo. J Virol Methods. 2018 Jun 22.  Abstract  
submitted by kickingbird at Jun, 28, 2018 from J Virol Methods. 2018 Jun 22 (via https://www.ncbi.nlm.nih.gov/pubmed/29940196)
BACKGROUND: Low pathogenic avian influenza (LPAI) H9N2 and infectious bronchitis virus (IBV) are important pathogens of poultry, causing important economic losses for the sector. Replication interference ...

Hong SC, etc.,al. Discrimination of Avian Influenza Virus using Host-cell Infection Fingerprinting by Sulfinate-based Fluorescence Superoxide Probe. Angew Chem Int Ed Engl. 2018 Jun 22.  Abstract  
submitted by kickingbird at Jun, 28, 2018 from Angew Chem Int Ed Engl. 2018 Jun 22 (via https://www.ncbi.nlm.nih.gov/pubmed/29933516)
Avian Influenza (AI) caused an annual epidemic outbreak that led to destroying tens of millions of poultry worldwide. Current gold standard AI diagnosis method is an embryonic egg-based hemagglutination ...

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