Wang J, Wiltse A, Zand MS. A Complex Dance: Measuring the Multidimensional Worlds of Influenza Virus Evolution and Anti-Influenza Immune Responses. Pathogens. 2019 Nov 15;8(4). Abstract
submitted by kickingbird at 4 days ago from Pathogens. 2019 Nov 15;8(4) (via https://www.mdpi.com/2076-0817/8/4/238)
The human antibody response to influenza virus infection or vaccination is as complicated as it is essential for protection against flu. The constant antigenic changes of the virus to escape human herd ...
Londrigan SL, et al. IFITM3 and type I interferons are important for the control of influenza A virus replication in murine macrophages. Virology. 2019 Nov 5;540:17-22.. Abstract
submitted by kickingbird at 4 days ago from Virology. 2019 Nov 5;540:17-22. (via https://www.ncbi.nlm.nih.gov/pubmed/31731106)
Abortive infection of macrophages serves as a "dead end" for most seasonal influenza A virus (IAV) strains, and it is likely to contribute to effective host defence. Interferon (IFN)-induced transmembrane ...
Harding AT, Haas GD, Chambers BS, Heaton NS. Influenza viruses that require 10 genomic segments as antiviral therapeutics. PLoS Pathog. 2019 Nov 15;15(11):e1008098.. Abstract
submitted by kickingbird at 4 days ago from PLoS Pathog. 2019 Nov 15;15(11):e1008098. (via https://journals.plos.org/plospathogens/article?id=10.1371/j)
Influenza A viruses (IAVs) encode their genome across eight, negative sense RNA segments. During viral assembly, the failure to package all eight segments, or packaging a mutated segment, renders the resulting ...
Li R, Zhang T, Xu J, Chang J, Xu B. Novel Reassortant Avian Influenza A(H3N8) Virus Isolated from a Wild Bird in Jiangxi, China. Microbiol Resour Announc. 2019 Nov 14;8(46).. Abstract
submitted by kickingbird at 4 days ago from Microbiol Resour Announc. 2019 Nov 14;8(46). (via https://mra.asm.org/content/8/46/e01163-19)
Here, we report the detection of a reassortant avian influenza A(H3N8) virus isolated from a wild bird in Poyang Lake, Jiangxi, China, in 2014. Phylogenetic analyses indicated that this virus is most likely ...
Sultan HA, et al. Efficacy of Clade 2.3.2 H5-Recombinant Baculovirus Vaccine in Protecting Muscovy and Pekin Ducks from Clade 22.214.171.124 H5N8 Highly Pathogenic Avian Influenza Infection. Avian Dis. 2019 Mar 1;63(sp1):219-229.. Abstract
submitted by kickingbird at 8 days ago from Avian Dis. 2019 Mar 1;63(sp1):219-229. (via https://www.ncbi.nlm.nih.gov/pubmed/31713400)
In late 2016, a highly pathogenic avian influenza (HPAI) virus subtype H5N8 clade 126.96.36.199 was reported in Egypt in migratory birds; subsequently, the virus spread to backyard and commercial poultry in ...
Schreiber A, et al. Type I interferon antagonistic properties of Influenza B virus polymerase proteins. Cell Microbiol. 2019 Nov 11:e13143. Abstract
submitted by kickingbird at 8 days ago from Cell Microbiol. 2019 Nov 11:e13143 (via https://onlinelibrary.wiley.com/doi/abs/10.1111/cmi.13143)
The innate immune system, in particular the type I interferon (IFN) response, is a powerful defense against virus infections. In turn, many if not all viruses have evolved various means to circumvent, ...
Antanasijevic A, Durst MA, Lavie A, Caffrey M. Identification of a pH Sensor in Influenza Hemagglutinin using X-ray Crystallography. J Struct Biol. 2019 Nov 2:107412. Abstract
submitted by kickingbird at 11 days ago from J Struct Biol. 2019 Nov 2:107412 (via https://www.ncbi.nlm.nih.gov/pubmed/31689502)
Hemagglutnin (HA) mediates entry of influenza virus through a series of conformational changes triggered by the low pH of the endosome. The residue or combination of residues acting as pH sensors has not ...
Kwon HI, et al. A Novel Neuraminidase-Dependent Hemagglutinin Cleavage Mechanism Enables the Systemic Spread of an H7N6 Avian Influenza Virus. MBio. 2019 Nov 5;10(6). Abstract
submitted by kickingbird at 11 days ago from MBio. 2019 Nov 5;10(6) (via https://mbio.asm.org/content/10/6/e02369-19)
n this study, we demonstrate a novel mechanism for hemagglutinin (HA) activation in a naturally occurring H7N6 avian influenza A virus strain, A/mallard duck/Korea/6L/2007 (A/Mdk/6L/07). This novel mechanism ...
Coombs KM, et al. Aptamer Profiling of A549 Cells Infected with Low-Pathogenicity and High-Pathogenicity Influenza Viruses. Viruses. 2019 Nov 5;11(11).. Abstract
submitted by kickingbird at 11 days ago from Viruses. 2019 Nov 5;11(11). (via https://www.mdpi.com/1999-4915/11/11/1028)
Influenza A viruses (IAVs) are important animal and human emerging and re-emerging pathogens that are responsible for yearly seasonal epidemics and sporadic pandemics. IAVs cause a wide range of clinical ...
Gambaryan AS, et al. Changes in the Receptor-Binding Properties of H3N2 Viruses during Long-Term Circulation in Humans. Biochemistry (Mosc). 2019 Oct;84(10):1177-1185. Abstract
submitted by kickingbird at 11 days ago from Biochemistry (Mosc). 2019 Oct;84(10):1177-1185 (via https://www.ncbi.nlm.nih.gov/pubmed/31694513)
It was previously shown that hemagglutinin residues Thr155, Glu158, and Ser228 are crucial for the recognition of Neu5Gc. In this study, we demonstrated that the ability to bind the Neu5Gc-terminated receptor ...
Brown JC, Barclay WS, Galiano M, Harvey R. Passage of influenza A/H3N2 viruses in human airway cells removes artefactual variants associated with neuraminidase-mediated binding. J Gen Virol. 2019 Nov 8.. Abstract
submitted by kickingbird at 11 days ago from J Gen Virol. 2019 Nov 8. (via https://www.microbiologyresearch.org/content/journal/jgv/10.)
Serological assays with modern influenza A/H3N2 viruses have become problematic due to the progressive reduction in the ability of viruses of this subtype to bind and agglutinate red blood cells (RBCs). ...
Chen F, Liu T, Xu J, Huang Y, Liu S, Yang J. Key amino acid residues of neuraminidase involved in influenza A virus entry. Pathog Dis. 2019 Nov 8.. Abstract
submitted by kickingbird at 11 days ago from Pathog Dis. 2019 Nov 8. (via https://academic.oup.com/femspd/advance-article-abstract/doi)
Generally, influenza virus neuraminidase (NA) plays a critical role in the release stage of influenza virus. Recently, it has been found that NA may promote influenza virus to access the target cells. ...
Tapia F, Laske T, Wasik MA, Rammhold M, Genzel Y. Production of Defective Interfering Particles of Influenza A Virus in Parallel Continuous Cultures at Two Residence Times-Insights From qPCR Measurements and Viral Dynamics Modeling. Front Bioeng Biotechnol. 2019 Oct 18;7:275. Abstract
submitted by kickingbird at 15 days ago from Front Bioeng Biotechnol. 2019 Oct 18;7:275 (via https://www.frontiersin.org/articles/10.3389/fbioe.2019.0027)
Defective interfering particles (DIPs) are a natural byproduct of influenza A virus (IAV) replication. DIPs interfere with the propagation and spread of infectious standard virus (STV), reduce virus yields ...
Zhang F, et al. Phenotypic Characterization of Chinese Rhesus Macaque Plasmablasts for Cloning Antigen-Specific Monoclonal Antibodies. Front Immunol. 2019 Oct 11;10:2426. Abstract
submitted by kickingbird at 15 days ago from Front Immunol. 2019 Oct 11;10:2426 (via https://www.frontiersin.org/articles/10.3389/fimmu.2019.0242)
Rhesus macaques (Macaca mulatta) are used as a human-relevant animal species for the evaluation of vaccines and as a source for cloning monoclonal antibodies (mAbs) that are highly similar to human-derived ...
Li J, Zhang K, Fan W, Zhang S, Li Y, Gu J, Zhou J,. Transcriptome Profiling Reveals Differential Effect of Interleukin-17A Upon Influenza Virus Infection in Human Cells. Front Microbiol. 2019 Oct 10;10:2344.. Abstract
submitted by kickingbird at 15 days ago from Front Microbiol. 2019 Oct 10;10:2344. (via https://www.frontiersin.org/articles/10.3389/fmicb.2019.0234)
Influenza A virus (IAV) has developed elegant strategies to utilize cellular proteins and pathways to promote replication and evade the host antiviral response. Identification of these sabotaged host factors ...
Yang J, Li H, Jia L, Lan X, Zhao Y, Bian H, Li Z. High expression levels of influenza virus receptors in airway of the HBV-transgenic mice. Epidemiol Infect. 2019 Nov 4;147:e297.. Abstract
submitted by kickingbird at 15 days ago from Epidemiol Infect. 2019 Nov 4;147:e297. (via https://www.cambridge.org/core/journals/epidemiology-and-inf)
In the human population, influenza A viruses are associated with acute respiratory illness and are responsible for millions of deaths annually. Avian and human influenza viruses typically have a different ...
Ampomah PB, Lim LHK. Influenza A virus-induced apoptosis and virus propagation. Apoptosis. 2019 Oct 30. Abstract
submitted by kickingbird at Nov, 3, 2019 from Apoptosis. 2019 Oct 30 (via https://www.ncbi.nlm.nih.gov/pubmed/31667646)
Influenza A viruses (IAVs) are respiratory pathogens that cause severe morbidity and mortality worldwide. They affect cellular processes such as proliferation, protein synthesis, autophagy, and apoptosis. ...
Stadlbauer D, et al. Broadly protective human antibodies that target the active site of influenza virus neuraminidase. Science. 2019 Oct 25;366(6464):499-504.. Abstract
submitted by kickingbird at Oct, 29, 2019 from Science. 2019 Oct 25;366(6464):499-504. (via https://science.sciencemag.org/content/366/6464/499)
Better vaccines against influenza virus are urgently needed to provide broader protection against diverse strains, subtypes, and types. Such efforts are assisted by the identification of novel broadly ...
Wu L, et al. Characterization of H7N9 avian influenza viruses isolated from duck meat products. Transbound Emerg Dis. 2019 Oct 25.. Abstract
submitted by kickingbird at Oct, 29, 2019 from Transbound Emerg Dis. 2019 Oct 25. (via https://onlinelibrary.wiley.com/doi/abs/10.1111/tbed.13398)
Avian influenza H7N9 viruses have caused five epidemic waves of human infections since the first human cases were reported in 2013. In 2016, the initial low pathogenic avian influenza (LPAI) H7N9 viruses ...
Harada Y, et al. Comparison of suspension MDCK cells, adherent MDCK cells, and LLC-MK2 cells for selective isolation of influenza viruses to be used as vaccine seeds. Influenza Other Respir Viruses. 2019 Oct 25.. Abstract
submitted by kickingbird at Oct, 29, 2019 from Influenza Other Respir Viruses. 2019 Oct 25. (via https://onlinelibrary.wiley.com/doi/full/10.1111/irv.12694)
BACKGROUND: Cell-based influenza vaccines can solve the problem of the frequent occurrence of egg adaptation-associated antigenic changes observed in egg-based vaccines. Seed viruses for cell-based vaccines ...
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