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2019-9-23 19:37:51

Chesnokov A, et al. Replicative fitness of seasonal influenza A viruses with decreased susceptibility to baloxavir. J Infect Dis. 2019 Sep 21..  Abstract  
submitted by kickingbird at 10 hours ago from J Infect Dis. 2019 Sep 21. (via https://academic.oup.com/jid/advance-article/doi/10.1093/inf)
Susceptibility of influenza A viruses to baloxavir can be affected by changes at amino acid residue 38 in polymerase acidic (PA) protein. Information on replicative fitness of PA-I38-substituted viruses ...

Bekking C, et al. Evaluation of bioaerosol samplers for the detection and quantification of influenza virus from artificial aerosols and influenza virus-infected ferrets. Influenza Other Respir Viruses. 2019 Sep 21.  Abstract  
submitted by kickingbird at 10 hours ago from Influenza Other Respir Viruses. 2019 Sep 21 (via https://onlinelibrary.wiley.com/doi/full/10.1111/irv.12678)
BACKGROUND: Bioaerosol sampling devices are necessary for the characterization of infectious bioaerosols emitted by naturally-infected hosts with acute respiratory virus infections. Assessment of these ...

Chastagner A, Enouf V, Peroz D, et al. Bidirectional Human-Swine Transmission of Seasonal Influenza A(H1N1)pdm09 Virus in Pig Herd, France, 2018. Emerg Infect Dis. 2019;25(10):1940-1943.  Abstract  
submitted by kickingbird at 1 days ago from Emerg Infect Dis. 2019;25(10):1940-1943 (via https://wwwnc.cdc.gov/eid/article/25/10/19-0068_article)
In 2018, a veterinarian became sick shortly after swabbing sows exhibiting respiratory syndrome on a farm in France. Epidemiologic data and genetic analyses revealed consecutive human-to-swine and swine-to-human ...

Wille M, Lisovski S, Risely A, et al. Serologic Evidence of Exposure to Highly Pathogenic Avian Influenza H5 Viruses in Migratory Shorebirds, Australia. Emerg Infect Dis. 2019;25(10):1903-1910.  Abstract  
submitted by kickingbird at 1 days ago from Emerg Infect Dis. 2019;25(10):1903-1910 (via https://wwwnc.cdc.gov/eid/article/25/10/19-0699_article)
Highly pathogenic avian influenza (HPAI) H5Nx viruses of the goose/Guangdong/96 lineage continue to cause outbreaks in poultry and wild birds globally. Shorebirds, known reservoirs of avian influenza viruses, ...

Bai R, et al. Antigenic Variation of Avian Influenza A(H5N6) Viruses, Guangdong Province, China, 2014-2018. Emerg Infect Dis. 2019 Oct;25(10):1932-1945.  Abstract  
submitted by kickingbird at 1 days ago from Emerg Infect Dis. 2019 Oct;25(10):1932-1945 (via https://wwwnc.cdc.gov/eid/article/25/10/19-0274_article)
Market surveillance showed continuing circulation of avian influenza A(H5N6) virus in live poultry markets in Guangdong Province in 2017, despite compulsory vaccination for avian influenza A(H5Nx) and ...

Pohlmann A, et al. Genetic Characterization and Zoonotic Potential of Highly Pathogenic Avian Influenza Virus A(H5N6/H5N5), Germany, 2017-2018. Emerg Infect Dis. 2019 Oct;25(10):1973-1976..  Abstract  
submitted by kickingbird at 1 days ago from Emerg Infect Dis. 2019 Oct;25(10):1973-1976. (via https://wwwnc.cdc.gov/eid/article/25/10/18-1931_article)
We genetically characterized highly pathogenic avian influenza virus A(H5N6) clade isolates found in Germany in 2017-2018 and assessed pathogenicity of representative H5N5 and H5N6 viruses in ...

Sheng T, Sun Y, Sun J, Prinz RA, Peng D, et al. Role of TGF-β-activated kinase 1 (TAK1) activation in H5N1 influenza A virus-induced c-Jun terminal kinase activation and virus replication. Virology. 2019 Sep 10;537:263-271.  Abstract  
submitted by kickingbird at 1 days ago from Virology. 2019 Sep 10;537:263-271 (via https://www.sciencedirect.com/science/article/abs/pii/S00426)
Activation of c-Jun terminal kinase (JNK) by the nonstructural protein 1 (NS1) of the H5N1 subtype of influenza A virus (IAV) plays an important role in inducing autophagy and virus replication. However, ...

Yu Z, Cheng K, He H, Wu J. A novel reassortant influenza A (H1N1) virus infection in swine in Shandong Province, eastern China. Transbound Emerg Dis. 2019 Sep 19..  Abstract  
submitted by kickingbird at 2 days ago from Transbound Emerg Dis. 2019 Sep 19. (via https://onlinelibrary.wiley.com/doi/abs/10.1111/tbed.13360)
Influenza A (H1N1) viruses are distributed worldwide and pose a threat to public health. Swine, as a natural host and mixing vessel of influenza A (H1N1) virus, play a critical role in the transmission ...

Blackburn RM, et al. Nosocomial transmission of influenza: A retrospective cross-sectional study using next generation sequencing at a hospital in England (2012-2014). Influenza Other Respir Viruses. 2019 Sep 19.  Abstract  
submitted by kickingbird at 2 days ago from Influenza Other Respir Viruses. 2019 Sep 19 (via https://onlinelibrary.wiley.com/doi/full/10.1111/irv.12679)
BACKGROUND: The extent of transmission of influenza in hospital settings is poorly understood. Next generation sequencing may improve this by providing information on the genetic relatedness of viral strains.OBJECTIVES: ...

Gao S, Zhang W, Lu C, Cao M, Cen S, Peng Y, Deng T. Identification of a type-specific promoter element that differentiates between influenza A and B viruses. J Virol. 2019 Sep 18.  Abstract  
submitted by kickingbird at 2 days ago from J Virol. 2019 Sep 18 (via https://jvi.asm.org/content/early/2019/09/12/JVI.01164-19)
Type A and type B influenza viruses (FluA and FluB) are two major human pathogens that share common structural and functional features. FluA and FluB could reassort within each type but never between them. ...

Ciminski K, et al. Bat influenza viruses transmit among bats but are poorly adapted to non-bat species. Nat Microbiol. 2019 Sep 16..  Abstract  
submitted by kickingbird at 2 days ago from Nat Microbiol. 2019 Sep 16. (via https://www.nature.com/articles/s41564-019-0556-9)
Major histocompatibility complex class II (MHC-II) molecules of multiple species function as cell-entry receptors for the haemagglutinin-like H18 protein of the bat H18N11 influenza A virus, enabling tropism ...

Nemoto M, et al. Mutated influenza A virus exhibiting reduced susceptibility to baloxavir marboxil from an experimentally infected horse.. J Gen Virol. 2019 Sep 17..  Abstract  
submitted by kickingbird at 2 days ago from J Gen Virol. 2019 Sep 17. (via https://www.ncbi.nlm.nih.gov/pubmed/31526451)
Baloxavir marboxil (BXM), an inhibitor of the cap-dependent endonuclease of the influenza virus polymerase acidic protein (PA), exerts an antiviral effect against influenza A virus. It has been available ...

Wang W, et al. Generation of a protective murine monoclonal antibody against the stem of influenza hemagglutinins from group 1 viruses and identification of resistance mutations against it. PLoS One. 2019 Sep 12;14(9):e0222436..  Abstract  
submitted by kickingbird at 9 days ago from PLoS One. 2019 Sep 12;14(9):e0222436. (via https://journals.plos.org/plosone/article?id=10.1371/journal)
Vaccines that elicit broadly cross-neutralizing antibodies, including antibodies that target the conserved stem of hemagglutinin (HA), are being developed as a strategy for next-generation influenza vaccines ...

Wasik BR, et al. Influenza Viruses in Mice: Deep Sequencing Analysis of Serial Passage and Effects of Sialic Acid Structural Variation. J Virol. 2019 Sep 11.  Abstract  
submitted by kickingbird at 9 days ago from J Virol. 2019 Sep 11 (via https://jvi.asm.org/content/early/2019/09/06/JVI.01039-19)
Influenza A viruses have regularly jumped to new host species to cause epidemics or pandemics, an evolutionary process that involves variation in the viral traits necessary to overcome host barriers and ...

Kim CW, Yoo HJ, Park JH, Oh JE, Lee HK. Exogenous Interleukin-33 Contributes to Protective Immunity via Cytotoxic T-Cell Priming against Mucosal Influenza Viral Infection. Viruses. 2019 Sep 10;11(9)..  Abstract  
submitted by kickingbird at 9 days ago from Viruses. 2019 Sep 10;11(9). (via https://www.mdpi.com/1999-4915/11/9/840)
Influenza is an infectious respiratory illness caused by the influenza virus. Though vaccines against influenza exist, they have limited efficacy. To additionally develop effective treatments, there is ...

Yao L, et al. Identification of antigenic epitopes in the hemagglutinin protein of H7 avian influenza virus. Avian Pathol. 2019 Sep 11.  Abstract  
submitted by kickingbird at 9 days ago from Avian Pathol. 2019 Sep 11 (via https://www.tandfonline.com/doi/abs/10.1080/03079457.2019.16)
The H7 subtype avian influenza virus (AIV) has been reported to infect not only poultry but also humans. The hemagglutinin (HA) protein is the major surface antigen of AIV and plays an important role in ...

Daikoku T, et al. Growth activation of influenza virus by trypsin and effect of T-705 (favipiravir) on trypsin-optimized growth condition. Acta Virol. 2019;63(3):309-315.  Abstract  
submitted by kickingbird at 9 days ago from Acta Virol. 2019;63(3):309-315 (via http://www.elis.sk/index.php?page=shop.product_details&flypa)
Influenza virus is activated by proteolytic cleavage of hemagglutinin by trypsin. After determining the optimal trypsin concentration, intracellular and extracellular influenza A/PR/8/34 (H1N1) and A/Victoria/361/2011 ...

Bai N, Zhang J, Li L, Jin Z. Evaluating the effect of virus mutation on the transmission of avian influenza H7N9 virus in China based on dynamical model. Math Biosci Eng. 2019 Apr 18;16(5):3393-3410..  Abstract  
submitted by kickingbird at 11 days ago from Math Biosci Eng. 2019 Apr 18;16(5):3393-3410. (via https://www.aimspress.com/article/10.3934/mbe.2019170)
In 2017, the low pathogenic avian influenza H7N9 virus in China had mutated into high pathogenicity to domestic poultry, and led to a large number of poultry death and human cases. To evaluate the effect ...

Saucedo O, Martcheva M, Annor A. Computing human to human Avian influenza R0 via transmission chains and parameter estimation. Math Biosci Eng. 2019 Apr 19;16(5):3465-3487..  Abstract  
submitted by kickingbird at 11 days ago from Math Biosci Eng. 2019 Apr 19;16(5):3465-3487. (via https://www.aimspress.com/article/10.3934/mbe.2019174)
The transmission of avian influenza between humans is extremely rare, and it mostly affects individuals who are in contact with infected family member. Although this scenario is uncommon, there have been ...

A Andrews M, T Bauch C. Parameterizing a dynamic influenza model using longitudinal versus age-stratified case notifications yields different predictions of vaccine impacts. Math Biosci Eng. 2019 Apr 29;16(5):3753-3770..  Abstract  
submitted by kickingbird at 11 days ago from Math Biosci Eng. 2019 Apr 29;16(5):3753-3770. (via https://www.aimspress.com/article/10.3934/mbe.2019186)
Dynamic transmission models of influenza are sometimes used in decision-making to identify which vaccination strategies might best reduce influenza-associated health burdens. Our goal was to use laboratory ...

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