Li Z, Zhao Y, Li Y, Chen X. Adjuvantation of Influenza Vaccines to Induce Cross-Protective Immunity. Vaccines (Basel). 2021 Jan 21;9(2):75. Abstract
submitted by kickingbird at 5 hours ago from Vaccines (Basel). 2021 Jan 21;9(2):75 (via https://www.mdpi.com/2076-393X/9/2/75)
Influenza poses a huge threat to global public health. Influenza vaccines are the most effective and cost-effective means to control influenza. Current influenza vaccines mainly induce neutralizing antibodies ...
Luczo JM, Ronzulli SL, Tompkins SM. Influenza A Virus Hemagglutinin and Other Pathogen Glycoprotein Interactions with NK Cell Natural Cytotoxicity Receptors NKp46, NKp44, and NKp30. Viruses. 2021 Jan 21;13(2):156. Abstract
submitted by kickingbird at 5 hours ago from Viruses. 2021 Jan 21;13(2):156 (via https://www.mdpi.com/1999-4915/13/2/156)
Natural killer (NK) cells are part of the innate immunity repertoire, and function in the recognition and destruction of tumorigenic and pathogen-infected cells. Engagement of NK cell activating receptors ...
Borchering RK, Gunning CE, Gokhale DV, Weedop KB,. Anomalous influenza seasonality in the United States and the emergence of novel influenza B viruses. Proc Natl Acad Sci U S A. 2021 Feb 2;118(5):e20123. Abstract
submitted by kickingbird at 5 hours ago from Proc Natl Acad Sci U S A. 2021 Feb 2;118(5):e20123 (via https://www.pnas.org/content/118/5/e2012327118)
The 2019/2020 influenza season in the United States began earlier than any season since the 2009 H1N1 pandemic, with an increase in influenza-like illnesses observed as early as August. Also noteworthy ...
Briand FX, Niqueux E, Schmitz A, Martenot C, Cherb. Highly Pathogenic Avian Influenza A(H5N8) Virus Spread by Short- and Long-Range Transmission, France, 2016-17. Emerg Infect Dis. 2021 Feb;27(2):508-516. Abstract
submitted by kickingbird at 5 hours ago from Emerg Infect Dis. 2021 Feb;27(2):508-516 (via https://wwwnc.cdc.gov/eid/article/27/2/20-2920_article)
We detected 3 genotypes of highly pathogenic avian influenza A(H5N8) virus in France during winter 2016-17. Genotype A viruses caused dramatic economic losses in the domestic duck farm industry in southwestern ...
Harshbarger WD, Deming D, Lockbaum GJ, Attatippaho. Unique structural solution from a V H 3-30 antibody targeting the hemagglutinin stem of influenza A viruses. Nat Commun. 2021 Jan 25;12(1):559. Abstract
submitted by kickingbird at 5 hours ago from Nat Commun. 2021 Jan 25;12(1):559 (via https://www.nature.com/articles/s41467-020-20879-6)
Broadly neutralizing antibodies (bnAbs) targeting conserved influenza A virus (IAV) hemagglutinin (HA) epitopes can provide valuable information for accelerating universal vaccine designs. Here, we report ...
Bantle CM, French CT, Cummings JE, Sadasivan S, Tr. Manganese exposure in juvenile C57BL/6 mice increases glial inflammatory responses in the substantia nigra following infection with H1N1 influenza virus. PLoS One. 2021 Jan 25;16(1):e0245171. Abstract
submitted by kickingbird at 20 hours ago from PLoS One. 2021 Jan 25;16(1):e0245171 (via https://journals.plos.org/plosone/article?id=10.1371/journal)
Infection with Influenza A virus can lead to the development of encephalitis and subsequent neurological deficits ranging from headaches to neurodegeneration. Post-encephalitic parkinsonism has been reported ...
Brázda V, Porubiaková O, Cantara A, Bohálová N, Co. G-quadruplexes in H1N1 influenza genomes. BMC Genomics. 2021 Jan 23;22(1):77. Abstract
submitted by kickingbird at 1 days ago from BMC Genomics. 2021 Jan 23;22(1):77 (via https://bmcgenomics.biomedcentral.com/articles/10.1186/s1286)
Background: Influenza viruses are dangerous pathogens. Seventy-Seven genomes of recently emerged genotype 4 reassortant Eurasian avian-like H1N1 virus (G4-EA-H1N1) are currently available. We investigated ...
Cao L, Lou J, Zhao S, Chan RWY, Chan M, Wu WKK, Ch. In silico prediction of influenza vaccine effectiveness by sequence analysis. Vaccine. 2021 Jan 19:S0264-410X(21)00006-2. Abstract
submitted by kickingbird at 3 days ago from Vaccine. 2021 Jan 19:S0264-410X(21)00006-2 (via https://www.sciencedirect.com/science/article/pii/S0264410X2)
The effectiveness of seasonal influenza vaccines varies with the matching of vaccine strains to circulating strains. Based on the genetic distance of hemagglutinin and neuraminidase gene of the influenza ...
Zhang C, Cui H, Wang Z, Dong S, Zhang C, Li J, Men. Pathogenicity and transmissibility assessment of two strains of human influenza virus isolated in China in 2018. J Int Med Res. 2021 Jan;49(1):300060520982832. Abstract
submitted by kickingbird at 4 days ago from J Int Med Res. 2021 Jan;49(1):300060520982832 (via https://journals.sagepub.com/doi/10.1177/0300060520982832)
Objective: Influenza season occurs every year in China, but its presentation was unusual in the period from December 2017 to early 2018. During this period, influenza activity was increasing across the ...
Zhang Y, Zheng QC. In Silico Analysis Revealed a Unique Binding but Ineffective Mode of Amantadine to Influenza Virus B M2 Channel. J Phys Chem Lett. 2021 Jan 22:1169-1174. Abstract
submitted by kickingbird at 4 days ago from J Phys Chem Lett. 2021 Jan 22:1169-1174 (via https://pubs.acs.org/doi/10.1021/acs.jpclett.0c03560)
The M2 proton channel of influenza A (AM2) and B (BM2) have a highly conserved function motif, considered as the effective target. As yet, there is no effective drug against BM2. Research showed that AM2 ...
Laleye AT, Bianco A, Shittu I, Sulaiman L, Fusaro. Genetic characterization of Highly Pathogenic Avian Influenza H5Nx clade 184.108.40.206b reveals independent introductions in Nigeria. Transbound Emerg Dis. 2021 Jan 21. Abstract
submitted by kickingbird at 4 days ago from Transbound Emerg Dis. 2021 Jan 21 (via https://pubmed.ncbi.nlm.nih.gov/33480188/)
Among recurrent sanitary emergencies able to spread rapidly worldwide, avian influenza is one of the main constraints for animal health and food security. In West Africa, Nigeria has been experiencing ...
Wang F, Wu J, Wang Y, Wan Z, Shao H, Qian K, Ye J,. Identification of key residues involved in the neuraminidase antigenic variation of H9N2 influenza virus. Microbes Infect. 2021 Jan 19:1-27.. Abstract
submitted by kickingbird at 7 days ago from Microbes Infect. 2021 Jan 19:1-27. (via https://www.tandfonline.com/doi/full/10.1080/22221751.2021.1)
Influenza A H9N2 virus causes economic loss to the poultry industry and has likely contributed to the genesis of H5N1 and H7N9 viruses. The neuraminidase (NA) of H9N2 virus, like hemagglutinin, is under ...
Li Y, Li M, Tian J, Bai X, Li Y. Genetic characteristics and pathogenicity of novel reassortant H6 viruses isolated from wild birds in China. Vet Microbiol. 2021 Jan 6;254:108978. Abstract
submitted by kickingbird at 9 days ago from Vet Microbiol. 2021 Jan 6;254:108978 (via https://www.sciencedirect.com/science/article/pii/S037811352)
During our routine surveillance, we isolated seven H6 avian influenza virus (AIV) strains, including three H6N1 strains, three H6N2 strains, and one H6N8 strain, from 3667 fresh fecal samples that were ...
Ashar HK, Pulavendran S, Rudd JM, Maram P, Achanta. Administration of a CXCR2 antagonist, SCH527123, together with oseltamivir suppresses NETosis and protects mice from lethal influenza and piglets from swine-influenza infection. Am J Pathol. 2021 Jan 13:S0002-9440(21)00002-X. Abstract
submitted by kickingbird at 10 days ago from Am J Pathol. 2021 Jan 13:S0002-9440(21)00002-X (via https://pubmed.ncbi.nlm.nih.gov/33453177/)
Excessive neutrophil influx, their released neutrophil extracellular traps (NETs) and extracellular histones are associated with disease severity in influenza-infected patients. Neutrophil chemokine receptor ...
Gao R, Gu M, Shi L, Liu K, Li X, Wang X, Hu J, Liu. N-linked glycosylation at site 158 of the HA protein of H5N6 highly pathogenic avian influenza virus is important for viral biological properties and host immune responses. Vet Res. 2021 Jan 13;52(1):8. Abstract
submitted by kickingbird at 13 days ago from Vet Res. 2021 Jan 13;52(1):8 (via https://veterinaryresearch.biomedcentral.com/articles/10.118)
Since 2014, clade 220.127.116.11 has become the dominant epidemic branch of the Asian lineage H5 subtype highly pathogenic avian influenza virus (HPAIV) in southern and eastern China, while the H5N6 subtype is ...
Suntronwong N, Klinfueng S, Korkong S, Vichaiwatta. Characterizing genetic and antigenic divergence from vaccine strain of influenza A and B viruses circulating in Thailand, 2017-2020. Sci Rep. 2021 Jan 12;11(1):735. Abstract
submitted by kickingbird at 13 days ago from Sci Rep. 2021 Jan 12;11(1):735 (via https://www.nature.com/articles/s41598-020-80895-w)
We monitored the circulating strains and genetic variation among seasonal influenza A and B viruses in Thailand between July 2017 and March 2020. The hemagglutinin gene was amplified and sequenced. We ...
Zhang S, Yu JL, He L, Gong L, Hou S, Zhu M, Wu JB,. Molecular characteristics of the H9N2 avian influenza viruses in live poultry markets in Anhui Province, China, 2013 to 2018. Health Sci Rep. 2021 Jan 6;4(1):e230. Abstract
submitted by kickingbird at 13 days ago from Health Sci Rep. 2021 Jan 6;4(1):e230 (via https://pubmed.ncbi.nlm.nih.gov/33437876/)
Background and aims: H9N2 subtype avian influenza virus (AIV) has low-pathogenicity but causes respiratory symptoms and drop in egg production in chicken with long-term virus shedding, resulting in great ...
El Zowalaty ME, DeBeauchmp J, Jeevan T, Franks J,. Molecular detection of influenza A viruses and H5 subtype among migratory Amur falcons amurensis and captive birds of prey. Transbound Emerg Dis. 2021 Jan 11. Abstract
submitted by kickingbird at 15 days ago from Transbound Emerg Dis. 2021 Jan 11 (via https://pubmed.ncbi.nlm.nih.gov/33428819/)
Influenza A viruses (IAV) and Newcastle disease viruses (NDV) are major human and animal health threats with geographic differences in prevalence, characteristics, and host populations. Currently, there ...
Du R, Cheng H, Cui Q, Peet NP, Gaisina IN, Rong L. Identification of a novel inhibitor targeting influenza A virus group 2 hemagglutinins. Antiviral Res. 2021 Jan 8:105013. Abstract
submitted by kickingbird at 15 days ago from Antiviral Res. 2021 Jan 8:105013 (via https://pubmed.ncbi.nlm.nih.gov/33428962/)
Influenza A virus (IAV) causes seasonal epidemics and occasional but devastating pandemics, which are major public health concerns. The putative antiviral therapeutics are useful for the treatment of influenza, ...
Gu L, Zhou Y, Wang G, Deng H, Song X, He X, Wang T. Spatial learning and memory impaired after infection of non-neurotropic influenza virus in BALB/c male mice. Biochem Biophys Res Commun. 2021 Jan 8;540:29-36. Abstract
submitted by kickingbird at 15 days ago from Biochem Biophys Res Commun. 2021 Jan 8;540:29-36 (via https://pubmed.ncbi.nlm.nih.gov/33429197/)
During the influenza pandemic or seasonal influenza outbreak, influenza infection can cause acute influenza-associated encephalopathy/encephalitis (IAE), even death. Patients with severe IAE will also ...
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