Broszeit F, van Beek RJ, Unione L, Bestebroer TM,. Glycan remodeled erythrocytes facilitate antigenic characterization of recent A/H3N2 influenza viruses. Nat Commun. 2021 Sep 14;12(1):5449. Abstract
submitted by kickingbird at 3 days ago from Nat Commun. 2021 Sep 14;12(1):5449 (via https://www.nature.com/articles/s41467-021-25713-1)
During circulation in humans and natural selection to escape antibody recognition for decades, A/H3N2 influenza viruses emerged with altered receptor specificities. These viruses lost the ability to agglutinate ...
Ferenczi M, Beckmann C, Klaassen M. Rainfall driven and wild-bird mediated avian influenza virus outbreaks in Australian poultry. BMC Vet Res. 2021 Sep 14;17(1):306.. Abstract
submitted by kickingbird at 3 days ago from BMC Vet Res. 2021 Sep 14;17(1):306. (via https://bmcvetres.biomedcentral.com/articles/10.1186/s12917-)
Globally, outbreaks of Avian Influenza Virus (AIV) in poultry continue to burden economies and endanger human, livestock and wildlife health. Wild waterbirds are often identified as possible sources for ...
Staller E, Sheppard CM, Baillon L, Frise R, Peacoc. A natural variant in ANP32B impairs influenza virus replication in human cells. J Gen Virol. 2021 Sep;102(9). Abstract
submitted by kickingbird at 3 days ago from J Gen Virol. 2021 Sep;102(9) (via https://www.microbiologyresearch.org/content/journal/jgv/10.)
Viruses require host factors to support their replication, and genetic variation in such factors can affect susceptibility to infectious disease. Influenza virus replication in human cells relies on ANP32 ...
Si L, Bai H, Oh CY, Jin L, Prantil-Baun R, Ingber. Clinically Relevant Influenza Virus Evolution Reconstituted in a Human Lung Airway-on-a-Chip. Microbiol Spectr. 2021 Sep 15:e0025721. Abstract
submitted by kickingbird at 3 days ago from Microbiol Spectr. 2021 Sep 15:e0025721 (via https://journals.asm.org/doi/10.1128/Spectrum.00257-21)
Human-to-human transmission of viruses, such as influenza viruses and coronaviruses, can promote virus evolution and the emergence of new strains with increased potential for creating pandemics. Clinical ...
Villalón-Letelier F, Brooks AG, Londrigan SL. MARCH8 Restricts Influenza A Virus Infectivity but Does Not Downregulate Viral Glycoprotein Expression at the Surface of Infected Cells. mBio. 2021 Sep 14:e0148421. Abstract
submitted by kickingbird at 4 days ago from mBio. 2021 Sep 14:e0148421 (via https://journals.asm.org/doi/10.1128/mBio.01484-21)
Membrane-associated RING-CH8 (MARCH8) impairs the cell surface expression of envelope glycoproteins from different viruses, reducing their incorporation into virions. Using stable cell lines with inducible ...
Zhang L, Zheng X, Li J, Wang G, Hu Z, Chen Y, Wang. Long noncoding RNA#45 exerts broad inhibitory effect on influenza a virus replication via its stem ring arms. Virulence. 2021 Dec;12(1):2443-2460. Abstract
submitted by kickingbird at 4 days ago from Virulence. 2021 Dec;12(1):2443-2460 (via https://www.tandfonline.com/doi/full/10.1080/21505594.2021.1)
A growing body of evidence suggests the pivotal role of long non-coding RNA (lncRNA) in influenza virus infection. Based on next-generation sequencing, we previously demonstrated that Lnc45 was distinctively ...
Ren L, Zhang W, Zhang J, Zhang J, Zhang H, Zhu Y,. Influenza A Virus (H1N1) Infection Induces Glycolysis to Facilitate Viral Replication. Virol Sin. 2021 Sep 14.. Abstract
submitted by kickingbird at 4 days ago from Virol Sin. 2021 Sep 14. (via https://link.springer.com/article/10.1007%2Fs12250-021-00433)
Viruses depend on host cellular metabolism to provide the energy and biosynthetic building blocks required for their replication. In this study, we observed that influenza A virus (H1N1), a single-stranded, ...
Li X, Qiao S, Zhao Y, Gu M, Gao R, Liu K, Ge Z, Ma. G1-like PB2 gene improves virus replication and competitive advantage of H9N2 virus. Virus Genes. 2021 Sep 14. Abstract
submitted by kickingbird at 4 days ago from Virus Genes. 2021 Sep 14 (via https://link.springer.com/article/10.1007%2Fs11262-021-01870)
H9N2 subtype avian influenza virus has dramatically evolved and undergone extensive reassortment since its emergence in early 1990s in China. The genotype S (G57), emerging in 2007 with the substitution ...
Borkenhagen LK, Allen MW, Runstadler JA. Influenza Virus Genotype to Phenotype Predictions Through Machine Learning: A Systematic Review. Emerg Microbes Infect. 2021 Sep 9:1-58.. Abstract
submitted by kickingbird at 5 days ago from Emerg Microbes Infect. 2021 Sep 9:1-58. (via https://www.tandfonline.com/doi/full/10.1080/22221751.2021.1)
Background: There is great interest in understanding the viral genomic predictors of phenotypic traits that allow influenza A viruses to adapt to or become more virulent in different hosts. Machine learning ...
Rüdiger D, Pelz L, Hein MD, Kupke SY, Reichl U.. Multiscale model of defective interfering particle replication for influenza A virus infection in animal cell culture. PLoS Comput Biol. 2021 Sep 7;17(9):e1009357. Abstract
submitted by kickingbird at 11 days ago from PLoS Comput Biol. 2021 Sep 7;17(9):e1009357 (via https://journals.plos.org/ploscompbiol/article?id=10.1371/jo)
Cell culture-derived defective interfering particles (DIPs) are considered for antiviral therapy due to their ability to inhibit influenza A virus (IAV) production. DIPs contain a large internal deletion ...
Zhang Z, Guo F, Roy A, Yang J, Luo W, Shen X, Irwi. Evolutionary perspectives and adaptation dynamics of human seasonal influenza viruses from 2009 to 2019: An insight from codon usage. Infect Genet Evol. 2021 Sep 3:105067. Abstract
submitted by kickingbird at 11 days ago from Infect Genet Evol. 2021 Sep 3:105067 (via https://www.sciencedirect.com/science/article/abs/pii/S15671)
The annually recurrent seasonal influenza viruses, namely, influenza A viruses (H1N1/pdm2009 and H3N2) and influenza B viruses, contribute substantially to human disease burden. Elucidation of host adaptation, ...
Nacken W, Schreiber A, Masemann D, Ludwig S. The Effector Domain of the Influenza A Virus Nonstructural Protein NS1 Triggers Host Shutoff by Mediating Inhibition and Global Deregulation of Host Transcription When Associated with Specific Structu. mBio. 2021 Sep 7:e0219621. Abstract
submitted by kickingbird at 11 days ago from mBio. 2021 Sep 7:e0219621 (via https://journals.asm.org/doi/10.1128/mBio.02196-21)
Host shutoff in influenza A virus (IAV) infection is a key process contributing to viral takeover of the cellular machinery and resulting in the downregulation of host gene expression. Analysis of nascently ...
Allen JD, Ross TM. Evaluation of Next-Generation H3 Influenza Vaccines in Ferrets Pre-Immune to Historical H3N2 Viruses. Front Immunol. 2021 Aug 12;12:707339. Abstract
submitted by kickingbird at 12 days ago from Front Immunol. 2021 Aug 12;12:707339 (via https://www.frontiersin.org/articles/10.3389/fimmu.2021.7073)
Each person has a unique immune history to past influenza virus infections. Exposure to influenza viruses early in life establishes memory B cell populations that influence future immune responses to influenza ...
Freyn AW, Pine M, Rosado VC, Benz M, Muramatsu H,. Antigen modifications improve nucleoside-modified mRNA-based influenza virus vaccines in mice. Mol Ther Methods Clin Dev. 2021 Jun 12;22:84-95. Abstract
submitted by kickingbird at 12 days ago from Mol Ther Methods Clin Dev. 2021 Jun 12;22:84-95 (via https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8390451/)
Nucleoside-modified, lipid nanoparticle-encapsulated mRNAs have recently emerged as suitable vaccines for influenza viruses and other pathogens in part because the platform allows delivery of multiple ...
Ganti K, Han J, Manicassamy B, Lowen AC. Rab11a mediates cell-cell spread and reassortment of influenza A virus genomes via tunneling nanotubes. PLoS Pathog. 2021 Sep 2;17(9):e1009321. Abstract
submitted by kickingbird at Sep, 3, 2021 from PLoS Pathog. 2021 Sep 2;17(9):e1009321 (via https://journals.plos.org/plospathogens/article?id=10.1371/j)
Influenza A virus [IAV] genomes comprise eight negative strand RNAs packaged into virions in the form of viral ribonucleoproteins [vRNPs]. Rab11a plays a crucial role in the transport of vRNPs from the ...
Abraham M, Beavis AC, Xiao P, Villinger FJ, Li Z,. Evaluation of a new viral vaccine vector in mice and rhesus macaques: J paramyxovirus (JPV)-expressing HA of influenza A virus H5N1. J Virol. 2021 Sep 1:JVI0132121. Abstract
submitted by kickingbird at Sep, 2, 2021 from J Virol. 2021 Sep 1:JVI0132121 (via https://journals.asm.org/doi/10.1128/JVI.01321-21)
H5N1, an avian influenza virus, is known to circulate in many Asian countries like Bangladesh, China, Cambodia, Indonesia, and Vietnam. The current FDA-approved H5N1 vaccine has a moderate level of efficacy. ...
Horio Y, Shichiri M, Isegawa Y. Development of a method for evaluating the mRNA transcription activity of influenza virus RNA-dependent RNA polymerase through real-time reverse transcription polymerase chain reaction. Virol J. 2021 Aug 28;18(1):177. Abstract
submitted by kickingbird at Aug, 30, 2021 from Virol J. 2021 Aug 28;18(1):177 (via https://virologyj.biomedcentral.com/articles/10.1186/s12985-)
Background: The development of an influenza RNA-dependent RNA polymerase (RdRp) inhibitor is required; therefore, a method for evaluating the activity of influenza RdRp needs to be developed. The current ...
Namba T, Tsuge M, Yashiro M, Saito Y, Liu K, Nishi. Anti-high mobility group box 1 monoclonal antibody suppressed hyper-permeability and cytokine production in human pulmonary endothelial cells infected with influenza A virus. Inflamm Res. 2021 Aug 29. Abstract
submitted by kickingbird at Aug, 30, 2021 from Inflamm Res. 2021 Aug 29 (via https://link.springer.com/article/10.1007%2Fs00011-021-01496)
Objective: High mobility group box-1 (HMGB1) has been reported to be involved in influenza A virus-induced acute respiratory distress syndrome (ARDS). We studied the efficacy of an anti-HMGB1 mAb using ...
Jerry C, Stallknecht DE, Leyson C, Berghaus R, Jor. Age-Associated Changes in Recombinant H5 Highly Pathogenic and Low Pathogenic Avian Influenza Hemagglutinin Tissue Binding in Domestic Poultry Species. Animals (Basel). 2021 Jul 28;11(8):2223. Abstract
submitted by kickingbird at Aug, 30, 2021 from Animals (Basel). 2021 Jul 28;11(8):2223 (via https://www.mdpi.com/2076-2615/11/8/2223)
The 2014 outbreak of clade 18.104.22.168A highly pathogenic avian influenza (HPAI) led to the culling of millions of commercial chickens and turkeys and death of various wild bird species. In this outbreak, ...
Tarek M, Naguib MM, Arafa AS, Tantawy LA, Selim KM. Epidemiology, Genetic Characterization, and Pathogenesis of Avian Influenza H5N8 Viruses Circulating in Northern and Southern Parts of Egypt, 2017-2019. Animals (Basel). 2021 Jul 26;11(8):2208. Abstract
submitted by kickingbird at Aug, 30, 2021 from Animals (Basel). 2021 Jul 26;11(8):2208 (via https://www.mdpi.com/2076-2615/11/8/2208)
Highly pathogenic avian influenza (HPAI) viruses of subtype H5N8 continue to circulate, causing huge economic losses and serious impact on poultry production worldwide. Recently, HPAIV H5N8 has been spreading ...
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