Li Y, Sun L, Zheng W, Madina Mahesutihan, et al. Phosphorylation and dephosphorylation of threonine 188 in nucleoprotein is crucial for the replication of influenza A virus. Virology 2018;520:30-38. Abstract
submitted by kickingbird at 1 hours ago from Virology 2018;520:30-38 (via https://www.ncbi.nlm.nih.gov/m/pubmed/29775781/)
Nucleoprotein (NP) is a major component of the viral ribonucleoprotein (vRNP) complex that is responsible for viral replication, transcription and packaging of influenza A virus. Phosphorylation of NP ...
Venkatesh D, Poen MJ, Bestebroer TM, Scheuer RD, e. Avian influenza viruses in wild birds: virus evolution in a multi-host ecosystem. J Virol 2018 May 16.. Abstract
submitted by kickingbird at 1 hours ago from J Virol 2018 May 16. (via https://www.ncbi.nlm.nih.gov/m/pubmed/29769347/)
Wild ducks and gulls are the major reservoirs for avian influenza A viruses (AIVs). The mechanisms that drive AIV evolution are complex at sites where various duck and gull species from multiple flyways ...
Richards KA, Treanor JJ, Nayak JL, Sant AJ, et al.. Overarching Immunodominance Patterns and Substantial Diversity in Specificity and Functionality in the Circulating Human Influenza A and B CD4 T Cell Repertoire. J Infect Dis 2018 May 12. Abstract
submitted by kickingbird at 1 hours ago from J Infect Dis 2018 May 12 (via https://www.ncbi.nlm.nih.gov/m/pubmed/29762692/)
There is limited information on the antigen specificity and functional potential of the influenza-specific CD4 T cell repertoire in humans. Here, ELISPOT assays were used to examine circulating CD4 T cell ...
Califano D, Furuya Y, Metzger DW.. Effects of Influenza on Alveolar Macrophage Viability Are Dependent on Mouse Genetic Strain. J Immunol 2018 May 14. Abstract
submitted by kickingbird at 1 hours ago from J Immunol 2018 May 14 (via https://www.ncbi.nlm.nih.gov/m/pubmed/29760191/)
Secondary bacterial coinfections following influenza virus pose a serious threat to human health. Therefore, it is of significant clinical relevance to understand the immunological causes of this increased ...
Lu C, Yin Y, Meng F, Dun Y, Pei K, Wang C. Discovery of (E)-1-amino-4-phenylbut-3-en-2-ol derivatives as novel neuraminidase inhibitors. Bioorg Med Chem Lett. 2018 May 4. pii: S0960-894X(. Abstract
submitted by kickingbird at 3 days ago from Bioorg Med Chem Lett. 2018 May 4. pii: S0960-894X( (via https://www.ncbi.nlm.nih.gov/pubmed/29748050)
Neuraminidase has been considered as an important target for designing agents against influenza viruses. In a discovery of anti-influenza agents with epigoitrin as the initial lead compound, a series of ...
Alymova IV, McCullers JA, Kamal RP, Vogel P. Virulent PB1-F2 residues: effects on fitness of H1N1 influenza A virus in mice and changes during evolution of human influenza A viruses. Sci Rep. 2018 May 10;8(1):7474.. Abstract
submitted by kickingbird at 3 days ago from Sci Rep. 2018 May 10;8(1):7474. (via https://www.ncbi.nlm.nih.gov/pubmed/29749408)
Specific residues of influenza A virus (IAV) PB1-F2 proteins may enhance inflammation or cytotoxicity. In a series of studies, we evaluated the function of these virulence-associated residues in the context ...
Perot BP, Boussier J, Yatim N. Autophagy diminishes the early interferon-β response to influenza A virus resulting in differential expression of interferon-stimulated genes. Cell Death Dis. 2018 May 10;9(5):539.. Abstract
submitted by kickingbird at 3 days ago from Cell Death Dis. 2018 May 10;9(5):539. (via https://www.ncbi.nlm.nih.gov/pubmed/29748576)
Influenza A virus (IAV) infection perturbs metabolic pathways such as autophagy, a stress-induced catabolic pathway that crosstalks with cellular inflammatory responses. However, the impact of autophagy ...
Wang Y, Li J, Yan W, Chen Q, Jiang Z, Zhang R. An active component containing pterodontic acid and pterodondiol isolated from Laggera pterodonta inhibits influenza A virus infection through the TLR7/MyD88/TRAF6/NF?κB signaling pathway. Mol Med Rep. 2018 May 2.. Abstract
submitted by kickingbird at 3 days ago from Mol Med Rep. 2018 May 2. (via https://www.ncbi.nlm.nih.gov/pubmed/29749442)
The influenza virus is a pathogen that can cause pandemic and epidemic outbreaks, and therefore represents a severe threat to human health. Antiviral drugs have an important role in the prevention and ...
Mandour YM, Breitinger U, Ma C, Wang J. Symmetric dimeric adamantanes for exploring the structure of two viroporins: influenza virus M2 and hepatitis C virus p7. Drug Des Devel Ther. 2018 Apr 30;12:1019-1031.. Abstract
submitted by kickingbird at 3 days ago from Drug Des Devel Ther. 2018 Apr 30;12:1019-1031. (via https://www.ncbi.nlm.nih.gov/pubmed/29750015)
Background: Adamantane-based compounds have been identified to interfere with the ion-channel activity of viroporins and thereby inhibit viral infection. To better understand the difference in the inhibition ...
Rudneva IA, Timofeeva TA, Mukasheva EA. Pleiotropic effects of hemagglutinin amino acid substitutions of influenza A(H1N1)pdm09 virus escape mutants. Virus Res. 2018 May 10. Abstract
submitted by kickingbird at 3 days ago from Virus Res. 2018 May 10 (via https://www.ncbi.nlm.nih.gov/pubmed/29753891)
In the present study we assessed pleiotropic characteristics of the antibody-selected mutations. We investigated pH optimum of fusion, temperatures of HA heat inactivation, in vivo and in vitro replication ...
Spence KL, O´Sullivan TL, Poljak Z, Greer AL. Using a computer simulation model to examine the impact of biosecurity measures during a facility-level outbreak of equine influenza. Can J Vet Res. 2018 Apr;82(2):89-96.. Abstract
submitted by kickingbird at 3 days ago from Can J Vet Res. 2018 Apr;82(2):89-96. (via https://www.ncbi.nlm.nih.gov/pubmed/29755187)
On-farm biosecurity measures are an important part of a control plan to minimize the introduction and spread of infectious diseases, such as equine influenza, in an equine facility. It can be challenging, ...
Jegede A, Fu Q, Berhane Y, Lin M, Kumar A. H9N2 avian influenza virus retained low pathogenicity after serial passage in chickens. Can J Vet Res. 2018 Apr;82(2):131-138. Abstract
submitted by kickingbird at 3 days ago from Can J Vet Res. 2018 Apr;82(2):131-138 (via https://www.ncbi.nlm.nih.gov/pubmed/29755193)
The H9N2 strains of avian influenza viruses (AIVs) circulate worldwide in poultry and cause sporadic infection in humans. To better understand the evolution of these viruses while circulating in poultry, ...
Brown Jordan A, Narang D, Essen SC, Brookes SM. Serological Evidence for Influenza A Virus Exposure in Wild Birds in Trinidad & Tobago. Vet Sci. 2018 May 9;5(2).. Abstract
submitted by kickingbird at 3 days ago from Vet Sci. 2018 May 9;5(2). (via https://www.ncbi.nlm.nih.gov/pubmed/29747454)
Migratory waterfowl and shorebirds are known to be important reservoirs for influenza A viruses (IAV) and they have been repeatedly implicated as causing avian influenza virus (AIV) outbreaks in domestic ...
Lee S, Hirohama M, Noguchi M, Nagata K, Kawaguchi. Influenza A virus infection triggers pyroptosis and apoptosis of respiratory epithelial cells through type I IFN signaling pathway in a mutually exclusive manner. J Virol. 2018 May 9. Abstract
submitted by kickingbird at 6 days ago from J Virol. 2018 May 9 (via https://www.ncbi.nlm.nih.gov/pubmed/29743359)
Respiratory epithelial cell death by influenza virus infection is responsible for induction of inflammatory responses, but the exact cell death mechanism is not understood. Here we showed that influenza ...
Lin J, Xia J, Zhang T, Zhang K, Yang Q. Genome-wide profiling of microRNAs reveals novel insights into the interactions between H9N2 avian influenza virus and avian dendritic cells. Oncogene. 2018 May 10. Abstract
submitted by kickingbird at 6 days ago from Oncogene. 2018 May 10 (via https://www.ncbi.nlm.nih.gov/pubmed/29743596)
The antigen-presenting ability of dendritic cells (DCs) plays an important and irreplaceable role in recognising and clearing viruses. Antiviral responses must rapidly defend against infection while minimising ...
Wang YF, Chang CF, Tsai HP, etc.,al. Glycan-binding preferences and genetic evolution of human seasonal influenza A(H3N2) viruses during 1999~2007 in Taiwan. PLoS One. 2018 May 10;13(5):e0196727.. Abstract
submitted by kickingbird at 6 days ago from PLoS One. 2018 May 10;13(5):e0196727. (via https://www.ncbi.nlm.nih.gov/pubmed/29746492)
It is generally agreed that human influenza virus preferentially binds to α-2,6-linked sialic acid-containing receptors, and mutations that change the binding preference may alter virus infectivity and ...
Howard A, Uyeki TM, Fergie J. Influenza-Associated Acute Necrotizing Encephalopathy in Siblings. J Pediatric Infect Dis Soc. 2018 May 4.. Abstract
submitted by kickingbird at 6 days ago from J Pediatric Infect Dis Soc. 2018 May 4. (via https://www.ncbi.nlm.nih.gov/pubmed/29741717)
Encephalopathy is an important complication associated with influenza, most frequently observed in young children, with a wide range of severity. The most severe category of influenza-associated encephalopathy ...
Yamaguchi E, Fujii K, Ogawa H, Imai K. First detection of influenza A virus genes from wild raccoons in Japan. Virus Genes. 2018 May 8.. Abstract
submitted by kickingbird at 6 days ago from Virus Genes. 2018 May 8. (via https://www.ncbi.nlm.nih.gov/pubmed/29740778)
Serological surveys have shown that wild raccoons are exposed to influenza A viruses (IAVs); however, no genetic evidence for this IAV infection has been found. In the present study, we first detected ...
Koliopoulos MG, etc.,al. Molecular mechanism of influenza A NS1-mediated TRIM25 recognition and inhibition. Nat Commun. 2018 May 8;9(1):1820.. Abstract
submitted by kickingbird at 6 days ago from Nat Commun. 2018 May 8;9(1):1820. (via https://www.ncbi.nlm.nih.gov/pubmed/29739942)
RIG-I is a viral RNA sensor that induces the production of type I interferon (IFN) in response to infection with a variety of viruses. Modification of RIG-I with K63-linked poly-ubiquitin chains, synthesised ...
Chen L, Xing C, Ma G, Luo J, et al.. N-Myc Downstream-Regulated Gene 1 Facilitates Influenza A Virus Replication by Suppressing Canonical NF-κB Signaling. Virus Res 2018 May 3. Abstract
submitted by kickingbird at 7 days ago from Virus Res 2018 May 3 (via https://www.ncbi.nlm.nih.gov/m/pubmed/29730307/)
The highly pathogenic avian influenza (HPAI) A/H5N1 virus hijacks host cellular machinery to complete its life cycle; identification of the host factors involved in viral replication may facilitate antiviral ...
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