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2019-6-17 23:24:15
Article

Wu H, Yang F, Xiao Y, Liu F, Yao H, Wu N. Adaptive amino acid substitutions enhance the virulence of an avian-origin H6N1 influenza virus in mice. Infect Genet Evol. 2019 Jun 11:103918.  Abstract  
submitted by kickingbird at 1 days ago from Infect Genet Evol. 2019 Jun 11:103918 (via https://www.sciencedirect.com/science/article/pii/S156713481)
The H6N1 subtype avian influenza virus (AIV) is a zoonotic infectious disease pathogen, which poses a threat to human health. In order to study the possible substitution of H6N1 AIV for mammals, an avian-origin ...

Yang L, et al. Emergence of waterfowl-originated gene cassettes in HPAI H7N9 viruses caused severe human infection in Fujian, China. Influenza Other Respir Viruses. 2019 Jun 11.  Abstract  
submitted by kickingbird at 3 days ago from Influenza Other Respir Viruses. 2019 Jun 11 (via https://onlinelibrary.wiley.com/doi/full/10.1111/irv.12657)
BACKGROUND: Highly pathogenic avian influenza (HPAI) A(H7N9) virus emerged and caused human infections during the 2016-2017 epidemic wave of influenza A(H7N9) viruses in China. We report a human infection ...

Thomaston JL, Wu Y, Polizzi N, Liu L, et al. X-ray crystal structure of the influenza A M2 proton channel S31N mutant in two conformational states: an open and shut case. J Am Chem Soc. 2019 Jun 11..  Abstract  
submitted by kickingbird at 3 days ago from J Am Chem Soc. 2019 Jun 11. (via https://pubs.acs.org/doi/10.1021/jacs.9b02196)
The amantadine-resistant S31N mutant of the influenza A M2 proton channel has become prevalent in currently circulating viruses. Here we have solved an X-ray crystal structure of M2(22-46) S31N that contains ...

Qiang X, Kou Z. Scoring amino acid mutation to predict pandemic risk of avian influenza virus. BMC Bioinformatics. 2019 Jun 10.  Abstract  
submitted by kickingbird at 4 days ago from BMC Bioinformatics. 2019 Jun 10 (via https://bmcbioinformatics.biomedcentral.com/articles/10.1186)
BACKGROUND: Avian influenza virus can directly cross species barriers and infect humans with high fatality. As antigen novelty for human host, the public health is being challenged seriously. The pandemic ...

Du W, et al. The 2nd sialic acid-binding site of influenza A virus neuraminidase is an important determinant of the hemagglutinin-neuraminidase-receptor balance. PLoS Pathog. 2019 Jun 10;15(6):e1007860.  Abstract  
submitted by kickingbird at 4 days ago from PLoS Pathog. 2019 Jun 10;15(6):e1007860 (via https://journals.plos.org/plospathogens/article?id=10.1371/j)
Influenza A virus (IAV) neuraminidase (NA) receptor-destroying activity and hemagglutinin (HA) receptor-binding affinity need to be balanced with the host receptor repertoire for optimal viral fitness. ...

Eladl AH, Alzayat AA, Ali HS, Fahmy HA, Ellakany H. Comparative molecular characterization, pathogenicity and seroprevalence of avian influenza virus H9N2 in commercial and backyard poultry flocks. Comp Immunol Microbiol Infect Dis. 2019 Jun;64:81-.  Abstract  
submitted by kickingbird at 6 days ago from Comp Immunol Microbiol Infect Dis. 2019 Jun;64:81- (via https://www.sciencedirect.com/science/article/pii/S014795711)
This study was conducted to perform the comparative molecular characterization of avian influenza virus (AIV) H9N2, pathogenicity and seroprevalence in commercial and backyard poultry flocks. Fifty commercial ...

Musharrafieh R, et al. The L46P mutant confers a novel allosteric mechanism of resistance towards the influenza A virus M2 S31N proton channel blockers. Mol Pharmacol. 2019 Jun 7.  Abstract  
submitted by kickingbird at 6 days ago from Mol Pharmacol. 2019 Jun 7 (via http://molpharm.aspetjournals.org/content/early/2019/06/07/m)
The FDA-approved influenza A antiviral amantadine inhibits the wild-type (WT) AM2 channel but not the S31N mutant predominantly found in circulating strains. In this study, serial viral passages were applied ...

Jia R, et al. Design, synthesis and biological evaluation of "Multi-Site"-binding influenza virus neuraminidase. Eur J Med Chem. 2019 May 30;178:64-80.  Abstract  
submitted by kickingbird at 6 days ago from Eur J Med Chem. 2019 May 30;178:64-80 (via https://www.sciencedirect.com/science/article/pii/S022352341)
Encouraged by our earlier discovery of neuraminidase inhibitors targeting 150-cavity or 430-cavity, herein, to yield more potent inhibitors, we designed, synthesized, and biologically evaluated a series ...

Artarini A, et al. Regulation of influenza a virus mRNA splicing by CLK1. Antiviral Res. 2019 Jun 6.  Abstract  
submitted by kickingbird at 6 days ago from Antiviral Res. 2019 Jun 6 (via https://www.sciencedirect.com/science/article/pii/S016635421)
Influenza A virus carries eight negative single-stranded RNAs and uses spliced mRNAs to increase the number of proteins produced from them. Several genome-wide screens for essential host factors for influenza ...

Bergmann S, Elbahesh H. Targeting the proviral host kinase, FAK, limits influenza a virus pathogenesis and NFkB-regulated pro-inflammatory responses. Virology. 2019 Jun 1;534:54-63..  Abstract  
submitted by kickingbird at 6 days ago from Virology. 2019 Jun 1;534:54-63. (via https://www.sciencedirect.com/science/article/abs/pii/S00426)
Influenza A virus (IAV) infections result in ~500,000 global deaths annually. Host kinases link multiple signaling pathways at various stages of infection and are attractive therapeutic target. Focal adhesion ...

Yuan B, et al. The tree shrew is a promising model for the study of influenza B virus infection. Virol J. 2019 Jun 7;16(1):77.  Abstract  
submitted by kickingbird at 7 days ago from Virol J. 2019 Jun 7;16(1):77 (via https://virologyj.biomedcentral.com/articles/10.1186/s12985-)
BACKGROUND: Influenza B virus is a main causative pathogen of annual influenza epidemics, however, research on influenza B virus in general lags behind that on influenza A viruses, one of the important ...

Ghafouri SA, et al. Full genome characterization of Iranian H5N8 highly pathogenic avian influenza virus from Hooded Crow (Corvus cornix), 2017: The first report. Comp Immunol Microbiol Infect Dis. 2019 Jun;64:73-.  Abstract  
submitted by kickingbird at 7 days ago from Comp Immunol Microbiol Infect Dis. 2019 Jun;64:73- (via https://www.sciencedirect.com/science/article/pii/S014795711)
During 2014-2017 Clade 2.3.4.4 H5N8 highly pathogenic avian influenza viruses (HPAIVs) have spread worldwide. In 2016, an epidemic of HPAIV H5N8 in Iran caused mass deaths among wild birds, and several ...

Kouba T, Drncová P, Cusack S. Structural snapshots of actively transcribing influenza polymerase. Nat Struct Mol Biol. 2019 Jun;26(6):460-470.  Abstract  
submitted by kickingbird at 8 days ago from Nat Struct Mol Biol. 2019 Jun;26(6):460-470 (via https://www.nature.com/articles/s41594-019-0232-z)
Influenza virus RNA-dependent RNA polymerase uses unique mechanisms to transcribe its single-stranded genomic viral RNA (vRNA) into messenger RNA. The polymerase is initially bound to a promoter comprising ...

Park SC, et al. Pathogenicity of clade 2.3.4.4 H5N6 highly pathogenic avian influenza virus in three chicken breeds from South Korea in 2016/2017. J Vet Sci. 2019 May;20(3):e27.  Abstract  
submitted by kickingbird at 8 days ago from J Vet Sci. 2019 May;20(3):e27 (via https://synapse.koreamed.org/DOIx.php?id=10.4142/jvs.2019.20)
In 2016, novel H5N6 highly pathogenic avian influenza virus emerged in Korea. During the outbreak, the virus caused the largest culling, especially in brown chicken lines. We determined the pathogenicity ...

Kim JI, et al. Novel small molecule targeting the hemagglutinin stalk of influenza viruses. J Virol. 2019 Jun 5..  Abstract  
submitted by kickingbird at 8 days ago from J Virol. 2019 Jun 5. (via https://jvi.asm.org/content/early/2019/05/30/JVI.00878-19)
Combating influenza is one of the perennial global public health issues to be managed. Antiviral drugs are useful for the treatment of influenza in the absence of an appropriate vaccine. However, the appearance ...

Nooruzzaman M, et al. A new reassortant clade 2.3.2.1a H5N1 highly pathogenic avian influenza virus causing recent outbreaks in ducks, geese, chickens and turkeys in Bangladesh. Transbound Emerg Dis. 2019 Jun 6..  Abstract  
submitted by kickingbird at 8 days ago from Transbound Emerg Dis. 2019 Jun 6. (via https://onlinelibrary.wiley.com/doi/abs/10.1111/tbed.13264)
A total of 15 dead or sick birds from 13 clinical outbreaks of avian influenza in ducks, geese, chickens and turkeys in 2017 in Bangladesh were examined. The presence of H5N1 influenza A virus in the affected ...

Zhong W, Levine MZ. Stockpiled avian influenza A(H7N9) vaccines induce robust, non-neutralizing functional antibodies against antigenically drifted 5th wave A(H7N9) viruses. J Infect Dis. 2019 Jun 5..  Abstract  
submitted by kickingbird at 8 days ago from J Infect Dis. 2019 Jun 5. (via https://academic.oup.com/jid/advance-article/doi/10.1093/inf)
Human infections caused by avian influenza A(H7N9) viruses have raised concerns of a pandemic. The capability of the current stockpiled A(H7N9) vaccines to induce cross-protective, non-neutralizing functional ...

Yu Z, Cheng K, Wang T, Ren Z, Wu J, He H, Gao Y. Two mutations in viral protein enhance the adaptation of waterfowl-origin H3N2 virus in murine model. Virus Res. 2019 Jun 4. pii: S0168-1702(19)30049-8.  Abstract  
submitted by kickingbird at 8 days ago from Virus Res. 2019 Jun 4. pii: S0168-1702(19)30049-8 (via https://www.sciencedirect.com/science/article/abs/pii/S01681)
After serial passage of a waterfowl-origin H3N2 subtype avian influenza virus in BALB/c mice, we obtained H3N2 mouse-adapted variants and identified eight amino acid substitutions in five viral proteins ...

Huang SY, et al. Novel Role for miR-1290 in Host Species Specificity of Influenza A Virus. Mol Ther Nucleic Acids. 2019 May 15;17:10-23..  Abstract  
submitted by kickingbird at 8 days ago from Mol Ther Nucleic Acids. 2019 May 15;17:10-23. (via https://www.cell.com/molecular-therapy-family/nucleic-acids/)
The role of microRNA (miRNA) in influenza A virus (IAV) host species specificity is not well understood as yet. Here, we show that a host miRNA, miR-1290, is induced through the extracellular signal-regulated ...

Meng W, et al. New evidence for the east-west spread of the highly pathogenic avian influenza H5N1 virus between Central Asian and east Asian-Australasian flyways in China. Emerg Microbes Infect. 2019;8(1):823-826..  Abstract  
submitted by kickingbird at 11 days ago from Emerg Microbes Infect. 2019;8(1):823-826. (via https://www.tandfonline.com/doi/full/10.1080/22221751.2019.1)
The spread of highly pathogenic avian influenza (HPAI) H5N1 virus is associated with wild fowl migration in East Asian-Australasian (EA) and Central Asian (CA) flyways. However, the spread of H5N1 virus ...

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