Jones TE. Oseltamivir - Current dosing recommendations reduce the therapeutic benefit in patients with mild to moderate renal function and/or large body mass. A review of the literature with recommendations to. her Drug Monit. 2020;10.1097/FTD.0000000000000797. Abstract
submitted by kickingbird at 2 days ago from her Drug Monit. 2020;10.1097/FTD.0000000000000797 (via https://pubmed.ncbi.nlm.nih.gov/32947554/)
Purpose: Oseltamivir is indicated for the treatment and prophylaxis of Influenza infections. Achieving therapeutic concentrations EARLY in the course of the infection impacts greatly on the magnitude of ...
Tang L, Tang W, Li X, et al. Avian Influenza Virus Prevalence and Subtype Diversity in Wild Birds in Shanghai, China, 2016-2018. Viruses. 2020;12(9):E1031. Abstract
submitted by kickingbird at 2 days ago from Viruses. 2020;12(9):E1031 (via https://www.mdpi.com/1999-4915/12/9/1031)
From 2016 to 2018, surveillance of influenza A viruses in wild birds was conducted in Shanghai, located at the East Asian-Australian flyway, China. A total of 5112 samples from 51 species of wild birds ...
Olsen SJ, Azziz-Baumgartner E, Budd AP, et al. Decreased Influenza Activity During the COVID-19 Pandemic — United States, Australia, Chile, and South Africa, 2020. MMWR Morb Mortal Wkly Rep. 2020;69(37):1305-1309. Abstract
submitted by kickingbird at 4 days ago from MMWR Morb Mortal Wkly Rep. 2020;69(37):1305-1309 (via https://www.cdc.gov/mmwr/volumes/69/wr/mm6937a6.htm)
After recognition of widespread community transmission of SARS-CoV-2, the virus that causes coronavirus disease 2019 (COVID-19), by mid- to late February 2020, indicators of influenza activity began to ...
Zhu Y, Wang R, Yu L, et al. Human TRA2A determines influenza A virus host adaptation by regulating viral mRNA splicing. Sci Adv. 2020;6(25):eaaz5764. Abstract
submitted by kickingbird at 4 days ago from Sci Adv. 2020;6(25):eaaz5764 (via https://advances.sciencemag.org/content/6/25/eaaz5764)
Several avian influenza A viruses (IAVs) have adapted to mammalian species, including humans. To date, the mechanisms enabling these host shifts remain incompletely understood. Here, we show that a host ...
Caliendo V, Leijten L, Begeman L, et al. Enterotropism of highly pathogenic avian influenza virus H5N8 from the 2016/2017 epidemic in some wild bird species. Vet Res. 2020;51(1):117. Abstract
submitted by kickingbird at 6 days ago from Vet Res. 2020;51(1):117 (via https://veterinaryresearch.biomedcentral.com/articles/10.118)
In 2016/2017, H5N8 highly pathogenic avian influenza (HPAI) virus of the Goose/Guangdong lineage spread from Asia to Europe, causing the biggest and most widespread HPAI epidemic on record in wild and ...
Bruce-Staskal PJ, Woods RM, Borisov OV, Massare MJ. Hemagglutinin from multiple divergent influenza A and B viruses bind to a distinct branched, sialylated poly-LacNAc glycan by surface plasmon resonance. Vaccine. 2020;S0264-410X(20)31078-1. Abstract
submitted by kickingbird at 6 days ago from Vaccine. 2020;S0264-410X(20)31078-1 (via https://www.sciencedirect.com/science/article/pii/S0264410X2)
Influenza viruses initiate infection via specific interactions of hemagglutinin (HA) with host cell surface sialic acid-containing glycans. Antigenic drift has resulted in HA amino acid sequence changes ...
Liu WJ, Wu Y, Bi Y, et al.. Emerging HxNy Influenza A Viruses. Cold Spring Harb Perspect Med. 2020;a038406. Abstract
submitted by kickingbird at 6 days ago from Cold Spring Harb Perspect Med. 2020;a038406 (via http://perspectivesinmedicine.cshlp.org/content/early/2020/0)
The continuous emergence and reemergence of diverse subtypes of influenza A viruses, which are known as "HxNy" and are mediated through the reassortment of viral genomes, account for seasonal epidemics, ...
Xia J, Kuang Y, Liang J, Jones M, Swain SL. Influenza Vaccine-Induced CD4 Effectors Require Antigen Recognition at an Effector Checkpoint to Generate CD4 Lung Memory and Antibody Production. J Immunol. 2020;ji2000597. Abstract
submitted by kickingbird at 6 days ago from J Immunol. 2020;ji2000597 (via https://www.jimmunol.org/content/early/2020/09/12/jimmunol.2)
Previously, we discovered that influenza-generated CD4 effectors must recognize cognate Ag at a defined effector checkpoint to become memory cells. Ag recognition was also required for efficient protection ...
Boussier J, Munier S, Achouri E, et al. RNA-seq accuracy and reproducibility for the mapping and quantification of influenza defective viral genomes. RNA. 2020;rna.077529.120. Abstract
submitted by kickingbird at 6 days ago from RNA. 2020;rna.077529.120 (via https://rnajournal.cshlp.org/content/early/2020/09/14/rna.07)
Like most RNA viruses, influenza viruses generate defective viral genomes (DVGs) with large internal deletions during replication. There is accumulating evidence supporting a biological relevance of such ...
Watkins LC, DeGrado WF, Voth GA. Influenza A M2 Inhibitor Binding Understood through Mechanisms of Excess Proton Stabilization and Channel Dynamics. J Am Chem Soc. 2020;10.1021/jacs.0c06419.. Abstract
submitted by kickingbird at 6 days ago from J Am Chem Soc. 2020;10.1021/jacs.0c06419. (via https://pubs.acs.org/doi/10.1021/jacs.0c06419)
Prevalent resistance to inhibitors that target the influenza A M2 proton channel has necessitated a continued drug design effort, supported by a sustained study of the mechanism of channel function and ...
Ruiz S, Jimenez-Bluhm P, Di Pillo F, et al. Temporal dynamics and the influence of environmental variables on the prevalence of avian influenza virus in main wetlands in central chile. Transbound Emerg Dis. 2020;10.1111/tbed.13831. Abstract
submitted by kickingbird at 6 days ago from Transbound Emerg Dis. 2020;10.1111/tbed.13831 (via https://pubmed.ncbi.nlm.nih.gov/32931631/)
Although wild birds are considered the main reservoir of the influenza A virus (IAV) in nature, empirical investigations exploring the interaction between the IAV prevalence in these populations and environmental ...
Steiner F, Pavlovic J. Subcellular localization of MxB determines its antiviral potential against influenza A virus. J Virol. 2020;JVI.00125-20. Abstract
submitted by kickingbird at 9 days ago from J Virol. 2020;JVI.00125-20 (via https://jvi.asm.org/content/early/2020/09/03/JVI.00125-20)
Mx proteins are interferon (IFN) type I (α/β) and type III (λ) induced effector proteins with intrinsic antiviral activity. Mammalian Mx proteins show different subcellular localizations and distinct yet ...
Liu Z, Geng X, Cui Z, Li W, Ou X, Liao G. Construction and identification of influenza plasmid pool imparting high yields to candidate vaccine viruses in Vero cell at low temperature. J Cell Mol Med. 2020;10.1111/jcmm.15672. Abstract
submitted by kickingbird at 12 days ago from J Cell Mol Med. 2020;10.1111/jcmm.15672 (via https://pubmed.ncbi.nlm.nih.gov/32902192/)
We generated plasmid pools for the rapid preparation of candidate vaccine strains, which could grow in the Vero cells at low temperature. Firstly, we cloned in the pHW2000 plasmid each of the eight gene ...
Peukes J, Xiong X, Erlendsson S, et al. The native structure of the assembled matrix protein 1 of influenza A virus. Nature. 2020;10.1038/s41586-020-2696-8. Abstract
submitted by kickingbird at 12 days ago from Nature. 2020;10.1038/s41586-020-2696-8 (via https://www.nature.com/articles/s41586-020-2696-8)
Influenza A virus causes millions of severe cases of disease during annual epidemics. The most abundant protein in influenza virions is matrix protein 1 (M1), which mediates virus assembly by forming an ...
Song J, Sun H, Sun H, et al. Swine microRNAs ssc-miR-221-3p and ssc-miR-222 restrict the cross-species infection of avian influenza virus. J Virol. 2020;JVI.01700-20. Abstract
submitted by kickingbird at 12 days ago from J Virol. 2020;JVI.01700-20 (via https://jvi.asm.org/content/early/2020/09/08/JVI.01700-20)
Avian influenza virus (AIV) can cross species barriers to infect humans and other mammals. However, these species-cross transmissions are most often dead-end infection due to host restriction. Current ...
El-Shesheny R, Franks J, Turner J, et al. Continued Evolution of H5Nx Avian Influenza Viruses in Bangladeshi Live Poultry Markets: Pathogenic Potential in Poultry and Mammalian Models. J Virol. 2020;JVI.01141-20. Abstract
submitted by kickingbird at 12 days ago from J Virol. 2020;JVI.01141-20 (via https://jvi.asm.org/content/early/2020/09/03/JVI.01141-20)
The genesis of novel influenza viruses through reassortment poses a continuing risk to public health. This is of particular concern in Bangladesh, where highly pathogenic avian influenza viruses of the ...
Kirkpatrick E, Henry C, McMahon M, et al. Characterization of novel cross-reactive influenza B virus hemagglutinin head specific antibodies that lack hemagglutinin inhibition activity. J Virol. 2020;JVI.01185-20. Abstract
submitted by kickingbird at 12 days ago from J Virol. 2020;JVI.01185-20 (via https://jvi.asm.org/content/early/2020/09/03/JVI.01185-20)
Humoral immune responses to influenza virus vaccines in elderly individuals are poorly adapted towards new antigenically drifted influenza virus strains. Instead, older individuals respond in an original ...
Kalonda A, Saasa N, Nkhoma P, et al. Avian Influenza Viruses Detected in Birds in Sub-Saharan Africa: A Systematic Review. Viruses. 2020;12(9):E993. Abstract
submitted by kickingbird at 12 days ago from Viruses. 2020;12(9):E993 (via https://pubmed.ncbi.nlm.nih.gov/32906666/)
In the recent past, sub-Saharan Africa has not escaped the devastating effects of avian influenza virus (AIV) in poultry and wild birds. This systematic review describes the prevalence, spatiotemporal ...
Liu M, Deng L, Wang D, Jiang T. Influenza activity during the outbreak of coronavirus disease 2019 in mainland China. Biosaf Health. 2020;10.1016/j.bsheal.2020.08.005. Abstract
submitted by kickingbird at 12 days ago from Biosaf Health. 2020;10.1016/j.bsheal.2020.08.005 (via https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7462755/)
Since coronavirus disease 2019 (COVID-19) might circulate in the following seasons, it is essential to understand how COVID-19 influences other respiratory diseases, especially influenza. In this study, ...
Dawson AR, Wilson GM, Freiberger EC, Mondal A, Coo. Phosphorylation controls RNA binding and transcription by the influenza virus polymerase. PLoS Pathog. 2020;16(9):e1008841. Abstract
submitted by kickingbird at Sep, 7, 2020 from PLoS Pathog. 2020;16(9):e1008841 (via https://journals.plos.org/plospathogens/article?id=10.1371/j)
The influenza virus polymerase transcribes and replicates the viral genome. The proper timing and balance of polymerase activity is important for successful replication. Genome replication is controlled ...
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