Zhou P, Qiu T, Wang X, Yang X, Shi H, Zhu C, Dai W. One HA stalk topping multiple heads as a novel influenza vaccine. Emerg Microbes Infect. 2023 Dec 4:2290838. Abstract
submitted by kickingbird at 5 days ago from Emerg Microbes Infect. 2023 Dec 4:2290838 (via https://www.tandfonline.com/doi/full/10.1080/22221751.2023.2)
Classic chimeric hemagglutinin (cHA) was designed to induce immune responses against the conserved stalk domain of HA. However, it is unclear whether combining more than one HA head domain onto one stalk ...
Yuan L, Li X, Li M, Bi R, Li Y, Song J, Li W, Yan. In silico design of a broad-spectrum multiepitope vaccine against influenza virus. Int J Biol Macromol. 2023 Nov 13:128071. Abstract
submitted by kickingbird at Nov, 16, 2023 from Int J Biol Macromol. 2023 Nov 13:128071 (via https://www.sciencedirect.com/science/article/abs/pii/S01418)
Influenza remains a global health concern due to its potential to cause pandemics as a result of rapidly mutating influenza virus strains. Existing vaccines often struggle to keep up with these rapidly ...
Spackman E, Suarez DL, Lee CW, Pantin-Jackwood MJ, Lee SA, Youk S, Ibrahim S. Efficacy of inactivated and RNA particle vaccines against a North American Clade 22.214.171.124b H5 highly pathogenic avian influenza virus in chickens. Vaccine. 2023 Nov 4:S0264-410X(23)01285-9. Abstract
submitted by kickingbird at Nov, 7, 2023 from Vaccine. 2023 Nov 4:S0264-410X(23)01285-9 (via https://www.sciencedirect.com/science/article/pii/S0264410X2)
Highly pathogenic avian influenza virus (HPAIV) has caused widespread outbreaks in poultry in the Americas. Because of the duration and extent of these outbreaks, vaccine use may be an additional tool ...
Li Y, Shang J, Wang Y, Luo J, Jiang W, Yin X, Zhan. Establishment of two assays based on reverse transcription recombinase-aided amplification technology for rapid detection of H5 subtype avian influenza virus. Microbiol Spectr. 2023 Oct 9:e0218623. Abstract
submitted by kickingbird at Oct, 12, 2023 from Microbiol Spectr. 2023 Oct 9:e0218623 (via https://journals.asm.org/doi/10.1128/spectrum.02186-23)
The avian influenza virus (AIV), a member of the type A influenza virus group, is harbored by avian hosts. The highly pathogenic H5 subtype of AIV has inflicted significant financial damage on the poultry ...
Yu J, Sreenivasan C, Sheng Z, Zhai SL, Wollman JW,. A recombinant chimeric influenza virus vaccine expressing the consensus H3 hemagglutinin elicits broad hemagglutination inhibition antibodies against divergent swine H3N2 influenza viruses. Vaccine. 2023 Sep 7:S0264-410X(23)01060-5. Abstract
submitted by kickingbird at Sep, 12, 2023 from Vaccine. 2023 Sep 7:S0264-410X(23)01060-5 (via https://pubmed.ncbi.nlm.nih.gov/37689544/)
The global distribution and ongoing evolution of type A swine influenza virus (IAV-S) continue to pose significant challenges against developing broadly protective vaccines to control swine influenza. ...
Chen YQ, Su GM, Zhang JH, Li B, Ma KX, Zhang X, Hu. HVT-vectored H7 vaccine protects chickens from lethal infection with the highly pathogenic H7N9 Avian influenza virus. Vet Microbiol. 2023 Aug 20;285:109852. Abstract
submitted by kickingbird at Sep, 10, 2023 from Vet Microbiol. 2023 Aug 20;285:109852 (via https://www.sciencedirect.com/science/article/abs/pii/S03781)
Since mid-2016, the highly pathogenic H7N9 subtype avian influenza virus (AIV) has threatened both public health and the poultry industry. Although a vaccination strategy has been deemed imperative to ...
Xiong F, Zhang C, Shang B, Zheng M, Wang Q, Ding Y. An mRNA-based broad-spectrum vaccine candidate confers cross-protection against heterosubtypic influenza A viruses. Emerg Microbes Infect. 2023 Sep 6:2256422. Abstract
submitted by kickingbird at Sep, 10, 2023 from Emerg Microbes Infect. 2023 Sep 6:2256422 (via https://www.tandfonline.com/doi/full/10.1080/22221751.2023.2)
Influenza virus is a prominent cause of respiratory illness in humans. Current influenza vaccines offer strain-specific immunity, while provide limited protection against drifted strains. Broad-spectrum ...
Le Y, Zhang J, Gong Z, Zhang Z, Nian X, Li X, Yu D. TRAF3 deficiency in MDCK cells improved sensitivity to the influenza A virus. Heliyon. 2023 Aug 21;9(9):e19246. Abstract
submitted by kickingbird at Sep, 10, 2023 from Heliyon. 2023 Aug 21;9(9):e19246 (via https://www.cell.com/heliyon/fulltext/S2405-8440(23)06454-X)
Tumor necrosis factor receptor-associated factor 3 (TRAF3), an adaptor protein, has significant and varying effects on immunity depending on cell types. The role of TRAF3 in Madin-Darby Canine Kidney Epithelial ...
David SC, Vadas O, Glas I, Schaub A, Luo B, D&acut. Inactivation mechanisms of influenza A virus under pH conditions encountered in aerosol particles as revealed by whole-virus HDX-MS. mSphere. 2023 Aug 18:e0022623. Abstract
submitted by kickingbird at Aug, 21, 2023 from mSphere. 2023 Aug 18:e0022623 (via https://journals.asm.org/doi/10.1128/msphere.00226-23)
Multiple respiratory viruses, including influenza A virus (IAV), can be transmitted via expiratory aerosol particles, and aerosol pH was recently identified as a major factor influencing airborne virus ...
Zhang J, Nian X, Liu B, Zhang Z, Zhao W, Han X, Ma. Development of MDCK-based quadrivalent split seasonal influenza virus vaccine with high safety and immunoprotection: A preclinical study. Antiviral Res. 2023 Jun 1:105639. Abstract
submitted by kickingbird at Jun, 4, 2023 from Antiviral Res. 2023 Jun 1:105639 (via https://www.sciencedirect.com/science/article/pii/S016635422)
Vaccination remains the best prevention strategy against influenza. The MDCK-based influenza vaccine prompted the development of innovative cell culture manufacturing processes. In the present study, we ...
Temte JL, Bell C, Goss MD, Reisdorf E, Tamerius J,. Adequacy of using a single nasal swab for rapid influenza diagnostic testing, PCR, and whole genome sequencing. PLOS Glob Public Health. 2023 May 24;3(5):e0001422. Abstract
submitted by kickingbird at May, 25, 2023 from PLOS Glob Public Health. 2023 May 24;3(5):e0001422 (via https://journals.plos.org/globalpublichealth/article?id=10.1)
Rapid influenza diagnostic tests (RIDT) demonstrate varying sensitivities, often necessitating reverse transcriptase polymerase chain reaction (RT-PCR) to confirm results. The two methods generally require ...
Rumfelt KE, Fitzsimmons WJ, Truscon R, Monto AS, M. A rapid and flexible microneutralization assay for serological assessment of influenza viruses. Influenza Other Respir Viruses. 2023;17(4):e13141. Abstract
submitted by kickingbird at May, 4, 2023 from Influenza Other Respir Viruses. 2023;17(4):e13141 (via https://onlinelibrary.wiley.com/doi/10.1111/irv.13141)
Background: Serological responses from influenza vaccination or infection are typically measured by hemagglutinin inhibition (HAI) or microneutralization (MN). Both methods are limited in feasibility, ...
Andrews SF, Cominsky LY, Shimberg GD, Gillespie RA. An influenza H1 hemagglutinin stem-only immunogen elicits a broadly cross-reactive B cell response in humans. Sci Transl Med. 2023 Apr 19;15(692):eade4976. Abstract
submitted by kickingbird at Apr, 20, 2023 from Sci Transl Med. 2023 Apr 19;15(692):eade4976 (via https://www.science.org/doi/10.1126/scitranslmed.ade4976)
Current yearly seasonal influenza vaccines primarily induce an antibody response directed against the immunodominant but continually diversifying hemagglutinin (HA) head region. These antibody responses ...
Widge AT, Hofstetter AR, Houser KV, Awan SF, Chen. An influenza hemagglutinin stem nanoparticle vaccine induces cross-group 1 neutralizing antibodies in healthy adults. Sci Transl Med. 2023 Apr 19;15(692):eade4790. Abstract
submitted by kickingbird at Apr, 20, 2023 from Sci Transl Med. 2023 Apr 19;15(692):eade4790 (via https://www.science.org/doi/10.1126/scitranslmed.ade4790)
Influenza vaccines could be improved by platforms inducing cross-reactive immunity. Immunodominance of the influenza hemagglutinin (HA) head in currently licensed vaccines impedes induction of cross-reactive ...
Van Poelvoorde LAE, Dufrasne FE, Van Gucht S, Sael. Development of Digital Droplet PCR Targeting the Influenza H3N2 Oseltamivir-Resistant E119V Mutation and Its Performance through the Use of Reverse Genetics Mutants. Curr Issues Mol Biol. 2023 Mar 17;45(3):2521-2532. Abstract
submitted by kickingbird at Apr, 1, 2023 from Curr Issues Mol Biol. 2023 Mar 17;45(3):2521-2532 (via https://www.mdpi.com/1467-3045/45/3/165)
The monitoring of antiviral-resistant influenza virus strains is important for public health given the availability and use of neuraminidase inhibitors and other antivirals to treat infected patients. ...
Liu Y, Zhao D, Zhang J, Huang X, Han K, Liu Q, Yan. Development of an Inactivated Avian Influenza Virus Vaccine against Circulating H9N2 in Chickens and Ducks. Vaccines (Basel). 2023 Mar 5;11(3):596. Abstract
submitted by kickingbird at Apr, 1, 2023 from Vaccines (Basel). 2023 Mar 5;11(3):596 (via https://www.mdpi.com/2076-393X/11/3/596)
Avian influenza virus (AIV) subtype H9N2 is the most widespread AIV in poultry worldwide, causing great economic losses in the global poultry industry. Chickens and ducks are the major hosts and play essential ...
Dong J, Dong Z, Feng P, Gao Y, Li J, Wang Y, Han L. Influenza Virus Carrying a Codon-Reprogrammed Neuraminidase Gene as a Strategy for Live Attenuated Vaccine. Vaccines (Basel). 2023 Feb 8;11(2):391. Abstract
submitted by kickingbird at Mar, 1, 2023 from Vaccines (Basel). 2023 Feb 8;11(2):391 (via https://www.mdpi.com/2076-393X/11/2/391)
Live attenuated influenza vaccines offer broader and longer-lasting protection in comparison to inactivated influenza vaccines. The neuraminidase (NA) surface glycoprotein of influenza A virus is essential ...
Nie J, Wang Q, Jin S, Yao X, Xu L, Chang Y, Ding F. Self-assembled multiepitope nanovaccine based on NoV P particles induces effective and lasting protection against H3N2 influenza virus. Nano Res. 2023 Feb 16:1-10. Abstract
submitted by kickingbird at Feb, 24, 2023 from Nano Res. 2023 Feb 16:1-10 (via https://link.springer.com/article/10.1007/s12274-023-5395-6)
Current seasonal influenza vaccines confer only limited coverage of virus strains due to the frequent genetic and antigenic variability of influenza virus (IV). Epitope vaccines that accurately target ...
Zhang Y, Zhu T, Xu S, Gu P, Cai G, Peng S, Liu Z,. Cationic Nanoparticle-Stabilized Vaccine Delivery System for the H9N2 Vaccine to Promote Immune Response in Chickens. Mol Pharm. 2023 Feb 16. Abstract
submitted by kickingbird at Feb, 19, 2023 from Mol Pharm. 2023 Feb 16 (via https://pubs.acs.org/doi/10.1021/acs.molpharmaceut.2c00805)
Chinese yam polysaccharides (CYPs) have received wide attention for their immunomodulatory activity. Our previous studies had discovered that the Chinese yam polysaccharide PLGA-stabilized Pickering emulsion ...
Vatzia E, Feest K, McNee A, Manjegowda T, Carr BV,. Immunization with matrix-, nucleoprotein and neuraminidase protects against H3N2 influenza challenge in pH1N1 pre-exposed pigs. NPJ Vaccines. 2023 Feb 15;8(1):19. Abstract
submitted by kickingbird at Feb, 17, 2023 from NPJ Vaccines. 2023 Feb 15;8(1):19 (via https://pubmed.ncbi.nlm.nih.gov/36792640/)
There is an urgent need for influenza vaccines providing broader protection that may decrease the need for annual immunization of the human population. We investigated the efficacy of heterologous prime ...
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