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2021-12-5 10:16:14

Yin Y, Wang J, Xu X, Zhou B, Chen S, Qin T, Peng D. Riboflavin as a Mucosal Adjuvant for Nasal Influenza Vaccine. Vaccines (Basel). 2021 Nov 9;9(11):1296.  Abstract  
submitted by kickingbird at 5 days ago from Vaccines (Basel). 2021 Nov 9;9(11):1296 (via https://www.mdpi.com/2076-393X/9/11/1296)
Intranasal immunization with whole inactivated virus (WIV) is an important strategy used for influenza prevention and control. However, a powerful mucosal adjuvant is required to improve nasal vaccine ...

Ye Q, Phan T, Hu WS, Liu X, Fan L, Tan WS, Zhao L. Transcriptomic Characterization Reveals Attributes of High Influenza Virus Productivity in MDCK Cells. Viruses. 2021 Nov 1;13(11):2200.  Abstract  
submitted by kickingbird at 5 days ago from Viruses. 2021 Nov 1;13(11):2200 (via https://www.mdpi.com/1999-4915/13/11/2200)
The Madin-Darby Canine Kidney (MDCK) cell line is among the most commonly used cell lines for the production of influenza virus vaccines. As cell culture-based manufacturing is poised to replace egg-based ...

Xiang H, Wen X, Wen Y, Zhang H, Cao S, Huang X, Wu. Development and application of a visual microarray for synchronously detecting H5N1, H7N9 and H9N2 avian influenza virus RNA. J Virol Methods. 2021 Nov 19:114371.  Abstract  
submitted by kickingbird at 11 days ago from J Virol Methods. 2021 Nov 19:114371 (via https://www.sciencedirect.com/science/article/abs/pii/S01660)
The aim of this study was to develop a microarray assay for the simultaneous detection of the H5, H7, H9, N1, N9 and N2 genes of the avian influenza virus (AIV) using a Nanogold-streptavidin and silver-stain-enhanced ...

Kim SH, Park YC, Song JM. Evaluation of the antigenic stability of influenza virus like particles after exposure to acidic or basic pH. Clin Exp Vaccine Res. 2021 Sep;10(3):252-258.  Abstract  
submitted by kickingbird at Oct, 28, 2021 from Clin Exp Vaccine Res. 2021 Sep;10(3):252-258 (via https://ecevr.org/DOIx.php?id=10.7774/cevr.2021.10.3.252)
Purpose: Virus-like particles (VLPs) are being developed as a promising vaccine platform and therapeutic delivery. Various strategies for effectively constructing VLPs have been studied, but relatively ...

Shinde V, Cho I, Plested JS, Agrawal S, Fiske J, C. Comparison of the safety and immunogenicity of a novel Matrix-M-adjuvanted nanoparticle influenza vaccine with a quadrivalent seasonal influenza vaccine in older adults: a phase 3 randomised controlle. ancet Infect Dis. 2021 Sep 23:S1473-3099(21)00192-.  Abstract  
submitted by kickingbird at Sep, 28, 2021 from ancet Infect Dis. 2021 Sep 23:S1473-3099(21)00192- (via https://www.thelancet.com/journals/laninf/article/PIIS1473-3)
Background: Improved seasonal influenza vaccines for older adults that can induce broadly cross-reactive antibodies and enhanced T-cell responses, particularly against A H3N2 viruses, while avoiding egg-adaptive ...

Park G, Kim HO, Lim JW, Park C, Yeom M, Song D, Ha. Rapid detection of influenza A (H1N1) virus by conductive polymer-based nanoparticle via optical response to virus-specific binding. Nano Res. 2021 Sep 21:1-9.  Abstract  
submitted by kickingbird at Sep, 28, 2021 from Nano Res. 2021 Sep 21:1-9 (via https://link.springer.com/article/10.1007%2Fs12274-021-3772-)
A recurrent pandemic with unpredictable viral nature has implied the need for a rapid diagnostic technology to facilitate timely and appropriate countermeasures against viral infections. In this study, ...

Kim DY, Kang YM, Cho HK, Park SJ, Lee MH, Lee YJ,. Development of a recombinant H9N2 influenza vaccine candidate against the Y280 lineage field virus and its protective efficacy. Vaccine. 2021 Sep 14:S0264-410X(21)01149-X.  Abstract  
submitted by kickingbird at Sep, 22, 2021 from Vaccine. 2021 Sep 14:S0264-410X(21)01149-X (via https://www.sciencedirect.com/science/article/pii/S0264410X2)
Since June 2020, a new H9N2 virus of the Y280 lineage has been epidemic in Korea. Initially, a Korean commercial vaccine against the Y280 and Y439 lineages of H9N2 was evaluated for use in SPF chickens. ...

Hegazy AME, Yehia N, Hassan AFI, El-Saadony MT, Ab. The potency of newly development H5N8 and H9N2 avian influenza vaccines against the isolated strains in laying hens from Egypt during 2019. Saudi J Biol Sci. 2021 Sep;28(9):5310-5316.  Abstract  
submitted by kickingbird at Sep, 2, 2021 from Saudi J Biol Sci. 2021 Sep;28(9):5310-5316 (via https://www.sciencedirect.com/science/article/pii/S1319562X2)
Avian influenza (AI) is a respiratory disease complex syndrome recently recorded in vaccinated flocks causing high economic losses. This study aimed to prepare inactivated vaccine from recently isolated ...

de Lara AC, Garrido-Mantilla J, Lopez-Moreno G, Ya. Effect of pooling udder skin wipes on the detection of influenza A virus in preweaning pigs. J Vet Diagn Invest. 2021 Aug 17:10406387211039462.  Abstract  
submitted by kickingbird at Aug, 19, 2021 from J Vet Diagn Invest. 2021 Aug 17:10406387211039462 (via https://journals.sagepub.com/doi/10.1177/10406387211039462)
Influenza A virus (IAV) active surveillance in pigs prior to weaning is commonly conducted by collecting individual samples, mostly nasal swabs. Recently, the use of udder skin wipes collected from lactating ...

Liu Y, Wang X, Zhou J, Shi S, Shen T, Chen L, Zhan. Development of PDA Nanoparticles for H9N2 Avian Influenza BPP-V/BP-IV Epitope Peptide Vaccines: Immunogenicity and Delivery Efficiency Improvement. Front Immunol. 2021 Jul 27;12:693972.  Abstract  
submitted by kickingbird at Aug, 16, 2021 from Front Immunol. 2021 Jul 27;12:693972 (via https://www.frontiersin.org/articles/10.3389/fimmu.2021.6939)
The protection of current influenza vaccines is limited due to the viral antigenic shifts and antigenic drifts. The universal influenza vaccine is a new hotspot in vaccine research that aims to overcome ...

Stinson JA, Boopathy AV, Cieslewicz BM, Zhang Y, H. Enhancing influenza vaccine immunogenicity and efficacy through infection mimicry using silk microneedles. Vaccine. 2021 Aug 11:S0264-410X(21)00957-9.  Abstract  
submitted by kickingbird at Aug, 16, 2021 from Vaccine. 2021 Aug 11:S0264-410X(21)00957-9 (via https://www.sciencedirect.com/science/article/pii/S0264410X2)
Traditional bolus vaccine administration leads to rapid clearance of vaccine from lymphoid tissue. However, there is increasing evidence suggesting that the kinetics of antigen delivery can impact immune ...

Sakala IG, Honda-Okubo Y, Li L, Baldwin J, Petrovs. A M2 protein-based universal influenza vaccine containing Advax-SM adjuvant provides newborn protection via maternal or neonatal immunization. Vaccine. 2021 Aug 3:S0264-410X(21)00914-2.  Abstract  
submitted by kickingbird at Aug, 9, 2021 from Vaccine. 2021 Aug 3:S0264-410X(21)00914-2 (via https://www.sciencedirect.com/science/article/pii/S0264410X2)
Background: Despite newborns being at increased risk of serious influenza infection, influenza vaccines are currently not recommended for use in infants under 6 months of age. We therefore sought to evaluate ...

El-Husseiny MH, Hagag NM, Pushko P, Tretyakova I,. Evaluation of Protective Efficacy of Influenza Virus Like Particles Prepared from H5N1 Virus of Clade in Chickens. Vaccines (Basel). 2021 Jul 1;9(7):715.  Abstract  
submitted by kickingbird at Aug, 9, 2021 from Vaccines (Basel). 2021 Jul 1;9(7):715 (via https://www.mdpi.com/2076-393X/9/7/715)
Highly pathogenic Avian Influenza (HPAI) viruses continue to cause severe economic losses in poultry species worldwide. HPAI virus of subtype H5N1 was reported in Egypt in 2006, and despite vaccination ...

Depelsenaire ACI, Witham K, Veitch M, Wells JW, An. Cellular responses at the application site of a high-density microarray patch delivering an influenza vaccine in a randomized, controlled phase I clinical trial. PLoS One. 2021 Jul 30;16(7):e0255282.  Abstract  
submitted by kickingbird at Jul, 31, 2021 from PLoS One. 2021 Jul 30;16(7):e0255282 (via https://journals.plos.org/plosone/article?id=10.1371/journal)
Microarray patches (MAPs) have the potential to be a safer, more acceptable, easier to use and more cost-effective method for administration of vaccines when compared to the needle and syringe. Since MAPs ...

Kang YM, Cho HK, Kim JH, Lee SJ, Park SJ, Kim DY,. Single dose of multi-clade virus-like particle vaccine protects chickens against clade and clade highly pathogenic avian influenza viruses. Sci Rep. 2021 Jul 2;11(1):13786.  Abstract  
submitted by kickingbird at Jul, 7, 2021 from Sci Rep. 2021 Jul 2;11(1):13786 (via https://www.nature.com/articles/s41598-021-93060-8)
Virus-like particles (VLPs) are recognized as an alternative vaccine platform that provide effective protection against various highly pathogenic avian influenza viruses (HPAIVs). Here, we developed multi-clade ...

Bissinger T, Wu Y, Marichal-Gallardo P, Riedel D,. Towards integrated production of an influenza A vaccine candidate with MDCK suspension cells. Biotechnol Bioeng. 2021 Jul 5.  Abstract  
submitted by kickingbird at Jul, 7, 2021 from Biotechnol Bioeng. 2021 Jul 5 (via https://onlinelibrary.wiley.com/doi/10.1002/bit.27876)
Seasonal influenza epidemics occur both in northern and southern hemispheres every year. Despite the differences in influenza virus surface antigens and virulence of seasonal subtypes, manufacturers are ...

Cáceres CJ, Cardenas-Garcia S, Jain A, Gay LC, Car. Development of a Novel Live Attenuated Influenza A Virus Vaccine Encoding the IgA-Inducing Protein. Vaccines (Basel). 2021 Jun 27;9(7):703.  Abstract  
submitted by kickingbird at Jul, 4, 2021 from Vaccines (Basel). 2021 Jun 27;9(7):703 (via https://www.mdpi.com/2076-393X/9/7/703)
Live attenuated influenza virus (LAIV) vaccines elicit a combination of systemic and mucosal immunity by mimicking a natural infection. To further enhance protective mucosal responses, we incorporated ...

White CL, Chiem K, Perez DR, Santos J, Cardenas Ga. A New Master Donor Virus for the Development of Live-Attenuated Influenza B Virus Vaccines. Viruses. 2021 Jun 30;13(7):1278.  Abstract  
submitted by kickingbird at Jul, 4, 2021 from Viruses. 2021 Jun 30;13(7):1278 (via https://www.mdpi.com/1999-4915/13/7/1278)
Influenza B viruses (IBV) circulate annually, with young children, the elderly and immunocompromised individuals being at high risk. Yearly vaccinations are recommended to protect against seasonally influenza ...

Bolton JS, Klim H, Wellens J, Edmans M, Obolski U,. An Antigenic Thrift-Based Approach to Influenza Vaccine Design. Vaccines (Basel). 2021 Jun 16;9(6):657.  Abstract  
submitted by kickingbird at Jul, 4, 2021 from Vaccines (Basel). 2021 Jun 16;9(6):657 (via https://www.mdpi.com/2076-393X/9/6/657)
The antigenic drift theory states that influenza evolves via the gradual accumulation of mutations, decreasing a host's immune protection against previous strains. Influenza vaccines are designed accordingly, ...

Wang Y, Li S, Dong C, Ma Y, Song Y, Zhu W, Kim J,. Skin vaccination with dissolvable microneedle patches incorporating influenza neuraminidase and flagellin protein nanoparticles induces broad immune protection against multiple influenza viruses. ACS Appl Bio Mater. 2021 Jun 21;4(6):4953-4961.  Abstract  
submitted by kickingbird at Jun, 29, 2021 from ACS Appl Bio Mater. 2021 Jun 21;4(6):4953-4961 (via https://pubs.acs.org/doi/10.1021/acsabm.1c00240)
We generated self-adjuvanted protein nanoparticles of conserved influenza antigens and immunized mice via skin vaccination with dissolvable microneedle patches (MNPs) to increase the strength and breadth ...

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