Wei J, Li Z, Yang Y, et al. A biomimetic VLP influenza vaccine with interior NP/exterior M2e antigens constructed through a temperature shift-based encapsulation strategy. Vaccine. 2020;S0264-410X(20)30915-4. Abstract
submitted by kickingbird at 8 days ago from Vaccine. 2020;S0264-410X(20)30915-4 (via https://www.sciencedirect.com/science/article/pii/S0264410X2)
Here we present a biomimetic strategy towards an influenza vaccine design based on hepatitis B virus core virus-like particles (HBc VLP). To this end, a temperature-shift based encapsulation process based ...
Wei J, Li Z, Yang Y, Ma G, Su Z, Zhang S. An apoferritin-haemagglutinin conjugate vaccine with encapsulated nucleoprotein antigen peptide from influenza virus confers enhanced cross protection. Bioconjug Chem. 2020;10.1021/acs.bioconjchem.0c00. Abstract
submitted by kickingbird at Jul, 18, 2020 from Bioconjug Chem. 2020;10.1021/acs.bioconjchem.0c00 (via https://pubmed.ncbi.nlm.nih.gov/32678574/)
Naturally occurring self-assembling ferritin nanoparticles have become widely appreciated for vaccine design. In this study, an apoferritin (AFt) nanocage was used as a carrier to construct a biomimetic ...
Paillot R, Regourd E, Behr-Gross ME. Establishment of a candidate equine influenza Florida Clade 2 strain A/eq/Richmond/1/07 horse antiserum as Ph. Eur. Biological Reference Preparation/OIE International Reference Reagent. Bio Sci Notes. 2020;2020:125-140. Abstract
submitted by kickingbird at Jul, 18, 2020 from Bio Sci Notes. 2020;2020:125-140 (via https://pubmed.ncbi.nlm.nih.gov/32677612/)
Equine influenza (EI) is an important respiratory disease of horses, with welfare and economic consequences. Vaccination remains one of the most efficient prevention methods available. Equine influenza ...
Yang G, Wang X, Yang Y, Yang R, Gowetski DB, Paula. Quantitation of residual valproic acid in flu vaccine drug substance. J Chromatogr B Analyt Technol Biomed Life Sci. 202. Abstract
submitted by kickingbird at Jul, 16, 2020 from J Chromatogr B Analyt Technol Biomed Life Sci. 202 (via https://pubmed.ncbi.nlm.nih.gov/32668376/)
Quantitative measurement of process-related impurities is a critical safety requirement for the production of drug substances of vaccine and therapeutic biologics. A simple and sensitive HPLC method has ...
Ellebedy AH, Nachbagauer R, Jackson KJL, et al. Adjuvanted H5N1 influenza vaccine enhances both cross-reactive memory B cell and strain-specific naive B cell responses in humans. Proc Natl Acad Sci U S A. 2020;201906613. Abstract
submitted by kickingbird at Jul, 15, 2020 from Proc Natl Acad Sci U S A. 2020;201906613 (via https://pubmed.ncbi.nlm.nih.gov/32661157/)
There is a need for improved influenza vaccines. In this study we compared the antibody responses in humans after vaccination with an AS03-adjuvanted versus nonadjuvanted H5N1 avian influenza virus inactivated ...
Mo J, Spackman E, Stephens CB. Identification of Optimal Sample Collection Devices and Sampling Locations for the Detection Environmental Viral Contamination in Wire Poultry Cages. Transbound Emerg Dis. 2020;10.1111/tbed.13721. Abstract
submitted by kickingbird at Jul, 10, 2020 from Transbound Emerg Dis. 2020;10.1111/tbed.13721 (via https://pubmed.ncbi.nlm.nih.gov/32643291/)
Environmental testing of poultry premises after an outbreak of an infectious disease like avian influenza (AI) or Newcastle disease, is essential to promptly verify virus-free status and subsequently return ...
Endo M, Tanishima M, Ibaragi K, et al. Clinical Phase II and III Studies of an AS03-adjuvanted H5N1 Influenza Vaccine Produced in an EB66 ? Cell Culture Platform. Influenza Other Respir Viruses. 2020;10.1111/irv.. Abstract
submitted by kickingbird at Jun, 26, 2020 from Influenza Other Respir Viruses. 2020;10.1111/irv. (via https://pubmed.ncbi.nlm.nih.gov/32579785/)
Background: We have developed an AS03-adjuvanted H5N1 influenza vaccine produced in an EB66? cell culture platform (KD-295). Objectives: In accordance with Japanese guidelines for development of pandemic ...
Lu PH, Ma YD, Fu CY, Lee GB. A structure-free digital microfluidic platform for detection of influenza a virus by using magnetic beads and electromagnetic forces. Lab Chip. 2020 Jan 20. Abstract
submitted by kickingbird at Jan, 21, 2020 from Lab Chip. 2020 Jan 20 (via https://www.ncbi.nlm.nih.gov/pubmed/31956865)
H1N1, a subtype of influenza A virus, has emerged as a global threat in the past decades. Due to its highly infectious nature, an accurate and rapid detection assay is urgently required. Therefore, this ...
Poh ZW, et al. Modification of neutralizing epitopes of hemagglutinin for the development of broadly protective H9N2 vaccine.. Vaccine. 2020 Jan 7. Abstract
submitted by kickingbird at Jan, 13, 2020 from Vaccine. 2020 Jan 7 (via https://www.sciencedirect.com/science/article/pii/S0264410X1)
The H9N2 avian influenza viruses cause significant economic losses in poultry worldwide and could potentially cause human pandemic. Currently, the available vaccines have limited efficacy due to antigenic ...
Guo J, et al. Development and fit-for-purpose verification of an LC-MS method for quantitation of hemagglutinin and neuraminidase proteins in influenza virus-like particle vaccine candidates. Anal Biochem. 2020 Jan 8:113577.. Abstract
submitted by kickingbird at Jan, 13, 2020 from Anal Biochem. 2020 Jan 8:113577. (via https://www.sciencedirect.com/science/article/pii/S000326971)
Recombinant influenza Virus-Like Particle (VLP) vaccines are promising vaccine candidates to prevent influenza, contain two major viral antigenic glycoproteins, Hemagglutinin (HA) and Neuraminidase (NA), ...
Krammer F, et al. Meeting report and review: Immunological assays and correlates of protection for next-generation influenza vaccines. Influenza Other Respir Viruses. 2019 Dec 13.. Abstract
submitted by kickingbird at Dec, 16, 2019 from Influenza Other Respir Viruses. 2019 Dec 13. (via https://onlinelibrary.wiley.com/doi/full/10.1111/irv.12706)
BACKGROUND: This report summarizes the discussions and conclusions from the "Immunological Assays and Correlates of Protection for Next-Generation Influenza Vaccines" meeting which took place in Siena, ...
Zhou Y, Li S, Bi S, Li N, Bi Y, Liu W, Wang B. Long-lasting protective immunity against H7N9 infection is induced by intramuscular or CpG-adjuvanted intranasal immunization with the split H7N9 vaccine. Int Immunopharmacol. 2019 Dec 2:106013.. Abstract
submitted by kickingbird at Dec, 8, 2019 from Int Immunopharmacol. 2019 Dec 2:106013. (via https://www.sciencedirect.com/science/article/pii/S156757691)
There is an urgent need for efficient vaccines against the highly pathogenic avian influenza A viral strain H7N9. The duration and intensity of the immune response to H7N9 critically impacts the epidemiology ...
Wang S, et al. Reverse transcription recombinase-aided amplification assay for H7 subtype avian influenza virus. Transbound Emerg Dis. 2019 Nov 12.. Abstract
submitted by kickingbird at Nov, 14, 2019 from Transbound Emerg Dis. 2019 Nov 12. (via https://onlinelibrary.wiley.com/doi/abs/10.1111/tbed.13411)
H7 subtype avian influenza virus infection is an emerging zoonosis in some Asian countries and an important avian disease worldwide. A rapid and simple test is needed to confirm infection in suspected ...
Hirotsu N, et al. Baloxavir marboxil in Japanese pediatric patients with influenza: safety and clinical and virologic outcomes. Clin Infect Dis. 2019 Sep 20.. Abstract
submitted by kickingbird at Sep, 22, 2019 from Clin Infect Dis. 2019 Sep 20. (via https://academic.oup.com/cid/advance-article/doi/10.1093/cid)
BACKGROUND: We assessed the safety and effectiveness of baloxavir marboxil administration in Japanese children with influenza.METHODS: This open-label study administered one weigth-adjusted dose of baloxavir ...
Nakamura K, et al. Systematic evaluation of suspension MDCK cells, adherent MDCK cells, and LLC-MK2 cells for preparing influenza vaccine seed virus. Vaccine. 2019 Sep 6.. Abstract
submitted by kickingbird at Sep, 12, 2019 from Vaccine. 2019 Sep 6. (via https://www.sciencedirect.com/science/article/pii/S0264410X1)
Suspension Madin-Darby canine kidney (MDCK) cells (MDCK-N), adherent MDCK cells (MDCK-C), and adherent rhesus monkey kidney LLC-MK2 cells (LLC-MK2D) were systematically evaluated for the preparation of ...
Coronel J, et al. Influenza A virus production in a single-use orbital shaken bioreactor with ATF or TFF perfusion systems. Vaccine. 2019 Jun 29. pii: S0264-410X(19)30764-9.. Abstract
submitted by kickingbird at Jul, 7, 2019 from Vaccine. 2019 Jun 29. pii: S0264-410X(19)30764-9. (via https://www.sciencedirect.com/science/article/pii/S0264410X1)
Driven by the concept of plug-and-play cell culture-based viral vaccine production using disposable bioreactors, we evaluated an orbital shaken bioreactor (OSB) for human influenza A virus production at ...
Zhao ZX, Cheng LP, Li M, Pang W, Wu FH. Discovery of novel acylhydrazone neuraminidase inhibitors. Eur J Med Chem. 2019 Apr 5;173:305-313. Abstract
submitted by kickingbird at Apr, 27, 2019 from Eur J Med Chem. 2019 Apr 5;173:305-313 (via https://www.sciencedirect.com/science/article/pii/S022352341)
Neuraminidase (NA) plays a crucial role in the replication and transmission of influenza virus. NA inhibitors have been developed as effective treatments for influenza A and B infections. In this paper, ...
Sawlwin DC, Graves Jones A, Albano FR. Modification of the vaccine manufacturing process improves the pyrogenicity profile of inactivated influenza vaccines in young children. Vaccine. 2019 Mar 29. pii: S0264-410X(19)30390-1.. Abstract
submitted by kickingbird at Apr, 4, 2019 from Vaccine. 2019 Mar 29. pii: S0264-410X(19)30390-1. (via https://www.sciencedirect.com/science/article/pii/S0264410X1)
BACKGROUND: There were increased reports of fevers and febrile reactions in young children (particularly children aged METHODS: For each study, fever rates (any grade and severe) were determined for the ...
Ross TM, et al. A computationally designed H5 antigen shows immunological breadth of coverage and protects against drifting avian strains. Vaccine. 2019 Mar 21.. Abstract
submitted by kickingbird at Mar, 26, 2019 from Vaccine. 2019 Mar 21. (via https://www.sciencedirect.com/science/article/pii/S0264410X1)
Since the first identification of the H5N1 Goose/Guangdong lineage in 1996, this highly pathogenic avian influenza virus has spread worldwide, becoming endemic in domestic poultry. Sporadic transmission ...
Lindert K, Leav B, Heijnen E, Barrett J, Nicolay U. MF59-Adjuvanted Seasonal Trivalent Influenza Vaccine: Pooled Analysis of Safety in Older Adults ≥65 Years of Age. Int J Infect Dis. 2019 Mar 20.. Abstract
submitted by kickingbird at Mar, 26, 2019 from Int J Infect Dis. 2019 Mar 20. (via https://www.ijidonline.com/article/S1201-9712(19)30149-3/pdf)
OBJECTIVE: To assess the long-term safety of MF59-adjuvanted trivalent influenza vaccine (aIIV3; Fluad?) in adults ≥65 years of age.METHODS: Data from 36 primary vaccination and 7 re-vaccination Phase ...
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