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2022-5-23 4:47:28

Lin X, Sheng Y, Zhang X, Li Z, Yang Y, Wu J, Su Z,. Oil-in-ionic liquid nanoemulsion-based intranasal delivery system for influenza split-virus vaccine. J Control Release. 2022 Apr 25:S0168-3659(22)00232.  Abstract  
submitted by kickingbird at Apr, 30, 2022 from J Control Release. 2022 Apr 25:S0168-3659(22)00232 (via https://pubmed.ncbi.nlm.nih.gov/35483639/)
Effective antigen delivery and immune stimulation in nasal mucosa determine the success of mucosal immunity. Here, an oil-in-ionic liquid (o/IL) nanoemulsion formulated with choline and niacin IL ([Cho][Nic]), ...

Gromadzka B, Chraniuk M, Hovhannisyan L, Uranowska. Characterization of Immune Response towards Generation of Universal Anti-HA-Stalk Antibodies after Immunization of Broiler Hens with Triple H5N1/NA-HA-M1 VLPs. Viruses. 2022 Mar 30;14(4):730.  Abstract  
submitted by kickingbird at Apr, 24, 2022 from Viruses. 2022 Mar 30;14(4):730 (via https://www.mdpi.com/1999-4915/14/4/730)
(1) Background: Avian influenza viruses (AIVs) promptly evade preexisting immunity by constantly altering the immunodominant neutralizing antibody epitopes (antigenic drift) or by procuring new envelope ...

Tian Y, Lee J, van der Maaden K, Bhide Y, de Vries. Intradermal administration of influenza vaccine with trehalose and pullulan-based dissolving microneedle arrays. J Pharm Sci. 2022 Feb 2:S0022-3549(22)00042-9.  Abstract  
submitted by kickingbird at Feb, 8, 2022 from J Pharm Sci. 2022 Feb 2:S0022-3549(22)00042-9 (via https://jpharmsci.org/article/S0022-3549(22)00042-9/fulltext)
Most influenza vaccines are administered via intramuscular injection which has several disadvantages that might jeopardize the compliance of vaccinees. Intradermal administration of dissolving-microneedle-arrays ...

Zhu D, Lv M, Bai Y, Wu J, He P. Cost-effectiveness analysis of quadrivalent seasonal influenza vaccines in Beijing: A modeling analysis. Vaccine. 2022 Jan 19:S0264-410X(22)00024-X.  Abstract  
submitted by kickingbird at Jan, 25, 2022 from Vaccine. 2022 Jan 19:S0264-410X(22)00024-X (via https://www.sciencedirect.com/science/article/pii/S0264410X2)
Background: Since 2007, Beijing has offered a free trivalent influenza vaccine (TIV) for residents aged ≥ 60 years and school students. The quadrivalent influenza vaccine (QIV) was administered to school ...

Qiao Y, Jin S, Nie J, Chang Y, Wang B, Guan S, Li. Hemagglutinin-based DNA vaccines containing trimeric self-assembling nanoparticles confer protection against influenza. J Leukoc Biol. 2022 Jan 17.  Abstract  
submitted by kickingbird at Jan, 19, 2022 from J Leukoc Biol. 2022 Jan 17 (via https://jlb.onlinelibrary.wiley.com/doi/10.1002/JLB.6A1021-5)
Influenza viruses continue to threaten public health, and currently available vaccines provide insufficient immunity against seasonal and pandemic influenza. The use of recombinant trimeric hemagglutinin ...

Sun W, Wang Z, Sun Y, Li D, Zhu M, Zhao M, Wang Y,. Safety, Immunogenicity, and Protective Efficacy of an H5N1 Chimeric Cold-Adapted Attenuated Virus Vaccine in a Mouse Model. Viruses. 2021 Dec 3;13(12):2420.  Abstract  
submitted by kickingbird at Dec, 29, 2021 from Viruses. 2021 Dec 3;13(12):2420 (via https://www.mdpi.com/1999-4915/13/12/2420)
H5N1 influenza virus is a threat to public health worldwide. The virus can cause severe morbidity and mortality in humans. We constructed an H5N1 influenza candidate virus vaccine from the A/chicken/Guizhou/1153/2016 ...

Yoo DS, Song YH, Choi DW, Lim JS, Lee K, Kang T. Machine Learning-driven dynamic risk prediction for highly pathogenic avian influenza at poultry farms, Republic of Korea: daily risk estimation for individual premises. Transbound Emerg Dis. 2021 Dec 13.  Abstract  
submitted by kickingbird at Dec, 15, 2021 from Transbound Emerg Dis. 2021 Dec 13 (via https://onlinelibrary.wiley.com/doi/10.1111/tbed.14419)
Highly pathogenic Avian influenza (HPAI) is a fatal zoonotic disease that damages the poultry industry and endangers human lives via exposure to the pathogen. A risk assessment model that precisely predicts ...

Yin Y, Wang J, Xu X, Zhou B, Chen S, Qin T, Peng D. Riboflavin as a Mucosal Adjuvant for Nasal Influenza Vaccine. Vaccines (Basel). 2021 Nov 9;9(11):1296.  Abstract  
submitted by kickingbird at Nov, 30, 2021 from Vaccines (Basel). 2021 Nov 9;9(11):1296 (via https://www.mdpi.com/2076-393X/9/11/1296)
Intranasal immunization with whole inactivated virus (WIV) is an important strategy used for influenza prevention and control. However, a powerful mucosal adjuvant is required to improve nasal vaccine ...

Ye Q, Phan T, Hu WS, Liu X, Fan L, Tan WS, Zhao L. Transcriptomic Characterization Reveals Attributes of High Influenza Virus Productivity in MDCK Cells. Viruses. 2021 Nov 1;13(11):2200.  Abstract  
submitted by kickingbird at Nov, 30, 2021 from Viruses. 2021 Nov 1;13(11):2200 (via https://www.mdpi.com/1999-4915/13/11/2200)
The Madin-Darby Canine Kidney (MDCK) cell line is among the most commonly used cell lines for the production of influenza virus vaccines. As cell culture-based manufacturing is poised to replace egg-based ...

Xiang H, Wen X, Wen Y, Zhang H, Cao S, Huang X, Wu. Development and application of a visual microarray for synchronously detecting H5N1, H7N9 and H9N2 avian influenza virus RNA. J Virol Methods. 2021 Nov 19:114371.  Abstract  
submitted by kickingbird at Nov, 24, 2021 from J Virol Methods. 2021 Nov 19:114371 (via https://www.sciencedirect.com/science/article/abs/pii/S01660)
The aim of this study was to develop a microarray assay for the simultaneous detection of the H5, H7, H9, N1, N9 and N2 genes of the avian influenza virus (AIV) using a Nanogold-streptavidin and silver-stain-enhanced ...

Kim SH, Park YC, Song JM. Evaluation of the antigenic stability of influenza virus like particles after exposure to acidic or basic pH. Clin Exp Vaccine Res. 2021 Sep;10(3):252-258.  Abstract  
submitted by kickingbird at Oct, 28, 2021 from Clin Exp Vaccine Res. 2021 Sep;10(3):252-258 (via https://ecevr.org/DOIx.php?id=10.7774/cevr.2021.10.3.252)
Purpose: Virus-like particles (VLPs) are being developed as a promising vaccine platform and therapeutic delivery. Various strategies for effectively constructing VLPs have been studied, but relatively ...

Shinde V, Cho I, Plested JS, Agrawal S, Fiske J, C. Comparison of the safety and immunogenicity of a novel Matrix-M-adjuvanted nanoparticle influenza vaccine with a quadrivalent seasonal influenza vaccine in older adults: a phase 3 randomised controlle. ancet Infect Dis. 2021 Sep 23:S1473-3099(21)00192-.  Abstract  
submitted by kickingbird at Sep, 28, 2021 from ancet Infect Dis. 2021 Sep 23:S1473-3099(21)00192- (via https://www.thelancet.com/journals/laninf/article/PIIS1473-3)
Background: Improved seasonal influenza vaccines for older adults that can induce broadly cross-reactive antibodies and enhanced T-cell responses, particularly against A H3N2 viruses, while avoiding egg-adaptive ...

Park G, Kim HO, Lim JW, Park C, Yeom M, Song D, Ha. Rapid detection of influenza A (H1N1) virus by conductive polymer-based nanoparticle via optical response to virus-specific binding. Nano Res. 2021 Sep 21:1-9.  Abstract  
submitted by kickingbird at Sep, 28, 2021 from Nano Res. 2021 Sep 21:1-9 (via https://link.springer.com/article/10.1007%2Fs12274-021-3772-)
A recurrent pandemic with unpredictable viral nature has implied the need for a rapid diagnostic technology to facilitate timely and appropriate countermeasures against viral infections. In this study, ...

Kim DY, Kang YM, Cho HK, Park SJ, Lee MH, Lee YJ,. Development of a recombinant H9N2 influenza vaccine candidate against the Y280 lineage field virus and its protective efficacy. Vaccine. 2021 Sep 14:S0264-410X(21)01149-X.  Abstract  
submitted by kickingbird at Sep, 22, 2021 from Vaccine. 2021 Sep 14:S0264-410X(21)01149-X (via https://www.sciencedirect.com/science/article/pii/S0264410X2)
Since June 2020, a new H9N2 virus of the Y280 lineage has been epidemic in Korea. Initially, a Korean commercial vaccine against the Y280 and Y439 lineages of H9N2 was evaluated for use in SPF chickens. ...

Hegazy AME, Yehia N, Hassan AFI, El-Saadony MT, Ab. The potency of newly development H5N8 and H9N2 avian influenza vaccines against the isolated strains in laying hens from Egypt during 2019. Saudi J Biol Sci. 2021 Sep;28(9):5310-5316.  Abstract  
submitted by kickingbird at Sep, 2, 2021 from Saudi J Biol Sci. 2021 Sep;28(9):5310-5316 (via https://www.sciencedirect.com/science/article/pii/S1319562X2)
Avian influenza (AI) is a respiratory disease complex syndrome recently recorded in vaccinated flocks causing high economic losses. This study aimed to prepare inactivated vaccine from recently isolated ...

de Lara AC, Garrido-Mantilla J, Lopez-Moreno G, Ya. Effect of pooling udder skin wipes on the detection of influenza A virus in preweaning pigs. J Vet Diagn Invest. 2021 Aug 17:10406387211039462.  Abstract  
submitted by kickingbird at Aug, 19, 2021 from J Vet Diagn Invest. 2021 Aug 17:10406387211039462 (via https://journals.sagepub.com/doi/10.1177/10406387211039462)
Influenza A virus (IAV) active surveillance in pigs prior to weaning is commonly conducted by collecting individual samples, mostly nasal swabs. Recently, the use of udder skin wipes collected from lactating ...

Liu Y, Wang X, Zhou J, Shi S, Shen T, Chen L, Zhan. Development of PDA Nanoparticles for H9N2 Avian Influenza BPP-V/BP-IV Epitope Peptide Vaccines: Immunogenicity and Delivery Efficiency Improvement. Front Immunol. 2021 Jul 27;12:693972.  Abstract  
submitted by kickingbird at Aug, 16, 2021 from Front Immunol. 2021 Jul 27;12:693972 (via https://www.frontiersin.org/articles/10.3389/fimmu.2021.6939)
The protection of current influenza vaccines is limited due to the viral antigenic shifts and antigenic drifts. The universal influenza vaccine is a new hotspot in vaccine research that aims to overcome ...

Stinson JA, Boopathy AV, Cieslewicz BM, Zhang Y, H. Enhancing influenza vaccine immunogenicity and efficacy through infection mimicry using silk microneedles. Vaccine. 2021 Aug 11:S0264-410X(21)00957-9.  Abstract  
submitted by kickingbird at Aug, 16, 2021 from Vaccine. 2021 Aug 11:S0264-410X(21)00957-9 (via https://www.sciencedirect.com/science/article/pii/S0264410X2)
Traditional bolus vaccine administration leads to rapid clearance of vaccine from lymphoid tissue. However, there is increasing evidence suggesting that the kinetics of antigen delivery can impact immune ...

Sakala IG, Honda-Okubo Y, Li L, Baldwin J, Petrovs. A M2 protein-based universal influenza vaccine containing Advax-SM adjuvant provides newborn protection via maternal or neonatal immunization. Vaccine. 2021 Aug 3:S0264-410X(21)00914-2.  Abstract  
submitted by kickingbird at Aug, 9, 2021 from Vaccine. 2021 Aug 3:S0264-410X(21)00914-2 (via https://www.sciencedirect.com/science/article/pii/S0264410X2)
Background: Despite newborns being at increased risk of serious influenza infection, influenza vaccines are currently not recommended for use in infants under 6 months of age. We therefore sought to evaluate ...

El-Husseiny MH, Hagag NM, Pushko P, Tretyakova I,. Evaluation of Protective Efficacy of Influenza Virus Like Particles Prepared from H5N1 Virus of Clade in Chickens. Vaccines (Basel). 2021 Jul 1;9(7):715.  Abstract  
submitted by kickingbird at Aug, 9, 2021 from Vaccines (Basel). 2021 Jul 1;9(7):715 (via https://www.mdpi.com/2076-393X/9/7/715)
Highly pathogenic Avian Influenza (HPAI) viruses continue to cause severe economic losses in poultry species worldwide. HPAI virus of subtype H5N1 was reported in Egypt in 2006, and despite vaccination ...

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