Zhang J, Nian X, Liu B, Zhang Z, Zhao W, Han X, Ma. Development of MDCK-based quadrivalent split seasonal influenza virus vaccine with high safety and immunoprotection: A preclinical study. Antiviral Res. 2023 Jun 1:105639. Abstract
submitted by kickingbird at 4 days ago from Antiviral Res. 2023 Jun 1:105639 (via https://www.sciencedirect.com/science/article/pii/S016635422)
Vaccination remains the best prevention strategy against influenza. The MDCK-based influenza vaccine prompted the development of innovative cell culture manufacturing processes. In the present study, we ...
Temte JL, Bell C, Goss MD, Reisdorf E, Tamerius J,. Adequacy of using a single nasal swab for rapid influenza diagnostic testing, PCR, and whole genome sequencing. PLOS Glob Public Health. 2023 May 24;3(5):e0001422. Abstract
submitted by kickingbird at 14 days ago from PLOS Glob Public Health. 2023 May 24;3(5):e0001422 (via https://journals.plos.org/globalpublichealth/article?id=10.1)
Rapid influenza diagnostic tests (RIDT) demonstrate varying sensitivities, often necessitating reverse transcriptase polymerase chain reaction (RT-PCR) to confirm results. The two methods generally require ...
Rumfelt KE, Fitzsimmons WJ, Truscon R, Monto AS, M. A rapid and flexible microneutralization assay for serological assessment of influenza viruses. Influenza Other Respir Viruses. 2023;17(4):e13141. Abstract
submitted by kickingbird at May, 4, 2023 from Influenza Other Respir Viruses. 2023;17(4):e13141 (via https://onlinelibrary.wiley.com/doi/10.1111/irv.13141)
Background: Serological responses from influenza vaccination or infection are typically measured by hemagglutinin inhibition (HAI) or microneutralization (MN). Both methods are limited in feasibility, ...
Andrews SF, Cominsky LY, Shimberg GD, Gillespie RA. An influenza H1 hemagglutinin stem-only immunogen elicits a broadly cross-reactive B cell response in humans. Sci Transl Med. 2023 Apr 19;15(692):eade4976. Abstract
submitted by kickingbird at Apr, 20, 2023 from Sci Transl Med. 2023 Apr 19;15(692):eade4976 (via https://www.science.org/doi/10.1126/scitranslmed.ade4976)
Current yearly seasonal influenza vaccines primarily induce an antibody response directed against the immunodominant but continually diversifying hemagglutinin (HA) head region. These antibody responses ...
Widge AT, Hofstetter AR, Houser KV, Awan SF, Chen. An influenza hemagglutinin stem nanoparticle vaccine induces cross-group 1 neutralizing antibodies in healthy adults. Sci Transl Med. 2023 Apr 19;15(692):eade4790. Abstract
submitted by kickingbird at Apr, 20, 2023 from Sci Transl Med. 2023 Apr 19;15(692):eade4790 (via https://www.science.org/doi/10.1126/scitranslmed.ade4790)
Influenza vaccines could be improved by platforms inducing cross-reactive immunity. Immunodominance of the influenza hemagglutinin (HA) head in currently licensed vaccines impedes induction of cross-reactive ...
Van Poelvoorde LAE, Dufrasne FE, Van Gucht S, Sael. Development of Digital Droplet PCR Targeting the Influenza H3N2 Oseltamivir-Resistant E119V Mutation and Its Performance through the Use of Reverse Genetics Mutants. Curr Issues Mol Biol. 2023 Mar 17;45(3):2521-2532. Abstract
submitted by kickingbird at Apr, 1, 2023 from Curr Issues Mol Biol. 2023 Mar 17;45(3):2521-2532 (via https://www.mdpi.com/1467-3045/45/3/165)
The monitoring of antiviral-resistant influenza virus strains is important for public health given the availability and use of neuraminidase inhibitors and other antivirals to treat infected patients. ...
Liu Y, Zhao D, Zhang J, Huang X, Han K, Liu Q, Yan. Development of an Inactivated Avian Influenza Virus Vaccine against Circulating H9N2 in Chickens and Ducks. Vaccines (Basel). 2023 Mar 5;11(3):596. Abstract
submitted by kickingbird at Apr, 1, 2023 from Vaccines (Basel). 2023 Mar 5;11(3):596 (via https://www.mdpi.com/2076-393X/11/3/596)
Avian influenza virus (AIV) subtype H9N2 is the most widespread AIV in poultry worldwide, causing great economic losses in the global poultry industry. Chickens and ducks are the major hosts and play essential ...
Dong J, Dong Z, Feng P, Gao Y, Li J, Wang Y, Han L. Influenza Virus Carrying a Codon-Reprogrammed Neuraminidase Gene as a Strategy for Live Attenuated Vaccine. Vaccines (Basel). 2023 Feb 8;11(2):391. Abstract
submitted by kickingbird at Mar, 1, 2023 from Vaccines (Basel). 2023 Feb 8;11(2):391 (via https://www.mdpi.com/2076-393X/11/2/391)
Live attenuated influenza vaccines offer broader and longer-lasting protection in comparison to inactivated influenza vaccines. The neuraminidase (NA) surface glycoprotein of influenza A virus is essential ...
Nie J, Wang Q, Jin S, Yao X, Xu L, Chang Y, Ding F. Self-assembled multiepitope nanovaccine based on NoV P particles induces effective and lasting protection against H3N2 influenza virus. Nano Res. 2023 Feb 16:1-10. Abstract
submitted by kickingbird at Feb, 24, 2023 from Nano Res. 2023 Feb 16:1-10 (via https://link.springer.com/article/10.1007/s12274-023-5395-6)
Current seasonal influenza vaccines confer only limited coverage of virus strains due to the frequent genetic and antigenic variability of influenza virus (IV). Epitope vaccines that accurately target ...
Zhang Y, Zhu T, Xu S, Gu P, Cai G, Peng S, Liu Z,. Cationic Nanoparticle-Stabilized Vaccine Delivery System for the H9N2 Vaccine to Promote Immune Response in Chickens. Mol Pharm. 2023 Feb 16. Abstract
submitted by kickingbird at Feb, 19, 2023 from Mol Pharm. 2023 Feb 16 (via https://pubs.acs.org/doi/10.1021/acs.molpharmaceut.2c00805)
Chinese yam polysaccharides (CYPs) have received wide attention for their immunomodulatory activity. Our previous studies had discovered that the Chinese yam polysaccharide PLGA-stabilized Pickering emulsion ...
Vatzia E, Feest K, McNee A, Manjegowda T, Carr BV,. Immunization with matrix-, nucleoprotein and neuraminidase protects against H3N2 influenza challenge in pH1N1 pre-exposed pigs. NPJ Vaccines. 2023 Feb 15;8(1):19. Abstract
submitted by kickingbird at Feb, 17, 2023 from NPJ Vaccines. 2023 Feb 15;8(1):19 (via https://pubmed.ncbi.nlm.nih.gov/36792640/)
There is an urgent need for influenza vaccines providing broader protection that may decrease the need for annual immunization of the human population. We investigated the efficacy of heterologous prime ...
Aslam S, Rajendran M, Kriti D, Kurland A, Johnson. Generation of a high yield vaccine backbone for influenza B virus in embryonated chicken eggs. NPJ Vaccines. 2023 Feb 10;8(1):12. Abstract
submitted by kickingbird at Feb, 12, 2023 from NPJ Vaccines. 2023 Feb 10;8(1):12 (via https://www.nature.com/articles/s41541-023-00603-3)
Influenza B virus (IBV) strains are one of the components of seasonal influenza vaccines in both trivalent and quadrivalent formulations. The vast majority of these vaccines are produced in embryonated ...
Neuzil KM, Anderson EJ, Frenck RW, Frey SE, Walter. Safety and Immunogenicity of Influenza A/H5N8 Virus Vaccine in Healthy Adults: Durability and Cross-reactivity of Antibody Responses. Clin Infect Dis. 2023 Jan 5:ciac982. Abstract
submitted by kickingbird at Jan, 9, 2023 from Clin Infect Dis. 2023 Jan 5:ciac982 (via https://academic.oup.com/cid/advance-article-abstract/doi/10)
Background: Influenza A/H5N8 viruses infect poultry and wild birds in many countries. In 2021, the first human A/H5N8 cases were reported.Methods: We conducted a phase I, cohort-randomized, double-blind, ...
Zhang J, Nian X, Li X, Huang S, Duan K, Li X, Yang. The Epidemiology of Influenza and the Associated Vaccines Development in China: A Review. Vaccines (Basel). 2022 Nov 6;10(11):1873. Abstract
submitted by kickingbird at Nov, 12, 2022 from Vaccines (Basel). 2022 Nov 6;10(11):1873 (via https://www.mdpi.com/2076-393X/10/11/1873)
Influenza prevention and control has been one of the biggest challenges encountered in the public health domain. The vaccination against influenza plays a pivotal role in the prevention of influenza, particularly ...
Kang T, Haque MM, Lee B, Hong KT, Hong SC, Kim Y,. Orthogonally-tunable and ER-targeting fluorophores detect avian influenza virus early infection. Nat Commun. 2022 Oct 4;13(1):5841. Abstract
submitted by kickingbird at Oct, 7, 2022 from Nat Commun. 2022 Oct 4;13(1):5841
Cell-based assays can monitor virus infection at a single-cell level with high sensitivity and cost-efficiency. For this purpose, it is crucial to develop molecular probes that respond selectively to physiological ...
Hiono T, Kobayashi D. Receptor-Binding Assay for Avian Influenza Viruses. Methods Mol Biol. 2022;2556:141-148. Abstract
submitted by kickingbird at Oct, 1, 2022 from Methods Mol Biol. 2022;2556:141-148 (via https://link.springer.com/protocol/10.1007/978-1-0716-2635-1)
It is well known that influenza viruses utilize host cell glycans for virus attachment factors via their major glycoprotein, hemagglutinin (HA), to initiate their invasion to host cells. Unlike well-known ...
Liu Y, Chen H, Duan W, Zhang X, He X, Nielsen R, M. Predicting Egg Passage Adaptations to Design Better Vaccines for the H3N2 Influenza Virus. Viruses. 2022 Sep 17;14(9):2065. Abstract
submitted by kickingbird at Sep, 23, 2022 from Viruses. 2022 Sep 17;14(9):2065 (via https://www.mdpi.com/1999-4915/14/9/2065)
Seasonal H3N2 influenza evolves rapidly, leading to an extremely poor vaccine efficacy. Substitutions employed during vaccine production using embryonated eggs (i.e., egg passage adaptation) contribute ...
Li C, Culhane MR, Schroeder DC, Cheeran MC, Galina. Vaccination decreases the risk of influenza A virus reassortment but not genetic variation in pigs. Elife. 2022 Sep 2;11:e78618. Abstract
submitted by kickingbird at Sep, 3, 2022 from Elife. 2022 Sep 2;11:e78618 (via https://elifesciences.org/articles/78618)
Although vaccination is broadly used in North American swine breeding herds, managing swine influenza is challenging primarily due to the continuous evolution of influenza A virus (IAV) and the ability ...
Shin Y, Kim J, Seok JH, Park H, Cha HR, Ko SH, Lee. Development of the H3N2 influenza microneedle vaccine for cross-protection against antigenic variants. Sci Rep. 2022 Jul 16;12(1):12189. Abstract
submitted by kickingbird at Jul, 18, 2022 from Sci Rep. 2022 Jul 16;12(1):12189 (via https://www.nature.com/articles/s41598-022-16365-2)
Due to the continuously mutating nature of the H3N2 virus, two aspects were considered when preparing the H3N2 microneedle vaccines: (1) rapid preparation and (2) cross-protection against multiple antigenic ...
Gao J, Li X, Klenow L, Malik T, Wan H, Ye Z, Danie. Antigenic comparison of the neuraminidases from recent influenza A vaccine viruses and 2019-2020 circulating strains. NPJ Vaccines. 2022 Jul 14;7(1):79. Abstract
submitted by kickingbird at Jul, 16, 2022 from NPJ Vaccines. 2022 Jul 14;7(1):79 (via https://www.nature.com/articles/s41541-022-00500-1)
Although viral-based influenza vaccines contain neuraminidase (NA or N) antigens from the recommended seasonal strains, NA is not extensively evaluated like hemagglutinin (H) during the strain selection ...
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