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2026-8-16 18:08:22
Article

Zhang YF, Xu R, Luo J, Ma Y, Xiao G, Liu Y. Identification of Mannose-Capped-Arabinomannan 101-mer as a Potential Influenza Virus Vaccine Adjuvant. Adv Sci (Weinh). 2026 Feb 3:e19843.  Abstract  
submitted by kickingbird at Feb, 4, 2026 from Adv Sci (Weinh). 2026 Feb 3:e19843 (via https://advanced.onlinelibrary.wiley.com/doi/10.1002/advs.20)
Many natural bacterial components as adjuvants can activate the host immune system, but the excessive toxicity and structure-identification challenge limit their applications and structure-activity relationship ...

ZHANG Le, LI Xiang, GAO Chuyi, ZHENG Jie, SHAN Qiu. The successful treatment of a case with severe human avian influenza A (H10N3) infection. Chinese Journal of Zoonoses, 2026, 42(2).  Abstract  
submitted by kickingbird at Feb, 4, 2026 from Chinese Journal of Zoonoses, 2026, 42(2)
We report the clinical characteristics and treatment of a human case with severe avian influenza A (H10N3) infection and provide a reference for the diagnosis and management of similar cases. A retrospective ...

Yang Y, Xu M, Zhang N, Yu Q, Wan Y, Xu C, Wu Y, Me. PA-X 122V broadly determines the host shutoff activity of influenza A viruses. mBio 0:e03433-25.  Abstract  
submitted by kickingbird at Feb, 3, 2026 from mBio 0:e03433-25 (via https://journals.asm.org/doi/10.1128/mbio.03433-25)
Multiple genes are involved in the pathogenicity of influenza A virus. Our previous study reported two naturally occurring amino acid mutations in the polymerase acidic (PA) protein as crucial determinants ...

Pulit-Penaloza, J.A., Kieran, T.J., Brock, N. et a. Advancing A(H5N1) influenza risk assessment in ferrets through comparative evaluation of airborne virus shedding patterns. Nat Commun (2026).  Abstract  
submitted by kickingbird at Feb, 3, 2026 from Nat Commun (2026) (via https://link.springer.com/article/10.1038/s41467-026-68931-1)
Recent A(H5N1) zoonotic cases linked to poultry and cattle in North America highlight the urgent need to assess the pandemic potential of emerging strains. Using male ferrets, we evaluate two B3.13 and ...

Sun, B., Sun, Y., Wang, H., Tang, X., Tang, W., Mi. Emergence of the novel PA-D27G mutation conferring reduced baloxavir susceptibility in influenza A viruses circulating in China, 2018-2025. Emerging Microbes & Infections, 15(1).  Abstract  
submitted by kickingbird at Feb, 3, 2026 from Emerging Microbes & Infections, 15(1) (via https://www.tandfonline.com/doi/full/10.1080/22221751.2026.2)
Seasonal influenza A viruses evolve rapidly, yet the emergence and molecular basis of resistance to the polymerase acidic (PA) inhibitor baloxavir marboxil (BXM), which is widely used in China, remain ...

Jianjun Wang, etc.,al. Aptamer Modified NPA Hollow Nanozymes with Intrinsic Peroxidase-Like Activity for Colorimetric Sensing of H1N1. Analytica Chimica Acta.  Abstract  
submitted by kickingbird at Feb, 3, 2026 from Analytica Chimica Acta (via https://www.sciencedirect.com/science/article/abs/pii/S00032)
A colorimetric sensor based on aptamer-functionalized nanozyme probes was successfully developed for the sensitive and specific detection of influenza A (H1N1) virus. In this study, trimetallic nickel-palladium-gold ...

Ling Tang, Rui Wang, Guimei He. Molecular Characteristics and Genetic Evolution of H1N1 Avian Influenza Virus from Wild birds in Shanghai, China. Poultry Science.  Abstract  
submitted by kickingbird at Feb, 3, 2026 from Poultry Science (via https://www.sciencedirect.com/science/article/pii/S003257912)
The H1N1 influenza virus is a major pandemic and seasonal pathogen with a broad host range, posing a substantial threat to human health and underscoring the need for continuous surveillance. Wild birds, ...

Yik Lim Hew, Claire Guinat, Manon Couty, Diletta F. Introduction and inter-species transmission dynamics of high pathogenicity avian influenza H5N1 viruses in Japan 2021-2025. Virus Evolution, 2026; veag005.  Abstract  
submitted by kickingbird at Feb, 3, 2026 from Virus Evolution, 2026; veag005 (via https://academic.oup.com/ve/advance-article/doi/10.1093/ve/v)
High pathogenicity avian influenza virus impacts poultry and wild birds worldwide. Since the introduction of clade 2.3.4.4b H5N1 isolates in Japan in late 2021, new cases have been reported in domestic ...

Xia, Y., Farrukee, R., Brooks, A.G. et al. Host restriction factor SAMHD1 does not restrict seasonal influenza virus replication in human epithelial or macrophage-like cells. Virol J (2026).  Abstract  
submitted by kickingbird at Feb, 2, 2026 from Virol J (2026) (via https://link.springer.com/article/10.1186/s12985-026-03065-w)
BackgroundSAM and HD domain-containing deoxynucleoside triphosphate triphosphohydrolase protein 1 (SAMHD1) is an intracellular protein that regulates a stable deoxynucleoside triphosphates (dNTPs) for ...

Hu J, Li J, Li Q, Jiang S, Cao Z, Chen H. Enhancing the stability of Influenza A reporter viruses by recoding the gfp gene. Virol Sin. 2026 Jan 29:S1995-820X(26)00011-8.  Abstract  
submitted by kickingbird at Feb, 2, 2026 from Virol Sin. 2026 Jan 29:S1995-820X(26)00011-8 (via https://www.sciencedirect.com/science/article/pii/S1995820X2)
Influenza A virus (IAV) is one of the most important zoonotic pathogens and can cause global influenza pandemics and seasonal influenza outbreaks. Generation of recombinant IAV expressing a fluorescent ...

Yang Xue, Yuki Tai, Hiromi Yamamoto, Daiki Mori, K. T cell help is a limiting factor for rare anti-influenza memory B cells to reenter germinal centers and generate potent broadly neutralizing antibodies. International Immunology, 2026;, dxag003.  Abstract  
submitted by kickingbird at Jan, 31, 2026 from International Immunology, 2026;, dxag003 (via https://academic.oup.com/intimm/advance-article-abstract/doi)
Development of vaccines eliciting broadly neutralizing influenza antibodies (bnAbs) is an extraordinary challenge. One hypothetical proposal is that CD4+ T cell help to rare immuno-subdominant bnAb class ...

Andrew Y Cho, Dong-Hun Lee, Alice Fusaro, Edoardo. Wild birds drive the introduction, maintenance, and spread of H5N1 clade 2.3.4.4b high pathogenicity avian influenza viruses in Spain, 2021-2022. Virus Evolution, 2026;, veag006.  Abstract  
submitted by kickingbird at Jan, 31, 2026 from Virus Evolution, 2026;, veag006 (via https://academic.oup.com/ve/advance-article/doi/10.1093/ve/v)
The 2021-2022 high pathogenicity avian influenza (HPAI) epizootic was the worst ever recorded in Europe in general and in Spain in particular. Between December 2021 and November 2022, H5N1 clade 2.3.4.4b ...

Xingyi Li, etc.,al. [preprint]FluNexus: a versatile web platform for antigenic prediction and visualization of influenza A viruses. https://doi.org/10.64898/2026.01.29.702696.  Abstract  
submitted by kickingbird at Jan, 31, 2026 from https://doi.org/10.64898/2026.01.29.702696 (via https://www.biorxiv.org/content/10.64898/2026.01.29.702696v1)
Influenza A viruses continuously undergo antigenic evolution to escape host immunity induced by previous infections or vaccinations, consequently causing seasonal epidemics and occasional pandemics. Antigenic ...

Acevedo HD, Beeler E, Crossley B, Armién AG, Hende. Salpingitis and multiorgan lesions caused by highly pathogenic avian influenza A(H5N1) virus in a cat associated with consumption of recalled raw milk in California. J Vet Diagn Invest. 2026 Jan 29:10406387251413563.  Abstract  
submitted by kickingbird at Jan, 31, 2026 from J Vet Diagn Invest. 2026 Jan 29:10406387251413563 (via https://journals.sagepub.com/doi/10.1177/10406387251413563)
A panzootic caused by highly pathogenic avian influenza (HPAI) A(H5N1) virus, clade 2.3.4.4b, has affected many animal species around the world since 2021. In March 2024, genotype B3.13 of this virus was ...

Lehman KA, Leibsle SR, Detwiler L, Gaborick C, McC. Detection of highly pathogenic avian influenza A(H5N1) virus 2.3.4.4b in alpacas. J Vet Diagn Invest. 2026 Jan 29:10406387251414557.  Abstract  
submitted by kickingbird at Jan, 31, 2026 from J Vet Diagn Invest. 2026 Jan 29:10406387251414557 (via https://journals.sagepub.com/doi/10.1177/10406387251414557)
Highly pathogenic avian influenza (HPAI) A(H5N1) virus, clade 2.3.4.4b, genotype 3.13, was first confirmed in dairy cattle in March 2024 in a Texas dairy herd and has since spread to other states, likely ...

Chu H, Hao Z, Zhang L, Lou Y, Hua Y, Gao W, Li F,. Evaluation of Rice Traits Containing H9N2 Subtype Avian Influenza HA Protein Before Commercialization. Curr Issues Mol Biol. 2025 Nov 26;47(12):986.  Abstract  
submitted by kickingbird at Jan, 31, 2026 from Curr Issues Mol Biol. 2025 Nov 26;47(12):986 (via https://www.mdpi.com/1467-3045/47/12/986)
The H9N2 avian influenza virus (AIV) is difficult to prevent and control because of its low pathogenicity and frequent mutation. In a previous study, the HA (hemagglutinin) protein of H9N2 was expressed ...

Tarbuck NN, Franks J, Jones JC, Kandeil A, DeBeauc. Retail Milk Monitoring of Influenza A(H5N1) in Dairy Cattle, United States, 2024-2025. Emerg Infect Dis. 2026 Feb.  Abstract  
submitted by kickingbird at Jan, 31, 2026 from Emerg Infect Dis. 2026 Feb (via https://wwwnc.cdc.gov/eid/article/32/2/25-1332_article)
US retail milk monitoring during April 13-May 3, 2024, identified influenza A(H5N1) viral RNA in 36% of retail milk samples, indicating widespread undetected infections in US dairy cows. After federal ...

Ying, Baoling et al. An intranasal adenoviral-vectored vaccine protects against highly pathogenic avian influenza H5N1 in naive and antigen-experienced animals. Cell Reports Medicine, January 30, 2026.  Abstract  
submitted by kickingbird at Jan, 31, 2026 from Cell Reports Medicine, January 30, 2026 (via https://www.cell.com/cell-reports-medicine/fulltext/S2666-37)
The emergence of highly pathogenic avian H5N1 influenza viruses in dairy cows and humans has increased the potential for another pandemic. To address this risk, we developed chimpanzee adenoviral (ChAd)-vectored ...

Daniel, Katharina et al. Pre-existing neutralizing antibodies against cattle-transmitted influenza A virus H5N1 are detectable in unexposed individuals. Immunity, January 30, 2026.  Abstract  
submitted by kickingbird at Jan, 31, 2026 from Immunity, January 30, 2026 (via https://www.cell.com/immunity/fulltext/S1074-7613(25)00569-2)
The transmission of influenza A virus H5N1 clade 2.3.4.4b from cattle to humans highlights the risk of an H5N1 pandemic. Pre-existing immunity strongly impacts the course and severity of viral infections, ...

Xiaolong Lu, etc.,al. The host RNA helicase DDX6 restricts avian influenza virus replication by targeting viral NP and modulating ISG15. Poultry Science.  Abstract  
submitted by kickingbird at Jan, 30, 2026 from Poultry Science (via https://www.sciencedirect.com/science/article/pii/S003257912)
The H7N9 subtype of avian influenza virus (AIV) poses a significant and ongoing threat to public health. As a critical structural and functional component, the viral nucleoprotein (NP) is abundantly expressed ...

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