Holly A. Coombes, etc.,al. [preprint]Infection of ratites with clade 2.3.4.4b HPAIV H5N1: Potential implications for zoonotic risk. https://doi.org/10.1101/2025.09.08.674895
We detected H5N1 high pathogenicity avian influenza in captive Greater Rhea (Rhea americana). Viral genetic analysis revealed the mammalian associated PB2-E627K mutation, indicating selection of mammalian-relevant mutations in ratites. Pathologic investigation of available tissues demonstrated severe multifocal necrotising inflammation, and a strong vasculotropism.
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