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2025-12-6 3:28:57
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Mutisari D, Muflihanah M, Wibawa H, Hendrawati F,. Phylogenetic analysis of HPAI H5N1 virus from duck swab specimens in Indonesia. J Adv Vet Anim Res. 2021 Jun 28;8(2):346-354..  Abstract  
submitted by kickingbird at Aug, 17, 2021 from J Adv Vet Anim Res. 2021 Jun 28;8(2):346-354. (via https://www.ejmanager.com/mnstemps/39/39-1617077743.pdf?t=16)
Objective: A phylogenetic study was carried out on the avian influenza virus (AIV) isolated from a disease outbreak in Sidenreng Rappang Regency, South Sulawesi, Indonesia, in 2018.Material and methods: ...

Wang Z, Chen Y, Chen H, Meng F, Tao S, Ma S, Qiao. A single amino acid at position 158 in hemagglutinin affects the antigenic property of Eurasian Avian-like H1N1 Swine influenza viruses. Transbound Emerg Dis. 2021 Aug 15.  Abstract  
submitted by kickingbird at Aug, 17, 2021 from Transbound Emerg Dis. 2021 Aug 15 (via https://onlinelibrary.wiley.com/doi/10.1111/tbed.14288)
Influenza viruses have been posing a great threat to public health and animal industry. The developed vaccines have been widely used to reduce the risk of potential pandemic; however, the ongoing antigenic ...

Liu Y, Wang X, Zhou J, Shi S, Shen T, Chen L, Zhan. Development of PDA Nanoparticles for H9N2 Avian Influenza BPP-V/BP-IV Epitope Peptide Vaccines: Immunogenicity and Delivery Efficiency Improvement. Front Immunol. 2021 Jul 27;12:693972.  Abstract  
submitted by kickingbird at Aug, 16, 2021 from Front Immunol. 2021 Jul 27;12:693972 (via https://www.frontiersin.org/articles/10.3389/fimmu.2021.6939)
The protection of current influenza vaccines is limited due to the viral antigenic shifts and antigenic drifts. The universal influenza vaccine is a new hotspot in vaccine research that aims to overcome ...

Faleye TOC, Adams D, Adhikari S, Sandrolini H, Hal. Use of hemagglutinin and neuraminidase amplicon-based high-throughput sequencing with variant analysis to detect co-infection and resolve identical consensus sequences of seasonal influenza in a unive. BMC Infect Dis. 2021 Aug 13;21(1):810.  Abstract  
submitted by kickingbird at Aug, 16, 2021 from BMC Infect Dis. 2021 Aug 13;21(1):810 (via https://bmcinfectdis.biomedcentral.com/articles/10.1186/s128)
Background: Local transmission of seasonal influenza viruses (IVs) can be difficult to resolve. Here, we study if coupling high-throughput sequencing (HTS) of hemagglutinin (HA) and neuraminidase (NA) ...

Meiring S, Tempia S, Dominic EM, de Gouveia L, McA. Excess invasive meningococcal disease associated with seasonal influenza, South Africa, 2003-2018. Clin Infect Dis. 2021 Aug 14:ciab702.  Abstract  
submitted by kickingbird at Aug, 16, 2021 from Clin Infect Dis. 2021 Aug 14:ciab702 (via https://academic.oup.com/cid/advance-article/doi/10.1093/cid)
Background: Invasive meningococcal disease (IMD) is a devastating illness with high mortality. Like influenza, endemic IMD is seasonal peaking in winter. Studies suggest that circulation of influenza virus ...

Stinson JA, Boopathy AV, Cieslewicz BM, Zhang Y, H. Enhancing influenza vaccine immunogenicity and efficacy through infection mimicry using silk microneedles. Vaccine. 2021 Aug 11:S0264-410X(21)00957-9.  Abstract  
submitted by kickingbird at Aug, 16, 2021 from Vaccine. 2021 Aug 11:S0264-410X(21)00957-9 (via https://www.sciencedirect.com/science/article/pii/S0264410X2)
Traditional bolus vaccine administration leads to rapid clearance of vaccine from lymphoid tissue. However, there is increasing evidence suggesting that the kinetics of antigen delivery can impact immune ...

Burnham AJ, Miller JR, Singh I, Billings EA, Rush. Novel isoforms of influenza virus PA-X and PB1-F2 indicated by automatic annotation. Virus Res. 2021 Aug 12:198545.  Abstract  
submitted by kickingbird at Aug, 16, 2021 from Virus Res. 2021 Aug 12:198545 (via https://www.sciencedirect.com/science/article/abs/pii/S01681)
The influenza A virus genome contains 8 gene segments encoding 10 commonly recognized proteins. Additional protein products have been identified including PB1-F2 and PA-X. We report in-silico identification ...

Tang J, Gao R, Liu L, Zhang S, Liu J, Li X, Fang Q. Substitution of I222L-E119V in neuraminidase from highly pathogenic avian influenza H7N9 virus exhibited synergistic resistance effect to oseltamivir in mice. Sci Rep. 2021 Aug 11;11(1):16293.  Abstract  
submitted by kickingbird at Aug, 13, 2021 from Sci Rep. 2021 Aug 11;11(1):16293 (via https://www.nature.com/articles/s41598-021-95771-4)
That the high frequency and good replication capacity of strains with reduced susceptibility to neuraminidase inhibitors (NAIs) in highly pathogenic avian influenza H7N9 (HPAI H7N9) virus made it a significance ...

Tang H, Jianshen C, Zou L, Cai C, Wang Y, Robertso. A mixed-methods study of stakeholders´ practices and attitudes on avian influenza H7N9 vaccination for the yellow broiler industry in Guangxi, China. Transbound Emerg Dis. 2021 Aug 11.  Abstract  
submitted by kickingbird at Aug, 12, 2021 from Transbound Emerg Dis. 2021 Aug 11 (via https://onlinelibrary.wiley.com/doi/10.1111/tbed.14286)
In response to a sudden increase in H7N9 human infections, China introduced a H5/H7 bivalent inactivated vaccine for poultry in Guangxi and Guangdong provinces in July 2017, which subsequently became integrated ...

Xu X, Zhang L, Chu JTS, Wang Y, Chin AWH, Chong TH. A novel mechanism of enhanced transcription activity and fidelity for influenza A viral RNA-dependent RNA polymerase. Nucleic Acids Res. 2021 Aug 11:gkab660..  Abstract  
submitted by kickingbird at Aug, 12, 2021 from Nucleic Acids Res. 2021 Aug 11:gkab660. (via https://academic.oup.com/nar/advance-article/doi/10.1093/nar)
During RNA elongation, the influenza A viral (IAV) RNA-dependent RNA polymerase (RdRp) residues in the active site interact with the triphosphate moiety of nucleoside triphosphate (NTP) for catalysis. ...

Kaplan BS, Anderson TK, Chang J, Santos J, Perez D. Evolution and antigenic advancement of N2 neuraminidase of swine influenza A viruses circulating in the United States following two separate introductions from human seasonal viruses. J Virol. 2021 Aug 11:JVI0063221.  Abstract  
submitted by kickingbird at Aug, 12, 2021 from J Virol. 2021 Aug 11:JVI0063221 (via https://journals.asm.org/doi/10.1128/JVI.00632-21)
Two separate introductions of human seasonal N2 neuraminidase genes were sustained in United States swine since 1998 (N2-98) and 2002 (N2-02). Herein, we characterized the antigenic evolution of the N2 ...

Sakala IG, Honda-Okubo Y, Li L, Baldwin J, Petrovs. A M2 protein-based universal influenza vaccine containing Advax-SM adjuvant provides newborn protection via maternal or neonatal immunization. Vaccine. 2021 Aug 3:S0264-410X(21)00914-2.  Abstract  
submitted by kickingbird at Aug, 9, 2021 from Vaccine. 2021 Aug 3:S0264-410X(21)00914-2 (via https://www.sciencedirect.com/science/article/pii/S0264410X2)
Background: Despite newborns being at increased risk of serious influenza infection, influenza vaccines are currently not recommended for use in infants under 6 months of age. We therefore sought to evaluate ...

Yang F, Xiao Y, Liu F, Cheng L, Yao H, Wu N, Wu H. Genetic analysis and biological characteristics of novel clade 2.3.4.4 reassortant H5N6 avian influenza viruses from poultry in Eastern China in 2016. Int J Infect Dis. 2021 Aug 5:S1201-9712(21)00632-9.  Abstract  
submitted by kickingbird at Aug, 9, 2021 from Int J Infect Dis. 2021 Aug 5:S1201-9712(21)00632-9 (via https://www.ijidonline.com/article/S1201-9712(21)00632-9/ful)
Objectives: The continuous evolution of highly pathogenic H5N6 avian influenza viruses (AIVs) causes outbreaks in wildfowls and poultry and occasional human infections. To better understand the genetic ...

Del Rosario JMM, da Costa KAS, Asbach B, Ferrara F. Exploiting Pan Influenza A and Pan Influenza B Pseudotype Libraries for Efficient Vaccine Antigen Selection. Vaccines (Basel). 2021 Jul 5;9(7):741.  Abstract  
submitted by kickingbird at Aug, 9, 2021 from Vaccines (Basel). 2021 Jul 5;9(7):741 (via https://www.mdpi.com/2076-393X/9/7/741)
We developed an influenza hemagglutinin (HA) pseudotype library encompassing Influenza A subtypes HA1-18 and Influenza B subtypes (both lineages) to be employed in influenza pseudotype microneutralization ...

El-Husseiny MH, Hagag NM, Pushko P, Tretyakova I,. Evaluation of Protective Efficacy of Influenza Virus Like Particles Prepared from H5N1 Virus of Clade 2.2.1.2 in Chickens. Vaccines (Basel). 2021 Jul 1;9(7):715.  Abstract  
submitted by kickingbird at Aug, 9, 2021 from Vaccines (Basel). 2021 Jul 1;9(7):715 (via https://www.mdpi.com/2076-393X/9/7/715)
Highly pathogenic Avian Influenza (HPAI) viruses continue to cause severe economic losses in poultry species worldwide. HPAI virus of subtype H5N1 was reported in Egypt in 2006, and despite vaccination ...

Zhang S, Tang X, Wang S, Shi F, Duan C, Bi F, Suo. Establishment of Recombinant Eimeria acervulina Expressing Multi-Copies M2e Derived from Avian Influenza Virus H9N2. Vaccines (Basel). 2021 Jul 16;9(7):791.  Abstract  
submitted by kickingbird at Aug, 9, 2021 from Vaccines (Basel). 2021 Jul 16;9(7):791 (via https://www.mdpi.com/2076-393X/9/7/791)
The potential of Eimeria parasites as live vaccine vectors has been reported with successful genetic manipulation on several species like E. tenella, E. mitis and E. necatrix. Among seven Eimeria species ...

Liu Y, Liu C, Dang A, Sun S, Zhang D, Wang M, Chen. Pathological analysis and genetic characterization of the first outbreak H5N8 subtype avian influenza virus isolated from wild swan in Shandong, China. Transbound Emerg Dis. 2021 Aug 6.  Abstract  
submitted by kickingbird at Aug, 9, 2021 from Transbound Emerg Dis. 2021 Aug 6 (via https://onlinelibrary.wiley.com/doi/10.1111/tbed.14279)
In January 2021, an outbreak of H5N8 subtype avian influenza was identified from wild mute swans (Cygnus olor) in an overwintering site located within Yellow River Delta Nature Reserve in Shandong, China ...

Lee YN, Lee DH, Shin JI, Si YJ, Lee JH, Baek YG, H. Pathogenesis and genetic characteristics of a novel reassortant low pathogenic avian influenza A(H7N6) virus isolated in Cambodia in 2019. Transbound Emerg Dis. 2021 Aug 4..  Abstract  
submitted by kickingbird at Aug, 5, 2021 from Transbound Emerg Dis. 2021 Aug 4. (via https://onlinelibrary.wiley.com/doi/10.1111/tbed.14256)
The first human case of zoonotic A(H7N4) avian influenza virus (AIV) infection was reported in early 2018 in China. Two months after this case, novel A(H7N4) viruses phylogenetically related to the Jiangsu ...

Finch J, Zuckerman M, Smith M. Investigating the potential sequence variation in the influenza A matrix genes during the 2018-2019 season in samples from a local population in London. J Virol Methods. 2021 Jul 30:114250..  Abstract  
submitted by kickingbird at Aug, 4, 2021 from J Virol Methods. 2021 Jul 30:114250. (via https://www.sciencedirect.com/science/article/abs/pii/S01660)
Recent publications have highlighted the emergence of mutations in the M1 gene of both influenza A H1N1pdm09 and H3N2 subtypes affecting the performance of commercial RT-PCR assays. Respiratory samples ...

Han AX, Felix Garza ZC, Welkers MR, Vigeveno RM, T. Within-host evolutionary dynamics of seasonal and pandemic human influenza A viruses in young children. Elife. 2021 Aug 3;10:e68917.  Abstract  
submitted by kickingbird at Aug, 4, 2021 from Elife. 2021 Aug 3;10:e68917 (via https://elifesciences.org/articles/68917)
The evolution of influenza viruses is fundamentally shaped by within-host processes. However, the within-host evolutionary dynamics of influenza viruses remain incompletely understood, in part because ...

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