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2024-3-2 15:57:04

Wang X, Zheng H, Gao R, Ren L, Jin M, Ji Z, Wang X. Genetically Related Avian Influenza H7N9 Viruses Exhibit Different Pathogenicity in Mice. Animals (Basel). 2023 Nov 28;13(23):3680
submited by kickingbird at Dec, 10, 2023 8:8 AM from Animals (Basel). 2023 Nov 28;13(23):3680

Avian influenza viruses can cross species barriers and adapt to mammals. The H7N9 subtype AIV that emerged in China in 2013 caused 1568 human infections, with a mortality rate of nearly 40%. We conducted a retrospective analysis of H7N9 viruses that were isolated in live poultry markets in 2013. We found that two avian-origin H7N9 isolates, A/chicken/Eastern China/JTC4/2013 and A/chicken/Eastern China/JTC11/2013, have a similar genetic background but exhibit different pathogenicity in mice. Whole-genome alignment of the two H7N9 viruses was carried out, and only six amino acid differences mapped in five genes, including the well-known virulence molecular marker PB2-E627K. Our retrospective analysis highlighted the importance of monitoring the adaptive mutations in avian influenza viruses with zoonotic potential.

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