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2026-5-30 21:23:16
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Mengting Huang, etc.,al. Enhanced Immunogenicity and Dose-Sparing Efficacy of SelfAmplifying RNA Vaccines Against Seasonal Influenza Across Subtypes. Emerging Microbes & Infections.  Abstract  
submitted by kickingbird at May, 5, 2026 from Emerging Microbes & Infections (via https://www.tandfonline.com/doi/full/10.1080/22221751.2026.2)
Recent clinical data on seasonal influenza mRNA vaccines have demonstrated suboptimal efficacy against the influenza B virus (IBV). We employed sequence optimization strategies that successfully enhanced ...

C. Stenkamp-Strahm, etc.,al. A longitudinal study of influenza A viral detection in bulk tank and pen-level milk collected from dairy farms in California affected by Highly Pathogenic Avian Influenza H5N1. Journal of Dairy Science.  Abstract  
submitted by kickingbird at May, 5, 2026 from Journal of Dairy Science (via https://www.sciencedirect.com/science/article/pii/S002203022)
Highly pathogenic avian influenza virus H5N1 has been infecting dairy herds in the US since its initial incursion into cows in early 2024. Although national strategies have aimed to detect affected herds ...

Mingyue Wang, etc.,al. A novel self-amplified RNA vaccine co-expressing NA and HA1 delivered by Salmonella confers potent protection against H9N2 influenza in chickens. Poultry Science.  Abstract  
submitted by kickingbird at May, 5, 2026 from Poultry Science (via https://www.sciencedirect.com/science/article/pii/S003257912)
The ongoing evolution of the H9N2 avian influenza virus presents a growing threat to both the poultry industry and public health. In this context, vaccination is not only a vital preventive measure but ...

Ghumra, D.P., Xu, M., Benegal, A. et al. Biofouling-resistant functionalized capacitive biosensor for rapid detection of zoonotic influenza. npj Biosensing 3, 27 (2026).  Abstract  
submitted by kickingbird at May, 5, 2026 from npj Biosensing 3, 27 (2026) (via https://www.nature.com/articles/s44328-026-00092-z)
Emerging zoonotic pathogens represent an escalating threat to global health, underscoring the need for rapid and effective testing strategies. Electrochemical biosensors offer a promising solution for ...

WPRO. Avian Influenza Weekly Update # 1043: 1 May 2026. WHO.  Abstract  
submitted by kickingbird at May, 4, 2026 from WHO (via https://www.who.int/westernpacific/publications/m/item/avian)
Avian influenza subtype A(HxNy) normally spreads in birds but can also infect humans. Human infections are primarily acquired through direct contact with infected poultry or contaminated environments. ...

Flagg M, Winski CJ, Brackney BG, Lutterman TR, Ort. Replication Efficiency of Contemporary Highly Pathogenic Avian Influenza A(H5N1) Virus Isolates in Human Nasal Epithelium Model. Emerg Infect Dis. 2026 May.  Abstract  
submitted by kickingbird at May, 4, 2026 from Emerg Infect Dis. 2026 May (via https://wwwnc.cdc.gov/eid/article/32/5/26-0053_article)
Replication of influenza A virus in human nasal epithelium affects transmissibility and disease. We compared virus replication and immune responses in human nasal epithelium infected with seasonal and ...

Dressler Aparna, Wagner-Wiening Christiane, Teg. Highly pathogenic avian influenza A(H5N1) in poultry and domestic cats and occupational exposure among veterinary and other first responders, Germany, February 2026. Euro Surveill. 2026;31(17):pii=2600293.  Abstract  
submitted by kickingbird at May, 3, 2026 from Euro Surveill. 2026;31(17):pii=2600293 (via https://www.eurosurveillance.org/content/10.2807/1560-7917.E)
In February 2026, a highly pathogenic avian influenza (HPAI) A(H5N1) outbreak in a poultry holding in Sigmaringen, Germany, affected poultry and domestic cats, with infection confirmed by RT-qPCR. A One ...

Hoxie, I., Vasilev, K., Clark, J. et al. A TRAC-478-adjuvanted recombinant N1 neuraminidase influenza virus vaccine induces balanced and broadly protective immune responses. npj Vaccines (2026).  Abstract  
submitted by kickingbird at May, 3, 2026 from npj Vaccines (2026) (via https://link.springer.com/article/10.1038/s41541-026-01456-2)
Licensed influenza vaccines primarily target the variable hemagglutinin protein and provide inadequate cross-protection against mismatched or drifted viral strains. One promising approach to enhance the ...

Ziejka RS, Brown JD, Thompson-Iritani S, Ramirez V. Human and Hunting Dog Interactions in the United States: Exploring Potential Transmission Pathways of Zoonotic Diseases and Highly Pathogenic Avian Influenza Virus. Veterinary Sciences. 2026; 13(5):449.  Abstract  
submitted by kickingbird at May, 2, 2026 from Veterinary Sciences. 2026; 13(5):449 (via https://www.mdpi.com/2306-7381/13/5/449)
Since 2022, numerous H5N1 highly pathogenic avian influenza virus (HPAIV) detections have been reported in wild and domestic mammals in North America. Although H5N1 HPAIV detections in dogs are rare, hunting ...

Benedetti E, Artuso MC, Byrne A, Garibotto MdB, Av. Emergence and Evolution of Triple Reassortant Highly Pathogenic Avian Influenza A(H5N1) Virus, Argentina, 2025. Viruses. 2026; 18(5):525.  Abstract  
submitted by kickingbird at May, 2, 2026 from Viruses. 2026; 18(5):525 (via https://www.mdpi.com/1999-4915/18/5/525)
The H5N1 subtype of highly pathogenic avian influenza (HPAI) poses a major zoonotic threat due to its high fatality rate and capacity for cross species transmission. In early 2025, Argentina detected a ...

Mingyue Wang, etc.,al. A novel self-amplified RNA vaccine co-expressing NA and HA1 delivered by Salmonella confers potent protection against H9N2 influenza in chickens. Poultry Science.  Abstract  
submitted by kickingbird at May, 2, 2026 from Poultry Science (via https://www.sciencedirect.com/science/article/pii/S003257912)
The ongoing evolution of the H9N2 avian influenza virus presents a growing threat to both the poultry industry and public health. In this context, vaccination is not only a vital preventive measure but ...

Min Zhu, etc.,al. Canine influenza virus at the human-animal interface: origins, adaptive evolution, and implications for public health. Virology.  Abstract  
submitted by kickingbird at May, 2, 2026 from Virology (via https://www.sciencedirect.com/science/article/abs/pii/S00426)
Canine influenza virus (CIV), an important lineage of influenza A virus (IAV) adapted to canine hosts, has emerged as a significant concern in zoonotic disease control. In recent years, CIV has exhibited ...

Fathelrahman E, Mohamed Ali M, Challa TG, Osman R,. Modeling and assessing Highly Pathogenic Avian Influenza (HPAI) spread, epidemiological control measures, and cost. PLoS One. 2026 Apr 30;21(4):e0340004.  Abstract  
submitted by kickingbird at May, 1, 2026 from PLoS One. 2026 Apr 30;21(4):e0340004 (via https://journals.plos.org/plosone/article?id=10.1371/journal)
Highly Pathogenic Avian Influenza (HPAI) is a highly contagious, transboundary disease that can affect animals and humans, posing significant health risks to both. This study aimed to prepare for a potential ...

Wang M, Laison EKE, Philippsen T, Ghaemi S, Liu J,. Mechanistic modelling of highly pathogenic avian influenza: A scoping review revealing critical gaps in cross-species transmission models. PLoS One. 2026 Apr 30;21(4):e0347929.  Abstract  
submitted by kickingbird at May, 1, 2026 from PLoS One. 2026 Apr 30;21(4):e0347929 (via https://journals.plos.org/plosone/article?id=10.1371/journal)
Background: Highly pathogenic avian influenza (HPAI) viruses, particularly subtypes such as H5N1 and H7N9, have caused widespread outbreaks in wild birds, poultry, livestock and occasionally humans, raising ...

Daines R, Sadeyen J, Chang P, Iqbal M. 0. Mapping hemagglutinin residues driving antigenic diversity in H5Nx avian influenza viruses. J Virol 0:e00095-26.  Abstract  
submitted by kickingbird at May, 1, 2026 from J Virol 0:e00095-26 (via https://journals.asm.org/doi/10.1128/jvi.00095-26)
Since its emergence in 1996, the H5 avian influenza virus (AIV) A/Goose/Guangdong/1/1996 (Gs/GD) hemagglutinin (HA) has evolved into over 30 genetically and antigenically distinct clades, including the ...

Wang W, Xing J, Jiang H, Lu F, Huang H, Zhang Y, S. Human infections with avian influenza A(H5) viruses with potential pandemic risk: 1997-2025. Natl Sci Rev. 2025 Nov 10;13(7):nwaf471.  Abstract  
submitted by kickingbird at May, 1, 2026 from Natl Sci Rev. 2025 Nov 10;13(7):nwaf471 (via https://academic.oup.com/nsr/article/doi/10.1093/nsr/nwaf471)
Highly pathogenic avian influenza (HPAI) A(H5) viruses have caused sporadic human infections since 1997, with recent detections in the Americas and Asia. However, the evolutionary dynamics of different ...

Ashraf M, Boivin W, Nguyen-Van-Tam JS, Nolan T, St. Development of an adjuvanted, higher-dose, cell-based influenza vaccine: combining advanced technologies to improve vaccine effectiveness. Expert Rev Vaccines. 2026 Apr 29:2667732.  Abstract  
submitted by kickingbird at May, 1, 2026 from Expert Rev Vaccines. 2026 Apr 29:2667732 (via https://www.tandfonline.com/doi/full/10.1080/14760584.2026.2)
Introduction: Influenza remains a significant public health burden, particularly for high-risk populations such as older adults and those with chronic diseases. Effectiveness of standard-dose egg-grown ...

Wongnak P, Seers T, Jittamala P, Imwong M, Schilli. Characterizing viral clearance kinetics in acute influenza. Philos Trans R Soc Lond B Biol Sci. 2026 Apr 30;38.  Abstract  
submitted by kickingbird at May, 1, 2026 from Philos Trans R Soc Lond B Biol Sci. 2026 Apr 30;38 (via https://royalsocietypublishing.org/rstb/article/381/1949/202)
Pharmacometric assessment of antiviral efficacy in acute influenza informs treatment decisions and pandemic preparedness. We characterized natural viral clearance in acute influenza to guide phase II trial ...

Sun X, Belser JA, Li Z-N, Liu F, Brock N, Pulit-Pe. Prior immunity to seasonal influenza A(H3N2) virus confers varying levels of cross-protection against challenge with clade 2.3.4.4b A(H5N1), A(H7N9), or A(H9N2) virus in a ferret model. Microbiol Spectr. 2026 Apr 30:e0397425.  Abstract  
submitted by kickingbird at May, 1, 2026 from Microbiol Spectr. 2026 Apr 30:e0397425 (via https://journals.asm.org/doi/10.1128/spectrum.03974-25)
Evaluating how prior immunity to seasonal influenza viruses influences subsequent zoonotic influenza A virus (IAV) infection in animal models is critical for pandemic preparedness. In this study, we investigated ...

Shuk Hang Li, etc.,al. Childhood immunological imprinting of cross-subtype antibodies targeting the hemagglutinin head domain of influenza viruses. Cell Host & Microbe.  Abstract  
submitted by kickingbird at May, 1, 2026 from Cell Host & Microbe (via https://www.sciencedirect.com/science/article/abs/pii/S19313)
Influenza virus cross-subtype antibodies targeting epitopes in the hemagglutinin (HA) head are rare because these epitopes are variable between influenza virus subtypes. We found that a large proportion ...

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