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2025-2-13 1:15:57
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Wang X, Dai J, Yang W, Yao Y, Zhang J, Liu K, Lu X. Spray vaccination with a safe and bivalent H9N2 recombinant chimeric NDV vector vaccine elicits complete protection against NDV and H9N2 AIV challenge. Vet Res. 2025 Jan 31;56(1):24.  Abstract  
submitted by kickingbird at 9 days ago from Vet Res. 2025 Jan 31;56(1):24 (via https://veterinaryresearch.biomedcentral.com/articles/10.118)
Newcastle disease virus (NDV) and H9N2 avian influenza virus (AIV) represent significant pathogenic risks to the poultry industry, leading to considerable economic losses. Vaccination is a widely used ...

Wang Z, Tian C, Zhu J, Wang S, Ao X, He Y, Chen H,. Avian influenza mRNA vaccine encoding hemagglutinin provides complete protection against divergent H5N1 viruses in specific-pathogen-free chickens. J Nanobiotechnology. 2025 Jan 29;23(1):55.  Abstract  
submitted by kickingbird at 13 days ago from J Nanobiotechnology. 2025 Jan 29;23(1):55 (via https://jnanobiotechnology.biomedcentral.com/articles/10.118)
Background: The rapid mutation of avian influenza virus (AIV) poses a significant threat to both the poultry industry and public health. Herein, we have successfully developed an mRNA-LNPs candidate vaccine ...

Zhang C, Hou J, Li Z, Shen Q, Bai H, Chen L, Shen. PROTAR Vaccine 2.0 generates influenza vaccines by degrading multiple viral proteins. Nat Chem Biol. 2025 Jan 15.  Abstract  
submitted by kickingbird at Jan, 17, 2025 from Nat Chem Biol. 2025 Jan 15 (via https://www.nature.com/articles/s41589-024-01813-z)
Manipulating viral protein stability using the cellular ubiquitin-proteasome system (UPS) represents a promising approach for developing live-attenuated vaccines. The first-generation proteolysis-targeting ...

Shen J, Li J, Shen Q, Hou J, Zhang C, Bai H, Ai X,. Proteolysis-targeting influenza vaccine strains induce broad-spectrum immunity and in vivo protection. Nat Microbiol. 2025 Jan 15.  Abstract  
submitted by kickingbird at Jan, 17, 2025 from Nat Microbiol. 2025 Jan 15 (via https://www.nature.com/articles/s41564-024-01908-2)
Generating effective live vaccines from intact viruses remains challenging owing to considerations of safety and immunogenicity. Approaches that can be applied in a systematic manner are needed. Here we ...

Gert Zimmer, etc.,al. [preprint]Immunization with a novel RNA replicon vaccine confers long-lasting protection against H5N1 avian influenza virus in 24 bird species. ttps://doi.org/10.1101/2025.01.15.633174.  Abstract  
submitted by kickingbird at Jan, 16, 2025 from ttps://doi.org/10.1101/2025.01.15.633174 (via https://www.biorxiv.org/content/10.1101/2025.01.15.633174v1)
Highly pathogenic avian influenza viruses (HPAIV) of subtype H5N1 (clade 2.3.4.4b) have spread worldwide and caused the death of hundreds of millions of wild birds and domestic poultry. Moreover, spill ...

Bia P, Losardo M, Manna A, Brusaferro S, Privitera. Selected microwave irradiation effectively inactivates airborne avian influenza A(H5N1) virus. Sci Rep. 2025 Jan 15;15(1):2021.  Abstract  
submitted by kickingbird at Jan, 16, 2025 from Sci Rep. 2025 Jan 15;15(1):2021 (via https://www.nature.com/articles/s41598-025-85376-6)
The highly pathogenic avian influenza A(H5N1) virus threatens animal and human health globally. Innovative strategies are crucial for mitigating risks associated with airborne transmission and preventing ...

Qingcui Wang, Biru Yang, Yaqi Zhu, Jiameng Pei, et. Trans-dimensional nanocoral gold foam interfaces affords ultrasensitive detection of influenza virus. Anal Chim Acta . 2025 Feb 1:1337:343576..  Abstract  
submitted by kickingbird at Jan, 14, 2025 from Anal Chim Acta . 2025 Feb 1:1337:343576. (via https://www.sciencedirect.com/science/article/abs/pii/S00032)
Development of sensitive and cost-effective strategies for detecting influenza viruses is crucial to combat the spread of infectious diseases. In this study, a novel trans-dimensional nanocoral gold foam ...

Jinha Song, etc.,al. Rapid and specific on-site H5Nx avian influenza diagnosis via RPA and PAM-independent CRISPR-Cas12a assay combined with anti-NP antibody-based viral RNA purification. Front. Vet. Sci.  Abstract  
submitted by kickingbird at Jan, 10, 2025 from Front. Vet. Sci (via https://www.frontiersin.org/journals/veterinary-science/arti)
Rapid and accurate detection of H5Nx avian influenza viruses is critical for effective surveillance and control measures. Currently, RT-qPCR with spin column RNA extraction is the gold standard for HPAIV ...

Ashraf MA, Raza MA, Imran A, Amjad MN. Next-generation vaccines for influenza B virus: advancements and challenges. Arch Virol. 2025 Jan 6;170(2):25.  Abstract  
submitted by kickingbird at Jan, 8, 2025 from Arch Virol. 2025 Jan 6;170(2):25 (via https://link.springer.com/article/10.1007/s00705-024-06210-4)
To battle seasonal outbreaks of influenza B virus infection, which continue to pose a major threat to world health, new and improved vaccines are urgently needed. In this article, we discuss the current ...

Yujia Yang, etc.,al. Rapid detection of Pan-Avian Influenza Virus and H5, H7, H9 subtypes of Avian Influenza Virus using CRISPR/Cas13a and lateral flow assay. Poultry Science February 2025.  Abstract  
submitted by kickingbird at Jan, 1, 2025 from Poultry Science February 2025 (via https://www.sciencedirect.com/science/article/pii/S003257912)
Avian Influenza Virus (AIV) has been prevalent worldwide in recent years, resulting in substantial economic losses in the poultry industry. More importantly, AIV is capable of cross-species transmission ...

Hannah L. Wallace, Jordan Wight, Mariana Baz, Barb. Longitudinal screening of retail milk from Canadian provinces reveals no detections of influenza A virus RNA (April–July 2024): leveraging a newly established pan-Canadian network for responding to em. Canadian Journal of Microbiology.  Abstract  
submitted by kickingbird at Dec, 18, 2024 from Canadian Journal of Microbiology (via https://cdnsciencepub.com/doi/10.1139/cjm-2024-0120)
Highly pathogenic avian influenza (HPAI) H5N1 has caused the deaths of more than 100 million birds since 2021, and human cases since 1997 have been associated with significant morbidity and mortality. ...

Chudan Liang, Zequn Wang, etc.,al. Rapidly quantification of intact infectious H1N1 virus using ICA-qPCR and PMA-qPCR. Biosafety and Health Available online 26 November.  Abstract  
submitted by kickingbird at Nov, 29, 2024 from Biosafety and Health Available online 26 November (via https://www.sciencedirect.com/science/article/pii/S259005362)
The increase in emerging and reemerging infectious diseases has underscored the need for the prompt monitoring of intact infectious viruses and the quick assessment of their infectivity. However, molecular ...

Kirby MK, Shu B, Keller MW, Wilson MM, Rambo-Marti. Discriminating North American Swine Influenza Viruses with a Portable, One-Step, Triplex Real-Time RT-PCR Assay, and Portable Sequencing. Viruses. 2024; 16(10):1557.  Abstract  
submitted by kickingbird at Oct, 22, 2024 from Viruses. 2024; 16(10):1557 (via https://www.mdpi.com/1999-4915/16/10/1557)
Swine harbors a genetically diverse population of swine influenza A viruses (IAV-S), with demonstrated potential to transmit to the human population, causing outbreaks and pandemics. Here, we describe ...

Lamb C, Pitre E, Ajufo S, Rigby C, Bisht K, Oade M. Quantification of influenza virus mini viral RNAs using Cas13. RNA. 2024 Oct 17:rna.080174.124.  Abstract  
submitted by kickingbird at Oct, 18, 2024 from RNA. 2024 Oct 17:rna.080174.124 (via https://rnajournal.cshlp.org/content/early/2024/10/17/rna.08)
Influenza A virus (IAV) RNA synthesis produces full-length and deletion-containing RNA molecules, which include defective viral genomes (DVG) and mini viral RNAs (mvRNA). Sequencing approaches have shown ...

Vatzia E, Paudyal B, Dema B, Carr BV, Sedaghat-Ros. Aerosol immunization with influenza matrix, nucleoprotein, or both prevents lung disease in pig. NPJ Vaccines. 2024 Oct 13;9(1):188.  Abstract  
submitted by kickingbird at Oct, 14, 2024 from NPJ Vaccines. 2024 Oct 13;9(1):188 (via https://www.nature.com/articles/s41541-024-00989-8)
Current influenza vaccines are strain-specific and require frequent updates to combat new strains, making a broadly protective influenza vaccine (BPIV) highly desirable. A promising strategy is to induce ...

Qin Li, etc.,al. Thin-film freeze-drying of an influenza virus hemagglutinin mRNA vaccine in unilamellar lipid nanoparticles with blebs. Journal of Controlled Release.  Abstract  
submitted by kickingbird at Oct, 13, 2024 from Journal of Controlled Release (via https://www.sciencedirect.com/science/article/abs/pii/S01683)
Messenger RNA (mRNA) vaccines have revolutionized the fight against infectious diseases and are poised to transform other therapeutic areas. Lipid nanoparticles (LNP) represent the most successful delivery ...

Tian Y, Lu X, Xiao D, Zhou C.. Long-Lasting Chemiluminescence Based on Functionalized Multicolor Protein Capsules for Multiple Visualization Detection of Avian Influenza Virus Biomarkers. Anal Chem. 2024 Oct 11.  Abstract  
submitted by kickingbird at Oct, 12, 2024 from Anal Chem. 2024 Oct 11 (via https://pubs.acs.org/doi/10.1021/acs.analchem.4c04248)
Long-lasting chemiluminescence (CL) emissions are necessary for improving the detection accuracy and expanding the application scope. Here, we have synthesized three oil-in-water (O/W) multicolor protein ...

Zhang YN, Gomes KB, Lee YZ, Ward G, Xie B, Auclair. A Single-Component Multilayered Self-Assembling Protein Nanoparticle Vaccine Based on Extracellular Domains of Matrix Protein 2 against Both Influenza A and B. Vaccines (Basel). 2024 Aug 28;12(9):975.  Abstract  
submitted by kickingbird at Oct, 1, 2024 from Vaccines (Basel). 2024 Aug 28;12(9):975 (via https://www.mdpi.com/2076-393X/12/9/975)
The development of an effective and broadly protective influenza vaccine against circulating and emerging strains remains elusive. In this study, we evaluated a potentially universal influenza vaccine ...

Zhao X, Zheng X, Yang X, Guo Q, Zhang Y, Lou J. Establishment of a Lateral Flow Dipstick Detection Method for Influenza A Virus Based on CRISPR/Cas12a System. China CDC Wkly. 2024 Sep 13;6(37):946-952.  Abstract  
submitted by kickingbird at Oct, 1, 2024 from China CDC Wkly. 2024 Sep 13;6(37):946-952 (via https://weekly.chinacdc.cn/en/article/doi/10.46234/ccdcw2024)
Objective: This study aimed to develop a rapid, visual PCR-CRISPR/Cas12-LFD method for detecting influenza A by utilizing the conserved region of the matrix protein gene.Method: We crafted universal degradation ...

Webby, R.J. The practical longevity of stockpiled A(H5N1) influenza vaccine. Nat Med (2024).  Abstract  
submitted by kickingbird at Sep, 27, 2024 from Nat Med (2024) (via https://www.nature.com/articles/s41591-024-03256-4)
Stockpiled A(H5N1) influenza vaccines made using viruses from the mid-2000s stimulate antibodies that cross-react with current strains, despite being separated by 20 years of viral evolution — supporting ...

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