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2024-2-24 7:33:07
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Yang Z, Yu S, Xu Y, Zhao Y, Li L, Sun J, Wang X, G. The Screening and Mechanism of Influenza-Virus Sensitive MDCK Cell Lines for Influenza Vaccine Production. Diseases. 2024 Jan 10;12(1):20.  Abstract  
submitted by kickingbird at Jan, 22, 2024 from Diseases. 2024 Jan 10;12(1):20 (via https://www.mdpi.com/2079-9721/12/1/20)
Influenza is a potentially fatal acute respiratory viral disease caused by the influenza virus. Influenza viruses vary in antigenicity and spread rapidly, resulting in seasonal epidemics. Vaccination is ...

Howard LM, Jensen TL, Goll JB, Gelber CE, Bradley. Metabolomic Signatures Differentiate Immune Responses in Avian Influenza Vaccine Recipients. J Infect Dis. 2024 Jan 5:jiad611.  Abstract  
submitted by kickingbird at Jan, 6, 2024 from J Infect Dis. 2024 Jan 5:jiad611 (via https://academic.oup.com/jid/advance-article-abstract/doi/10)
Background: Avian influenza viruses pose significant risk to human health. Vaccines targeting the hemagglutinin of these viruses are poorly immunogenic without the use of adjuvants.Methods: Twenty healthy ...

Chen X, Huang Y, Gao P, Wu F, Han Y, Zhang C, Hu Z. Engineering of novel hemagglutinin biosensors for rapid detection and drug screening of Influenza A H7N9 virus. Int J Biol Macromol. 2023 Dec 30:129126.  Abstract  
submitted by kickingbird at Jan, 3, 2024 from Int J Biol Macromol. 2023 Dec 30:129126 (via https://www.sciencedirect.com/science/article/abs/pii/S01418)
New pathogenic influenza virus strains are constantly emerging, posing a serious risk to both human health and economic growth. To effectively control the spread of this virus, there is an urgent need ...

Wen F, Wang C, Guo J, Yu H, Yuan S, Li Y, Li Z, Hu. Development and application of a triplex real-time PCR assay for the detection of H3, H4, and H5 subtypes of avian influenza virus. Poult Sci. 2023 Nov 30;103(2):103333.  Abstract  
submitted by kickingbird at Dec, 20, 2023 from Poult Sci. 2023 Nov 30;103(2):103333 (via https://www.sciencedirect.com/science/article/pii/S003257912)
Avian influenza virus (AIV) poses a significant threat to the poultry industry and public health. Among the diverse AIV subtypes, H3, H4, and H5 are frequently detected in waterfowl and live poultry markets ...

Kapczynski DR, Chrzastek K, Shanmugasundaram R, Zs. Efficacy of recombinant H5 vaccines delivered in ovo or day of age in commercial broilers against the 2015 U.S. H5N2 clade 2.3.4.4c highly pathogenic avian Influenza virus. Virol J. 2023 Dec 15;20(1):298.  Abstract  
submitted by kickingbird at Dec, 17, 2023 from Virol J. 2023 Dec 15;20(1):298 (via https://virologyj.biomedcentral.com/articles/10.1186/s12985-)
Background: Avian influenza is a highly contagious, agriculturally relevant disease that can severely affect the poultry industry and food supply. Eurasian-origin H5Nx highly pathogenic avian influenza ...

Li Y, Shang J, Luo J, Zhang F, Meng G, Feng Y, Jia. Rapid detection of H5 subtype avian influenza virus using CRISPR Cas13a based-lateral flow dipstick. Front Microbiol. 2023 Nov 29;14:1283210.  Abstract  
submitted by kickingbird at Dec, 15, 2023 from Front Microbiol. 2023 Nov 29;14:1283210 (via https://www.frontiersin.org/articles/10.3389/fmicb.2023.1283)
Due to its high mortality rate, highly pathogenic avian influenza (HPAI), a notifiable animal illness designated by the World Organisation for Animal Health (WOAH), has caused enormous financial losses ...

Zhou P, Qiu T, Wang X, Yang X, Shi H, Zhu C, Dai W. One HA stalk topping multiple heads as a novel influenza vaccine. Emerg Microbes Infect. 2023 Dec 4:2290838.  Abstract  
submitted by kickingbird at Dec, 5, 2023 from Emerg Microbes Infect. 2023 Dec 4:2290838 (via https://www.tandfonline.com/doi/full/10.1080/22221751.2023.2)
Classic chimeric hemagglutinin (cHA) was designed to induce immune responses against the conserved stalk domain of HA. However, it is unclear whether combining more than one HA head domain onto one stalk ...

Yuan L, Li X, Li M, Bi R, Li Y, Song J, Li W, Yan. In silico design of a broad-spectrum multiepitope vaccine against influenza virus. Int J Biol Macromol. 2023 Nov 13:128071.  Abstract  
submitted by kickingbird at Nov, 16, 2023 from Int J Biol Macromol. 2023 Nov 13:128071 (via https://www.sciencedirect.com/science/article/abs/pii/S01418)
Influenza remains a global health concern due to its potential to cause pandemics as a result of rapidly mutating influenza virus strains. Existing vaccines often struggle to keep up with these rapidly ...

Spackman E, Suarez DL, Lee CW, Pantin-Jackwood MJ, Lee SA, Youk S, Ibrahim S. Efficacy of inactivated and RNA particle vaccines against a North American Clade 2.3.4.4b H5 highly pathogenic avian influenza virus in chickens. Vaccine. 2023 Nov 4:S0264-410X(23)01285-9.  Abstract  
submitted by kickingbird at Nov, 7, 2023 from Vaccine. 2023 Nov 4:S0264-410X(23)01285-9 (via https://www.sciencedirect.com/science/article/pii/S0264410X2)
Highly pathogenic avian influenza virus (HPAIV) has caused widespread outbreaks in poultry in the Americas. Because of the duration and extent of these outbreaks, vaccine use may be an additional tool ...

Li Y, Shang J, Wang Y, Luo J, Jiang W, Yin X, Zhan. Establishment of two assays based on reverse transcription recombinase-aided amplification technology for rapid detection of H5 subtype avian influenza virus. Microbiol Spectr. 2023 Oct 9:e0218623.  Abstract  
submitted by kickingbird at Oct, 12, 2023 from Microbiol Spectr. 2023 Oct 9:e0218623 (via https://journals.asm.org/doi/10.1128/spectrum.02186-23)
The avian influenza virus (AIV), a member of the type A influenza virus group, is harbored by avian hosts. The highly pathogenic H5 subtype of AIV has inflicted significant financial damage on the poultry ...

Yu J, Sreenivasan C, Sheng Z, Zhai SL, Wollman JW,. A recombinant chimeric influenza virus vaccine expressing the consensus H3 hemagglutinin elicits broad hemagglutination inhibition antibodies against divergent swine H3N2 influenza viruses. Vaccine. 2023 Sep 7:S0264-410X(23)01060-5.  Abstract  
submitted by kickingbird at Sep, 12, 2023 from Vaccine. 2023 Sep 7:S0264-410X(23)01060-5 (via https://pubmed.ncbi.nlm.nih.gov/37689544/)
The global distribution and ongoing evolution of type A swine influenza virus (IAV-S) continue to pose significant challenges against developing broadly protective vaccines to control swine influenza. ...

Chen YQ, Su GM, Zhang JH, Li B, Ma KX, Zhang X, Hu. HVT-vectored H7 vaccine protects chickens from lethal infection with the highly pathogenic H7N9 Avian influenza virus. Vet Microbiol. 2023 Aug 20;285:109852.  Abstract  
submitted by kickingbird at Sep, 10, 2023 from Vet Microbiol. 2023 Aug 20;285:109852 (via https://www.sciencedirect.com/science/article/abs/pii/S03781)
Since mid-2016, the highly pathogenic H7N9 subtype avian influenza virus (AIV) has threatened both public health and the poultry industry. Although a vaccination strategy has been deemed imperative to ...

Xiong F, Zhang C, Shang B, Zheng M, Wang Q, Ding Y. An mRNA-based broad-spectrum vaccine candidate confers cross-protection against heterosubtypic influenza A viruses. Emerg Microbes Infect. 2023 Sep 6:2256422.  Abstract  
submitted by kickingbird at Sep, 10, 2023 from Emerg Microbes Infect. 2023 Sep 6:2256422 (via https://www.tandfonline.com/doi/full/10.1080/22221751.2023.2)
Influenza virus is a prominent cause of respiratory illness in humans. Current influenza vaccines offer strain-specific immunity, while provide limited protection against drifted strains. Broad-spectrum ...

Le Y, Zhang J, Gong Z, Zhang Z, Nian X, Li X, Yu D. TRAF3 deficiency in MDCK cells improved sensitivity to the influenza A virus. Heliyon. 2023 Aug 21;9(9):e19246.  Abstract  
submitted by kickingbird at Sep, 10, 2023 from Heliyon. 2023 Aug 21;9(9):e19246 (via https://www.cell.com/heliyon/fulltext/S2405-8440(23)06454-X)
Tumor necrosis factor receptor-associated factor 3 (TRAF3), an adaptor protein, has significant and varying effects on immunity depending on cell types. The role of TRAF3 in Madin-Darby Canine Kidney Epithelial ...

David SC, Vadas O, Glas I, Schaub A, Luo B, D&acut. Inactivation mechanisms of influenza A virus under pH conditions encountered in aerosol particles as revealed by whole-virus HDX-MS. mSphere. 2023 Aug 18:e0022623.  Abstract  
submitted by kickingbird at Aug, 21, 2023 from mSphere. 2023 Aug 18:e0022623 (via https://journals.asm.org/doi/10.1128/msphere.00226-23)
Multiple respiratory viruses, including influenza A virus (IAV), can be transmitted via expiratory aerosol particles, and aerosol pH was recently identified as a major factor influencing airborne virus ...

Zhang J, Nian X, Liu B, Zhang Z, Zhao W, Han X, Ma. Development of MDCK-based quadrivalent split seasonal influenza virus vaccine with high safety and immunoprotection: A preclinical study. Antiviral Res. 2023 Jun 1:105639.  Abstract  
submitted by kickingbird at Jun, 4, 2023 from Antiviral Res. 2023 Jun 1:105639 (via https://www.sciencedirect.com/science/article/pii/S016635422)
Vaccination remains the best prevention strategy against influenza. The MDCK-based influenza vaccine prompted the development of innovative cell culture manufacturing processes. In the present study, we ...

Temte JL, Bell C, Goss MD, Reisdorf E, Tamerius J,. Adequacy of using a single nasal swab for rapid influenza diagnostic testing, PCR, and whole genome sequencing. PLOS Glob Public Health. 2023 May 24;3(5):e0001422.  Abstract  
submitted by kickingbird at May, 25, 2023 from PLOS Glob Public Health. 2023 May 24;3(5):e0001422 (via https://journals.plos.org/globalpublichealth/article?id=10.1)
Rapid influenza diagnostic tests (RIDT) demonstrate varying sensitivities, often necessitating reverse transcriptase polymerase chain reaction (RT-PCR) to confirm results. The two methods generally require ...

Rumfelt KE, Fitzsimmons WJ, Truscon R, Monto AS, M. A rapid and flexible microneutralization assay for serological assessment of influenza viruses. Influenza Other Respir Viruses. 2023;17(4):e13141.  Abstract  
submitted by kickingbird at May, 4, 2023 from Influenza Other Respir Viruses. 2023;17(4):e13141 (via https://onlinelibrary.wiley.com/doi/10.1111/irv.13141)
Background: Serological responses from influenza vaccination or infection are typically measured by hemagglutinin inhibition (HAI) or microneutralization (MN). Both methods are limited in feasibility, ...

Andrews SF, Cominsky LY, Shimberg GD, Gillespie RA. An influenza H1 hemagglutinin stem-only immunogen elicits a broadly cross-reactive B cell response in humans. Sci Transl Med. 2023 Apr 19;15(692):eade4976.  Abstract  
submitted by kickingbird at Apr, 20, 2023 from Sci Transl Med. 2023 Apr 19;15(692):eade4976 (via https://www.science.org/doi/10.1126/scitranslmed.ade4976)
Current yearly seasonal influenza vaccines primarily induce an antibody response directed against the immunodominant but continually diversifying hemagglutinin (HA) head region. These antibody responses ...

Widge AT, Hofstetter AR, Houser KV, Awan SF, Chen. An influenza hemagglutinin stem nanoparticle vaccine induces cross-group 1 neutralizing antibodies in healthy adults. Sci Transl Med. 2023 Apr 19;15(692):eade4790.  Abstract  
submitted by kickingbird at Apr, 20, 2023 from Sci Transl Med. 2023 Apr 19;15(692):eade4790 (via https://www.science.org/doi/10.1126/scitranslmed.ade4790)
Influenza vaccines could be improved by platforms inducing cross-reactive immunity. Immunodominance of the influenza hemagglutinin (HA) head in currently licensed vaccines impedes induction of cross-reactive ...

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