Yang F, Xiao Y, Liu F, Yao H, Wu N, Wu H. Development of a Monoclonal Antibody-Based Antigen Capture Enzyme-Linked Immunosorbent Assay for Detection of H7N9 Subtype Avian Influenza Virus. J Med Virol. 2020;10.1002/jmv.26292. Abstract
submitted by kickingbird at 17 hours ago from J Med Virol. 2020;10.1002/jmv.26292 (via https://pubmed.ncbi.nlm.nih.gov/32648948/)
In order to establish a rapid detection method for H7N9 avian influenza virus (AIV), monoclonal antibodies (mAbs) against hemagglutinin (HA) of H7N9 were developed to establish an antigen capture enzyme-linked ...
Guk K, Kim H, Lee M, et al.. Development of A4 Antibody for Detection of Neuraminidase I223R/H275Y-associated Antiviral Multidrug-Resistant Influenza Virus. Nat Commun. 2020;11(1):3418. Published 2020 Jul 9.. Abstract
submitted by kickingbird at 17 hours ago from Nat Commun. 2020;11(1):3418. Published 2020 Jul 9. (via https://pubmed.ncbi.nlm.nih.gov/32647286/)
The emergence and spread of antiviral drug-resistant viruses have been a worldwide challenge and a great concern for patient care. We report A4 antibody specifically recognizing and binding to the mutant ...
Cheng C, Li J, Liu W, Xu L, Zhang Z. Modelling Analysis Revealed the Distinct Global Transmission Patterns of Influenza A Viruses and Their Influencing Factors. Integr Zool. 2020;10.1111/1749-4877.12469. Abstract
submitted by kickingbird at 2 days ago from Integr Zool. 2020;10.1111/1749-4877.12469 (via https://onlinelibrary.wiley.com/doi/abs/10.1111/1749-4877.12)
Influenza A virus has caused huge damage to human health and poultry production worldwide, but its global transmission patterns and influencing factors remains unclear. Here, by using the Nearest Genetic ...
Mo J, Spackman E, Stephens CB. Identification of Optimal Sample Collection Devices and Sampling Locations for the Detection Environmental Viral Contamination in Wire Poultry Cages. Transbound Emerg Dis. 2020;10.1111/tbed.13721. Abstract
submitted by kickingbird at 3 days ago from Transbound Emerg Dis. 2020;10.1111/tbed.13721 (via https://pubmed.ncbi.nlm.nih.gov/32643291/)
Environmental testing of poultry premises after an outbreak of an infectious disease like avian influenza (AI) or Newcastle disease, is essential to promptly verify virus-free status and subsequently return ...
Li L, Wu H, Li Q, et al. SOCS3-deficient Lung Epithelial Cells Uptaking Neutrophil-Derived SOCS3 Worsens Lung Influenza Infection. Mol Immunol. 2020;125:51-62. Abstract
submitted by kickingbird at 3 days ago from Mol Immunol. 2020;125:51-62 (via https://pubmed.ncbi.nlm.nih.gov/32645550/)
Suppressor of cytokine signaling 3 (SOCS3) is a negative regulator of TBK1 and interferon pathway and the expression of SOCS3 is closely correlated with symptoms of influenza patients. However, whether ...
Maier HE, Kuan G, Gresh L, et al. Obesity Is Associated With Increased Susceptibility to Influenza A (H1N1pdm) but Not H3N2 Infection. Clin Infect Dis. 2020;ciaa928. Abstract
submitted by kickingbird at 3 days ago from Clin Infect Dis. 2020;ciaa928 (via https://pubmed.ncbi.nlm.nih.gov/32642771/)
Background: Obesity has been shown to increase the risk of severe outcomes and death for influenza virus infections. However, we don't understand the influence of obesity on susceptibility to infection ...
Scarpino SV, Scott JG, Eggo RM, Clements B, Dimitr. Socioeconomic Bias in Influenza Surveillance. PLoS Comput Biol. 2020;16(7):e1007941. Abstract
submitted by kickingbird at 3 days ago from PLoS Comput Biol. 2020;16(7):e1007941 (via https://pubmed.ncbi.nlm.nih.gov/32644990/)
Individuals in low socioeconomic brackets are considered at-risk for developing influenza-related complications and often exhibit higher than average influenza-related hospitalization rates. This disparity ...
Arai Y, Elgendy EM, Daidoji T, et al. H9N2 Influenza Virus Infections in Human Cells Require a Balance Between NA Sialidase Activity and HA Receptor Affinity. J Virol. 2020;JVI.01210-20.. Abstract
submitted by kickingbird at 3 days ago from J Virol. 2020;JVI.01210-20. (via https://pubmed.ncbi.nlm.nih.gov/32641475/)
Some avian influenza (AI) viruses have a deletion of up to 20-30 amino acids in their NA stalk. This has been associated with changes in virus replication and host range. Currently prevalent H9N2 AI viruses ...
Zanin M, DeBeauchamp J, Vangala G, Webby RJ, Husai. Histone Deacetylase 6 Knockout Mice Exhibit Higher Susceptibility to Influenza A Virus Infection. Viruses. 2020;12(7):E728. Abstract
submitted by kickingbird at 3 days ago from Viruses. 2020;12(7):E728 (via https://pubmed.ncbi.nlm.nih.gov/32640546/)
The host innate defence against influenza virus infection is an intricate system with a plethora of antiviral factors involved. We have identified host histone deacetylase 6 (HDAC6) as an anti-influenza ...
Ikematsu H, Hayden FG, Kawaguchi K, et al. Baloxavir Marboxil for Prophylaxis Against Influenza in Household Contacts. N Engl J Med. 2020;10.1056/NEJMoa1915341. Abstract
submitted by kickingbird at 3 days ago from N Engl J Med. 2020;10.1056/NEJMoa1915341 (via https://pubmed.ncbi.nlm.nih.gov/32640124/)
Background: Baloxavir marboxil (baloxavir) is a polymerase acidic protein (PA) endonuclease inhibitor with clinical efficacy in the treatment of uncomplicated influenza, including in outpatients at increased ...
Dong X, Xiong J, Huang C, et al. Human H9N2 Avian Influenza Infection: Epidemiological and Clinical Characterization of 16 Cases in China. Virol Sin. 2020;10.1007/s12250-020-00248-9. Abstract
submitted by kickingbird at 4 days ago from Virol Sin. 2020;10.1007/s12250-020-00248-9 (via https://link.springer.com/article/10.1007/s12250-020-00248-9)
The first human infections with avian influenza virus (AIV) H9N2 were reported in 1998 (Guo et al. 1999). As of October 18th, 2019, 59 cases of human infection with H9N2 have been reported globally, including ...
Chen C, Liu Z, Liu L, Wang J, Jin Q. Enhanced Potency of a Broad H7N9-Neutralizing Antibody HNIgGA6 Through Structure-Based Design. Front Microbiol. 2020;11:1313. Abstract
submitted by kickingbird at 4 days ago from Front Microbiol. 2020;11:1313 (via https://pubmed.ncbi.nlm.nih.gov/32636820/)
H7N9 influenza virus was first isolated in 2013 and has caused five epidemic waves among humans to date. Treatment opinions are currently limited. Previously, we characterized a human neutralizing antibody, ...
Feng Z, Zhu W, Yang L, et al. Epidemiology and Genotypic Diversity of Eurasian Avian-Like H1N1 Swine Influenza Viruses in China. Virol Sin. 2020;10.1007/s12250-020-00257-8. Abstract
submitted by kickingbird at 4 days ago from Virol Sin. 2020;10.1007/s12250-020-00257-8 (via https://pubmed.ncbi.nlm.nih.gov/32638231/)
Eurasian avian-like H1N1 (EA H1N1) swine influenza virus (SIV) outside European countries was first detected in Hong Kong Special Administrative Region (Hong Kong, SAR) of China in 2001. Afterwards, EA ...
Gupta SD, Hoque MA, Fournié G, Henning J. Patterns of Avian Influenza A (H5) and A (H9) Virus Infection in Backyard, Commercial Broiler and Layer Chicken Farms in Bangladesh. ransbound Emerg Dis. 2020;10.1111/tbed.13657. Abstract
submitted by kickingbird at 4 days ago from ransbound Emerg Dis. 2020;10.1111/tbed.13657 (via https://pubmed.ncbi.nlm.nih.gov/32639112/)
In order to control Highly Pathogenic Avian Influenza (HPAI) H5N1 and Low Pathogenic Avian Influenza (LPAI) H9N2 virus spread in endemically infected countries, a detailed understanding of infection patterns ...
Sieben C, Sezgin E, Eggeling C, Manley S. Influenza A Viruses Use Multivalent Sialic Acid Clusters for Cell Binding and Receptor Activation. PLoS Pathog. 2020;16(7):e1008656. Abstract
submitted by kickingbird at 4 days ago from PLoS Pathog. 2020;16(7):e1008656 (via https://pubmed.ncbi.nlm.nih.gov/32639985/)
Influenza A virus (IAV) binds its host cell using the major viral surface protein hemagglutinin (HA). HA recognizes sialic acid, a plasma membrane glycan that functions as the specific primary attachment ...
Arevalo P, McLean HQ, Belongia EA, Cobey S. Earliest Infections Predict the Age Distribution of Seasonal Influenza A Cases. Elife. 2020;9:e50060. Abstract
submitted by kickingbird at 5 days ago from Elife. 2020;9:e50060 (via https://pubmed.ncbi.nlm.nih.gov/32633233/)
Seasonal variation in the age distribution of influenza A cases suggests that factors other than age shape susceptibility to medically attended infection. We ask whether these differences can be partly ...
Phipps KL, Ganti K, Jacobs NT, et al. Collective Interactions Augment Influenza A Virus Replication in a Host-Dependent Manner. Nat Microbiol. 2020;10.1038/s41564-020-0749-2. Abstract
submitted by kickingbird at 5 days ago from Nat Microbiol. 2020;10.1038/s41564-020-0749-2 (via https://pubmed.ncbi.nlm.nih.gov/32632248/)
Infection with a single influenza A virus (IAV) is only rarely sufficient to initiate productive infection. Instead, multiple viral genomes are often required in a given cell. Here, we show that the reliance ...
Arevalo CP, Le Sage V, Bolton MJ, et al. Original Antigenic Sin Priming of Influenza Virus Hemagglutinin Stalk Antibodies. Proc Natl Acad Sci U S A . 2020 Jul 6;201920321. Abstract
submitted by kickingbird at 5 days ago from Proc Natl Acad Sci U S A . 2020 Jul 6;201920321 (via https://pubmed.ncbi.nlm.nih.gov/32631992/)
Immunity to influenza viruses can be long-lived, but reinfections with antigenically distinct viral strains and subtypes are common. Reinfections can boost antibody responses against viral strains first ...
Müller NF, Stolz U, Dudas G, Stadler T, Vaughan TG. Bayesian Inference of Reassortment Networks Reveals Fitness Benefits of Reassortment in Human Influenza Viruses. Proc Natl Acad Sci U S A. 2020;201918304. Abstract
submitted by kickingbird at 5 days ago from Proc Natl Acad Sci U S A. 2020;201918304 (via https://pubmed.ncbi.nlm.nih.gov/32631984/)
Reassortment is an important source of genetic diversity in segmented viruses and is the main source of novel pathogenic influenza viruses. Despite this, studying the reassortment process has been constrained ...
Kim HM, Lee N, Kim MS, Kang C, Chung YS. Characterization of Neuraminidase Inhibitor-Resistant Influenza Virus Isolates From Immunocompromised Patients in the Republic of Korea. Virol J. 2020;17(1):94. Abstract
submitted by kickingbird at 5 days ago from Virol J. 2020;17(1):94 (via https://pubmed.ncbi.nlm.nih.gov/32631440/)
Background: The emergence of influenza viruses resistant to anti-influenza drugs is a threat to global public health. The Korea Centers for Disease Control and Prevention operates the Korea Influenza and ...
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