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2019-10-19 10:18:42
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Chan WM, et al. Development and evaluation of a conventional RT-PCR for differentiating emerging influenza B/Victoria lineage viruses with hemagglutinin amino acid deletion from B/Yamagata lineage viruses. J Med Virol. 2019 Oct 14.  Abstract  
submitted by kickingbird at 2 days ago from J Med Virol. 2019 Oct 14 (via https://onlinelibrary.wiley.com/doi/abs/10.1002/jmv.25607)
BACKGROUND: Recent influenza B/Victoria lineage viruses contain amino-acid deletions at positions 162-164 of the haemagglutinin (HA) protein. These amino acid deletions have affected the detection of B/Victoria ...

Moriyama M, Koshiba T, Ichinohe T. Influenza A virus M2 protein triggers mitochondrial DNA-mediated antiviral immune responses. Nat Commun. 2019 Oct 11;10(1):4624..  Abstract  
submitted by kickingbird at 5 days ago from Nat Commun. 2019 Oct 11;10(1):4624. (via https://www.nature.com/articles/s41467-019-12632-5)
Cytosolic mitochondrial DNA (mtDNA) activates cGAS-mediated antiviral immune responses, but the mechanism by which RNA viruses stimulate mtDNA release remains unknown. Here we show that viroporin activity ...

An SH, et al. Novel Mutations Evading Avian Immunity around the Receptor Binding Site of the Clade 2.3.2.1c Hemagglutinin Gene Reduce Viral Thermostability and Mammalian Pathogenicity. Viruses. 2019 Oct 9;11(10)..  Abstract  
submitted by kickingbird at 5 days ago from Viruses. 2019 Oct 9;11(10). (via https://www.mdpi.com/1999-4915/11/10/923)
Abstract: Since 2007, highly pathogenic clade 2.3.2 H5N1 avian influenza A (A(H5N1)) viruses have evolved to clade 2.3.2.1a, b, and c; currently only 2.3.2.1c A(H5N1) viruses circulate in wild birds and ...

Laporte M, et al. Hemagglutinin cleavability, acid-stability and temperature dependence optimize influenza B virus for replication in human airways. J Virol. 2019 Oct 9. pii: JVI.01430-19..  Abstract  
submitted by kickingbird at 7 days ago from J Virol. 2019 Oct 9. pii: JVI.01430-19. (via https://jvi.asm.org/content/early/2019/10/03/JVI.01430-19)
Influenza A virus (IAV) and influenza B virus (IBV) cause yearly epidemics with significant morbidity and mortality. When zoonotic IAVs enter the human population, the viral hemagglutinin (HA) requires ...

Hensen L, et al. Hemagglutinin-dependent tropism of H5N1 and H7N9 influenza viruses to human endothelial cells is determined by reduced stability of the HA which allows the virus to cope with inefficient endosomal aci. J Virol. 2019 Oct 9. pii: JVI.01223-19..  Abstract  
submitted by kickingbird at 7 days ago from J Virol. 2019 Oct 9. pii: JVI.01223-19. (via https://jvi.asm.org/content/early/2019/10/03/JVI.01223-19)
Previous studies revealed that certain avian influenza A viruses (IAVs), including zoonotic H5N1 and H7N9 IAVs, infect cultured human lung microvascular endothelial cells (HULEC) more efficiently than ...

Monteagudo PL, et al. Differential modulation of innate immune responses in human primary cells by influenza A viruses carrying human or avian non-structural 1 proteins. J Virol. 2019 Oct 9. pii: JVI.00999-19.  Abstract  
submitted by kickingbird at 7 days ago from J Virol. 2019 Oct 9. pii: JVI.00999-19 (via https://jvi.asm.org/content/early/2019/10/03/JVI.00999-19)
The influenza A virus (IAV) non-structural protein 1 (NS1) contributes to disease pathogenesis through the inhibition of host innate immune responses. Dendritic cells (DCs) release interferons (IFN), pro-inflammatory ...

Kong H, et al. Identification of key amino acids in the PB2 and M1 proteins of H7N9 influenza virus that affect its transmission in guinea pigs. J Virol. 2019 Oct 9.  Abstract  
submitted by kickingbird at 7 days ago from J Virol. 2019 Oct 9 (via https://jvi.asm.org/content/early/2019/10/03/JVI.01180-19)
Efficient human-to-human transmission is a prerequisite for a novel influenza virus to cause an influenza pandemic; however, the genetic determinants of influenza virus transmission are still not fully ...

Sautto GA, Ross TM. Hemagglutinin consensus-based prophylactic approaches to overcome influenza virus diversity. Vet Ital. 2019 Sep 30;55(3):195-201..  Abstract  
submitted by kickingbird at 7 days ago from Vet Ital. 2019 Sep 30;55(3):195-201. (via http://www.izs.it/vet_italiana/2019/55_3/VetIt_1944_10352_1.)
Each year millions of people are infected by influenza viruses, and this causes a substantial economic and health burden on our society. Influenza epidemics and pandemics are attributable to the ongoing ...

Kamiki H, et al. Adaptation of H3N2 canine influenza virus to feline cell culture. PLoS One. 2019 Oct 10;14(10):e0223507..  Abstract  
submitted by kickingbird at 7 days ago from PLoS One. 2019 Oct 10;14(10):e0223507. (via https://journals.plos.org/plosone/article?id=10.1371/journal)
H3N2 canine influenza viruses are prevalent in Asian and North American countries. During circulation of the viruses in dogs, these viruses are occasionally transmitted to cats. If this canine virus causes ...

Kode SS, Pawar SD, Tare DS, Keng SS, Mullick J. Amantadine resistance markers among low pathogenic avian influenza H9N2 viruses isolated from poultry in India, during 2009~2017. Microb Pathog. 2019 Oct 7:103779.  Abstract  
submitted by kickingbird at 7 days ago from Microb Pathog. 2019 Oct 7:103779 (via https://www.sciencedirect.com/science/article/pii/S088240101)
Antiviral susceptibility screening of avian influenza (AI) H9N2 viruses is crucial considering their role at the animal-human interface and potential to cause human infections. The Matrix 2 (M2) inhibitors ...

Fujimoto Y, Inoue H, Ozawa M, Matsuu A. Serological survey of influenza A virus infection in Japanese wild boars (Sus scrofa leucomystax). Microbiol Immunol. 2019 Oct 9..  Abstract  
submitted by kickingbird at 8 days ago from Microbiol Immunol. 2019 Oct 9. (via https://onlinelibrary.wiley.com/doi/abs/10.1111/1348-0421.12)
We conducted a serological survey to detect antibodies against influenza A virus (IAV) in Japanese wild boars in Kagoshima prefecture, Japan, between 2014 and 2017. Sero-prevalence against a pandemic-like ...

Nishioka K, Daidoji T, Nakaya T. Demethylation around the transcriptional start site of the IFN-β gene induces IFN-β production and protection against influenza virus infection. Biochem Biophys Res Commun. 2019 Oct 5..  Abstract  
submitted by kickingbird at 8 days ago from Biochem Biophys Res Commun. 2019 Oct 5. (via https://www.sciencedirect.com/science/article/pii/S0006291X1)
Seasonal influenza is related to lifestyle-associated risk factors and it has been suggested that the epigenetic state of the individual plays an important role in the severity of infection. It is well ...

Yang L, et al. Tandem mass tag-based quantitative proteomic analysis of lycorine treatment in highly pathogenic avian influenza H5N1 virus infection. PeerJ. 2019 Oct 2;7:e7697..  Abstract  
submitted by kickingbird at 8 days ago from PeerJ. 2019 Oct 2;7:e7697. (via https://peerj.com/articles/7697/)
Highly pathogenic H5N1 influenza viruses (HPAIV) cause rapid systemic illness and death in susceptible animals, leading to a disease with high morbidity and mortality rates. Although vaccines and drugs ...

Buffin S, et al. Influenza A and B virus-like particles produced in mammalian cells are highly immunogenic and induce functional antibodies. Vaccine. 2019 Oct 4..  Abstract  
submitted by kickingbird at 8 days ago from Vaccine. 2019 Oct 4. (via https://www.sciencedirect.com/science/article/pii/S0264410X1)
Influenza virus-like particles (VLPs) represent an attractive alternative to traditional influenza vaccine formulations. Influenza VLPs mimic the natural virus while lacking the genetic material, are easily ...

Chastagner A, et al. Virus persistence in pig herds led to successive reassortment events between swine and human influenza A viruses, resulting in the emergence of a novel triple-reassortant swine influenza virus. Vet Res. 2019 Oct 7;50(1):77.  Abstract  
submitted by kickingbird at 8 days ago from Vet Res. 2019 Oct 7;50(1):77 (via https://veterinaryresearch.biomedcentral.com/articles/10.118)
This report describes the detection of a triple reassortant swine influenza A virus of H1avN2 subtype. It evolved from an avian-like swine H1avN1 that first acquired the N2 segment from a seasonal H3N2, ...

Butler J, et al. Insights into the Acquisition of Virulence of Avian Influenza Viruses during a Single Passage in Ferrets. Viruses. 2019 Oct 4;11(10).  Abstract  
submitted by kickingbird at 8 days ago from Viruses. 2019 Oct 4;11(10) (via https://www.mdpi.com/1999-4915/11/10/915)
Circulating avian influenza viruses pose a significant threat, with human infections occurring infrequently but with potentially severe consequences. To examine the dynamics and locale of the adaptation ...

Buthelezi NM, et al. Exploring the impact of H5N1 neuraminidase (H274Y) mutation on Peramivir: A bio-computational study from a molecular perspective. J Biomol Struct Dyn. 2019 Oct 6:1-11..  Abstract  
submitted by kickingbird at 10 days ago from J Biomol Struct Dyn. 2019 Oct 6:1-11. (via https://www.tandfonline.com/doi/abs/10.1080/07391102.2019.16)
List of Abbreviations ARDS Acute Respiratory Distress Syndrome HA Haemagglutinin GAFF General Amber force field MD Molecular Dynamic NA Neuraminidase NAI Neuraminidase Inhibitor PCA Principal Component ...

Soda K, Sakita M, Usui T, Ito H, Ito T. H5N8 avian influenza virus acquires enhanced pathogenicity after a single passage in chicken. Vet Microbiol. 2019 Oct;237:108381.  Abstract  
submitted by kickingbird at 12 days ago from Vet Microbiol. 2019 Oct;237:108381 (via https://www.sciencedirect.com/science/article/pii/S037811351)
The H5N8 highly pathogenic avian influenza viruses (HPAIVs) isolated in Japan during the 2014-2015 winter differed in their pathogenicity in chickens. In the present study, we examined the possibility ...

Cantan B, Luyt CE, Martin-Loeches I. Influenza Infections and Emergent Viral Infections in Intensive Care Unit. Semin Respir Crit Care Med. 2019 Aug;40(4):488-497.  Abstract  
submitted by kickingbird at 12 days ago from Semin Respir Crit Care Med. 2019 Aug;40(4):488-497 (via https://www.thieme-connect.de/products/ejournals/abstract/10)
Critically ill patients are admitted to an intensive care unit (ICU) for multiple reasons. In this study, we aim to analyze the current evidence and findings associated with influenza and other emergent ...

Huang S, et al. Macrophage PPAR-γ suppresses long-term lung fibrotic sequelae following acute influenza infection. PLoS One. 2019 Oct 4;14(10):e0223430..  Abstract  
submitted by kickingbird at 13 days ago from PLoS One. 2019 Oct 4;14(10):e0223430. (via https://journals.plos.org/plosone/article?id=10.1371/journal)
Influenza virus causes a heterogeneous respiratory infectious disease ranging from self-limiting symptoms to non-resolving pathology in the lungs. Worldwide, seasonal influenza infections claim ~500,000 ...

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