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2025-12-17 19:27:02
Article

Blondin-Brosseau M, Zhang W, Gravel C, Harlow J, L. Survival of influenza virus H1N1 and murine norovirus in raw milk cheeses. Appl Environ Microbiol. 2025 Oct 31:e0188125.  Abstract  
submitted by kickingbird at Nov, 1, 2025 from Appl Environ Microbiol. 2025 Oct 31:e0188125 (via https://journals.asm.org/doi/10.1128/aem.01881-25)
The spillover of highly pathogenic avian influenza (HPAI) to dairy cattle and its presence at high titers in raw milk has created a concern that consumption of dairy products made from unpasteurized milk ...

Pattiyakumbura TT, De Silva I, Bowatte A, Perera S. Complete genome analysis of human influenza C virus co-infection with WU polyomavirus in a Sri Lankan child: A brief report. Access Microbiol. 2025 Oct 29;7(10):000968.v3.  Abstract  
submitted by kickingbird at Nov, 1, 2025 from Access Microbiol. 2025 Oct 29;7(10):000968.v3 (via https://www.microbiologyresearch.org/content/journal/acmi/10)
Background. Influenza C virus (ICV) is a lesser known member of the Orthomyxoviridae family, primarily causing respiratory tract infections in children. Co-infection with WU polyomavirus (WUPyV), a recently ...

C. Stenkamp-Strahm, J. Lombard, B. Melody, P. Brin. [preprint]Influenza A Virus detection in Bulk Tank and Pen Level Milk from Dairies Affected by Highly Pathogenic Avian Influenza H5N1. https://doi.org/10.1101/2025.10.26.25338833.  Abstract  
submitted by kickingbird at Oct, 30, 2025 from https://doi.org/10.1101/2025.10.26.25338833 (via https://www.medrxiv.org/content/10.1101/2025.10.26.25338833v)
Highly pathogenic avian influenza virus H5N1 has been infecting dairy herds in the U.S. since its initial incursion into cows in early 2024. Although national strategies have aimed to detect affected herds, ...

Jingze Liu, etc.,al. [preprint]Deciphering the Antigenic Evolution of Seasonal Influenza A Viruses with PREDAC-Transformer: From Antigenic Clustering to Key Site Identification. https://doi.org/10.1101/2025.10.29.684974.  Abstract  
submitted by kickingbird at Oct, 30, 2025 from https://doi.org/10.1101/2025.10.29.684974 (via https://www.biorxiv.org/content/10.1101/2025.10.29.684974v1)
Seasonal influenza viruses undergo continuous antigenic drift due to mutations in the hemagglutinin (HA) protein, rendering vaccines ineffective and posing a significant global public health challenge. ...

Yo Shimazu, etc.,al. [preprint]Evaluation of therapeutic effect of baloxavir marboxil against high pathogenicity avian influenza virus infection in duck model. https://doi.org/10.1101/2025.10.24.684283.  Abstract  
submitted by kickingbird at Oct, 30, 2025 from https://doi.org/10.1101/2025.10.24.684283 (via https://www.biorxiv.org/content/10.1101/2025.10.24.684283v1)
Since 2020, high pathogenicity avian influenza virus (HPAIV) infections in wild birds have been frequently reported. Because HPAIV infection has occasionally caused outbreaks in captive rare birds, application ...

Han, X., Ma, R., Ma, X., Chen, H., Zhao, T., Liu,. Development of a broad-spectrum nasal live attenuated influenza vaccine based on mosaic antigen design against influenza B viruses. Emerging Microbes & Infections, 14(1).  Abstract  
submitted by kickingbird at Oct, 30, 2025 from Emerging Microbes & Infections, 14(1) (via https://www.tandfonline.com/doi/full/10.1080/22221751.2025.2)
Influenza B virus (IBV) causes significant seasonal disease burden, and frequent antigenic drift limits the effectiveness of conventional vaccines. To address this, we designed mosaic haemagglutinin (HA) ...

Fernando Capelastegui, Vidhi Dholakia, etc.,al. [preprint]An evolutionary approach to identify mammalian adaptive mutations in the avian influenza polymerase complex. https://doi.org/10.1101/2025.10.27.684835.  Abstract  
submitted by kickingbird at Oct, 29, 2025 from https://doi.org/10.1101/2025.10.27.684835 (via https://www.biorxiv.org/content/10.1101/2025.10.27.684835v1)
Avian influenza viruses (AIVs) are a global public health risk; human infection is typically associated with high mortality. While the relationship between several mammalian adaptive mutations and host ...

Sahar Mahmood, Saumya S. Thomas, etc.,al. Understanding limitations to successful avian influenza virus isolation from wild birds. Journal of Virological Methods.  Abstract  
submitted by kickingbird at Oct, 28, 2025 from Journal of Virological Methods (via https://www.sciencedirect.com/science/article/abs/pii/S01660)
Whilst molecular methods which detect viral nucleic acid have replaced more traditional assays such as virus isolation (VI) as frontline diagnostic assays for avian influenza virus (AIV), the ability to ...

Shriver, Leah P. et al. Integrative multi-omics analysis in vivo identifies influenza virus host factors. iScience, Volume 28, Issue 11, 113644.  Abstract  
submitted by kickingbird at Oct, 28, 2025 from iScience, Volume 28, Issue 11, 113644 (via https://www.cell.com/iscience/fulltext/S2589-0042(25)01905-4)
nfluenza A virus (IAV) infection remodels cellular processes to support viral replication. The modulation of host factors by the virus drives pathogenesis during infection, and these factors may serve ...

Wang Y, Jiang L, Li Q, Li M, Shi W, et al. TRIM45 restricts influenza virus infection through modulating the chaperone-mediated autophagic degradation of viral PB2 protein. PLOS Pathogens 21(10): e1013630.  Abstract  
submitted by kickingbird at Oct, 27, 2025 from PLOS Pathogens 21(10): e1013630 (via https://journals.plos.org/plospathogens/article?id=10.1371/j)
The host defense system employs elaborate mechanisms to combat invading viruses. Here, we demonstrate that tripartite motif containing 45 (TRIM45) restricts the replication of different subtypes of influenza ...

Aawar MA, Srivastava A. Random Forest of epidemiological models for Influenza forecasting. Epidemics. 2025 Oct 21;53:100862.  Abstract  
submitted by kickingbird at Oct, 26, 2025 from Epidemics. 2025 Oct 21;53:100862 (via https://www.sciencedirect.com/science/article/pii/S175543652)
Forecasting the hospitalizations caused by the Influenza virus is vital for public health planning so hospitals can be better prepared for an influx of patients. Many forecasting methods have been used ...

Al-Dalawi L, Yang J, Blanchard AM, Clark M, Chang. Research note: Use of in vitro and in ovo approaches to characterise avian influenza viruses and assess species specific responses to infection. Poult Sci. 2025 Oct 19;104(12):105987.  Abstract  
submitted by kickingbird at Oct, 26, 2025 from Poult Sci. 2025 Oct 19;104(12):105987 (via https://www.sciencedirect.com/science/article/pii/S003257912)
Circulation of avian influenza viruses (AIVs) in domestic and wild birds poses a major health threat, requiring a rapid approach to characterize and identify high-risk strains. We evaluated virus replication ...

Cardenas M, Compton S, Hunt A, Chopra P, Perez DR,. Protocol to measure the kinetics of MHC class II-influenza A binding using biolayer interferometry. STAR Protoc. 2025 Oct 23;6(4):104155.  Abstract  
submitted by kickingbird at Oct, 26, 2025 from STAR Protoc. 2025 Oct 23;6(4):104155 (via https://www.sciencedirect.com/science/article/pii/S266616672)
Recent work has shown that major histocompatibility complex (MHC) class II is a functional receptor for some influenza A virus (FLUAV) subtypes. Here, we present a protocol to measure the kinetics of MHC ...

Hay JA, Zhu H, Jiang CQ, Kwok KO, Shen R, Kucharsk. Reconstructed influenza A/H3N2 infection histories reveal variation in incidence and antibody dynamics over the life course. PLoS Biol. 2024 Nov 7;22(11):e3002864. doi: 10.137.  Abstract  
submitted by kickingbird at Oct, 25, 2025 from PLoS Biol. 2024 Nov 7;22(11):e3002864. doi: 10.137 (via https://journals.plos.org/plosbiology/article?id=10.1371/jou)
Humans experience many influenza infections over their lives, resulting in complex and varied immunological histories. Although experimental and quantitative analyses have improved our understanding of ...

Zhang J, Cao R, Wang Y, Sun Y, Ji X, Liu P, Liu K,. Influenza virus infection reprograms cholesterol biosynthesis to facilitate virus replication by the TAK1-RORγ axis. PLoS Pathog. 2025 Oct 24;21(10):e1013646.  Abstract  
submitted by kickingbird at Oct, 25, 2025 from PLoS Pathog. 2025 Oct 24;21(10):e1013646 (via https://journals.plos.org/plospathogens/article?id=10.1371/j)
Infection and replication of enveloped viruses require host cells to supply substantial amounts of cellular cholesterol for processes such as binding, entry, trafficking, assembly, and budding. However, ...

Sung-dae Park, Yeonsu Oh, Dae Sung Yoo. Combating highly pathogenic avian influenza in South Korea: A 15-year retrospective and forward-looking study. Preventive Veterinary Medicine.  Abstract  
submitted by kickingbird at Oct, 25, 2025 from Preventive Veterinary Medicine (via https://www.sciencedirect.com/science/article/abs/pii/S01675)
Highly Pathogenic Avian Influenza (HPAI), caused by the Orthomyxoviridae family of RNA viruses, poses a serious threat to the global poultry industry, resulting in severe economic losses and raising public ...

Tommaso Alfonsi et al. Lightweight multiscale early warning system for influenza A spillovers. Sci. Adv.11,eadz7312(2025).  Abstract  
submitted by kickingbird at Oct, 25, 2025 from Sci. Adv.11,eadz7312(2025) (via https://www.science.org/doi/10.1126/sciadv.adz7312)
Spillovers of zoonotic Influenza A viruses (IAVs) into farmed animals and humans have the potential to trigger epidemics or even global pandemics. We introduce FluWarning, a highly efficient and elegant ...

Taeyong Kwon Kwon, etc.,al. [preprint]Pigs lacking Natural Killer T cells have altered cellular responses to influenza. https://doi.org/10.1101/2025.10.23.684238.  Abstract  
submitted by kickingbird at Oct, 25, 2025 from https://doi.org/10.1101/2025.10.23.684238 (via https://www.biorxiv.org/content/10.1101/2025.10.23.684238v1)
It is increasingly recognized that innate T cells such as natural killer T (NKT) cells, mucosal associated invariant T (MAIT) cells, and γδ T cells play an important role in shaping adaptive immune responses ...

Larsen, B.B., Kimchi, O., Dunkley, O.R.S. et al. RNA structure modulates Cas13 activity and enables mismatch detection. Nat Biotechnol (2025).  Abstract  
submitted by kickingbird at Oct, 25, 2025 from Nat Biotechnol (2025) (via https://link.springer.com/article/10.1038/s41587-025-02868-6)
Cas13 is activated by the hybridization of a CRISPR RNA to a complementary single-stranded RNA protospacer in a target RNA. While Cas13 is not activated by double-stranded RNA in vitro, it robustly targets ...

Zhang C, Jin Y, Cui H, Wang Z, Chen Z, Zhang L, So. Cross-Species Transmission Risks of a Quail-Origin H7N9 Influenza Virus from China Between Avian and Mammalian Hosts. Viruses. 2025; 17(10):1402.  Abstract  
submitted by kickingbird at Oct, 25, 2025 from Viruses. 2025; 17(10):1402 (via https://www.mdpi.com/1999-4915/17/10/1402)
The H7N9 influenza viruses, which are capable of causing severe respiratory syndrome in humans, were first discovered to infect humans in 2013 and continue to pose a persistent public health threat. Quail ...

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