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2024-3-29 21:03:10
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Zhang Y, Cui P, Shi J, Chen Y, Zeng X, Jiang Y, Ti. Key Amino Acid Residues That Determine the Antigenic Properties of Highly Pathogenic H5 Influenza Viruses Bearing the Clade 2.3.4.4 Hemagglutinin Gene. Viruses. 2023 Nov 13;15(11):2249..  Abstract  
submitted by kickingbird at Nov, 27, 2023 from Viruses. 2023 Nov 13;15(11):2249. (via https://www.mdpi.com/1999-4915/15/11/2249)
The H5 subtype highly pathogenic avian influenza viruses bearing the clade 2.3.4.4 HA gene have been pervasive among domestic poultry and wild birds worldwide since 2014, presenting substantial risks to ...

Al-Shalan HAM, Hu D, Wang P, Uddin J, Chopra A, Gr. Transcriptomic Profiling of Influenza A Virus-Infected Mouse Lung at Recovery Stage Using RNA Sequencing. Viruses. 2023 Oct 31;15(11):2198.  Abstract  
submitted by kickingbird at Nov, 27, 2023 from Viruses. 2023 Oct 31;15(11):2198 (via https://www.mdpi.com/1999-4915/15/11/2198)
Influenza A virus (IAV) is known to cause mild to severe respiratory illness. Under some conditions, the infection can lead to pneumonia (viral or bacterial), acute respiratory distress syndrome, and other ...

Kong D, He Y, Wang J, Chi L, Ao X, Ye H, Qiu W, Zh. A single immunization with H5N1 virus-like particle vaccine protects chickens against divergent H5N1 influenza viruses and vaccine efficacy is determined by adjuvant and dosage. Emerg Microbes Infect. 2023 Nov 23:2287682.  Abstract  
submitted by kickingbird at Nov, 27, 2023 from Emerg Microbes Infect. 2023 Nov 23:2287682 (via https://www.tandfonline.com/doi/full/10.1080/22221751.2023.2)
The H5N1 subtype highly pathogenic avian influenza virus (HPAIV) reveals high variability and threatens poultry production and public health. To prevent the spread of H5N1 HPAIV, we developed an H5N1 virus-like ...

Rabie-Rudsari M, Behboudi E, Ranjkesh A, Kaveh K,. Molecular identification of Neuraminidase Gene Mutations in Influenza A/H1N1 and A/H3N2 Isolates of Mazandaran province, north of Iran. J Glob Antimicrob Resist. 2023 Nov 20:S2213-7165(2.  Abstract  
submitted by kickingbird at Nov, 27, 2023 from J Glob Antimicrob Resist. 2023 Nov 20:S2213-7165(2 (via https://www.sciencedirect.com/science/article/pii/S221371652)
Objectives: The neuraminidase (NA) mutations causing resistance to NA inhibitors (NAIs) mostly compromise the fitness of influenza viruses. Considering the importance of these mutations, constant monitoring ...

Baechlein C, Kleinschmidt S, Hartmann D, Kammeyer. Neurotropic Highly Pathogenic Avian Influenza A(H5N1) Virus in Red Foxes, Northern Germany. Emerg Infect Dis. 2023 Dec;29(12):2509-2512.  Abstract  
submitted by kickingbird at Nov, 22, 2023 from Emerg Infect Dis. 2023 Dec;29(12):2509-2512 (via https://pubmed.ncbi.nlm.nih.gov/37987587/)
In a 1-year survey of wild terrestrial predators in northern Germany, we found that 5 of 110 foxes were infected with contemporary avian influenza A(H5N1) viruses, forming a temporal cluster during January?March ...

Bessière P, Hayes B, Filaire F, Lèbre L, Vergne T,. Optimizing environmental viral surveillance: bovine serum albumin increases RT-qPCR sensitivity for high pathogenicity avian influenza H5Nx virus detection from dust samples. Microbiol Spectr. 2023 Nov 20:e0305523.  Abstract  
submitted by kickingbird at Nov, 21, 2023 from Microbiol Spectr. 2023 Nov 20:e0305523 (via https://journals.asm.org/doi/10.1128/spectrum.03055-23)
With the circulation of high pathogenicity avian influenza viruses having intensified considerably in recent years, the European Union is considering the vaccination of farmed birds. A prerequisite for ...

Naiqing Xu, etc.,al. Mutations in HA and PA affect the transmissibility of H7N9 avian influenza virus in chickens. Veterinary Microbiology.  Abstract  
submitted by kickingbird at Nov, 20, 2023 from Veterinary Microbiology (via https://www.sciencedirect.com/science/article/abs/pii/S03781)
Low pathogenic (LP) H7N9 avian influenza virus (AIV) emerged in 2013 and had spread widely over several months in China, experienced a noteworthy reduction in isolation rate in poultry and human since ...

Guo Y, Bai X, Liu Z, Liang B, Zheng Y, Dankar S, P. Exploring the alternative virulence determinants PB2 S155N and PA S49Y/D347G that promote mammalian adaptation of the H9N2 avian influenza virus in mice. Vet Res. 2023 Oct 19;54(1):97.  Abstract  
submitted by kickingbird at Nov, 20, 2023 from Vet Res. 2023 Oct 19;54(1):97 (via https://veterinaryresearch.biomedcentral.com/articles/10.118)
The occurrence of human infections caused by avian H9N2 influenza viruses has raised concerns regarding the potential for human epidemics and pandemics. The molecular basis of viral adaptation to a new ...

Wan Z, Gong J, Sang J, Jiang W, Zhao Z, Tang T, Li. Identification of key residues of B cell epitopes in hemagglutinin of H6 influenza A virus. Microbiol Spectr. 2023 Oct 26:e0205923.  Abstract  
submitted by kickingbird at Nov, 20, 2023 from Microbiol Spectr. 2023 Oct 26:e0205923 (via https://journals.asm.org/doi/10.1128/spectrum.02059-23)
H6 influenza A viruses are enzootic and genetically diverse in both domestic poultry and wild birds, occasionally causing spillovers to mammals, including humans, posing threat to public health. However, ...

Ramey AM, Scott LC, Ahlstrom CA, Buck EJ, Williams. Molecular detection and characterization of highly pathogenic H5N1 clade 2.3.4.4b avian influenza viruses among hunter-harvested wild birds provides evidence for three independent introductions into A. Virology. 2023 Nov 10;589:109938.  Abstract  
submitted by kickingbird at Nov, 20, 2023 from Virology. 2023 Nov 10;589:109938 (via https://www.sciencedirect.com/science/article/pii/S004268222)
We detected and characterized highly pathogenic avian influenza viruses among hunter-harvested wild waterfowl inhabiting western Alaska during September-October 2022 using a molecular sequencing pipeline ...

Cao M, Jia Q, Li J, Zhao L, Zhu L, Zhang Y, Li S,. Naturally occurring PAE206K point mutation in 2009 H1N1 pandemic influenza viruses impairs viral replication at high temperatures. Virol Sin. 2023 Nov 16:S1995-820X(23)00137-2.  Abstract  
submitted by kickingbird at Nov, 20, 2023 from Virol Sin. 2023 Nov 16:S1995-820X(23)00137-2 (via https://www.sciencedirect.com/science/article/pii/S1995820X2)
The emergence of influenza virus A pandemic H1N1 in April 2009 marked the first pandemic of the 21st century. In this study, we observed significant differences in the polymerase activities of two clinical ...

Onkhonova G, Gudymo A, Kosenko M, Marchenko V, Ryz. Quantitative measurement of influenza virus transmission in animal model: an overview of current state. Biophys Rev. 2023 Sep 7;15(5):1359-1366.  Abstract  
submitted by kickingbird at Nov, 20, 2023 from Biophys Rev. 2023 Sep 7;15(5):1359-1366 (via https://link.springer.com/article/10.1007/s12551-023-01113-1)
Influenza virus transmission is a crucial factor in understanding the spread of the virus within populations and developing effective control strategies. Studying the transmission patterns of influenza ...

Gang LU, Fei-yan ZHENG, Yu-qing XIAO, Ran SHAO, Ji. Role of feline ANP32 proteins in regulating polymerase activity of influenza A virus. Journal of Integrative Agriculture, 2023.  Abstract  
submitted by kickingbird at Nov, 17, 2023 from Journal of Integrative Agriculture, 2023 (via https://www.sciencedirect.com/science/article/pii/S209531192)
Recently, increasing natural infection cases and experimental animal challenge studies demonstrated domestic cats are susceptible to multiple subtypes influenza A virus (IAV) infections. Notably, some ...

Xu Naiqing, Xinen Tang, Xin Wang, Miao Cai, Xiaowe. Hemagglutinin affects replication, stability and airborne transmission of the H9N2 subtype avian influenza virus. Virology, Volume 589, 2024.  Abstract  
submitted by kickingbird at Nov, 17, 2023 from Virology, Volume 589, 2024 (via https://www.sciencedirect.com/science/article/pii/S004268222)
H9N2 subtype avian influenza virus (AIV) can transmit by direct as well as airborne contacts. It has been widespread in poultry and continued to contribute to zoonotic spillover events by providing its ...

Yi-na XU, Hai-ling LI, Hao-yu LENG, Chao-fan SU, S. Genetic and Biological Properties of H10Nx influenza viruses in China. Journal of Integrative Agriculture, 2023.  Abstract  
submitted by kickingbird at Nov, 17, 2023 from Journal of Integrative Agriculture, 2023 (via https://www.sciencedirect.com/science/article/pii/S209531192)
H10 subtype avian influenza viruses (AIV) have been circulating in China for forty years. H10 AIVs in China have expanded their host range from wild birds to domestic poultry and mammals, even human. Most ...

Ariful Islam, Sarah Munro, Mohammad Mahmudul Hassa. The role of vaccination and environmental factors on outbreaks of high pathogenicity avian influenza H5N1 in Bangladesh. One Health, 2023, 100655.  Abstract  
submitted by kickingbird at Nov, 17, 2023 from One Health, 2023, 100655 (via https://www.sciencedirect.com/science/article/pii/S235277142)
High Pathogenicity Avian Influenza (HPAI) H5N1 outbreaks continue to wreak havoc on the global poultry industry and threaten the health of wild bird populations, with sporadic spillover in humans and other ...

Lei R, Kim W, Lv H, Mou Z, Scherm MJ, Schmitz AJ,. Leveraging vaccination-induced protective antibodies to define conserved epitopes on influenza N2 neuraminidase. Immunity. 2023 Nov 14;56(11):2621-2634.e6.  Abstract  
submitted by kickingbird at Nov, 16, 2023 from Immunity. 2023 Nov 14;56(11):2621-2634.e6 (via https://www.cell.com/immunity/fulltext/S1074-7613(23)00445-4)
There is growing appreciation for neuraminidase (NA) as an influenza vaccine target; however, its antigenicity remains poorly characterized. In this study, we isolated three broadly reactive N2 antibodies ...

Ma L, Zheng H, Ke X, Gui R, Yao Z, Xiong J, Chen Q. Mutual antagonism of mouse-adaptation mutations in HA and PA proteins on H9N2 virus replication. Virol Sin. 2023 Nov 13:S1995-820X(23)00136-0.  Abstract  
submitted by kickingbird at Nov, 16, 2023 from Virol Sin. 2023 Nov 13:S1995-820X(23)00136-0 (via https://www.sciencedirect.com/science/article/pii/S1995820X2)
Avian H9N2 viruses have wide host range among the influenza A viruses. However, knowledge of H9N2 mammalian adaptation is limited. To explore the molecular basis of the adaptation to mammals, we performed ...

Zhao Y, Chen P, Hu Y, Liu J, Jiang Y, Zeng X, Deng. Recombinant duck enteritis virus bearing the hemagglutinin genes of H5 and H7 influenza viruses is an ideal multivalent live vaccine in ducks. Emerg Microbes Infect. 2023 Nov 15:2284301.  Abstract  
submitted by kickingbird at Nov, 16, 2023 from Emerg Microbes Infect. 2023 Nov 15:2284301 (via https://www.tandfonline.com/doi/full/10.1080/22221751.2023.2)
Due to the fact that many avian influenza viruses that kill chickens are not lethal to ducks, farmers are reluctant to use avian influenza inactivated vaccines on ducks. Large numbers of unvaccinated ducks ...

Xing X, Shi J, Cui P, Yan C, Zhang Y, Zhang Y, Wan. Evolution and biological characterization of H5N1 influenza viruses bearing the clade 2.3.2.1 hemagglutinin gene. Emerg Microbes Infect. 2023 Nov 15:2284294.  Abstract  
submitted by kickingbird at Nov, 16, 2023 from Emerg Microbes Infect. 2023 Nov 15:2284294 (via https://www.tandfonline.com/doi/full/10.1080/22221751.2023.2)
H5N1 avian influenza viruses bearing the clade 2.3.2.1 hemagglutinin (HA) gene have been widely detected in birds and poultry in several countries. During our routine surveillance, we isolated 28 H5N1 ...

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