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2026-3-18 9:09:49
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Etori A. Moreira, etc.,al. [preprint]Bovine-derived influenza A virus (H5N1) shows efficient replication in well-differentiated human nasal epithelial cells without requiring genetic adaptation. https://doi.org/10.64898/2026.01.16.699876.  Abstract  
submitted by kickingbird at Jan, 18, 2026 from https://doi.org/10.64898/2026.01.16.699876 (via https://www.biorxiv.org/content/10.64898/2026.01.16.699876v1)
Highly pathogenic avian influenza H5N1 viruses of clade 2.3.4.4b have caused widespread avian mortality and sporadic mammalian infections, raising concerns about their potential for efficient replication ...

Dholakia, V., Quantrill, J.L., Richardson, S.A.S.. Polymerase mutations underlie early adaptation of H5N1 influenza virus to dairy cattle and other mammals. Nat Commun (2026).  Abstract  
submitted by kickingbird at Jan, 18, 2026 from Nat Commun (2026) (via https://link.springer.com/article/10.1038/s41467-026-68306-6)
In 2024, an unprecedented outbreak of H5N1 high pathogenicity avian influenza was detected in dairy cattle in the USA resulting in spillbacks into poultry, wild birds and other mammals including humans. ...

Skowronski DM, Ranadheera C, Kaweski SE, Sabaiduc. Cross-reactive H5N1 neuraminidase antibodies by age and influenza A imprinting cohorts of the past century: population-based serosurvey, British Columbia, Canada. J Infect Dis. 2026 Jan 16:jiag030.  Abstract  
submitted by kickingbird at Jan, 17, 2026 from J Infect Dis. 2026 Jan 16:jiag030 (via https://academic.oup.com/jid/advance-article/doi/10.1093/inf)
Background: Pre-existing immunity to emerging influenza viruses informs pandemic risk assessment. We compared cross-reactive neuraminidase (NA) antibody levels against avian influenza A(H5N1) by age and ...

Rosu ME, Westgeest KB, de Graaf M, Hauser BM, Ture. Molecular basis of 60 years of antigenic evolution of human influenza A(H3N2) virus neuraminidase. Cell Host Microbe. 2026 Jan 14;34(1):103-115.e9.  Abstract  
submitted by kickingbird at Jan, 17, 2026 from Cell Host Microbe. 2026 Jan 14;34(1):103-115.e9 (via https://www.cell.com/cell-host-microbe/abstract/S1931-3128(2)
Human influenza A viruses escape antibody-mediated immunity through changes in the hemagglutinin (HA) and neuraminidase (NA) glycoproteins. HA antigenic evolution has been studied extensively, with more ...

Ou G, Ma W, Mo Y, Hu J, Tang T. Absolute humidity drives seasonal influenza A transmission in Hong Kong through social contact modulation: Evidence from compartmental modeling. Infect Dis Model. 2025 Dec 7;11(2):671-682.  Abstract  
submitted by kickingbird at Jan, 17, 2026 from Infect Dis Model. 2025 Dec 7;11(2):671-682 (via https://www.sciencedirect.com/science/article/pii/S246804272)
Background: Prior studies propose a U-shaped humidity-influenza relationship, yet the interplay between humidity-driven contact behaviors and transmission dynamics remains unclear.Objective: The study ...

Xue L, Guo T, Feng Y, San Z, Wang D, Guo L. An influenza D virus in D/Yama2019 lineage from stillbirth fetus of cattle in China. J Vet Med Sci. 2026 Jan 14.  Abstract  
submitted by kickingbird at Jan, 17, 2026 from J Vet Med Sci. 2026 Jan 14 (via https://www.jstage.jst.go.jp/article/jvms/advpub/0/advpub_25)
Influenza D virus (IDV), a respiratory pathogen primarily affecting cattle, is known to have the potential to infect a wide range of animal species. In this study, a novel IDV strain, designated D/JLSL ...

Iervolino, M., Günther, A., Begeman, L. et al. The expanding H5N1 avian influenza panzootic causes high mortality of skuas in Antarctica. Sci Rep (2026).  Abstract  
submitted by kickingbird at Jan, 16, 2026 from Sci Rep (2026) (via https://link.springer.com/article/10.1038/s41598-025-34736-3)
High pathogenicity avian influenza virus H5N1 subtype (H5N1 HPAIV), clade 2.3.4.4b, is expanding its host and geographical range, and invaded Antarctica in 2023. Although mortality in Antarctic wildlife ...

Li H, Yan W, Liu X, Gao B, Peng J, Jiang F, Cui Q,. Emergence and Phylodynamics of Influenza D Virus in Northeast China Reveal Sporadic Detection and Predominance of the D/Yamagata/2019 Lineage in Cattle. Viruses. 2026; 18(1):93.  Abstract  
submitted by kickingbird at Jan, 15, 2026 from Viruses. 2026; 18(1):93 (via https://www.mdpi.com/1999-4915/18/1/93)
Influenza D virus (IDV), an emerging orthomyxovirus with zoonotic potential, infects diverse hosts, causes respiratory disease, and remains poorly characterized in China despite its global expansion. From ...

Gioula G, Exindari M. The Airway Microbiome as a Modulator of Influenza Virus Infection: Mechanistic Insights and Translational Perspectives-Review. Pathogens. 2026; 15(1):63.  Abstract  
submitted by kickingbird at Jan, 15, 2026 from Pathogens. 2026; 15(1):63 (via https://www.mdpi.com/2076-0817/15/1/63)
Outcomes of influenza virus infection vary widely across individuals, reflecting not only viral genetics and host factors but also the composition and function of the airway microbiome. Over the past few ...

Mironenko A, Muzyka N, Teteriuk N, Radchenko L, Po. Genetic Characterization of Avian Influenza Virus A (H1N1) Isolated from a Fieldfare Turdus pilaris in Ukraine. Microbiology Research. 2026; 17(1):19.  Abstract  
submitted by kickingbird at Jan, 15, 2026 from Microbiology Research. 2026; 17(1):19 (via https://www.mdpi.com/2036-7481/17/1/19)
Avian influenza viruses are predominantly associated with waterfowl and shorebirds, and are rarely detected in other avian hosts in nature. In 2021, an H1N1 virus was isolated from a Fieldfare Turdus pilaris ...

Agerlin, M.V., Larsen, L.E., Weber, N.R. et al. Influenza A virus infection dynamics in two sow herds and effects of interventions. Porc Health Manag (2026).  Abstract  
submitted by kickingbird at Jan, 15, 2026 from Porc Health Manag (2026) (via https://link.springer.com/article/10.1186/s40813-025-00481-2)
BackgroundThe epidemiology of swine influenza A virus (swIAV) has undergone a change from causing mainly epidemic infections to continuous endemic circulation within herds. Several studies have traced ...

Brittany A Seibert, etc.,al. [preprint]Trimester-Dependent Vertical Transmission of H5N1 Influenza Virus Through Placental and Mammary Routes Impairs Offspring Development. https://doi.org/10.1101/2025.07.07.663583.  Abstract  
submitted by kickingbird at Jan, 14, 2026 from https://doi.org/10.1101/2025.07.07.663583 (via https://www.biorxiv.org/content/10.1101/2025.07.07.663583v4)
Avian influenza H5N1 has pandemic potential and historically has caused more severe disease in pregnant women than the general population. With increasing transmission of H5N1 detected among placental ...

Butt, S.L., de Oliveira, P.S.B., Rani, R. et al. Novel recombinant H5-based vaccine provides effective protection against H5N1 influenza virus in cats. npj Vaccines (2026).  Abstract  
submitted by kickingbird at Jan, 13, 2026 from npj Vaccines (2026) (via https://link.springer.com/article/10.1038/s41541-025-01369-6)
The emergence and broad circulation of highly pathogenic avian influenza (HPAI) H5N1 virus in wild birds and its spillover into dairy cows with sustained transmission in this species pose a major risk ...

Caputo V, Libera M, Campos Mota Y, Nagashima K, Mo. Extended Heterosubtypic Neutralization and Preclinical Model In Vivo Protection from Clade 2.3.4.4b H5 Influenza Virus Infection by Broadly Neutralizing Antibodies. Vaccines. 2026; 14(1):71.  Abstract  
submitted by kickingbird at Jan, 12, 2026 from Vaccines. 2026; 14(1):71 (via https://www.mdpi.com/2076-393X/14/1/71)
Background/Objective: The influenza virus remains one of the most prevalent respiratory pathogens, posing significant global health and economic challenges. According to the World Health Organization, ...

Giselle GK Ng, etc.,al. [preprint]Haemagglutinin 162-164 deletions enhance influenza B/Victoria virus fitness and virulence in vivo. https://doi.org/10.64898/2026.01.08.698527.  Abstract  
submitted by kickingbird at Jan, 11, 2026 from https://doi.org/10.64898/2026.01.08.698527 (via https://www.biorxiv.org/content/10.64898/2026.01.08.698527v1)
Influenza B viruses cause substantial respiratory disease and seasonal outbreaks. Despite decades of circulation in humans, only the B/Victoria lineage persisted after the COVID-19 pandemic. Continual ...

Zhu, W., Xu, Z., Wang, X., Li, X., Li, Z., Dong, G. Low-replication influenza virus mediates high pathogenicity through an inflammation-driven lung-heart-brain axis in mice. Emerging Microbes & Infections, 15(1).  Abstract  
submitted by kickingbird at Jan, 10, 2026 from Emerging Microbes & Infections, 15(1) (via https://www.tandfonline.com/doi/full/10.1080/22221751.2025.2)
The outcomes of viral infections typically correlate with viral load in host tissues. In this study, we identified a H3N2 strain A/Environment/Guangxi/44461/2019 (GX19) that induced rapid mortality in ...

Ibrahim, M., Said, A., Wahba, M. A., & Yehia, N. Genetic and antigenic analysis of the highly pathogenic avian influenza H5N8 virus clade 2.3.4.4b isolated from waterfowl in Egypt during 2022; evidence of brain-specific HA mutations. British Poultry Science, 1–10.  Abstract  
submitted by kickingbird at Jan, 10, 2026 from British Poultry Science, 1–10 (via https://www.tandfonline.com/doi/full/10.1080/00071668.2025.2)
1. This study characterised the H5N8 highly pathogenic avian influenza (HPAI) viruses, clade 2.3.4.4b from backyard waterfowl selected from Menoufia governorate during 2022. Genetic and antigenic analysis ...

Myint AP, Shirreff G, Baillie V, Bal A, Boutros CF. Association of influenza viral genetic information with severity markers in patients hospitalised with influenza: multicentre retrospective cohort study. BMJ Open. 2026 Jan 8;16(1):e111643.  Abstract  
submitted by kickingbird at Jan, 10, 2026 from BMJ Open. 2026 Jan 8;16(1):e111643 (via https://bmjopen.bmj.com/content/16/1/e111643)
Objective: The objective of this study was to determine the association between viral subtype/clade and disease severity.Design: Multicentre retrospective cohort study.Setting: This study used data from ...

Wu SX, Davis CN, Arnold M, Tildesley MJ. The role of ducks in detecting Highly Pathogenic Avian Influenza in small-scale backyard poultry farms. PLoS Comput Biol. 2026 Jan 9;22(1):e1013357.  Abstract  
submitted by kickingbird at Jan, 10, 2026 from PLoS Comput Biol. 2026 Jan 9;22(1):e1013357 (via https://journals.plos.org/ploscompbiol/article?id=10.1371/jo)
Previous research efforts on highly pathogenic H5N1 avian influenza (HPAI) suggest that different avian species exhibit a varied severity of clinical signs after infection. Waterfowl, such as ducks or ...

Adachi, K., Handharyani, E., Ueno, S. Tsukamoto Y. Comparative Hemagglutination of Avian Influenza A/H5N1 Viruses by Erythrocytes from Ostrich, Emu, Japanese Quail, Chicken and Horse. Open Journal of Veterinary Medicine, 16, 1-15.  Abstract  
submitted by kickingbird at Jan, 9, 2026 from Open Journal of Veterinary Medicine, 16, 1-15 (via https://www.scirp.org/journal/paperinformation?paperid=14855)
Influenza A viruses initiate infection when the envelope glycoprotein hemagglutinin (HA) binds sialic?acid-containing receptors on host cells and mediates membrane fusion. HA?mediated cross?linking of ...

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