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2014-11-27 2:23:14
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WJ Song, etc.,al. The K526R substitution in viral protein ?PB2 enhances the effects of E627K on influenza virus replication. Nature Communications 5, Article number: 5509, doi.  Abstract  
submitted by kickingbird at 5 days ago from Nature Communications 5, Article number: 5509, doi
Host-adaptive strategies, such as the E627K substitution in the ?PB2 protein, are critical for replication of avian influenza A viruses in mammalian hosts. Here we show that mutation ?PB2-K526R is present ...

MR.Gomma, AS Kayed, etc.,al. Avian Influenza A(H5N1) and A(H9N2) Seroprevalence and Risk Factors for Infection Among Egyptians: A Prospective, Controlled Seroepidemiological Study. J Infect Dis. (2014).  Abstract  
submitted by kickingbird at Nov, 2, 2014 from J Infect Dis. (2014)
Background.?A(H5N1) and A(H9N2) avian influenza viruses are enzootic in Egyptian poultry, and most A(H5N1) human cases since 2009 have occurred in Egypt. Our understanding of the epidemiology of avian ...

Qi W, Su S, Xiao C, et al. Antibodies against H10N8 Avian Influenza Virus among Animal Workers in Guangdong Province before November 30, 2013, the First Recognized Human H10N8 Case. BMC Medicine 2014, 12:205.  Abstract  
submitted by kickingbird at Oct, 30, 2014 from BMC Medicine 2014, 12:205
BackgroundConsidered an epicenter of pandemic influenza virus generation, southern China has recently seen an increasing number of human H7N9 infections. However, it is not the only threat. On 30 November ...

Wang XY, Chai CL, Li FD, He F, Yu Z, Wang XX, Shan. Epidemiology of human infections with avian influenza A(H7N9) virus in the two waves before and after October 2013 in Zhejiang province, China. Epidemiol Infect. 2014 Oct 7.  Abstract  
submitted by kickingbird at Oct, 12, 2014 from Epidemiol Infect. 2014 Oct 7
We compared the epidemiological and clinical features of avian influenza A(H7N9) virus infections in the population in Zhejiang province, China, between March and April 2013 (first wave) and October 2013 ...

CHIN AW, Li OT, Mok CK, Ng MK, et al. Influenza A viruses with different amino acid residues at PB2-627 display distinct replication properties in vitro and in vivo: Revealing the sequence plasticity of PB2-627 position. Virology. 2014 Sep 25;468-470C:545-555..  Abstract  
submitted by kickingbird at Oct, 6, 2014 from Virology. 2014 Sep 25;468-470C:545-555.
Sequence analyses of influenza PB2 sequences indicate that the 627 position almost exclusively contains either lysine (K) or glutamic acid (E), suggesting a high sequence constraint at this genetic marker. ...


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