Li Z, Zhao Y, Li Y, Chen X. Adjuvantation of Influenza Vaccines to Induce Cross-Protective Immunity. Vaccines (Basel). 2021 Jan 21;9(2):75. Abstract
submitted by kickingbird at 6 hours ago from Vaccines (Basel). 2021 Jan 21;9(2):75 (via https://www.mdpi.com/2076-393X/9/2/75)
Influenza poses a huge threat to global public health. Influenza vaccines are the most effective and cost-effective means to control influenza. Current influenza vaccines mainly induce neutralizing antibodies ...
Luczo JM, Ronzulli SL, Tompkins SM. Influenza A Virus Hemagglutinin and Other Pathogen Glycoprotein Interactions with NK Cell Natural Cytotoxicity Receptors NKp46, NKp44, and NKp30. Viruses. 2021 Jan 21;13(2):156. Abstract
submitted by kickingbird at 6 hours ago from Viruses. 2021 Jan 21;13(2):156 (via https://www.mdpi.com/1999-4915/13/2/156)
Natural killer (NK) cells are part of the innate immunity repertoire, and function in the recognition and destruction of tumorigenic and pathogen-infected cells. Engagement of NK cell activating receptors ...
Borchering RK, Gunning CE, Gokhale DV, Weedop KB,. Anomalous influenza seasonality in the United States and the emergence of novel influenza B viruses. Proc Natl Acad Sci U S A. 2021 Feb 2;118(5):e20123. Abstract
submitted by kickingbird at 6 hours ago from Proc Natl Acad Sci U S A. 2021 Feb 2;118(5):e20123 (via https://www.pnas.org/content/118/5/e2012327118)
The 2019/2020 influenza season in the United States began earlier than any season since the 2009 H1N1 pandemic, with an increase in influenza-like illnesses observed as early as August. Also noteworthy ...
Briand FX, Niqueux E, Schmitz A, Martenot C, Cherb. Highly Pathogenic Avian Influenza A(H5N8) Virus Spread by Short- and Long-Range Transmission, France, 2016-17. Emerg Infect Dis. 2021 Feb;27(2):508-516. Abstract
submitted by kickingbird at 6 hours ago from Emerg Infect Dis. 2021 Feb;27(2):508-516 (via https://wwwnc.cdc.gov/eid/article/27/2/20-2920_article)
We detected 3 genotypes of highly pathogenic avian influenza A(H5N8) virus in France during winter 2016-17. Genotype A viruses caused dramatic economic losses in the domestic duck farm industry in southwestern ...
Harshbarger WD, Deming D, Lockbaum GJ, Attatippaho. Unique structural solution from a V H 3-30 antibody targeting the hemagglutinin stem of influenza A viruses. Nat Commun. 2021 Jan 25;12(1):559. Abstract
submitted by kickingbird at 6 hours ago from Nat Commun. 2021 Jan 25;12(1):559 (via https://www.nature.com/articles/s41467-020-20879-6)
Broadly neutralizing antibodies (bnAbs) targeting conserved influenza A virus (IAV) hemagglutinin (HA) epitopes can provide valuable information for accelerating universal vaccine designs. Here, we report ...
Bantle CM, French CT, Cummings JE, Sadasivan S, Tr. Manganese exposure in juvenile C57BL/6 mice increases glial inflammatory responses in the substantia nigra following infection with H1N1 influenza virus. PLoS One. 2021 Jan 25;16(1):e0245171. Abstract
submitted by kickingbird at 20 hours ago from PLoS One. 2021 Jan 25;16(1):e0245171 (via https://journals.plos.org/plosone/article?id=10.1371/journal)
Infection with Influenza A virus can lead to the development of encephalitis and subsequent neurological deficits ranging from headaches to neurodegeneration. Post-encephalitic parkinsonism has been reported ...
Brázda V, Porubiaková O, Cantara A, Bohálová N, Co. G-quadruplexes in H1N1 influenza genomes. BMC Genomics. 2021 Jan 23;22(1):77. Abstract
submitted by kickingbird at 1 days ago from BMC Genomics. 2021 Jan 23;22(1):77 (via https://bmcgenomics.biomedcentral.com/articles/10.1186/s1286)
Background: Influenza viruses are dangerous pathogens. Seventy-Seven genomes of recently emerged genotype 4 reassortant Eurasian avian-like H1N1 virus (G4-EA-H1N1) are currently available. We investigated ...
Reemers S, Verstegen I, Basten S, Hubers W, van de. A broad spectrum HVT-H5 avian influenza vector vaccine which induces a rapid onset of immunity. Vaccine. 2021 Jan 19:S0264-410X(21)00022-0. Abstract
submitted by kickingbird at 3 days ago from Vaccine. 2021 Jan 19:S0264-410X(21)00022-0 (via https://www.sciencedirect.com/science/article/pii/S0264410X2)
Current methods to combat highly pathogenic avian influenza (HPAI) outbreaks in poultry rely on stamping out and preventive culling, which can lead to high economic losses and invoke ethical resistance. ...
Cao L, Lou J, Zhao S, Chan RWY, Chan M, Wu WKK, Ch. In silico prediction of influenza vaccine effectiveness by sequence analysis. Vaccine. 2021 Jan 19:S0264-410X(21)00006-2. Abstract
submitted by kickingbird at 3 days ago from Vaccine. 2021 Jan 19:S0264-410X(21)00006-2 (via https://www.sciencedirect.com/science/article/pii/S0264410X2)
The effectiveness of seasonal influenza vaccines varies with the matching of vaccine strains to circulating strains. Based on the genetic distance of hemagglutinin and neuraminidase gene of the influenza ...
Zhang C, Cui H, Wang Z, Dong S, Zhang C, Li J, Men. Pathogenicity and transmissibility assessment of two strains of human influenza virus isolated in China in 2018. J Int Med Res. 2021 Jan;49(1):300060520982832. Abstract
submitted by kickingbird at 4 days ago from J Int Med Res. 2021 Jan;49(1):300060520982832 (via https://journals.sagepub.com/doi/10.1177/0300060520982832)
Objective: Influenza season occurs every year in China, but its presentation was unusual in the period from December 2017 to early 2018. During this period, influenza activity was increasing across the ...
Garrido-Mantilla J, Sanhueza J, Alvarez J, Culhane. Impact of nurse sows on influenza A virus transmission in pigs under field conditions. Prev Vet Med. 2021 Jan 5;188:105257. Abstract
submitted by kickingbird at 4 days ago from Prev Vet Med. 2021 Jan 5;188:105257 (via https://www.sciencedirect.com/science/article/pii/S016758772)
Piglets prior to weaning play a central role in maintaining influenza infections in breeding herds and the use of nurse sows is a common practice to adopt piglets that fall behind and that otherwise would ...
Lorbach JN, Fitzgerald T, Nolan C, Nolting JM, Tre. Gaps in Serologic Immunity against Contemporary Swine-Origin Influenza A Viruses among Healthy Individuals in the United States. Viruses. 2021 Jan 18;13(1):E127. Abstract
submitted by kickingbird at 4 days ago from Viruses. 2021 Jan 18;13(1):E127 (via https://www.mdpi.com/1999-4915/13/1/127)
Influenza A Viruses (IAV) in domestic swine (IAV-S) are associated with sporadic zoonotic transmission at the human-animal interface. Previous pandemic IAVs originated from animals, which emphasizes the ...
Zhang Y, Zheng QC. In Silico Analysis Revealed a Unique Binding but Ineffective Mode of Amantadine to Influenza Virus B M2 Channel. J Phys Chem Lett. 2021 Jan 22:1169-1174. Abstract
submitted by kickingbird at 4 days ago from J Phys Chem Lett. 2021 Jan 22:1169-1174 (via https://pubs.acs.org/doi/10.1021/acs.jpclett.0c03560)
The M2 proton channel of influenza A (AM2) and B (BM2) have a highly conserved function motif, considered as the effective target. As yet, there is no effective drug against BM2. Research showed that AM2 ...
Laleye AT, Bianco A, Shittu I, Sulaiman L, Fusaro. Genetic characterization of Highly Pathogenic Avian Influenza H5Nx clade 184.108.40.206b reveals independent introductions in Nigeria. Transbound Emerg Dis. 2021 Jan 21. Abstract
submitted by kickingbird at 4 days ago from Transbound Emerg Dis. 2021 Jan 21 (via https://pubmed.ncbi.nlm.nih.gov/33480188/)
Among recurrent sanitary emergencies able to spread rapidly worldwide, avian influenza is one of the main constraints for animal health and food security. In West Africa, Nigeria has been experiencing ...
Wang F, Wu J, Wang Y, Wan Z, Shao H, Qian K, Ye J,. Identification of key residues involved in the neuraminidase antigenic variation of H9N2 influenza virus. Microbes Infect. 2021 Jan 19:1-27.. Abstract
submitted by kickingbird at 7 days ago from Microbes Infect. 2021 Jan 19:1-27. (via https://www.tandfonline.com/doi/full/10.1080/22221751.2021.1)
Influenza A H9N2 virus causes economic loss to the poultry industry and has likely contributed to the genesis of H5N1 and H7N9 viruses. The neuraminidase (NA) of H9N2 virus, like hemagglutinin, is under ...
Li Y, Li M, Tian J, Bai X, Li Y. Genetic characteristics and pathogenicity of novel reassortant H6 viruses isolated from wild birds in China. Vet Microbiol. 2021 Jan 6;254:108978. Abstract
submitted by kickingbird at 9 days ago from Vet Microbiol. 2021 Jan 6;254:108978 (via https://www.sciencedirect.com/science/article/pii/S037811352)
During our routine surveillance, we isolated seven H6 avian influenza virus (AIV) strains, including three H6N1 strains, three H6N2 strains, and one H6N8 strain, from 3667 fresh fecal samples that were ...
Shih PW, Chan TC, King CC. Risk Mapping of Highly Pathogenic Avian Influenza H5 during 2012-2017 in Taiwan with Spatial Bayesian Modeling: Implications for Surveillance and Control Policies. Transbound Emerg Dis. 2021 Jan 16. Abstract
submitted by kickingbird at 10 days ago from Transbound Emerg Dis. 2021 Jan 16 (via https://pubmed.ncbi.nlm.nih.gov/33452860/)
During 2012-2017, a total of 1,144 highly pathogenic avian influenza (HPAI) H5 outbreaks were reported in Taiwan. We conjectured the current 3-km radius of the post-outbreak containment policy could fail ...
Ashar HK, Pulavendran S, Rudd JM, Maram P, Achanta. Administration of a CXCR2 antagonist, SCH527123, together with oseltamivir suppresses NETosis and protects mice from lethal influenza and piglets from swine-influenza infection. Am J Pathol. 2021 Jan 13:S0002-9440(21)00002-X. Abstract
submitted by kickingbird at 10 days ago from Am J Pathol. 2021 Jan 13:S0002-9440(21)00002-X (via https://pubmed.ncbi.nlm.nih.gov/33453177/)
Excessive neutrophil influx, their released neutrophil extracellular traps (NETs) and extracellular histones are associated with disease severity in influenza-infected patients. Neutrophil chemokine receptor ...
Liu S, Huang Z, Deng X, Zou X, Li H, Mu S, Cao B. Identification of key candidate biomarkers for severe influenza infection by integrated bioinformatical analysis and initial clinical validation. J Cell Mol Med. 2021 Jan 14. Abstract
submitted by kickingbird at 11 days ago from J Cell Mol Med. 2021 Jan 14 (via https://pubmed.ncbi.nlm.nih.gov/33448094/)
One of the key barriers for early identification and intervention of severe influenza cases is a lack of reliable immunologic indicators. In this study, we utilized differentially expressed genes screening ...
Vousden N, Bunch K, Knight M; UKOSS Influenza Co-I. Incidence, risk factors and impact of seasonal influenza in pregnancy: A national cohort study. PLoS One. 2021 Jan 15;16(1):e0244986. Abstract
submitted by kickingbird at 11 days ago from PLoS One. 2021 Jan 15;16(1):e0244986 (via https://journals.plos.org/plosone/article?id=10.1371/journal)
Background: Pregnant women are particularly vulnerable to severe infection from influenza resulting in poor neonatal outcomes. The majority of evidence relates to pandemic 2009 A/H1N1 influenza. The objective ...
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