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2020-1-20 15:32:36

Chan M, et al. H7N9 Influenza Virus Containing a Polybasic HA Cleavage Site Requires Minimal Host Adaptation to Obtain a Highly Pathogenic Disease Phenotype in Mice. Viruses. 2020 Jan 5;12(1)..  Abstract  
submitted by kickingbird at 1 days ago from Viruses. 2020 Jan 5;12(1). (via https://www.mdpi.com/1999-4915/12/1/65)
Low pathogenic avian influenza (LPAI) H7N9 viruses have recently evolved to gain a polybasic cleavage site in the hemagglutinin (HA) protein, resulting in variants with increased lethality in poultry that ...

Qu B, Li X, Cardona CJ, Xing Z. Reassortment and adaptive mutations of an emerging avian influenza virus H7N4 subtype in China. PLoS One. 2020 Jan 17;15(1):e0227597..  Abstract  
submitted by kickingbird at 1 days ago from PLoS One. 2020 Jan 17;15(1):e0227597. (via https://journals.plos.org/plosone/article?id=10.1371/journal)
Human infections with avian influenza viruses including H5, H7 and H9 hemagglutinin subtypes occur at a low rate. Among human infections with H7 viruses, regional outbreaks with H7N2, H7N3, H7N7 and H7N9 ...

Aegerter H, et al. Influenza-induced monocyte-derived alveolar macrophages confer prolonged antibacterial protection. Nat Immunol. 2020 Jan 13.  Abstract  
submitted by kickingbird at 3 days ago from Nat Immunol. 2020 Jan 13 (via https://www.nature.com/articles/s41590-019-0568-x)
Despite the prevalence and clinical importance of influenza, its long-term effect on lung immunity is unclear. Here we describe that following viral clearance and clinical recovery, at 1?month after infection ...

Salomon A, et al. Influenza increases invasive meningococcal disease risk in temperate countries. Clin Microbiol Infect. 2020 Jan 11..  Abstract  
submitted by kickingbird at 3 days ago from Clin Microbiol Infect. 2020 Jan 11. (via https://www.clinicalmicrobiologyandinfection.com/article/S11)
OBJECTIVES: Invasive meningococcal disease (IMD) is a severe bacterial infection that displays wintertime seasonality in temperate countries. Mechanisms driving seasonality are poorly understood and may ...

Kupke SY, et al. Single-Cell Analysis Uncovers a Vast Diversity in Intracellular Viral Defective Interfering RNA Content Affecting the Large Cell-to-Cell Heterogeneity in Influenza A Virus Replication. Viruses. 2020 Jan 7;12(1).  Abstract  
submitted by kickingbird at 3 days ago from Viruses. 2020 Jan 7;12(1) (via https://www.mdpi.com/1999-4915/12/1/71)
Virus replication displays a large cell-to-cell heterogeneity; yet, not all sources of this variability are known. Here, we study the effect of defective interfering (DI) particle (DIP) co-infection on ...

Daidoji T, et al. Infection of Human Tracheal Epithelial Cells by H5 Avian Influenza Virus Is Regulated by the Acid Stability of Hemagglutinin and the pH of Target Cell Endosomes. Viruses. 2020 Jan 9;12(1).  Abstract  
submitted by kickingbird at 3 days ago from Viruses. 2020 Jan 9;12(1) (via https://www.mdpi.com/1999-4915/12/1/82)
Despite the possible relationships between tracheal infection and concomitant infection of the terminal part of the lower respiratory tract (bronchioles/alveoli), the behavior of avian influenza viruses ...

Novoseltseva AA, et al. Structural and Functional Aspects of G-Quadruplex Aptamers Which Bind a Broad Range of Influenza A Viruses. Biomolecules. 2020 Jan 10;10(1).  Abstract  
submitted by kickingbird at 3 days ago from Biomolecules. 2020 Jan 10;10(1) (via https://www.mdpi.com/2218-273X/10/1/119)
An aptamer is a synthetic oligonucleotide with a unique spatial structure that provides specific binding to a target. To date, several aptamers to hemagglutinin of the influenza A virus have been described, ...

Wang C, et al. Cell-to-Cell Variation in Defective Virus Expression and Effects on Host Responses during Influenza Virus Infection. mBio. 2020 Jan 14;11(1). pii: e02880-19..  Abstract  
submitted by kickingbird at 3 days ago from mBio. 2020 Jan 14;11(1). pii: e02880-19. (via https://mbio.asm.org/content/11/1/e02880-19)
Virus and host factors contribute to cell-to-cell variation in viral infections and determine the outcome of the overall infection. However, the extent of the variability at the single-cell level and how ...

Broomand Z, Mayahi M, Hosseini H, Valadbeigi S. Detection and Isolation of H9N2 Subtype of Avian Influenza Virus in House Sparrows (Passer domesticus) of Ahvaz, Iran. Arch Razi Inst. 2019 Dec;74(4):439-444.  Abstract  
submitted by kickingbird at 3 days ago from Arch Razi Inst. 2019 Dec;74(4):439-444 (via http://archrazi.areeo.ac.ir/article_120195.html)
Avian influenza (AI) is an acute infectious disease with worldwide significance causing extensive economic losses in the poultry industry. Avian influenza viruses (AIVs) belong to the family Orthomyxoviridae ...

Tare DS, Kode SS, Hurt AC, Pawar SD. Assessing the susceptibility of highly pathogenic avian influenza H5N1 viruses to oseltamivir using embryonated chicken eggs. Indian J Med Res. 2019 Nov;150(5):486-491..  Abstract  
submitted by kickingbird at 3 days ago from Indian J Med Res. 2019 Nov;150(5):486-491. (via http://www.ijmr.org.in/article.asp?issn=0971-5916;year=2019;)
Background & objectives: The susceptibility of influenza viruses to neuraminidase inhibitors (NAIs) is studied using enzyme-based assays, sequence analysis and in vitro and in vivo studies. Oseltamivir ...

Dai Z, Zhang L, Yu Q, Liu L, Yang M, Fan K. Early Administration of Oseltamivir Within 48 Hours After Onset of Flulike Symptoms Can Reduce the Risk of Influenza B Virus-Associated Pneumonia in Hospitalized Pediatric Patients with Influenza B Vi. Pediatr Infect Dis J. 2020 Feb;39(2):e20-e22.  Abstract  
submitted by kickingbird at 4 days ago from Pediatr Infect Dis J. 2020 Feb;39(2):e20-e22 (via https://journals.lww.com/pidj/FullText/2020/02000/Early_Admi)
We conducted a retrospective study to identify the risk factors for pneumonia in hospitalized pediatric patients with influenza B infection. Receiving oseltamivir within the first 48 hours of onset and ...

Cov├ęs-Datson EM, et al. A molecularly engineered antiviral banana lectin inhibits fusion and is efficacious against influenza virus infection in vivo. Proc Natl Acad Sci U S A. 2020 Jan 13.  Abstract  
submitted by kickingbird at 4 days ago from Proc Natl Acad Sci U S A. 2020 Jan 13 (via https://www.pnas.org/content/early/2020/01/09/1915152117)
There is a strong need for a new broad-spectrum antiinfluenza therapeutic, as vaccination and existing treatments are only moderately effective. We previously engineered a lectin, H84T banana lectin (H84T), ...

Stoimenov GM, et al. Pathological Changes in Natural Infection of Pheasants with Highly Pathogenic Avian Influenza A (H5N8) in Bulgaria. J Vet Res. 2019 Dec 19;63(4):497-502.  Abstract  
submitted by kickingbird at 4 days ago from J Vet Res. 2019 Dec 19;63(4):497-502 (via https://content.sciendo.com/view/journals/jvetres/63/4/artic)
Introduction: The study of histopathological changes caused by influenza A (H5N8) viral infection in bird species is essential for the understanding of their role in the spread of this highly infectious ...

Simusika P, et al. An evaluation of the Zambia influenza sentinel surveillance system, 2011-2017. BMC Health Serv Res. 2020 Jan 13;20(1):35..  Abstract  
submitted by kickingbird at 4 days ago from BMC Health Serv Res. 2020 Jan 13;20(1):35. (via https://bmchealthservres.biomedcentral.com/articles/10.1186/)
BACKGROUND: Over the past decade, influenza surveillance has been established in several African countries including Zambia. However, information on the on data quality and reliability of established influenza ...

Omi J, et al. The inducible amphisome isolates viral hemagglutinin and defends against influenza A virus infection. Nat Commun. 2020 Jan 9;11(1):162..  Abstract  
submitted by kickingbird at 7 days ago from Nat Commun. 2020 Jan 9;11(1):162. (via https://www.nature.com/articles/s41467-019-13974-w)
The emergence of drug-resistant influenza type A viruses (IAVs) necessitates the development of novel anti-IAV agents. Here, we target the IAV hemagglutinin (HA) protein using multivalent peptide library ...

Li B, et al. Genome-wide CRISPR screen identifies host dependency factors for influenza A virus infection. Nat Commun. 2020 Jan 9;11(1):164..  Abstract  
submitted by kickingbird at 7 days ago from Nat Commun. 2020 Jan 9;11(1):164. (via https://www.nature.com/articles/s41467-019-13965-x)
Host dependency factors that are required for influenza A virus infection may serve as therapeutic targets as the virus is less likely to bypass them under drug-mediated selection pressure. Previous attempts ...

Xu S, et al. Comparative Pathogenicity and Transmissibility of Pandemic H1N1, Avian H5N1, and Human H7N9 Influenza Viruses in Tree Shrews. Front Microbiol. 2019 Dec 20;10:2955..  Abstract  
submitted by kickingbird at 7 days ago from Front Microbiol. 2019 Dec 20;10:2955. (via https://www.frontiersin.org/articles/10.3389/fmicb.2019.0295)
Influenza A viruses (IAVs) continuously challenge the poultry industry and human health. Studies of IAVs are still hampered by the availability of suitable animal models. Chinese tree shrews (Tupaia belangeri ...

Cheng KL, et al. Avian Influenza Virus Detection Rates in Poultry and Environment at Live Poultry Markets, Guangdong, China. Emerg Infect Dis. 2020 Mar 17;26(3).  Abstract  
submitted by kickingbird at 7 days ago from Emerg Infect Dis. 2020 Mar 17;26(3) (via https://wwwnc.cdc.gov/eid/article/26/3/19-0888_article)
We report the use of environmental samples to assess avian influenza virus activity in chickens at live poultry markets in China. Results of environmental and chicken samples correlate moderately well. ...

Gao C, et al. Association Between Cardiac Injury and Mortality in Hospitalized Patients Infected With Avian Influenza A (H7N9) Virus. Crit Care Med. 2020 Jan 9..  Abstract  
submitted by kickingbird at 7 days ago from Crit Care Med. 2020 Jan 9. (via https://journals.lww.com/ccmjournal/Abstract/onlinefirst/Ass)
OBJECTIVES: To evaluate the prevalence of cardiac injury and its association with mortality in hospitalized patients infected with avian influenza A (H7N9) virus.DESIGN: Retrospective cohort study.SETTING: ...

Reeves AB, et al. Field-based method for assessing duration of infectivity for influenza A viruses in the environment. J Virol Methods. 2020 Jan 7:113818..  Abstract  
submitted by kickingbird at 7 days ago from J Virol Methods. 2020 Jan 7:113818. (via https://www.sciencedirect.com/science/article/abs/pii/S01660)
Understanding influenza A virus (IAV) persistence in wetlands is limited by a paucity of field studies relating to the maintenance of infectivity over time. The duration of IAV infectivity in water has ...

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