S. Yamayoshi, etc.,al. Enhanced Replication of Highly Pathogenic Influenza A(H7N9) Virus in Humans. EID Vol 24, No. 4. Abstract
submitted by kickingbird at 2 days ago from EID Vol 24, No. 4 (via https://wwwnc.cdc.gov/eid/article/24/4/17-1509_article)
To clarify the threat posed by emergence of highly pathogenic influenza A(H7N9) virus infection among humans, we characterized the viral polymerase complex. Polymerase basic 2–482R, polymerase basic 2–588V, ...
Brianne J. Lindsay, etc.,al. Morphological characterization of a plant-made virus-like particle vaccine bearing influenza virus hemagglutinins by electron microscopy. Vaccine 14 March 2018. Abstract
submitted by kickingbird at 2 days ago from Vaccine 14 March 2018 (via https://www.sciencedirect.com/science/article/pii/S0264410X1)
Plant-made virus-like particle (VLP) vaccines that display wild-type influenza hemagglutinin (HA) are rapidly advancing through clinical trials. Produced by transient transfection of Nicotiana benthamiana, ...
Kathleen A. Stellrecht. Incidence of matrix genes mutations affecting PCR tests among influenza H3N2 clades circulating during the 2014/15 season. Diagnostic Microbiology&Infectious Diseases. Abstract
submitted by kickingbird at 2 days ago from Diagnostic Microbiology&Infectious Diseases (via http://www.dmidjournal.com/article/S0732-8893(18)30054-3/ful)
Influenza circulating during the 2014/15 season was associated with significant drift and the emergence of new H3N2 subgroups. It was also known that mutations were accumulating in the WHO-recommended ...
Kwang Il Jung, etc.,al. Influenza A virus-induced autophagy contributes to enhancement of virus infectivity by SOD1 downregulation in alveolar epithelial cells. Biochemical and Biophysical Research Communication. Abstract
submitted by kickingbird at 2 days ago from Biochemical and Biophysical Research Communication (via https://www.sciencedirect.com/science/article/pii/S0006291X1)
Infection with influenza A virus (IAV) A/WSN/1933 (H1N1) causes oxidative stress and severe lung injury. We have demonstrated that the generation of reactive oxygen species (ROS) during IAV infection is ...
Ishiguro N. et al. Clinical effectiveness of four neuraminidase inhibitors(oseltamivir, zanamivir, laninamivir,and peramivir) for children with influenza A and B in the 2014-2015 to 2016-2017 influenza seasons in Japan. J Infect Chemother. 2018 Feb 24. Abstract
submitted by kickingbird at 4 days ago from J Infect Chemother. 2018 Feb 24 (via https://www.ncbi.nlm.nih.gov/pubmed/29487035)
The clinical effectiveness of four neuraminidase inhibitors (NAIs) (oseltamivir, zanamivir, laninamivir, and peramivir) for children aged 0 months to 18 years with influenza A and B were investigated in ...
Lee IW, etc.,al. Comparison of the virulence and transmissibility of canine H3N2 influenza viruses and characterization of their canine adaptation factors. Emerg Microbes Infect. 2018 Mar 7;7(1):17. Abstract
submitted by kickingbird at 12 days ago from Emerg Microbes Infect. 2018 Mar 7;7(1):17 (via https://www.ncbi.nlm.nih.gov/pubmed/29511200)
Recent canine influenza outbreaks have raised concerns about the generation of pathogenic variants that may pose a threat to public health. Here, we examine avian-like H3N2 canine influenza viruses (CIVs) ...
Jin H, etc.,al. Evolution of H9N2 avian influenza virus in embryonated chicken eggs with or without homologous vaccine antibodies. BMC Vet Res. 2018 Mar 6;14(1):71.. Abstract
submitted by kickingbird at 12 days ago from BMC Vet Res. 2018 Mar 6;14(1):71. (via https://www.ncbi.nlm.nih.gov/pubmed/29510698)
BACKGROUND: Vaccines constitute a unique selective pressure, different from natural selection, drives the evolution of influenza virus. In this study, A/Chicken/Shanghai/F/1998 (H9N2) was continually passaged ...
Czako R, Vogel L, Sutton T, Matsuoka Y, et al. H5N2 vaccine viruses on Russian and US live attenuated influenza virus backbones demonstrate similar infectivity, immunogenicity and protection in ferrets. Vaccine 2018 Mar 1.. Abstract
submitted by kickingbird at 12 days ago from Vaccine 2018 Mar 1. (via https://www.ncbi.nlm.nih.gov/m/pubmed/29503113/)
The continued detection of zoonotic influenza infections, most notably due to the avian influenza A H5N1 and H7N9 subtypes, underscores the need for pandemic preparedness. Decades of experience with live ...
Erbelding EJ, Post D, Stemmy E, Roberts PC, et al. A Universal Influenza Vaccine: The Strategic Plan for the National Institute of Allergy and Infectious Diseases. J Infect Dis 2018 Feb 28. Abstract
submitted by kickingbird at 12 days ago from J Infect Dis 2018 Feb 28 (via https://www.ncbi.nlm.nih.gov/m/pubmed/29506129/)
A priority for the National Institute of Allergy and Infectious Diseases (NIAID) is development of an influenza vaccine providing durable protection against multiple influenza strains, including those ...
Tinoco R, Carrette F, Henriquez ML, Fujita Y, et a. Fucosyltransferase Induction during Influenza Virus Infection Is Required for the Generation of Functional Memory CD4+ T Cells. J Immunol 2018 Feb 28. Abstract
submitted by kickingbird at 12 days ago from J Immunol 2018 Feb 28 (via https://www.ncbi.nlm.nih.gov/m/pubmed/29491007/)
T cells mediating influenza viral control are instructed in lymphoid and nonlymphoid tissues to differentiate into memory T cells that confer protective immunity. The mechanisms by which influenza virus-specific ...
Kwon JJ, Choi WS, Jeong JH, Kim EH, et al. An I436N substitution confers resistance of influenza A(H1N1)pdm09 viruses to multiple neuraminidase inhibitors without affecting viral fitness. J Gen Virol 2018;99:292-302. Abstract
submitted by kickingbird at 12 days ago from J Gen Virol 2018;99:292-302 (via https://www.ncbi.nlm.nih.gov/m/pubmed/29493493/)
The resistance of influenza viruses to neuraminidase (NA) inhibitors (NAIs; i.e. oseltamivir, zanamivir, peramivir and laninamivir) can be associated with several NA substitutions, with differing effects ...
Takizawa N, Kimura T, Watanabe T, Shibasaki M, et. Anti-influenza virus activity of a salcomine derivative mediated by inhibition of viral RNA synthesis. Arch Virol 2018 Mar 1. Abstract
submitted by kickingbird at 12 days ago from Arch Virol 2018 Mar 1 (via https://www.ncbi.nlm.nih.gov/m/pubmed/29497849/)
Influenza virus infection is a major threat to global health. Although vaccines and anti-influenza virus drugs are available, annual influenza virus epidemics result in severe illness, and an influenza ...
Musharrafieh R, Ma C, Wang J. Profiling the in vitro drug-resistance mechanism of influenza A viruses towards the AM2-S31N proton channel blockers. Antiviral Res 2018 Mar 5.. Abstract
submitted by kickingbird at 12 days ago from Antiviral Res 2018 Mar 5. (via https://www.ncbi.nlm.nih.gov/m/pubmed/29518414/)
The majority of human influenza A viruses currently in circulation carry the amantadine-resistant AM2-S31N channel mutation. We previously discovered a series of AM2-S31N inhibitors with potent antiviral ...
Shirin Hosseini, Esther Wilk, Kristin Michaelsen-P. Long-term neuroinflammation induced by influenza A virus infection and the impact on hippocampal neuron morphology and function. Journal of Neuroscience 27 February 2018. Abstract
submitted by kickingbird at Mar, 1, 2018 from Journal of Neuroscience 27 February 2018 (via http://www.jneurosci.org/content/early/2018/02/28/JNEUROSCI.)
Acute influenza infection has been reported to be associated with neurological symptoms. However, the long-term consequences for the CNS of an infection with neurotropic but also with non-neurotropic influenza ...
Siri E. H?berg,etc.,al. Epilepsy in Children After Pandemic Influenza Vaccination. Pediatrics Feb 2018. Abstract
submitted by kickingbird at Mar, 1, 2018 from Pediatrics Feb 2018 (via http://pediatrics.aappublications.org/content/early/2018/02/)
OBJECTIVES: To determine if pandemic influenza vaccination was associated with an increased risk of epilepsy in children.METHODS: Information from Norwegian registries from 2006 through 2014 on all children ...
P Terebuh, etc.,al. Human Infection with Avian Influenza A(H7N2) Virus – Virginia, 2002. Influenza and other respiratory viruses Feb 2018. Abstract
submitted by kickingbird at Mar, 1, 2018 from Influenza and other respiratory viruses Feb 2018 (via http://onlinelibrary.wiley.com/doi/10.1111/irv.12546/abstrac)
AbstractBackgroundIn March 2002, an outbreak of low-pathogenic avian influenza (LPAI) A(H7N2) was detected among commercial poultry operations in Virginia.MethodsWe performed a serosurvey of 80 government ...
A Ramey,etc.,al. Lessons learned from research and surveillance directed at highly pathogenic influenza A viruses in wild birds inhabiting North America. Virology Volume 518, May 2018, Pages 55-63. Abstract
submitted by kickingbird at Mar, 1, 2018 from Virology Volume 518, May 2018, Pages 55-63 (via https://www.sciencedirect.com/science/article/pii/S004268221)
Following detections of highly pathogenic (HP) influenza A viruses (IAVs) in wild birds inhabiting East Asia after the turn of the millennium, the intensity of sampling of wild birds for IAVs increased ...
Scoizec A, Niqueux E, Thomas R, Daniel P, Schmitz. Airborne Detection of H5N8 Highly Pathogenic Avian Influenza Virus Genome in Poultry Farms, France. Front. Vet. Sci., 13 February 2018. Abstract
submitted by kickingbird at Mar, 1, 2018 from Front. Vet. Sci., 13 February 2018 (via https://www.frontiersin.org/articles/10.3389/fvets.2018.0001)
In southwestern France, during the winter of 2016–2017, the rapid spread of highly pathogenic avian influenza H5N8 outbreaks despite the implementation of routine control measures, raised the question ...
Jiafa Liu,etc.,al. Sudden emergence of human infections with H7N9 avian influenza A virus in Hubei province, central China. Scientific Reportsvolume 8, Article number: 2486. Abstract
submitted by kickingbird at Mar, 1, 2018 from Scientific Reportsvolume 8, Article number: 2486 (via https://www.nature.com/articles/s41598-018-20988-9)
There have been five waves of H7N9 avian influenza virus (AIV) infection in humans since its initial emergence in China in 2013, posing a significant threat to public health. Hubei province was free local ...
Dan Xiang,etc.,al. Convergent Evolution of Human-Isolated H7N9 Avian Influenza A Viruses. The Journal of Infectious Diseases 09 Feb 2018. Abstract
submitted by kickingbird at Mar, 1, 2018 from The Journal of Infectious Diseases 09 Feb 2018 (via https://academic.oup.com/jid/advance-article-abstract/doi/10)
BackgroundAvian influenza A virus (AIV) H7N9 has caused five epidemic waves of human infections in China since 2013. AIVs may face strong selection to adapt to novel conditions when establishing themselves ...
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