Yang Xue, Yuki Tai, Hiromi Yamamoto, Daiki Mori, K. T cell help is a limiting factor for rare anti-influenza memory B cells to reenter germinal centers and generate potent broadly neutralizing antibodies. International Immunology, 2026;, dxag003. Abstract
submitted by kickingbird at 17 hours ago from International Immunology, 2026;, dxag003 (via https://academic.oup.com/intimm/advance-article-abstract/doi)
Development of vaccines eliciting broadly neutralizing influenza antibodies (bnAbs) is an extraordinary challenge. One hypothetical proposal is that CD4+ T cell help to rare immuno-subdominant bnAb class ... Andrew Y Cho, Dong-Hun Lee, Alice Fusaro, Edoardo. Wild birds drive the introduction, maintenance, and spread of H5N1 clade 2.3.4.4b high pathogenicity avian influenza viruses in Spain, 2021-2022. Virus Evolution, 2026;, veag006. Abstract
submitted by kickingbird at 17 hours ago from Virus Evolution, 2026;, veag006 (via https://academic.oup.com/ve/advance-article/doi/10.1093/ve/v)
The 2021-2022 high pathogenicity avian influenza (HPAI) epizootic was the worst ever recorded in Europe in general and in Spain in particular. Between December 2021 and November 2022, H5N1 clade 2.3.4.4b ... Xingyi Li, etc.,al. [preprint]FluNexus: a versatile web platform for antigenic prediction and visualization of influenza A viruses. https://doi.org/10.64898/2026.01.29.702696. Abstract
submitted by kickingbird at 18 hours ago from https://doi.org/10.64898/2026.01.29.702696 (via https://www.biorxiv.org/content/10.64898/2026.01.29.702696v1)
Influenza A viruses continuously undergo antigenic evolution to escape host immunity induced by previous infections or vaccinations, consequently causing seasonal epidemics and occasional pandemics. Antigenic ... Acevedo HD, Beeler E, Crossley B, Armién AG, Hende. Salpingitis and multiorgan lesions caused by highly pathogenic avian influenza A(H5N1) virus in a cat associated with consumption of recalled raw milk in California. J Vet Diagn Invest. 2026 Jan 29:10406387251413563. Abstract
submitted by kickingbird at 18 hours ago from J Vet Diagn Invest. 2026 Jan 29:10406387251413563 (via https://journals.sagepub.com/doi/10.1177/10406387251413563)
A panzootic caused by highly pathogenic avian influenza (HPAI) A(H5N1) virus, clade 2.3.4.4b, has affected many animal species around the world since 2021. In March 2024, genotype B3.13 of this virus was ... Lehman KA, Leibsle SR, Detwiler L, Gaborick C, McC. Detection of highly pathogenic avian influenza A(H5N1) virus 2.3.4.4b in alpacas. J Vet Diagn Invest. 2026 Jan 29:10406387251414557. Abstract
submitted by kickingbird at 18 hours ago from J Vet Diagn Invest. 2026 Jan 29:10406387251414557 (via https://journals.sagepub.com/doi/10.1177/10406387251414557)
Highly pathogenic avian influenza (HPAI) A(H5N1) virus, clade 2.3.4.4b, genotype 3.13, was first confirmed in dairy cattle in March 2024 in a Texas dairy herd and has since spread to other states, likely ... Tikhonova D, Andreev E, Akhmetova A, Meshcheryakov. Specific determination of influenza virus A by SERS-active spike-like track-etched membranes. Anal Chim Acta. 2026 Feb 22;1388:345100. Abstract
submitted by kickingbird at 18 hours ago from Anal Chim Acta. 2026 Feb 22;1388:345100 (via https://www.sciencedirect.com/science/article/abs/pii/S00032)
Rapid specific sensors, ready for several particles' detection per probe, are essential for disease diagnostics at the early stages before the symptom manifestation. Infectious diseases represent a prominent ... Chu H, Hao Z, Zhang L, Lou Y, Hua Y, Gao W, Li F,. Evaluation of Rice Traits Containing H9N2 Subtype Avian Influenza HA Protein Before Commercialization. Curr Issues Mol Biol. 2025 Nov 26;47(12):986. Abstract
submitted by kickingbird at 18 hours ago from Curr Issues Mol Biol. 2025 Nov 26;47(12):986 (via https://www.mdpi.com/1467-3045/47/12/986)
The H9N2 avian influenza virus (AIV) is difficult to prevent and control because of its low pathogenicity and frequent mutation. In a previous study, the HA (hemagglutinin) protein of H9N2 was expressed ... Tarbuck NN, Franks J, Jones JC, Kandeil A, DeBeauc. Retail Milk Monitoring of Influenza A(H5N1) in Dairy Cattle, United States, 2024-2025. Emerg Infect Dis. 2026 Feb. Abstract
submitted by kickingbird at 18 hours ago from Emerg Infect Dis. 2026 Feb (via https://wwwnc.cdc.gov/eid/article/32/2/25-1332_article)
US retail milk monitoring during April 13-May 3, 2024, identified influenza A(H5N1) viral RNA in 36% of retail milk samples, indicating widespread undetected infections in US dairy cows. After federal ... Ying, Baoling et al. An intranasal adenoviral-vectored vaccine protects against highly pathogenic avian influenza H5N1 in naive and antigen-experienced animals. Cell Reports Medicine, January 30, 2026. Abstract
submitted by kickingbird at 18 hours ago from Cell Reports Medicine, January 30, 2026 (via https://www.cell.com/cell-reports-medicine/fulltext/S2666-37)
The emergence of highly pathogenic avian H5N1 influenza viruses in dairy cows and humans has increased the potential for another pandemic. To address this risk, we developed chimpanzee adenoviral (ChAd)-vectored ... Daniel, Katharina et al. Pre-existing neutralizing antibodies against cattle-transmitted influenza A virus H5N1 are detectable in unexposed individuals. Immunity, January 30, 2026. Abstract
submitted by kickingbird at 18 hours ago from Immunity, January 30, 2026 (via https://www.cell.com/immunity/fulltext/S1074-7613(25)00569-2)
The transmission of influenza A virus H5N1 clade 2.3.4.4b from cattle to humans highlights the risk of an H5N1 pandemic. Pre-existing immunity strongly impacts the course and severity of viral infections, ... Xiaolong Lu, etc.,al. The host RNA helicase DDX6 restricts avian influenza virus replication by targeting viral NP and modulating ISG15. Poultry Science. Abstract
submitted by kickingbird at 2 days ago from Poultry Science (via https://www.sciencedirect.com/science/article/pii/S003257912)
The H7N9 subtype of avian influenza virus (AIV) poses a significant and ongoing threat to public health. As a critical structural and functional component, the viral nucleoprotein (NP) is abundantly expressed ... Brcko, I. C., de Souza, V. C., Jeronimo Lima, A. R. Phylodynamic reconstruction of H1N1pdm09 influenza virus transmission in Brazil: a decade of evolutionary dynamics. Emerging Microbes & Infections, 15(1). Abstract
submitted by kickingbird at 2 days ago from Emerging Microbes & Infections, 15(1) (via https://www.tandfonline.com/doi/full/10.1080/22221751.2026.2)
The H1N1pdm09 influenza virus, which emerged in 2009 following a unique reassortment of swine-origin gene segments, rapidly replaced the seasonal H1N1 strain and triggered the first influenza pandemic ... Kieran Dee, etc.,al. [preprint]Subclade K influenza A (H3N2) viruses display partial immune escape with preserved cross-neutralisation in a UK population. https://doi.org/10.64898/2026.01.27.26344933. Abstract
submitted by kickingbird at 2 days ago from https://doi.org/10.64898/2026.01.27.26344933 (via https://www.medrxiv.org/content/10.64898/2026.01.27.26344933)
We examined whether the recent emergence of influenza A(H3N2) subclade K, associated with an unusually early influenza season in the Northern hemisphere, was accompanied by a reduction in human population ... Kong H, Yang J, Shi J, Cui P, Zeng X, Liu W, He X,. Protective Efficacy of a Hemagglutinin-Based mRNA Vaccine Against H5N1 Influenza Virus Challenge in Lactating Dairy Cows. Research (Wash D C). 2026 Jan 26;9:1104. Abstract
submitted by kickingbird at 3 days ago from Research (Wash D C). 2026 Jan 26;9:1104 (via https://spj.science.org/doi/10.34133/research.1104)
Highly pathogenic avian influenza H5N1 virus has spread to over 1,080 dairy farms across 18 states in the United States, resulting in 41 human infections and posing serious risks to both animal and public ... Dupas MC, Vincenti-Gonzalez MF, Dhingra M, Guinat. Global risk mapping of highly pathogenic avian influenza H5N1 and H5Nx in the light of epidemic episodes occurring from 2020 onwards. Elife. 2026 Jan 28;14:RP104748. Abstract
submitted by kickingbird at 3 days ago from Elife. 2026 Jan 28;14:RP104748 (via https://elifesciences.org/articles/104748)
Avian influenza (AI) is a highly contagious viral disease affecting poultry and wild water birds, posing significant global challenges due to its high mortality rates and economic impacts. Highly pathogenic ... Zhong JC, Zhong S, Touyon L, Ho F, Au NYM, Cheng S. Repeat influenza vaccination effects in 2021/22 and 2022/23 in a community-based cohort in Hong Kong. J Infect Dis. 2026 Jan 28:jiag051. Abstract
submitted by kickingbird at 3 days ago from J Infect Dis. 2026 Jan 28:jiag051 (via https://academic.oup.com/jid/advance-article/doi/10.1093/inf)
Background: Repeated annual influenza vaccination has been associated with attenuated immune responses and reduced clinical effectiveness. Most studies of repeat vaccination immunogenicity have focused ... Ye, Y., Shuai, H., Song, Y. et al. Genomic features associated with sustained mammalian transmission of avian influenza A viruses. Nat Microbiol (2026). Abstract
submitted by kickingbird at 4 days ago from Nat Microbiol (2026) (via https://link.springer.com/article/10.1038/s41564-025-02257-4)
Comparably few lineages of influenza A virus (IAV) have evolved long-term sustained transmission in mammals. The reasons remain largely unknown, and the possibility of avian IAVs evolving sustained mammalian ... Morel, G., Pham, A., Morgenstern, C. et al. An outbreak of highly pathogenic avian influenza H5N1 could impact the dairy cattle sector and the broader economy in the United States. Commun Earth Environ (2026). Abstract
submitted by kickingbird at 4 days ago from Commun Earth Environ (2026) (via https://link.springer.com/article/10.1038/s43247-025-03153-9)
The outbreak of Highly Pathogenic Avian Influenza H5N1 in U.S. dairy cattle poses substantial risks to public health, economic sustainability of farming, and global food systems. Using a Computable General ... Zorian T Thornton, etc.,al. [preprint]antigen-prime: Simulating coupled genetic and antigenic evolution of influenza virus. https://doi.org/10.64898/2026.01.23.701420. Abstract
submitted by kickingbird at 5 days ago from https://doi.org/10.64898/2026.01.23.701420 (via https://www.biorxiv.org/content/10.64898/2026.01.23.701420v1)
Seasonal influenza virus undergoes rapid antigenic drift to escape population immunity. Computational methods can be used to organize viral genetic diversity into antigenically similar variants and estimate ... Belser, J.A., Brock, N., Sun, X. et al. Oseltamivir and baloxavir monotherapy and combination therapy efficacy against clade 2.3.4.4b A(H5N1) influenza virus infection in ferrets. Commun Biol (2026). Abstract
submitted by kickingbird at 5 days ago from Commun Biol (2026) (via https://link.springer.com/article/10.1038/s42003-026-09607-w)
Neuraminidase inhibitors (NAIs) and cap-dependent endonuclease inhibitors (CENIs) represent two classes of antiviral drugs recommended for early treatment of patients with seasonal influenza A virus (IAV) ... 9775 items, 20/Page, Page[1/489][|<<] [|<] [1] [2] [3] [4] [5] [6] [7] [8] [9] [10] [>|] [>>|] |
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