Drori Y, Jacob-Hirsch J, Pando R, Glatman-Freedman. Influenza A Virus Inhibits RSV Infection via a Two-Wave Expression of IFIT Proteins. Viruses. 2020 Oct 16;12(10):E1171. Abstract
submitted by kickingbird at 2 days ago from Viruses. 2020 Oct 16;12(10):E1171 (via https://www.mdpi.com/1999-4915/12/10/1171)
Influenza viruses and respiratory syncytial virus (RSV) are respiratory viruses that primarily circulate worldwide during the autumn and winter seasons. Seasonal surveillance has shown that RSV infection ...
Li S, Qiao Y, Xu Y, Li P, Nie J, Zhao Q, Chai W, S. Identification of Linear Peptide Immunogens with Verified Broad-spectrum Immunogenicity from the Conserved Regions within the Hemagglutinin Stem Domain of H1N1 Influenza Virus. Immunol Invest. 2020 Oct 20:1-14. Abstract
submitted by kickingbird at 3 days ago from Immunol Invest. 2020 Oct 20:1-14 (via https://www.tandfonline.com/doi/abs/10.1080/08820139.2020.18)
Background: Influenza A viruses (IAVs) induce acute respiratory disease and cause severe epidemics and pandemics. Since IAVs exhibit antigenic variation and genome reassortment, the development of broad-spectrum ...
Ohta M, Bannai H, Nemoto M, Kambayashi Y, Tamura N. Antibody Responses Against Equine Influenza Virus Induced by Concurrent and by Consecutive Use of an Inactivated Equine Influenza Virus Vaccine and a Modified Live Equine Herpesvirus Type 1 Vaccine in. J Equine Vet Sci. 2020 Nov;94:103221. Abstract
submitted by kickingbird at 3 days ago from J Equine Vet Sci. 2020 Nov;94:103221 (via https://www.sciencedirect.com/science/article/abs/pii/S07370)
An inactivated equine influenza virus (EIV) vaccine and a live equine herpesvirus type 1 (EHV-1) vaccine are usually administered concurrently to Thoroughbred racehorses in Japan. The objective of this ...
Nemoto M, Okita N, Kitahata M, Bannai H, Tsujimura. Evaluation of cobas Influenza A/B & RSV Test for Diagnosis of Equine Influenza. J Equine Vet Sci. 2020 Nov;94:103249. Abstract
submitted by kickingbird at 3 days ago from J Equine Vet Sci. 2020 Nov;94:103249 (via https://www.sciencedirect.com/science/article/abs/pii/S07370)
A rapid and sensitive diagnostic method is needed to help prevent the spread of equine influenza virus. The cobas Influenza A/B & RSV test for the cobas Liat system (Roche Diagnostics) is based on real-time ...
Hauge SH, Bakken IJ, de Blasio BF, H?berg SE. Risk conditions in children hospitalized with influenza in Norway, 2017~2019. BMC Infect Dis. 2020 Oct 19;20(1):769. Abstract
submitted by kickingbird at 3 days ago from BMC Infect Dis. 2020 Oct 19;20(1):769 (via https://bmcinfectdis.biomedcentral.com/articles/10.1186/s128)
Background: Norwegian children are more frequently hospitalized with influenza than adults. Little is known about the characteristics of these children. Our aim was to investigate the presence of pre-existing ...
Yang K, Xie J, Xie R, Pan Y, Liu R, Chen P. Real-Time Forecast of Influenza Outbreak Using Dynamic Network Marker Based on Minimum Spanning Tree. Biomed Res Int. 2020 Oct 1;2020:7351398. Abstract
submitted by kickingbird at 4 days ago from Biomed Res Int. 2020 Oct 1;2020:7351398 (via https://www.hindawi.com/journals/bmri/2020/7351398/)
The influenza pandemic is a wide-ranging threat to people's health and property all over the world. Developing effective strategies for predicting the influenza outbreak which may prevent or at least get ...
Shu B, Kirby MK, Warnes C, Sessions WM, Davis WG,. Detection and discrimination of influenza B Victoria lineage deletion variant viruses by real-time RT-PCR. Euro Surveill. 2020 Oct;25(41). Abstract
submitted by kickingbird at 4 days ago from Euro Surveill. 2020 Oct;25(41) (via https://www.eurosurveillance.org/content/10.2807/1560-7917.E)
BackgroundDuring the 2016/17 influenza season, influenza B/VIC lineage variant viruses emerged with two (K162N163) or three (K162N163D164) amino acid (aa) deletions in the haemagglutinin (HA) protein. ...
Martin BE, Harris JD, Sun J, Koelle K, Brooke CB. Cellular co-infection can modulate the efficiency of influenza A virus production and shape the interferon response. PLoS Pathog. 2020 Oct 16;16(10):e1008974. Abstract
submitted by kickingbird at 4 days ago from PLoS Pathog. 2020 Oct 16;16(10):e1008974 (via https://journals.plos.org/plospathogens/article?id=10.1371/j)
During viral infection, the numbers of virions infecting individual cells can vary significantly over time and space. The functional consequences of this variation in cellular multiplicity of infection ...
Horman WSJ, Nguyen THO, Kedzierska K, Butler J, Sh. The Dynamics of the Ferret Immune Response During H7N9 Influenza Virus Infection. Front Immunol. 2020 Sep 24;11:559113. Abstract
submitted by kickingbird at 4 days ago from Front Immunol. 2020 Sep 24;11:559113 (via https://www.frontiersin.org/articles/10.3389/fimmu.2020.5591)
As the recent outbreak of SARS-CoV-2 has highlighted, the threat of a pandemic event from zoonotic viruses, such as the deadly influenza A/H7N9 virus subtype, continues to be a major global health concern. ...
Yang J, Huang X, Liu Y, Zhao D, Han K, Zhang L, Li. Analysis of the microRNA expression profiles of chicken dendritic cells in response to H9N2 avian influenza virus infection. Vet Res. 2020 Oct 17;51(1):132. Abstract
submitted by kickingbird at 4 days ago from Vet Res. 2020 Oct 17;51(1):132 (via https://veterinaryresearch.biomedcentral.com/articles/10.118)
MicroRNA (miRNA) plays a key role in virus-host interactions. Here, we employed deep sequencing technology to determine cellular miRNA expression profiles in chicken dendritic cells infected with H9N2 ...
Hu J, Kong M, Cui Z, Gao Z, Ma C, Hu Z, Jiao X, Li. PA-X protein of H5N1 avian influenza virus inhibits NF-kappaB activity, a potential mechanism for PA-X counteracting the host innate immune responses. Vet Microbiol. 2020 Sep 18;250:108838. Abstract
submitted by kickingbird at 10 days ago from Vet Microbiol. 2020 Sep 18;250:108838 (via https://www.sciencedirect.com/science/article/pii/S037811352)
PA-X is a fusion protein of influenza virus which plays a crucial role in modulating influenza virus-induced host innate immune response and subsequent pathogenicity. However, the potential mechanism of ...
Sitaras I, Spackman E, de Jong MCM, Parris DJ. Selection and Antigenic Characterization of Immune-Escape Mutants of H7N2 Low Pathogenic Avian Influenza Virus Using Homologous Polyclonal Sera. Virus Res. 2020 Oct 9:198188. Abstract
submitted by kickingbird at 10 days ago from Virus Res. 2020 Oct 9:198188 (via https://www.sciencedirect.com/science/article/pii/S016817022)
Understanding the dynamics of the selection of influenza A immune escape variants by serum antibody is critical for designing effective vaccination programs for animals, especially poultry where large ...
Heindel DW, Koppolu S, Zhang Y, Kasper B, Meche L,. Glycomic analysis of host response reveals high mannose as a key mediator of influenza severity. Proc Natl Acad Sci U S A. 2020 Oct 12:202008203. Abstract
submitted by kickingbird at 10 days ago from Proc Natl Acad Sci U S A. 2020 Oct 12:202008203 (via https://www.pnas.org/content/early/2020/10/09/2008203117)
Influenza virus infections cause a wide variety of outcomes, from mild disease to 3 to 5 million cases of severe illness and ～290,000 to 645,000 deaths annually worldwide. The molecular mechanisms underlying ...
Liu Z, Guo Y, Zhao L, Liu Q, Tian M, Huang N, Fan. Analysis of the circRNAs expression profile in mouse lung with H7N9 influenza A virus infection. Genomics. 2020 Oct 10:S0888-7543(20)31961-3. Abstract
submitted by kickingbird at 10 days ago from Genomics. 2020 Oct 10:S0888-7543(20)31961-3 (via https://www.sciencedirect.com/science/article/pii/S088875432)
Influenza A virus is a single-stranded RNA virus that can cause great mortality and economic loss worldwide. Circular RNAs (circRNAs) are non-coding RNAs that have been shown to have important functions ...
Zhang Z, Zhang H, Xu L, Guo X, Wang W, Ji Y, Lin C. Selective usage of ANP32 proteins by influenza B virus polymerase: Implications in determination of host range. PLoS Pathog. 2020 Oct 12;16(10):e1008989. Abstract
submitted by kickingbird at 11 days ago from PLoS Pathog. 2020 Oct 12;16(10):e1008989 (via https://journals.plos.org/plospathogens/article?id=10.1371/j)
The influenza B virus (IBV) causes seasonal influenza and has accounted for an increasing proportion of influenza outbreaks. IBV mainly causes human infections and has not been found to spread in poultry. ...
Zykova AA, Blokhina EA, Kotlyarov RY, Stepanova LA. Highly Immunogenic Nanoparticles Based on a Fusion Protein Comprising the M2e of Influenza A Virus and a Lipopeptide. Viruses. 2020 Oct 6;12(10):E1133. Abstract
submitted by kickingbird at 12 days ago from Viruses. 2020 Oct 6;12(10):E1133 (via https://www.mdpi.com/1999-4915/12/10/1133)
The highly conserved extracellular domain of the transmembrane protein M2 (M2e) of the influenza A virus is a promising target for the development of broad-spectrum vaccines. However, M2e is a poor immunogen ...
Correia R, Fernandes B, Alves PM, Carrondo MJT, Ro. Improving Influenza HA-Vlps Production in Insect High Five Cells via Adaptive Laboratory Evolution. Vaccines (Basel). 2020 Oct 7;8(4):E589. Abstract
submitted by kickingbird at 12 days ago from Vaccines (Basel). 2020 Oct 7;8(4):E589 (via https://www.mdpi.com/2076-393X/8/4/589)
The use of non-standard culture conditions has proven efficient to increase cell performance and recombinant protein production in different cell hosts. However, the establishment of high-producing cell ...
Guilfoyle K, Major D, Skeldon S, James H, Tingsted. Protective efficacy of a polyvalent influenza A DNA vaccine against both homologous (H1N1pdm09) and heterologous (H5N1) challenge in the ferret model. Vaccine. 2020 Oct 6:S0264-410X(20)31233-0. Abstract
submitted by kickingbird at 12 days ago from Vaccine. 2020 Oct 6:S0264-410X(20)31233-0 (via https://www.sciencedirect.com/science/article/pii/S0264410X2)
This study describes the protective efficacy of a novel influenza plasmid DNA vaccine in the ferret challenge model. The rationally designed polyvalent influenza DNA vaccine encodes haemagglutinin and ...
Brehony C, Dunford L, Bennett C, O´Donnell J. Neuraminidase characterisation reveals very low levels of antiviral resistance and the presence of mutations associated with reduced antibody effectiveness in the Irish influenza 2018/2019 season. J Clin Virol. 2020 Oct 1;132:104653. Abstract
submitted by kickingbird at 12 days ago from J Clin Virol. 2020 Oct 1;132:104653 (via https://www.sciencedirect.com/science/article/pii/S138665322)
Neuraminidase inhibitor (NAI) resistance levels globally are currently low. However, as antivirals are increasingly being used, and even in the absence of selective pressure, resistance may increase or ...
Arai Y, Kawashita N, Elgendy EM, Ibrahim MS, Daido. PA mutations inherited during viral evolution act cooperatively to increase replication of contemporary H5N1 influenza virus with an expanded host range. J Virol. 2020 Oct 7:JVI.01582-20. Abstract
submitted by kickingbird at 13 days ago from J Virol. 2020 Oct 7:JVI.01582-20 (via https://jvi.asm.org/content/early/2020/10/02/JVI.01582-20)
Adaptive mutations and/or reassortments in avian influenza virus polymerase subunits PA, PB1 and PB2 are one of the major factors enabling the virus to overcome the species barrier to infect humans. The ...
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