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2026-2-1 21:14:27
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Xia M, Huang P, Vago FS, Jiang W, Tan M. Pseudovirus nanoparticles targeting the receptor binding HA1 domains of influenza viruses elicited high HA1-specific antibody responses and protected mice against mortality caused by influenza virus c. Vaccine. 2024 Dec 7:126585.  Abstract  
submitted by kickingbird at Dec, 9, 2024 from Vaccine. 2024 Dec 7:126585 (via https://www.sciencedirect.com/science/article/abs/pii/S02644)
The continually high disease burden of influenza and the relatively low effectiveness of current influenza vaccines call for enhanced vaccine strategies. We previously generated unique S-HA1 pseudovirus ...

Chothe SK, Srinivas S, Misra S, Nallipogu NC, Gilb. Marked Neurotropism and Potential Adaptation of H5N1 Clade 2.3.4.4.b Virus in Naturally Infected Domestic Cats. Emerg Microbes Infect. 2024 Dec 9:2440498.  Abstract  
submitted by kickingbird at Dec, 9, 2024 from Emerg Microbes Infect. 2024 Dec 9:2440498 (via https://www.tandfonline.com/doi/full/10.1080/22221751.2024.2)
In April 2024, ten cats died in a rural South Dakota (SD) residence, showing respiratory and neurological symptoms. Necropsy and laboratory testing of two cats confirmed H5N1 clade 2.3.4.4b infection. ...

Mancini P, Brandtner D, Veneri C, Bonanno Ferraro. Evaluation of Trends in Influenza A and B Viruses in Wastewater and Human Surveillance Data: Insights from the 2022-2023 Season in Italy. Food Environ Virol. 2024 Dec 7;17(1):6.  Abstract  
submitted by kickingbird at Dec, 8, 2024 from Food Environ Virol. 2024 Dec 7;17(1):6 (via https://link.springer.com/article/10.1007/s12560-024-09622-2)
Wastewater-based epidemiology (WBE) is a recognized, dynamic approach to monitoring the transmission of pathogens in communities through urban wastewater. This study aimed to detect and quantify influenza ...

Gunasekara E, Hair-Bejo M, Aini I, Omar AR. Molecular characterisation of novel reassortants of the G57 genotype of low-pathogenic avian influenza H9N2 virus isolated from poultry farms in Malaysia. Arch Virol. 2024 Dec 7;170(1):3.  Abstract  
submitted by kickingbird at Dec, 8, 2024 from Arch Virol. 2024 Dec 7;170(1):3 (via https://link.springer.com/article/10.1007/s00705-024-06159-4)
In late 2017, Malaysia reported repeated outbreaks of low-pathogenic avian influenza virus (LPAI) H9N2 infections in commercial poultry flocks. Two H9N2 viruses, A/chicken/Malaysia/Negeri Sembilan/UPM994/2018 ...

Isabela Carvalho Brcko, etc.,al. Comprehensive Molecular Epidemiology of Influenza Viruses in Brazil: Insights from a Nationwide Analysis. Virus Evolution, veae102.  Abstract  
submitted by kickingbird at Dec, 7, 2024 from Virus Evolution, veae102 (via https://academic.oup.com/ve/advance-article/doi/10.1093/ve/v)
Influenza A and B viruses represent significant global health threats, contributing substantially to morbidity and mortality rates. However, a comprehensive understanding of the molecular epidemiology ...

Feixia Gao, Qi Wang, Chenchen Qiu, etc.,al. Pandemic preparedness of effective vaccines for the outbreak of newly H5N1 highly pathogenic avian influenza virus. Virologica Sinica.  Abstract  
submitted by kickingbird at Dec, 7, 2024 from Virologica Sinica (via https://www.sciencedirect.com/science/article/pii/S1995820X2)
Highly pathogenic avian influenza (HPAI) viruses such as H5N1, H5N8, H5N6 and H5N2 have been circulating worldwide, posing serious threats to both poultry farming and public health. Notably, the H5N1, ...

Jiawei Luo, etc.,al. The PB1 protein of H9N2 influenza A virus inhibits antiviral innate immunity by targeting MAVS for TRIM25-mediated autophagic degradation. Poultry Science.  Abstract  
submitted by kickingbird at Dec, 7, 2024 from Poultry Science (via https://www.sciencedirect.com/science/article/pii/S003257912)
The proteins encoded by Influenza A virus (IAV) evade the innate immune system through diverse strategies to facilitate their replication. However, the regulatory mechanisms remain not fully understood. ...

Nuo Xu, etc.,al. The evolution of hemagglutinin-158 and neuraminidase-88 glycosylation sites modulates antigenicity and pathogenicity of clade 2.3.2.1 H5N1 avian influenza viruses. Veterinary Microbiology.  Abstract  
submitted by kickingbird at Dec, 7, 2024 from Veterinary Microbiology (via https://www.sciencedirect.com/science/article/abs/pii/S03781)
Clade 2.3.2.1 of the H5N1 avian influenza virus (AIV) evolved into several subclades. However, the effect of glycosylation on the biological characteristics of hemagglutinin (HA) and/or neuraminidase (NA) ...

Damdinjav B, Raveendran S, Mojsiejczuk L, Ankhanba. Evidence of Influenza A(H5N1) Spillover Infections in Horses, Mongolia. Emerg Infect Dis. 2025 Jan.  Abstract  
submitted by kickingbird at Dec, 7, 2024 from Emerg Infect Dis. 2025 Jan (via https://wwwnc.cdc.gov/eid/article/31/1/24-1266_article)
Recent outbreaks of influenza A(H5N1) have affected many mammal species. We report serologic evidence of H5N1 virus infection in horses in Mongolia. Because H3N8 equine influenza virus is endemic in many ...

Loureiro CL, Bonetti V, Jaspe RC, Sulbaran Y, Alca. Analysis of the Monophyletic Lineage of Avian Influenza H5N1 Which Circulated in Venezuelan Birds During the 2022–2023 Outbreak. Microorganisms. 2024; 12(12):2519.  Abstract  
submitted by kickingbird at Dec, 7, 2024 from Microorganisms. 2024; 12(12):2519 (via https://www.mdpi.com/2076-2607/12/12/2519)
Avian influenza subtype H5N1 has caused outbreaks worldwide since 1996, with the emergence of the Guandong lineage in China. The current clade 2.3.4.4b has evolved from this lineage, with increased virulence ...

Matthew L Turnbull, etc.,al. [preprint]POLYGENIC DETERMINANTS OF H5N1 ADAPTATION TO BOVINE CELLS. https://doi.org/10.1101/2024.11.29.626120.  Abstract  
submitted by kickingbird at Dec, 6, 2024 from https://doi.org/10.1101/2024.11.29.626120 (via https://www.biorxiv.org/content/10.1101/2024.11.29.626120v1)
H5N1 avian influenza virus (lineage 2.3.4.4b, B3.13 genotype) has caused, unexpectedly, a large outbreak in dairy cattle in North America. It is critical to ascertain how this virus has specifically adapted ...

Lv H, Teo QW, Lee C-CD, Liang W, Choi D, Mao KJ, A. Differential antigenic imprinting effects between influenza H1N1 hemagglutinin and neuraminidase in a mouse model. J Virol. 2024 Dec 5:e0169524.  Abstract  
submitted by kickingbird at Dec, 6, 2024 from J Virol. 2024 Dec 5:e0169524 (via https://journals.asm.org/doi/10.1128/jvi.01695-24)
Understanding how immune history influences influenza immunity is essential for developing effective vaccines and therapeutic strategies. This study examines the antigenic imprinting of influenza hemagglutinin ...

Lin TH, Zhu X, Wang S, Zhang D, McBride R, Yu W, B. A single mutation in bovine influenza H5N1 hemagglutinin switches specificity to human receptors. Science. 2024 Dec 6;386(6726):1128-1134.  Abstract  
submitted by kickingbird at Dec, 6, 2024 from Science. 2024 Dec 6;386(6726):1128-1134 (via https://www.science.org/doi/10.1126/science.adt0180)
In 2024, several human infections with highly pathogenic clade 2.3.4.4b bovine influenza H5N1 viruses in the United States raised concerns about their capability for bovine-to-human or even human-to-human ...

PAHO. Epidemiological Alert Human Cases of Avian Influenza A(H5N1) in the Americas Region - 3 December 2024. PAHO.  Abstract  
submitted by kickingbird at Dec, 5, 2024 from PAHO (via https://www.paho.org/sites/default/files/2024-12/2024-dec-3-)
Human cases of avian influenza A(H5) have been reported in the Americas Region since 2022, with an increase in the last two months, including some cases for which the source of infection is unknown. Given ...

Yang K, Nizami S, Hu S, Zou L, Deng H, Xie J, Guo. Genetic diversity of highly pathogenic avian influenza H5N6 and H5N8 viruses in poultry markets in Guangdong, China, 2020~2022. J Virol. 2024 Dec 4:e0114524.  Abstract  
submitted by kickingbird at Dec, 5, 2024 from J Virol. 2024 Dec 4:e0114524 (via https://journals.asm.org/doi/10.1128/jvi.01145-24)
H5 highly pathogenic avian influenza (HPAI) viruses of the A/Goose/Guangdong/1/96 (Gs/Gd) lineage continue to evolve and cause outbreaks in domestic poultry and wild birds, with sporadic spillover infections ...

Hidano A, Koeut D, Holt H, Leung W, Krean S, Chhim. Transmission of Swine Influenza A Viruses along Pig Value Chains, Cambodia, 2020~2022. Emerg Infect Dis. 2024;30(12):2669-2673.  Abstract  
submitted by kickingbird at Dec, 4, 2024 from Emerg Infect Dis. 2024;30(12):2669-2673 (via https://wwwnc.cdc.gov/eid/article/30/12/24-0695_article)
We analyzed >4,000 pig samples from slaughterhouses in Cambodia and found higher influenza A seroprevalence (40.0%) and prevalence (1.5%) among pigs from commercial farms than smallholder farms (seroprevalence ...

Tosheva II, Filaire F, Rijnink WF, de Meulder D, v. Influenza A(H5N1) shedding in air corresponds to transmissibility in mammals. Nat Microbiol. 2024 Dec 2.  Abstract  
submitted by kickingbird at Dec, 4, 2024 from Nat Microbiol. 2024 Dec 2 (via https://www.nature.com/articles/s41564-024-01885-6)
An increase in spillover events of highly pathogenic avian influenza A(H5N1) viruses to mammals suggests selection of viruses that transmit well in mammals. Here we use air-sampling devices to continuously ...

Guilfoyle K, Mirolo M, van Amerongen G, van der Ne. Susceptibility of calf lung slice cultures to H5N1 influenza virus. Emerg Microbes Infect. 2024 Dec 3:2432368.  Abstract  
submitted by kickingbird at Dec, 4, 2024 from Emerg Microbes Infect. 2024 Dec 3:2432368 (via https://www.tandfonline.com/doi/full/10.1080/22221751.2024.2)
The current outbreak of HPAI H5N1 virus infections in dairy cattle in the USA underscores the need for easily accessible methods to rapidly assess host susceptibility for infection with known and emerging ...

Deng Y-M, Wille M, Dapat C, Xie R, Lay O, Peck H,. Influenza A(H5N1) Virus Clade 2.3.2.1a in Traveler Returning to Australia from India, 2024. Emerg Infect Dis. 2025 Jan.  Abstract  
submitted by kickingbird at Dec, 4, 2024 from Emerg Infect Dis. 2025 Jan (via https://wwwnc.cdc.gov/eid/article/31/1/24-1210_article)
We report highly pathogenic avian influenza A(H5N1) virus clade 2.3.2.1a in a child traveler returning to Australia from India. The virus was a previously unreported reassortant consisting of clade 2.3.2.1a, ...

Yao YR, Ma K, Li YS, Tan HR, Zhang JY, Zhang ZM, L. Characteristics of the Spatiotemporal Distribution of Influenza Incidence and Its Driving Factors Among Residents in Mainland China From 2004 to 2018. Geohealth. 2024 Nov 30;8(12):e2024GH001181.  Abstract  
submitted by kickingbird at Dec, 3, 2024 from Geohealth. 2024 Nov 30;8(12):e2024GH001181 (via https://agupubs.onlinelibrary.wiley.com/doi/10.1029/2024GH00)
Influenza is an acute respiratory infection that spreads rapidly and widely in densely populated areas with low vaccination coverage. The trends and drivers of the spatial and temporal dynamics of influenza ...

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