Human cases of avian influenza A(H5) have been reported in the Americas Region since 2022, with an increase in the last two months, including some cases for which the source of infection is unknown. Given this, the Pan American Health Organization / World Health Organization (PAHO / WHO) urges Member States to continue strengthening their capacities for detection, epidemiological investigation, notification, and timely response to human cases of avian influenza A(H5). In addition, PAHO/WHO invites Member States to share virus samples with WHO Collaborating Centers to support risk analysis and candidate vaccine viruses.