Cox A, Schmierer J, D´Angelo J, Smith A, Lev. A Mutated PB1 Residue 319 Synergizes with the PB2 N265S Mutation of the Live Attenuated Influenza Vaccine to Convey Temperature Sensitivity. Viruses. 2020 Oct 31;12(11):E1246. Abstract
submitted by kickingbird at Nov, 5, 2020 from Viruses. 2020 Oct 31;12(11):E1246 (via https://www.mdpi.com/1999-4915/12/11/1246)
Current influenza vaccines have modest efficacy. This is especially true for current live attenuated influenza vaccines (LAIV), which have been inferior to the inactivated versions in recent years. Therefore, ...
Liu B, Wang Y, Liu Y, Chen Y, Liu Y, Cong X, Ji Y,. Molecular evolution and characterization of hemagglutinin and neuraminidase of influenza A(H1N1)pdm09 viruses isolated in Beijing, China, during the 2017-2018 and 2018-2019 influenza seasons. Arch Virol. 2020 Nov 3. Abstract
submitted by kickingbird at Nov, 5, 2020 from Arch Virol. 2020 Nov 3 (via https://link.springer.com/article/10.1007/s00705-020-04869-z)
We investigated and analysed the molecular evolution of hemagglutinin (HA) and neuraminidase (NA) of influenza A(H1N1)pdm09 virus during the 2017-2018 and 2018-2019 influenza seasons in Beijing, China. ...
Shinde V, Cai R, Plested J, Cho I, Fiske J, Pham X. Induction of Cross-reactive Hemagglutination Inhibiting Antibody and Polyfunctional CD4+ T-cell Responses by a Recombinant Matrix-M-Adjuvanted Hemagglutinin Nanoparticle Influenza Vaccine. Clin Infect Dis. 2020 Nov 4:ciaa1673. Abstract
submitted by kickingbird at Nov, 5, 2020 from Clin Infect Dis. 2020 Nov 4:ciaa1673 (via https://academic.oup.com/cid/advance-article/doi/10.1093/cid)
Background: Recurrent reports of suboptimal influenza vaccine effectiveness have renewed calls to develop improved, broadly cross-protective influenza vaccines. Here, we evaluated the safety and immunogenicity ...
Escalera-Zamudio, M., Golden, M., Gutiérrez, B. et. Parallel evolution in the emergence of highly pathogenic avian influenza A viruses. Nat Commun 11, 5511 (2020). Abstract
submitted by kickingbird at Nov, 5, 2020 from Nat Commun 11, 5511 (2020) (via https://www.nature.com/articles/s41467-020-19364-x)
Parallel molecular evolution and adaptation are important phenomena commonly observed in viruses. Here, we exploit parallel molecular evolution to understand virulence evolution in avian influenza viruses ...
Alnaeem AA, Al-Shabeb A, Hemida MG. Evaluation of the immune status of birds and domestic and companion animals for the influenza A virus in Eastern Saudi Arabia. Vet World. 2020 Sep;13(9):1966-1969. Abstract
submitted by kickingbird at Nov, 3, 2020 from Vet World. 2020 Sep;13(9):1966-1969 (via http://www.veterinaryworld.org/Vol.13/September-2020/30.html)
Background and aim: Influenza type A virus infections are still one of the major concerns for the health of humans and various species of domestic and companion animals. Wild birds play an essential role ...
Perez-Vilar S, Hu M, Weintraub E, Arya D, Lufkin B. Guillain-Barré Syndrome After High-Dose Influenza Vaccine Administration in the United States, 2018-2019 Season. J Infect Dis. 2020 Nov 2:jiaa543. Abstract
submitted by kickingbird at Nov, 3, 2020 from J Infect Dis. 2020 Nov 2:jiaa543 (via https://academic.oup.com/jid/advance-article/doi/10.1093/inf)
Background: The Vaccine Safety Datalink (VSD) identified a statistical signal for an increased risk of Guillain-Barré syndrome (GBS) in days 1-42 after 2018-2019 high-dose influenza vaccine (IIV3-HD) administration. ...
Wang X, Lin L, Yu Y, Yan Y, Ojha NK, Zhou J. The N-terminal residual arginine 19 of influenza A virus NS1 protein is required for its nuclear localization and RNA binding. Vet Microbiol. 2020 Oct 14;251:108895. Abstract
submitted by kickingbird at Nov, 2, 2020 from Vet Microbiol. 2020 Oct 14;251:108895 (via https://www.sciencedirect.com/science/article/pii/S037811352)
RNA binding ability and cellular distribution are important for nonstructural protein 1 (NS1) of influenza A virus to act as a viral regulatory factor to control virus life cycle. In this study, we identified ...
Huang SW, Wang SF. The Effects of Genetic Variation on H7N9 Avian Influenza Virus Pathogenicity. Viruses. 2020 Oct 28;12(11):E1220. Abstract
submitted by kickingbird at Nov, 2, 2020 from Viruses. 2020 Oct 28;12(11):E1220 (via https://www.mdpi.com/1999-4915/12/11/1220)
Since the H7N9 avian influenza virus emerged in China in 2013, there have been five seasonal waves which have shown human infections and caused high fatality rates in infected patients. A multibasic amino ...
Choo H, Kim M, Choi J, Shin J, Shin SY. Influenza Screening via Deep Learning Using a Combination of Epidemiological and Patient-Generated Health Data: Development and Validation Study. J Med Internet Res. 2020 Oct 29;22(10):e21369. Abstract
submitted by kickingbird at Oct, 31, 2020 from J Med Internet Res. 2020 Oct 29;22(10):e21369 (via https://www.jmir.org/2020/10/e21369/)
Background: Screening for influenza in primary care is challenging due to the low sensitivity of rapid antigen tests and the lack of proper screening tests.Objective: The aim of this study was to develop ...
Elsobky Y, El Afandi G, Abdalla E, Byomi A, Reddy. Possible ramifications of climate variability on HPAI-H5N1 outbreak occurrence: Case study from the Menoufia, Egypt. PLoS One. 2020 Oct 29;15(10):e0240442. Abstract
submitted by kickingbird at Oct, 31, 2020 from PLoS One. 2020 Oct 29;15(10):e0240442 (via https://journals.plos.org/plosone/article?id=10.1371/journal)
Long endemicity of the Highly Pathogenic Avian Influenza (HPAI) H5N1 subtype in Egypt poses a lot of threats to public health. Contrary to what is previously known, outbreaks have been circulated continuously ...
Wang W, Chen X, Wang Y, Lai S, Yang J, Cowling BJ,. Serological evidence of human infection with avian influenza A(H7N9) virus: a systematic review and meta-analysis. J Infect Dis. 2020 Oct 29:jiaa679. Abstract
submitted by kickingbird at Oct, 31, 2020 from J Infect Dis. 2020 Oct 29:jiaa679 (via https://academic.oup.com/jid/advance-article/doi/10.1093/inf)
Background: The extent of human infections with avian influenza A(H7N9) virus, including mild and asymptomatic infections, is uncertain.Methods: We performed a systematic review and meta-analysis of serosurveys ...
Lee K, Yu D, Martínez-López B, Yoon H, Kang SI, Ho. Fine-scale tracking of wild waterfowl and their impact on highly pathogenic avian influenza outbreaks in the Republic of Korea, 2014-2015. Sci Rep. 2020 Oct 29;10(1):18631. Abstract
submitted by kickingbird at Oct, 31, 2020 from Sci Rep. 2020 Oct 29;10(1):18631 (via https://www.nature.com/articles/s41598-020-75698-y)
Wild migratory waterfowl are considered one of the most important reservoirs and long-distance carriers of highly pathogenic avian influenza (HPAI). Our study aimed to explore the spatial and temporal ...
Chen S, Miao X, Huangfu D, Zhao X, Zhang M, Qin T,. H5N1 Avian Influenza Virus without 80-84 Amino Acid Deletion at the NS1 Protein Hijacks the Innate Immune System of Dendritic Cells for an Enhanced Mammalian Pathogenicity. Transbound Emerg Dis. 2020 Oct 30. doi: 10.1111/tb. Abstract
submitted by kickingbird at Oct, 31, 2020 from Transbound Emerg Dis. 2020 Oct 30. doi: 10.1111/tb (via https://onlinelibrary.wiley.com/doi/10.1111/tbed.13904)
NS gene is generally considered to be related to the virulence of highly pathogenic avian influenza virus (AIVs). In recent years, the strains with 5 amino acids added to the 80-84 positions of the NS1 ...
Kamiya Y, Fujisawa T, Katsumata M, Yasui H, Suzuki. Influenza A virus enhances ciliary activity and mucociliary clearance via TLR3 in airway epithelium. Respir Res. 2020 Oct 27;21(1):282. Abstract
submitted by kickingbird at Oct, 29, 2020 from Respir Res. 2020 Oct 27;21(1):282 (via https://respiratory-research.biomedcentral.com/articles/10.1)
Background: Viral respiratory tract infections, such as influenza A virus (IAV), are common and life-threatening illnesses worldwide. The mechanisms by which viruses are removed from the respiratory tract ...
Bamunuarachchi G, Yang X, Huang C, Liang Y, Guo Y,. MicroRNA-206 Inhibits Influenza A Virus Replication by Targeting Tankyrase 2. Cell Microbiol. 2020 Oct 25:e13281. Abstract
submitted by kickingbird at Oct, 28, 2020 from Cell Microbiol. 2020 Oct 25:e13281 (via https://onlinelibrary.wiley.com/doi/10.1111/cmi.13281)
Due to the frequent mutations, influenza A virus (IAV) becomes resistant to anti-viral drugs targeting influenza viral proteins. There are increasing interests in anti-viral agents that target host cellular ...
Sharma A, Batra J, Stuchlik O, Reed MS, Pohl J, Ch. Influenza A Virus Nucleoprotein Activates the JNK Stress-Signaling Pathway for Viral Replication by Sequestering Host Filamin A Protein. Front Microbiol. 2020 Sep 25;11:581867. Abstract
submitted by kickingbird at Oct, 28, 2020 from Front Microbiol. 2020 Sep 25;11:581867 (via https://www.frontiersin.org/articles/10.3389/fmicb.2020.5818)
Influenza A virus (IAV) poses a major threat to global public health and is known to employ various strategies to usurp the host machinery for survival. Due to its fast-evolving nature, IAVs tend to escape ...
Burke DF, Mantell RG, Pitt CE, Wales DJ. Energy Landscape for the Membrane Fusion Pathway in Influenza A Hemagglutinin From Discrete Path Samplin. Front Chem. 2020 Sep 25;8:575195. Abstract
submitted by kickingbird at Oct, 28, 2020 from Front Chem. 2020 Sep 25;8:575195 (via https://www.frontiersin.org/articles/10.3389/fchem.2020.5751)
The conformational change associated with membrane fusion for Influenza A Hemagglutinin is investigated with a model based upon pre- and post-fusion structures of the HA2 component. We employ computational ...
Poulson R, Carter D, Beville S, Niles L, Dey A, Mi. Influenza A Viruses in Ruddy Turnstones ( Arenaria interpres); Connecting Wintering and Migratory Sites with an Ecological Hotspot at Delaware Bay. Viruses. 2020 Oct 22;12(11):E1205. Abstract
submitted by kickingbird at Oct, 28, 2020 from Viruses. 2020 Oct 22;12(11):E1205 (via https://www.mdpi.com/1999-4915/12/11/1205)
Each May for over three decades, avian influenza A viruses (IAVs) have been isolated from shorebirds and gulls (order Charadriiformes) at Delaware Bay (DE Bay), USA, which is a critical stopover site for ...
Liu LQ, Li Z, Jiao M, Lu J, Zhou JF, Li XY, Liu J,. Development and Assessment of Two Highly Pathogenic Avian Influenza (HPAI) H5N6 Candidate Vaccine Viruses for Pandemic Preparedness. Biomed Environ Sci. 2020 Sep 20;33(9):670-679. Abstract
submitted by kickingbird at Oct, 28, 2020 from Biomed Environ Sci. 2020 Sep 20;33(9):670-679 (via http://www.besjournal.com/en/article/doi/10.3967/bes2020.088)
Objective: In China, 24 cases of human infection with highly pathogenic avian influenza (HPAI) H5N6 virus have been confirmed since the first confirmed case in 2014. Therefore, we developed and assessed ...
Quandelacy TM, Cummings DAT, Jiang CQ, Yang B, Kwo. Using serological measures to estimate influenza incidence in the presence of secular trends in exposure and immuno-modulation of antibody response. Influenza Other Respir Viruses. 2020 Oct 27. Abstract
submitted by kickingbird at Oct, 28, 2020 from Influenza Other Respir Viruses. 2020 Oct 27 (via https://onlinelibrary.wiley.com/doi/10.1111/irv.12807)
Background: Influenza infection is often measured by a fourfold antibody titer increase over an influenza season (ie seroconversion). However, this approach may fail when influenza seasons are less distinct ...
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