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2026-2-1 3:15:47
Article

Butt, S.L., de Oliveira, P.S.B., Rani, R. et al. Novel recombinant H5-based vaccine provides effective protection against H5N1 influenza virus in cats. npj Vaccines (2026).  Abstract  
submitted by kickingbird at Jan, 13, 2026 from npj Vaccines (2026) (via https://link.springer.com/article/10.1038/s41541-025-01369-6)
The emergence and broad circulation of highly pathogenic avian influenza (HPAI) H5N1 virus in wild birds and its spillover into dairy cows with sustained transmission in this species pose a major risk ...

WPRO. Avian Influenza Weekly Update # 1028: 09 January 2026. WHO.  Abstract  
submitted by kickingbird at Jan, 13, 2026 from WHO (via https://www.who.int/westernpacific/publications/m/item/avian)
Avian influenza subtype A(HxNy) normally spreads in birds but can also infect humans. Human infections are primarily acquired through direct contact with infected poultry or contaminated environments. ...

Gwon S-H, Park S-I, Jeong H, Kim D, Son Y, Lee M-a. Fatal H5N1 Highly Pathogenic Avian Influenza with Retrograde Neuroinvasion in a Free-Ranging Leopard Cat (Prionailurus bengalensis) During a Wild Bird Outbreak in South Korea. Animals. 2026; 16(2):200.  Abstract  
submitted by kickingbird at Jan, 12, 2026 from Animals. 2026; 16(2):200 (via https://www.mdpi.com/2076-2615/16/2/200)
Highly pathogenic avian influenza (HPAI) H5N1 clade 2.3.4.4b viruses spread efficiently via migratory wild birds and increasingly infect mammals. The leopard cat (Prionailurus bengalensis) is an endangered ...

Caputo V, Libera M, Campos Mota Y, Nagashima K, Mo. Extended Heterosubtypic Neutralization and Preclinical Model In Vivo Protection from Clade 2.3.4.4b H5 Influenza Virus Infection by Broadly Neutralizing Antibodies. Vaccines. 2026; 14(1):71.  Abstract  
submitted by kickingbird at Jan, 12, 2026 from Vaccines. 2026; 14(1):71 (via https://www.mdpi.com/2076-393X/14/1/71)
Background/Objective: The influenza virus remains one of the most prevalent respiratory pathogens, posing significant global health and economic challenges. According to the World Health Organization, ...

Wei J, Cen P, Lu Y, Bi D, Tan S, Li Y, Liu S, Lu N. Clinical Features and Management of a Critical Human Case of H10N3 Avian Influenza: A Case Report and Literature Review. Int J Infect Dis. 2026 Jan 8:108367.  Abstract  
submitted by kickingbird at Jan, 11, 2026 from Int J Infect Dis. 2026 Jan 8:108367 (via https://www.ijidonline.com/article/S1201-9712(26)00002-0/ful)
Background: Since the first human case of H10N3 Avian Influenza in Jiangsu, China (April 2021), three cases have been reported globally. However, clinical and treatment data remain limited. Therefore, ...

Giselle GK Ng, etc.,al. [preprint]Haemagglutinin 162-164 deletions enhance influenza B/Victoria virus fitness and virulence in vivo. https://doi.org/10.64898/2026.01.08.698527.  Abstract  
submitted by kickingbird at Jan, 11, 2026 from https://doi.org/10.64898/2026.01.08.698527 (via https://www.biorxiv.org/content/10.64898/2026.01.08.698527v1)
Influenza B viruses cause substantial respiratory disease and seasonal outbreaks. Despite decades of circulation in humans, only the B/Victoria lineage persisted after the COVID-19 pandemic. Continual ...

Carlos Abelardo dos Santos, etc.,al. [preprint]Isothermal Detection of Influenza D using RT-LAMP. https://doi.org/10.64898/2026.01.09.698603.  Abstract  
submitted by kickingbird at Jan, 11, 2026 from https://doi.org/10.64898/2026.01.09.698603 (via https://www.biorxiv.org/content/10.64898/2026.01.09.698603v1)
The Orthomyxoviridae family includes influenza D virus (IDV), an emerging pathogen primarily affecting cattle and swine, with evidence of cross-species transmission and potential zoonotic risk. Although ...

Whitlow H, Gokool S, Clapp G, Bueno I, Logunleko M. Biosecurity Uptake and Perceived Risk of Avian Influenza Among People in Contact With Birds. Zoonoses Public Health. 2026 Jan 6.  Abstract  
submitted by kickingbird at Jan, 10, 2026 from Zoonoses Public Health. 2026 Jan 6 (via https://onlinelibrary.wiley.com/doi/10.1111/zph.70034)
Introduction: Recent intercontinental spread of highly pathogenic avian influenza (HPAI) A(H5N1) among kept and wild birds, and transmission to mammalian hosts, including cattle and humans, has heightened ...

Zhu, W., Xu, Z., Wang, X., Li, X., Li, Z., Dong, G. Low-replication influenza virus mediates high pathogenicity through an inflammation-driven lung-heart-brain axis in mice. Emerging Microbes & Infections, 15(1).  Abstract  
submitted by kickingbird at Jan, 10, 2026 from Emerging Microbes & Infections, 15(1) (via https://www.tandfonline.com/doi/full/10.1080/22221751.2025.2)
The outcomes of viral infections typically correlate with viral load in host tissues. In this study, we identified a H3N2 strain A/Environment/Guangxi/44461/2019 (GX19) that induced rapid mortality in ...

Ibrahim, M., Said, A., Wahba, M. A., & Yehia, N. Genetic and antigenic analysis of the highly pathogenic avian influenza H5N8 virus clade 2.3.4.4b isolated from waterfowl in Egypt during 2022; evidence of brain-specific HA mutations. British Poultry Science, 1–10.  Abstract  
submitted by kickingbird at Jan, 10, 2026 from British Poultry Science, 1–10 (via https://www.tandfonline.com/doi/full/10.1080/00071668.2025.2)
1. This study characterised the H5N8 highly pathogenic avian influenza (HPAI) viruses, clade 2.3.4.4b from backyard waterfowl selected from Menoufia governorate during 2022. Genetic and antigenic analysis ...

Young-Jae Si, etc.,al. Early Detection and Genetic Characterization of Clade 2.3.4.4b H5N1 and H5N9 Highly Pathogenic Avian Influenza Viruses at the Onset of Fall Migration in Wild Birds during October 2025 in South Korea. Front. Cell. Infect. Microbiol.  Abstract  
submitted by kickingbird at Jan, 10, 2026 from Front. Cell. Infect. Microbiol (via https://www.frontiersin.org/journals/cellular-and-infection-)
Highly pathogenic avian influenza (HPAI) viruses of clade 2.3.4.4b continue to diversify through reassortment with co-circulating low-pathogenic avian influenza (LPAI) viruses and are repeatedly introduced ...

Myint AP, Shirreff G, Baillie V, Bal A, Boutros CF. Association of influenza viral genetic information with severity markers in patients hospitalised with influenza: multicentre retrospective cohort study. BMJ Open. 2026 Jan 8;16(1):e111643.  Abstract  
submitted by kickingbird at Jan, 10, 2026 from BMJ Open. 2026 Jan 8;16(1):e111643 (via https://bmjopen.bmj.com/content/16/1/e111643)
Objective: The objective of this study was to determine the association between viral subtype/clade and disease severity.Design: Multicentre retrospective cohort study.Setting: This study used data from ...

Wu SX, Davis CN, Arnold M, Tildesley MJ. The role of ducks in detecting Highly Pathogenic Avian Influenza in small-scale backyard poultry farms. PLoS Comput Biol. 2026 Jan 9;22(1):e1013357.  Abstract  
submitted by kickingbird at Jan, 10, 2026 from PLoS Comput Biol. 2026 Jan 9;22(1):e1013357 (via https://journals.plos.org/ploscompbiol/article?id=10.1371/jo)
Previous research efforts on highly pathogenic H5N1 avian influenza (HPAI) suggest that different avian species exhibit a varied severity of clinical signs after infection. Waterfowl, such as ducks or ...

Takashita Emi, etc.,al. Baloxavir susceptibility of seasonal influenza viruses during the first seven seasons of clinical use in Japan, 2017/18 to 2023/24. Euro Surveill. 2026;31(1):pii=2500336.  Abstract  
submitted by kickingbird at Jan, 10, 2026 from Euro Surveill. 2026;31(1):pii=2500336 (via https://www.eurosurveillance.org/content/10.2807/1560-7917.E)
Baloxavir marboxil, a cap-dependent endonuclease inhibitor, was approved in Japan on 23 February 2018 for the treatment of influenza A and B virus infections, making Japan the first country to authorise ...

Adachi, K., Handharyani, E., Ueno, S. Tsukamoto Y. Comparative Hemagglutination of Avian Influenza A/H5N1 Viruses by Erythrocytes from Ostrich, Emu, Japanese Quail, Chicken and Horse. Open Journal of Veterinary Medicine, 16, 1-15.  Abstract  
submitted by kickingbird at Jan, 9, 2026 from Open Journal of Veterinary Medicine, 16, 1-15 (via https://www.scirp.org/journal/paperinformation?paperid=14855)
Influenza A viruses initiate infection when the envelope glycoprotein hemagglutinin (HA) binds sialic?acid-containing receptors on host cells and mediates membrane fusion. HA?mediated cross?linking of ...

Jenny J. Ahn, etc.,al. [preprint]Influenza hemagglutinin subtypes have different sequence constraints despite sharing extremely similar structures. https://doi.org/10.64898/2026.01.05.697808.  Abstract  
submitted by kickingbird at Jan, 9, 2026 from https://doi.org/10.64898/2026.01.05.697808 (via https://www.biorxiv.org/content/10.64898/2026.01.05.697808v1)
Hemagglutinins (HA) from different influenza A virus subtypes share as little as ~40% amino acid identity, yet their protein structure and cell entry function are highly conserved. Here we examine the ...

Mei M, Zhang X, Wu Q, Xu M, Zhao Y. Virulence and transmission characteristic of H3N8 avian influenza virus circulating in chickens in China. Virulence. 2026 Jan 7:2613516.  Abstract  
submitted by kickingbird at Jan, 9, 2026 from Virulence. 2026 Jan 7:2613516 (via https://www.tandfonline.com/doi/full/10.1080/21505594.2026.2)
Influenza H3N8 viruses have been frequently isolated from chicken farms. However, comprehensive characterization of their virological properties, molecular evolution, virulence, and risk of spillover into ...

Lucas M. Ferreri, etc.,al. [preprint]Within-host adaptive evolution is limited by genetic drift in experimental human influenza A virus infections. https://doi.org/10.64898/2026.01.07.698006.  Abstract  
submitted by kickingbird at Jan, 9, 2026 from https://doi.org/10.64898/2026.01.07.698006 (via https://www.biorxiv.org/content/10.64898/2026.01.07.698006v1)
Selection of advantageous mutations drives the emergence of dominant variants during seasonal influenza epidemics. However, within-host detection of such variants remains rare, limiting our understanding ...

Claudia Trombetta, etc.,al. [preprint]Serological investigation of influenza D virus in cats and dogs in Europe. https://doi.org/10.64898/2026.01.03.697426.  Abstract  
submitted by kickingbird at Jan, 9, 2026 from https://doi.org/10.64898/2026.01.03.697426 (via https://www.biorxiv.org/content/10.64898/2026.01.03.697426v1)
A multicentric European study investigated the seroprevalence of influenza D virus (IDV) in domestic cats and dogs. Serum samples from Italy, France and Ukraine (2015-2018, 2020, 2023- 2024) showed no ...

Ishida, H., Murakami, H., Mizuno, S. et al. Development of an influenza D virus with an eight- or nine-segment genome. Sci Rep (2026).  Abstract  
submitted by kickingbird at Jan, 9, 2026 from Sci Rep (2026) (via https://link.springer.com/article/10.1038/s41598-025-34838-y)
Influenza D virus (IDV) contains seven genome segments. The M and NS segments are regulated via splicing to express two proteins each (P42 and M1 from the M segment and NS1 and NS2 from the NS segment). ...

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