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2025-12-5 16:31:24
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Hao M, Wu J, Ji L, Zhao Y, Zhang S, Guan Y, Li L,. Pathogenicity, transmissibility, and receptor binding of a human-isolated influenza A (H10N5) virus. mBio. 2025 Jul 8:e0073125.  Abstract  
submitted by kickingbird at Jul, 9, 2025 from mBio. 2025 Jul 8:e0073125 (via https://journals.asm.org/doi/10.1128/mbio.00731-25)
Recently, human infections with H10 influenza viruses, including H10N8 and H10N3, have been reported. In January 2024, a case of H10N5 and H3N2 co-infection was reported in Zhejiang Province, China, which ...

Chen, T., Ouyang, A., Zou, J. et al. Rab27a regulates the transport of influenza virus membrane proteins to the plasma membrane. Nat Commun 16, 6271 (2025).  Abstract  
submitted by kickingbird at Jul, 9, 2025 from Nat Commun 16, 6271 (2025) (via https://www.nature.com/articles/s41467-025-61587-3)
The molecular mechanisms underlying the transport of influenza A virus (IAV) membrane proteins to the cell surface remain largely unclear. In this study, siRNA screening identifies Rab27a as a critical ...

Sanchez-Rojas IC, Bonilla-Aldana DK, Solarte-Jimen. Highly Pathogenic Avian Influenza (H5N1) Clade 2.3.4.4b in Cattle: A Rising One Health Concern. Animals. 2025; 15(13):1963.  Abstract  
submitted by kickingbird at Jul, 7, 2025 from Animals. 2025; 15(13):1963 (via https://www.mdpi.com/2076-2615/15/13/1963)
Highly pathogenic avian influenza (HPAI) H5N1, particularly clade 2.3.4.4b, has demonstrated an unprecedented capacity for cross-species transmission, with recent reports confirming its presence in dairy ...

Neil Paprocki, Jeff Kidd, Courtney J. Conway. Increased Mortality Rates Caused by Highly Pathogenic Avian Influenza Virus in a Migratory Raptor. Ecology and Evolution.  Abstract  
submitted by kickingbird at Jul, 7, 2025 from Ecology and Evolution (via https://onlinelibrary.wiley.com/doi/10.1002/ece3.71715)
Highly pathogenic avian influenza virus (HPAIV) has caused extensive mortalities in wild birds with a disproportionate impact on raptors since 2021. The population-level impact of HPAIV can be informed ...

Zhang, X., Wang, Y., Li, X. et al. Prevalence of Avian Influenza Viruses and Biomolecular Analysis of H9N2 Subtype in Live Poultry Markets from 2021 to 2023 in Changsha, China. Food Environ Virol 17, 38 (2025).  Abstract  
submitted by kickingbird at Jul, 7, 2025 from Food Environ Virol 17, 38 (2025) (via https://link.springer.com/article/10.1007/s12560-025-09652-4)
Environmental monitoring of avian influenza virus (AIV) in live poultry markets (LPMs) is vital for health risk forewarning, and survey of AIV environmental prevalence and biomolecular analysis of keystone ...

Kristen Coleman, etc.,al. [preprint]Highly Pathogenic Avian Influenza A(H5N1) Outbreak Among House Cats: A Case Series Involving Oseltamivir Treatment. https://doi.org/10.21203/rs.3.rs-7015836/v1.  Abstract  
submitted by kickingbird at Jul, 7, 2025 from https://doi.org/10.21203/rs.3.rs-7015836/v1 (via https://www.researchsquare.com/article/rs-7015836/v1)
We present a highly pathogenic avian influenza A(H5N1) outbreak among four domestic cats from the same household within close proximity to a dairy farm in Tulare, California – the epicenter of the H5N1 ...

Young-Jae Si, etc.,al. First Detection of Clade 2.3.4.4b H5N1 Highly Pathogenic Avian Influenza Virus in a Wild Leopard cat (Prionailurus bengalensis) in South Korea. Front. Vet. Sci..  Abstract  
submitted by kickingbird at Jul, 7, 2025 from Front. Vet. Sci. (via https://www.frontiersin.org/journals/veterinary-science/arti)
The A/goose/Guangdong/1/1996 (Gs/GD) lineage of highly pathogenic avian influenza (HPAI) viruses initially identified in China in 1996 and have evolved over subsequent decades, characterized by accumulation ...

Danuta M Skowronski, etc.,al. [preprint]Neuraminidase imprinting and the age-related risk of zoonotic influenza. https://doi.org/10.1101/2025.07.03.25330844.  Abstract  
submitted by kickingbird at Jul, 6, 2025 from https://doi.org/10.1101/2025.07.03.25330844 (via https://www.medrxiv.org/content/10.1101/2025.07.03.25330844v)
Highly pathogenic avian influenza of the H5N1 subtype has shown recent unprecedented expansion in its geographic and host range, increasing the pandemic threat. The younger age of H5N1 versus H7N9 avian ...

Urban, C., Vrancken, B., Patrono, L.V. et al. An ancient influenza genome from Switzerland allows deeper insights into host adaptation during the 1918 flu pandemic in Europe. BMC Biol 23, 179 (2025).  Abstract  
submitted by kickingbird at Jul, 6, 2025 from BMC Biol 23, 179 (2025) (via https://link.springer.com/article/10.1186/s12915-025-02282-z)
BackgroundFrom 1918 to 1920, the largest influenza A virus (IAV) pandemic known to date spread globally causing between 20 to 100 million deaths. Historical records have captured critical aspects of the ...

Mostafa, A., Nogales, A. & Martinez-Sobrido, L. Highly pathogenic avian influenza H5N1 in the United States: recent incursions and spillover to cattle. npj Viruses 3, 54 (2025).  Abstract  
submitted by kickingbird at Jul, 6, 2025 from npj Viruses 3, 54 (2025) (via https://www.nature.com/articles/s44298-025-00138-5)
Since Spring 2024, new genotypes of highly pathogenic avian influenza (HPAI) H5N1 clade 2.3.4.4b have been identified in the United States (US). These HPAI H5N1 genotypes have caused unprecedented multi-state ...

WHO. Considerations for use of avian influenza A(H5) vaccines during the interpandemic and emergence periods: report of a WHO virtual scientific consultation, September 2024. WHO.  Abstract  
submitted by kickingbird at Jul, 6, 2025 from WHO (via https://www.who.int/westernpacific/publications/i/item/97892)
WHO conducted a virtual scientific expert consultation on A(H5) vaccines and vaccination. This report provides an overview of the landscape of A(H5) vaccines and summarizes options for Member States' potential ...

Xuan Wang, etc.,al. A time-resolved luminescence assay using time-to-space conversion strategy for the sensitive detection of influenza virus on a microfluidic chip. Biosensors and Bioelectronics.  Abstract  
submitted by kickingbird at Jul, 5, 2025 from Biosensors and Bioelectronics (via https://www.sciencedirect.com/science/article/abs/pii/S09565)
Time-resolved luminescence assay improves detection sensitivity through eliminating background signal interference. However, it typically requires expensive and bulky instruments equipped with a pulsed ...

Yuefeng Wang, etc.,al. Metabolomic Profiling of Plasma Reveals Differential Disease Severity Markers in avian influenza A(H7N9) infection Patients. International Journal of Infectious Diseases.  Abstract  
submitted by kickingbird at Jul, 5, 2025 from International Journal of Infectious Diseases (via https://www.sciencedirect.com/science/article/pii/S120197122)
ObjectivesAvian influenza such as H7N9 is currently a major global public health risk, and at present, there is a lack of relevant diagnostic and treatment markers.MethodsWe collected plasma samples from ...

Jianzhong Shi, Huihui Kong, Pengfei Cui, Guohua De. H5N1 virus invades the mammary glands of dairy cattle through “mouth-to-teat” transmission. National Science Review, 2025;, nwaf262.  Abstract  
submitted by kickingbird at Jul, 4, 2025 from National Science Review, 2025;, nwaf262 (via https://academic.oup.com/nsr/advance-article/doi/10.1093/nsr)
H5N1 influenza outbreaks have been reported on more than 1,070 dairy farms across 17 states in the US. Damage to the mammary gland and high levels of virus in milk were common features of the infected ...

European Food Safety Authority (EFSA), Julio Alvar. Risk posed by the HPAI virus H5N1, Eurasian lineage goose/Guangdong clade 2.3.4.4b. genotype B3.13, currently circulating in the US. EFSA Journal, 23(7), e9508.  Abstract  
submitted by kickingbird at Jul, 4, 2025 from EFSA Journal, 23(7), e9508 (via https://efsa.onlinelibrary.wiley.com/doi/10.2903/j.efsa.2025)
The emergence of highly pathogenic avian influenza (HPAI) A(H5N1), clade 2.3.4.4b, genotype B3.13 in U.S. dairy cattle marks a significant shift in the virus' host range and epidemiological profile. Infected ...

Flavio Cargnin Faccin, etc.,al. [preprint]Experimental infection and viral pathogenesis of a human isolate of H5N1 highly pathogenic avian influenza strain in Jersey cows. https://doi.org/10.21203/rs.3.rs-6915991/v1.  Abstract  
submitted by kickingbird at Jul, 4, 2025 from https://doi.org/10.21203/rs.3.rs-6915991/v1 (via https://www.researchsquare.com/article/rs-6915991/v1)
Highly pathogenic avian influenza H5N1 viruses have circulated globally since 1996. In recent years, clade 2.3.4.4b H5N1 viruses have crossed the species barrier into multiple species, including dairy ...

Durazzi, F., Koopmans, M.P.G., Fouchier, R.A.M. et. Language models learn to represent antigenic properties of human influenza A(H3) virus. Sci Rep 15, 21364 (2025).  Abstract  
submitted by kickingbird at Jul, 3, 2025 from Sci Rep 15, 21364 (2025) (via https://link.springer.com/article/10.1038/s41598-025-03275-2)
Given that influenza vaccine effectiveness depends on a good antigenic match between the vaccine and circulating viruses, it is important to assess the antigenic properties of newly emerging variants continuously. ...

Higgins D, Looker J, Sunnucks R, Carruthers J, Fin. Introducing a framework for within-host dynamics and mutations modelling of H5N1 influenza infection in humans. J R Soc Interface. 2025 Jul;22(228):20240910.  Abstract  
submitted by kickingbird at Jul, 3, 2025 from J R Soc Interface. 2025 Jul;22(228):20240910 (via https://royalsocietypublishing.org/doi/10.1098/rsif.2024.091)
Avian influenza A(H5N1) poses a public health risk due to its pandemic potential should the virus mutate to become human-to-human transmissible. To date, reported influenza A(H5N1) human cases have typically ...

Zhang, L. et al. Neutralizing activity against bovine H5N1 HPAIV (clade 2.3.4.4b) in human plasma after seasonal influenza vaccination. Emerging Microbes & Infections, 1 Jul 2025.  Abstract  
submitted by kickingbird at Jul, 2, 2025 from Emerging Microbes & Infections, 1 Jul 2025 (via https://www.tandfonline.com/doi/full/10.1080/22221751.2025.2)
H5Ny highly pathogenic avian influenza viruses (HPAIV) cause significant mortality in birds and have led to fatal cases in humans and other mammals, though sustained transmission in mammals is rare, except ...

Kam, T.T., Bui, C.H., Yeung, HW. et al. Viral characterization of the reassortants between canine influenza H3N2 and human pandemic (2009) H1N1 and avian H9N2 viruses in canine ex vivo tracheal explants. Virol J 22, 218 (2025).  Abstract  
submitted by kickingbird at Jul, 2, 2025 from Virol J 22, 218 (2025) (via https://link.springer.com/article/10.1186/s12985-025-02836-1)
BackgroundIn 2007, the canine influenza H3N2 virus (H3N2-CIV) first emerged in the canine population in South Korea. The virus had since spread internationally and continues to circulate in the canines. ...

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