Rohaim MA, El Naggar RF, Madbouly Y, AbdelSabour M. Comparative infectivity and transmissibility studies of wild-bird and chicken-origin highly pathogenic avian influenza viruses H5N8 in chickens. Comp Immunol Microbiol Infect Dis. 2021 Feb;74:101. Abstract
submitted by kickingbird at Feb, 22, 2021 from Comp Immunol Microbiol Infect Dis. 2021 Feb;74:101 (via https://www.sciencedirect.com/science/article/abs/pii/S01479)
Despite the recent advances in avian influenza viruses surveillance and genomic data, fundamental questions concerning the ecology and evolution of these viruses remain elusive. In Egypt, H5N8 highly pathogenic ... Youk SS, Leyson CM, Seibert BA, Jadhao S, Perez DR. Mutations in PB1, NP, HA, and NA Contribute to Increased Virus Fitness of H5N2 Highly Pathogenic Avian Influenza Virus Clade 2.3.4.4 in Chickens. J Virol. 2020 Dec 2:JVI.01675-20. Abstract
submitted by kickingbird at Feb, 22, 2021 from J Virol. 2020 Dec 2:JVI.01675-20 (via https://jvi.asm.org/content/95/5/e01675-20)
The H5N8 highly pathogenic avian influenza (HPAI) clade 2.3.4.4 virus spread to North America by wild birds and reassorted to generate the H5N2 HPAI virus that caused the poultry outbreak in the United ... Sánchez-González R, Ramis A, Nofrarías M, Wali N,. Infectivity and pathobiology of H7N1 and H5N8 high pathogenicity avian influenza viruses for pigeons ( Columba livia var. domestica). Avian Pathol. 2021 Feb;50(1):98-106. Abstract
submitted by kickingbird at Feb, 22, 2021 from Avian Pathol. 2021 Feb;50(1):98-106 (via https://www.tandfonline.com/doi/abs/10.1080/03079457.2020.18)
Avian influenza (AI) is one of the most important viral diseases in poultry, wildlife and humans. Available data indicate that pigeons play a minimum role in the epidemiology of AI. However, a degree of ... Pronier C, Gacouin A, Lagathu G, Le Tulzo Y, Tadié. Respiratory Influenza viral load as a marker of poor prognosis in patients with severe symptoms. J Clin Virol. 2021 Feb 12;136:104761. Abstract
submitted by kickingbird at Feb, 22, 2021 from J Clin Virol. 2021 Feb 12;136:104761 (via https://www.sciencedirect.com/science/article/abs/pii/S13866)
Background: The link between influenza virus (IV) viral load (VL) in respiratory samples and disease severity is not clearly established. This study was designed to assess IV-VL in respiratory samples ... Chang LJ, Anderson EJ, Jeanfreau R, He Y, Hicks B,. Safety and immunogenicity of high doses of quadrivalent influenza vaccine in children 6 months through <18 years of age: A randomized controlled phase II dose-finding trial. Vaccine. 2021 Feb 18:S0264-410X(21)00162-6. Abstract
submitted by kickingbird at Feb, 22, 2021 from Vaccine. 2021 Feb 18:S0264-410X(21)00162-6 (via https://www.sciencedirect.com/science/article/pii/S0264410X2)
Quadrivalent high-dose inactivated influenza vaccine (Fluzone? High-Dose Quadrivalent, IIV4-HD) was licensed in the USA in 2019 for adults ≥ 65 years of age. This Phase II study examined safety and immunogenicity ... Park BR, Kim KH, Kotomina T, Kim MC, Kwon YM, Jeev. Broad cross protection by recombinant live attenuated influenza H3N2 seasonal virus expressing conserved M2 extracellular domain in a chimeric hemagglutinin. Sci Rep. 2021 Feb 18;11(1):4151. Abstract
submitted by kickingbird at Feb, 20, 2021 from Sci Rep. 2021 Feb 18;11(1):4151 (via https://pubmed.ncbi.nlm.nih.gov/33603072/)
Hemagglutinin (HA)-based current vaccines provide suboptimum cross protection. Influenza A virus contains an ion channel protein M2 conserved extracellular domain (M2e), a target for developing universal ... de Lusignan S, Lopez Bernal J, Byford R, Amirthali. Influenza and Respiratory Virus Surveillance, Vaccine Uptake, and Effectiveness at a Time of Cocirculating COVID-19: Protocol for the English Primary Care Sentinel System for 2020-2021. JMIR Public Health Surveill. 2021 Feb 19;7(2):e243. Abstract
submitted by kickingbird at Feb, 20, 2021 from JMIR Public Health Surveill. 2021 Feb 19;7(2):e243 (via https://publichealth.jmir.org/2021/2/e24341/)
Background: The Oxford-Royal College of General Practitioners (RCGP) Research and Surveillance Centre (RSC) and Public Health England (PHE) are commencing their 54th season of collaboration at a time when ... Boikos C, Fischer L, O´Brien D, Vasey J, Syl. Relative Effectiveness of Adjuvanted Trivalent Inactivated Influenza Vaccine Versus Egg-Derived Quadrivalent Inactivated Influenza Vaccines and High-Dose Trivalent Influenza Vaccine in Preventing Infl. Clin Infect Dis. 2021 Feb 19:ciab152. Abstract
submitted by kickingbird at Feb, 20, 2021 from Clin Infect Dis. 2021 Feb 19:ciab152 (via https://academic.oup.com/cid/advance-article/doi/10.1093/cid)
Background: The effectiveness of standard, egg-derived quadrivalent influenza vaccines (IIV4) may be reduced in adults ≥65 years of age, largely due to immunosenescence. An MF59?-adjuvanted trivalent influenza ... Liu L, Li Z, Zhou J, Lu J, Li X, Liu J, Xiao N, Wa. The effect of single amino acid substitution at position 220 in the hemagglutinin glycoprotein on avian influenza H7N9 candidate vaccine virus. Virus Genes. 2021 Feb 19. Abstract
submitted by kickingbird at Feb, 20, 2021 from Virus Genes. 2021 Feb 19 (via https://link.springer.com/article/10.1007/s11262-021-01827-y)
Influenza vaccines represent the most effective preventive strategy to control influenza virus infections; however, adaptive mutations frequently occur in the hemagglutinin (HA) glycoprotein during the ... Wu MJ, Chung JR, Kim SS, Jackson ML, Jackson LA, B. Influenza vaccination coverage among persons seeking outpatient medical care for acute respiratory illness in five states in the United States, 2011-2012 through 2018-2019. Vaccine. 2021 Feb 15:S0264-410X(21)00106-7. Abstract
submitted by kickingbird at Feb, 19, 2021 from Vaccine. 2021 Feb 15:S0264-410X(21)00106-7 (via https://www.sciencedirect.com/science/article/pii/S0264410X2)
Background: In the United States (U.S.), annual influenza vaccination has been recommended for all persons aged ≥6 months with the Healthy People 2020 coverage target of 70%. However, vaccination coverage ... Li X, Gu M, Zheng Q, Gao R, Liu X. Packaging signal of influenza A virus. Virol J. 2021 Feb 17;18(1):36. Abstract
submitted by kickingbird at Feb, 19, 2021 from Virol J. 2021 Feb 17;18(1):36 (via https://pubmed.ncbi.nlm.nih.gov/33596956/)
Influenza A virus (IAV) contains a genome with eight single-stranded, negative-sense RNA segments that encode 17 proteins. During its assembly, all eight separate viral RNA (vRNA) segments are incorporated ... Yang S, Ning S, Kou SC. Use Internet search data to accurately track state level influenza epidemics. Sci Rep. 2021 Feb 17;11(1):4023. Abstract
submitted by kickingbird at Feb, 19, 2021 from Sci Rep. 2021 Feb 17;11(1):4023 (via https://pubmed.ncbi.nlm.nih.gov/33597556/)
For epidemics control and prevention, timely insights of potential hot spots are invaluable. Alternative to traditional epidemic surveillance, which often lags behind real time by weeks, big data from ... Yang F, Xiao Y, Liu F, Yao H, Wu N, Wu H. Isolation and characterization of two novel reassortant H5N6 avian influenza viruses from waterfowl in eastern China. Arch Virol. 2021 Feb 17. Abstract
submitted by kickingbird at Feb, 19, 2021 from Arch Virol. 2021 Feb 17 (via https://pubmed.ncbi.nlm.nih.gov/33598814/)
Waterfowl are considered to be the natural hosts of avian influenza virus. In 2017, two reassortant highly pathogenic H5N6 avian influenza viruses of clade 2.3.4.4, subclade II, were identified in wild ... Kjaer LJ, Hjulsager CK, Larsen LE, Boklund AE, Hal. Landscape effects and spatial patterns of avian influenza virus in Danish wild birds, 2006-2020. Transbound Emerg Dis. 2021 Feb 18. Abstract
submitted by kickingbird at Feb, 19, 2021 from Transbound Emerg Dis. 2021 Feb 18 (via https://onlinelibrary.wiley.com/doi/10.1111/tbed.14040)
Avian influenza (AI) is a contagious disease of birds with zoonotic potential. AI virus (AIV) can infect most bird species, but clinical signs and mortality vary. Assessing the distribution and factors ... Le Sage V, Jones JE, Kormuth KA, Fitzsimmons WJ, N. Pre-existing heterosubtypic immunity provides a barrier to airborne transmission of influenza viruses. PLoS Pathog. 2021 Feb 18;17(2):e1009273. Abstract
submitted by kickingbird at Feb, 19, 2021 from PLoS Pathog. 2021 Feb 18;17(2):e1009273 (via https://journals.plos.org/plospathogens/article?id=10.1371/j)
Human-to-human transmission of influenza viruses is a serious public health threat, yet the precise role of immunity from previous infections on the susceptibility to airborne infection is still unknown. ... Kaku N, Hashiguchi K, Akamatsu N, Wakigawa F, Mats. Evaluation of a novel rapid TRC assay for the detection of influenza using nasopharyngeal swabs and gargle samples. Eur J Clin Microbiol Infect Dis. 2021 Feb 16. Abstract
submitted by kickingbird at Feb, 17, 2021 from Eur J Clin Microbiol Infect Dis. 2021 Feb 16 (via https://pubmed.ncbi.nlm.nih.gov/33594599/)
We evaluated a novel transcription-reverse transcription concerted reaction (TRC) assay that can detect influenza A and B within 15 min using nasopharyngeal swab and gargle samples obtained from patients ... Li APY, Cohen CA, Leung NHL, Fang VJ, Gangappa S,. Immunogenicity of standard, high-dose, MF59-adjuvanted, and recombinant-HA seasonal influenza vaccination in older adults. NPJ Vaccines. 2021 Feb 16;6(1):25. Abstract
submitted by kickingbird at Feb, 17, 2021 from NPJ Vaccines. 2021 Feb 16;6(1):25 (via https://pubmed.ncbi.nlm.nih.gov/33594050/)
The vaccine efficacy of standard-dose seasonal inactivated influenza vaccines (S-IIV) can be improved by the use of vaccines with higher antigen content or adjuvants. We conducted a randomized controlled ... Roubidoux EK, Carre?o JM, McMahon M, Jiang K, van. Mutations in the Hemagglutinin Stalk Domain Do Not Permit Escape from a Protective, Stalk-Based Vaccine-Induced Immune Response in the Mouse Model. mBio. 2021 Feb 16;12(1):e03617-20. Abstract
submitted by kickingbird at Feb, 17, 2021 from mBio. 2021 Feb 16;12(1):e03617-20 (via https://mbio.asm.org/content/12/1/e03617-20)
Current seasonal influenza virus vaccines target regions of the hemagglutinin (HA) head domain that undergo constant antigenic change, forcing the painstaking annual reformulation of vaccines. The development ... Freyn AW, Han J, Guthmiller JJ, Bailey MJ, Neu K,. Influenza hemagglutinin-specific IgA Fc-effector functionality is restricted to stalk epitopes. Proc Natl Acad Sci U S A. 2021 Feb 23;118(8):e2018. Abstract
submitted by kickingbird at Feb, 17, 2021 from Proc Natl Acad Sci U S A. 2021 Feb 23;118(8):e2018 (via https://www.pnas.org/content/118/8/e2018102118)
In this study, we utilized a panel of human immunoglobulin (Ig) IgA monoclonal antibodies isolated from the plasmablasts of eight donors after 2014/2015 influenza virus vaccination (Fluarix) to study the ... Wang B, Su Q, Luo J, Li M, Wu Q, Chang H, Du J, Hu. Differences in Highly Pathogenic H5N6 Avian Influenza Viral Pathogenicity and Inflammatory Response in Chickens and Ducks. Front Microbiol. 2021 Jan 29;12:593202. Abstract
submitted by kickingbird at Feb, 16, 2021 from Front Microbiol. 2021 Jan 29;12:593202 (via https://www.frontiersin.org/articles/10.3389/fmicb.2021.5932)
Infection with H5N6 highly pathogenic avian influenza virus caused high mortality in chickens, while ducks often appear to be asymptomatic. But, some recent H5Nx subtype viruses could cause high mortality ... 9542 items, 20/Page, Page[197/478][|<<] [|<] [191] [192] [193] [194] [195] [196] [197] [198] [199] [200] [>|] [>>|] |
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