Li J, et al. Protective efficacy of an inactivated chimeric H5 avian influenza vaccine against H5 highly pathogenic avian influenza virus clades 2.3.4.4 and 2.3.2.1. J Gen Virol. 2018 Oct 25. Abstract
submitted by kickingbird at Oct, 27, 2018 from J Gen Virol. 2018 Oct 25 (via https://www.ncbi.nlm.nih.gov/pubmed/30358528)
The H5 subtype of highly pathogenic avian influenza (HPAI) viruses pose a serious challenge to public health and the poultry industry in China. In this study, we generated a chimeric QH/KJ recombinant ... Kim TH, Zhou H. Overexpression of Chicken IRF7 Increased Viral Replication and Programmed Cell Death to the Avian Influenza Virus Infection Through TGF-Beta/FoxO Signaling Axis in DF-1. Front Genet. 2018 Sep 25;9:415. Abstract
submitted by kickingbird at Oct, 27, 2018 from Front Genet. 2018 Sep 25;9:415 (via https://www.ncbi.nlm.nih.gov/pubmed/30356848)
During mammalian viral infections, interferon regulatory factor 7 (IRF7) partners with IRF3 to regulate the type I interferon response. In chickens, however, it is still unclear how IRF7 functions in the ... An Y, Parsons LM, Jankowska E, Melnyk D, et al. N-Glycosylation of Seasonal Influenza Vaccine Hemagglutinins: Implication for potency testing and immune processing. J Virol. 2018 Oct 24.. Abstract
submitted by kickingbird at Oct, 27, 2018 from J Virol. 2018 Oct 24. (via https://www.ncbi.nlm.nih.gov/pubmed/30355697)
Prior to each annual flu season, health authorities recommend three or four virus strains for inclusion in the annual influenza vaccine: a Type A:H1N1, a Type A:H3N2, and one or two Type B viruses. Antigenic ... Dornfeld D, et al. Eurasian avian-like swine influenza A viruses escape human MxA restriction by distinct mutations in their nucleoprotein. J Virol. 2018 Oct 24.. Abstract
submitted by kickingbird at Oct, 27, 2018 from J Virol. 2018 Oct 24. (via https://www.ncbi.nlm.nih.gov/pubmed/30355693)
To cross the human species barrier, influenza A viruses (IAV) of avian origin have to overcome the interferon-induced host restriction factor MxA by acquiring distinct mutations in their nucleoprotein ... Gaba A, Xu F, Lu Y, Park HS, Liu G, Zhou Y. THE NS1 PROTEIN OF INFLUENZA A VIRUS PARTICIPATES IN NECROPTOSIS BY INTERACTING WITH MLKL AND INCREASING ITS OLIGOMERIZATION AND MEMBRANE TRANSLOCATION. J Virol. 2018 Oct 24. Abstract
submitted by kickingbird at Oct, 27, 2018 from J Virol. 2018 Oct 24 (via https://jvi.asm.org/content/early/2018/10/19/JVI.01835-18.lo)
Elimination of infected cells by programmed cell death is a well-recognized host defense mechanism to control the spread of infection. In addition to apoptosis, necroptosis is also one of the mechanisms ... Santos JJS, et al. Plasticity of amino acid residue 145 near the receptor binding site of H3 swine influenza A viruses and its impact on receptor binding and antibody recognition. J Virol. 2018 Oct 24. Abstract
submitted by kickingbird at Oct, 27, 2018 from J Virol. 2018 Oct 24 (via https://www.ncbi.nlm.nih.gov/pubmed/30355680)
The hemagglutinin (HA), a glycoprotein on the surface of influenza A virus (IAV), initiates the virus life cycle by binding to terminal sialic acid (SA) residues on host cells. The HA gradually accumulates ... Wu J, Ke C, Lau EHY, Song Y, Cheng KL, Zou L, et a. Influenza H5/H7 Virus Vaccination in Poultry and Reduction of Zoonotic Infections, Guangdong Province, China, 2017~18. Emerg Infect Dis. 2019 Jan. Abstract
submitted by kickingbird at Oct, 27, 2018 from Emerg Infect Dis. 2019 Jan (via https://wwwnc.cdc.gov/eid/article/25/1/18-1259_article)
We compared the detection frequency of avian influenza H7 subtypes at live poultry markets in Guangdong Province, China, before and after the introduction of a bivalent H5/H7 vaccine in poultry. The vaccine ... Hird SM, Ganz H, Eisen JA, Boyce WM. The Cloacal Microbiome of Five Wild Duck Species Varies by Species and Influenza A Virus Infection Status. mSphere. 2018 Oct 24;3(5).. Abstract
submitted by kickingbird at Oct, 27, 2018 from mSphere. 2018 Oct 24;3(5). (via https://www.ncbi.nlm.nih.gov/pubmed/30355662)
Waterfowl, especially ducks of the genus Anas, are natural reservoir species for influenza A virus (IAV). Duck populations contain nearly all the known diversity of IAVs, and the birds are asymptomatic ... Wu H, Yang F, Liu F, Lu R, Peng X, Chen B, Yao H. Isolation and characterization of novel reassortant H6N1 avian influenza viruses from chickens in Eastern China. Virol J. 2018 Oct 24;15(1):164.. Abstract
submitted by kickingbird at Oct, 27, 2018 from Virol J. 2018 Oct 24;15(1):164. (via https://www.ncbi.nlm.nih.gov/pubmed/30355336)
BACKGROUND: The H6N1 subtype of avian influenza viruses (AIVs) can infect people with an influenza-like illness; the H6N1 viruses possess the ability for zoonotic transmission from avians into mammals, ... Wei D, et al. Genome-wide characterization of the seasonal H3N2 virus in Shanghai reveals natural temperature-sensitive strains conferred by the I668V mutation in the PA subunit. Emerg Microbes Infect. 2018 Oct 23;7(1):171. Abstract
submitted by kickingbird at Oct, 27, 2018 from Emerg Microbes Infect. 2018 Oct 23;7(1):171 (via https://www.ncbi.nlm.nih.gov/pubmed/30353004)
Seasonal H3N2 influenza viruses are recognized as major epidemic viruses, exhibiting complex seasonal patterns in regions with temperate climates. To investigate the influence of viral evolution and mutations ... Bedi S, Noda T, Kawaoka Y, Ono A. A Defect in Influenza A Virus Particle Assembly Specific to Primary Human Macrophages. MBio. 2018 Oct 23;9(5). Abstract
submitted by kickingbird at Oct, 27, 2018 from MBio. 2018 Oct 23;9(5) (via https://www.ncbi.nlm.nih.gov/pubmed/30352935)
Influenza A virus (IAV) propagates efficiently in epithelial cells, its primary target in the respiratory tract. In contrast, productive infection of most IAV strains is either blocked or highly inefficient ... Goldhill DH, et al. The mechanism of resistance to favipiravir in influenza. Proc Natl Acad Sci U S A. 2018 Oct 23.. Abstract
submitted by kickingbird at Oct, 27, 2018 from Proc Natl Acad Sci U S A. 2018 Oct 23. (via https://www.ncbi.nlm.nih.gov/pubmed/30352857)
Favipiravir is a broad-spectrum antiviral that has shown promise in treatment of influenza virus infections. While emergence of resistance has been observed for many antiinfluenza drugs, to date, clinical ... Euro Surveill. 2018;23(43):pii=1700732. Influenza vaccine effectiveness in reducing severe outcomes over six influenza seasons, a case-case analysis, Spain, 2010/11 to 2015/16. Godoy Pere, Romero Arantxa, Soldevila Núria, Torn. Abstract
submitted by kickingbird at Oct, 26, 2018 from Godoy Pere, Romero Arantxa, Soldevila Núria, Torn (via https://www.eurosurveillance.org/content/10.2807/1560-7917.E)
Introduction When influenza vaccination is ineffective in preventing influenza virus infection, it may still reduce the severity of influenza-associated disease. Here, we estimate the effect of influenza ... Yanmei Hu, et al. Structure–Property Relationship Studies of Influenza A Virus AM2-S31N Proton Channel Blockers. ACS Med. Chem. Lett.. Abstract
submitted by kickingbird at Oct, 26, 2018 from ACS Med. Chem. Lett. (via https://pubs.acs.org/doi/abs/10.1021/acsmedchemlett.8b00336)
Majority of current circulating influenza A viruses carry the S31N mutation in their M2 genes, rendering AM2-S31N as a high profile antiviral drug target. With our continuous interest in developing AM2-S31N ... Duwell MM, Blythe D, Radebaugh MW, et al. Influenza A(H3N2) Variant Virus Outbreak at Three Fairs - Maryland, 2017. MMWR Morb Mortal Wkly Rep 2018;67:1169–1173.. Abstract
submitted by kickingbird at Oct, 26, 2018 from MMWR Morb Mortal Wkly Rep 2018;67:1169–1173. (via https://www.cdc.gov/mmwr/volumes/67/wr/mm6742a1.htm)
On September 17, 2017, the Maryland Department of Agriculture (MDA) was notified by fair and 4-H officials of ill swine at agricultural fair A, held September 14–17. That day, investigation of the 107 ... Yu G, Tsan-Yuk Lam T, Zhu H, Guan Y. Two methods for mapping and visualizing associated data on phylogeny using ggtree. Mol Biol Evol. 2018 Oct 23.. Abstract
submitted by kickingbird at Oct, 24, 2018 from Mol Biol Evol. 2018 Oct 23. (via https://www.ncbi.nlm.nih.gov/pubmed/30351396)
Ggtree is a comprehensive R package for visualizing and annotating phylogenetic trees with associated data. It can also map and visualize associated external data on phylogenies with two general methods. ... Teirlinck AC, et al. The incidence of symptomatic infection with influenza virus in the Netherlands 2011/2012 through 2016/2017, estimated using Bayesian evidence synthesis. Epidemiol Infect. 2018 Oct 23:1-6. Abstract
submitted by kickingbird at Oct, 24, 2018 from Epidemiol Infect. 2018 Oct 23:1-6 (via https://www.ncbi.nlm.nih.gov/pubmed/30348244)
Due to differences in the circulation of influenza viruses, distribution and antigenic drift of A subtypes and B lineages, and susceptibility to infection in the population, the incidence of symptomatic ... Denney L, Ho LP. The role of respiratory epithelium in host defence against influenza virus infection. Biomed J. 2018 Aug;41(4):218-233.. Abstract
submitted by kickingbird at Oct, 24, 2018 from Biomed J. 2018 Aug;41(4):218-233. (via https://www.ncbi.nlm.nih.gov/pubmed/30348265)
The respiratory epithelium is the major interface between the environment and the host. Sophisticated barrier, sensing, anti-microbial and immune regulatory mechanisms have evolved to help maintain homeostasis ... Toledo-Rueda W, et al. Antiviral resistance markers in influenza virus sequences in Mexico, 2000~2017. Infect Drug Resist. 2018 Oct 11;11:1751-1756. Abstract
submitted by kickingbird at Oct, 24, 2018 from Infect Drug Resist. 2018 Oct 11;11:1751-1756 (via https://www.ncbi.nlm.nih.gov/pubmed/30349332)
Background: Influenza causes high rates of morbidity and mortality. Genetic variability of influenza viruses generates resistance to antivirals, which are of two types, since they act on two different ... Credille CV, et al. Structure-Activity Relationships in Metal-Binding Pharmacophores for Influenza Endonuclease. J Med Chem. 2018 Oct 16. Abstract
submitted by kickingbird at Oct, 24, 2018 from J Med Chem. 2018 Oct 16 (via https://www.ncbi.nlm.nih.gov/pubmed/30351002)
Metalloenzymes represent an important target space for drug discovery. A limitation to the early development of metalloenzyme inhibitors has been the lack of established structure-activity relationships ... 7558 items, 20/Page, Page[185/378][|<<] [|<] [181] [182] [183] [184] [185] [186] [187] [188] [189] [190] [>|] [>>|] |
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