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Chamberlain N, et al. Lung epithelial protein disulfide isomerase A3 (PDIA3) plays an important role in influenza infection, inflammation, and airway mechanics. Redox Biol. 2019 Jan 29;22:101129.  Abstract  
submitted by kickingbird at Feb, 11, 2019 from Redox Biol. 2019 Jan 29;22:101129 (via https://www.ncbi.nlm.nih.gov/pubmed/30735910)
Protein disulfide isomerases (PDI) are a family of redox chaperones that catalyze formation or isomerization of disulfide bonds in proteins. Previous studies have shown that one member, PDIA3, interacts ...

Wang P, et al. Structural and functional definition of a vulnerable site on the hemagglutinin of highly pathogenic avian influenza A virus H5N1. J Biol Chem. 2019 Feb 8..  Abstract  
submitted by kickingbird at Feb, 11, 2019 from J Biol Chem. 2019 Feb 8. (via https://www.ncbi.nlm.nih.gov/pubmed/30737282)
Most neutralizing antibodies against highly pathogenic avian influenza A virus H5N1 recognize the receptor-binding site (RBS) on the globular head domain and the stem of H5N1 hemagglutinin (HA). Through ...

Moriyama M, Ichinohe T. High ambient temperature dampens adaptive immune responses to influenza A virus infection. Proc Natl Acad Sci U S A. 2019 Feb 4..  Abstract  
submitted by kickingbird at Feb, 8, 2019 from Proc Natl Acad Sci U S A. 2019 Feb 4. (via https://www.ncbi.nlm.nih.gov/pubmed/30718396)
Although climate change may expand the geographical distribution of several vector-borne diseases, the effects of environmental temperature in host defense to viral infection in vivo are unknown. Here, ...

Sato M, et al. Generation of bat-derived influenza viruses and their reassortants. Sci Rep. 2019 Feb 4;9(1):1158..  Abstract  
submitted by kickingbird at Feb, 8, 2019 from Sci Rep. 2019 Feb 4;9(1):1158. (via https://www.ncbi.nlm.nih.gov/pubmed/30718752)
Two novel influenza A virus-like genomes were detected in fruit bats in Central and South America. However, the biological properties of these bat-derived influenza viruses (BatIVs) are still largely unknown ...

Zhao Z, et al. A Novel Reassortant Avian H7N6 Influenza Virus Is Transmissible in Guinea Pigs via Respiratory Droplets. Front Microbiol. 2019 Jan 22.  Abstract  
submitted by kickingbird at Feb, 8, 2019 from Front Microbiol. 2019 Jan 22 (via https://www.ncbi.nlm.nih.gov/pubmed/30723462)
Since 2013, H7N9 and H5N6 avian influenza viruses (AIVs) have caused sporadic human infections and deaths and continued to circulate in the poultry industry. Since 2014, H7N6 viruses which might be reassortants ...

Rajao DS, Vincent AL, Perez DR. Adaptation of Human Influenza Viruses to Swine. Front Vet Sci. 2019 Jan 22;5:347.  Abstract  
submitted by kickingbird at Feb, 8, 2019 from Front Vet Sci. 2019 Jan 22;5:347 (via https://www.ncbi.nlm.nih.gov/pubmed/30723723)
A large diversity of influenza A viruses (IAV) within the H1N1/N2 and H3N2 subtypes circulates in pigs globally, with different lineages predominating in specific regions of the globe. A common characteristic ...

Turner HL, et al. Potent anti-influenza H7 human monoclonal antibody induces separation of hemagglutinin receptor-binding head domains. PLoS Biol. 2019 Feb 4;17(2):e3000139..  Abstract  
submitted by kickingbird at Feb, 5, 2019 from PLoS Biol. 2019 Feb 4;17(2):e3000139. (via https://www.ncbi.nlm.nih.gov/pubmed/30716060)
Seasonal influenza virus infections can cause significant morbidity and mortality, but the threat from the emergence of a new pandemic influenza strain might have potentially even more devastating consequences. ...

Prost K, et al. Bioaerosol and surface sampling for the surveillance of influenza A virus in swine. Transbound Emerg Dis. 2019 Feb 4..  Abstract  
submitted by kickingbird at Feb, 5, 2019 from Transbound Emerg Dis. 2019 Feb 4. (via https://www.ncbi.nlm.nih.gov/pubmed/30715792)
BACKGROUND: Influenza A virus in swine is of significant importance to human and veterinary public health. Environmental sampling techniques that prove practical would enhance surveillance for influenza ...

Krammer F, Palese P. Universal influenza virus vaccines that target the conserved hemagglutinin stalk and conserved sites in the head domain. J Infect Dis. 2019 Jan 31.  Abstract  
submitted by kickingbird at Feb, 5, 2019 from J Infect Dis. 2019 Jan 31 (via https://www.ncbi.nlm.nih.gov/pubmed/30715353)
Due to limitations of current influenza virus vaccines, new vaccines that mediate broad protection and show high efficacy against seasonal and pandemic viruses are urgently needed. The conserved stalk ...

Rolfes MA, et al. Effects of Influenza Vaccination in the United States during the 2017~2018 Influenza Season. Clin Infect Dis. 2019 Feb 2..  Abstract  
submitted by kickingbird at Feb, 5, 2019 from Clin Infect Dis. 2019 Feb 2. (via https://www.ncbi.nlm.nih.gov/pubmed/30715278)
Background: The severity of the 2017-2018 influenza season in the U.S. was high with influenza A(H3N2) viruses predominating. We report influenza vaccine effectiveness (VE) and estimate the number of vaccine ...

Korem M, et al. Intensive care admissions and associated severity of influenza B versus A during influenza B-vaccine mismatched seasons. Clin Infect Dis. 2019 Feb 1.  Abstract  
submitted by kickingbird at Feb, 5, 2019 from Clin Infect Dis. 2019 Feb 1 (via https://www.ncbi.nlm.nih.gov/pubmed/30715225)
Patients admitted to hospital with influenza B and A in Jerusalem, Israel, 2015-2016/2017-2018, demonstrated similar rates of ICU admission and associated disease severity. Most (63%) influenza B-ICU patients ...

Kayed AS, et al. Surveillance for avian influenza viruses in wild birds at live bird markets, Egypt, 2014~2016. Influenza Other Respir Viruses. 2019 Feb 3..  Abstract  
submitted by kickingbird at Feb, 5, 2019 from Influenza Other Respir Viruses. 2019 Feb 3. (via https://www.ncbi.nlm.nih.gov/pubmed/30714323)
AIM: Egypt is the habitat for a large number of bird species and serves as a vital stopover for millions of migratory birds during their annual migration between the Palearctic and Afrotropical ecozones. ...

Streltsov VA, Schmidt PM, McKimm-Breschkin JL. Structure of an Influenza A virus N9 neuraminidase with a tetrabrachion-domain stalk. Acta Crystallogr F Struct Biol Commun. 2019 Feb 1;.  Abstract  
submitted by kickingbird at Feb, 5, 2019 from Acta Crystallogr F Struct Biol Commun. 2019 Feb 1; (via https://www.ncbi.nlm.nih.gov/pubmed/30713159)
The influenza neuraminidase (NA) is a homotetramer with head, stalk, transmembrane and cytoplasmic regions. The structure of the NA head with a stalk has never been determined. The NA head from an N9 subtype ...

Soli R, Kaabi B, Barhoumi M, Maktoof C, et al. Bayesian Phylogenetic Analysis of the Influenza-A virus genomes isolated in Tunisia, and Determination of Potential Recombination Events. Mol Phylogenet Evol. 2019 Jan 29..  Abstract  
submitted by kickingbird at Feb, 3, 2019 from Mol Phylogenet Evol. 2019 Jan 29. (via https://www.ncbi.nlm.nih.gov/pubmed/30708173)
The influenza-A virus (IAV) causes seasonal epidemics and presents a pandemic risk with the possibility of genetic re-assortment, allowing the emergence of new strains. The evolution of IAVes is done most ...

Linster M, et al. The molecular basis for antigenic drift of human A/H2N2 influenza viruses. J Virol. 2019 Jan 30..  Abstract  
submitted by kickingbird at Feb, 3, 2019 from J Virol. 2019 Jan 30. (via https://www.ncbi.nlm.nih.gov/pubmed/30700609)
Influenza A/H2N2 viruses caused a pandemic in 1957 and continued to circulate in humans until 1968. The antigenic evolution of A/H2N2 viruses over time and the amino acid substitutions responsible for ...

Osthus D, Daughton AR, Priedhorsky R. Even a good influenza forecasting model can benefit from internet-based nowcasts, but those benefits are limited. PLoS Comput Biol. 2019 Feb 1;15(2):e1006599..  Abstract  
submitted by kickingbird at Feb, 3, 2019 from PLoS Comput Biol. 2019 Feb 1;15(2):e1006599. (via https://www.ncbi.nlm.nih.gov/pubmed/30707689)
The ability to produce timely and accurate flu forecasts in the United States can significantly impact public health. Augmenting forecasts with internet data has shown promise for improving forecast accuracy ...

Yang CY, Chen RJ, Chou WL, Lee YJ, Lo YS. An Integrated Influenza Surveillance Framework Based on National Influenza-Like Illness Incidence and Multiple Hospital Electronic Medical Records for Early Prediction of Influenza Epidemics: Design a. J Med Internet Res. 2019 Feb 1;21(2):e12341.  Abstract  
submitted by kickingbird at Feb, 3, 2019 from J Med Internet Res. 2019 Feb 1;21(2):e12341 (via https://www.ncbi.nlm.nih.gov/pubmed/30707099)
BACKGROUND: Influenza is a leading cause of death worldwide and contributes to heavy economic losses to individuals and communities. Therefore, the early prediction of and interventions against influenza ...

Yohei Yamauchi. Quantum dots crack the influenza uncoating puzzle. Proc Natl Acad Sci U S A. 2019 Jan 31.  Abstract  
submitted by kickingbird at Feb, 3, 2019 from Proc Natl Acad Sci U S A. 2019 Jan 31 (via https://www.pnas.org/content/early/2019/01/30/1822089116)
One hundred years ago, the devastating 1918–1919 Spanish influenza pandemic took the lives of 50 to 100 million people, or 3 to 5% of the world population (1). Influenza A virus (IAV) pandemics occur when ...

Christensen SR, et al. Assessing the protective potential of H1N1 influenza virus hemagglutinin head and stalk antibodies in humans. J Virol. 2019 Jan 30.  Abstract  
submitted by kickingbird at Feb, 3, 2019 from J Virol. 2019 Jan 30 (via https://www.ncbi.nlm.nih.gov/pubmed/30700610)
Seasonal influenza viruses are a major cause of human disease worldwide. Most neutralizing antibodies (Abs) elicited by influenza viruses target the head domain of the hemagglutinin (HA) protein. Anti-HA ...

Thielen P, et al. Complete Genome Sequence of an Influenza D Virus Strain Identified in a Pig with Subclinical Infection in the United States. Microbiol Resour Announc. 2019 Jan 24;8(4).  Abstract  
submitted by kickingbird at Feb, 3, 2019 from Microbiol Resour Announc. 2019 Jan 24;8(4) (via https://www.ncbi.nlm.nih.gov/pubmed/30701240)
Influenza D virus was first described in 2011 from a pig with respiratory disease; however, recent evidence indicates that cattle are the major viral reservoir. Here, we describe the genome sequence of ...

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