Ali M, et al. Prevalence and Phylogenetics of H9N2 in Backyard and Commercial Poultry in Pakistan. Avian Dis. 2018 Dec;62(4):416-424.. Abstract
submitted by kickingbird at May, 28, 2019 from Avian Dis. 2018 Dec;62(4):416-424. (via https://bioone.org/journals/Avian-Diseases/volume-62/issue-4)
Surveillance of H9N2 is currently focused on areas central to the commercial poultry industry. This study determined the prevalence of H9N2 virus in commercial and backyard poultry flocks in Punjab Province, ... Oxford JS, Gill D. A possible European origin of the Spanish influenza and the first attempts to reduce mortality to combat superinfecting bacteria: an opinion from a virologist and a military historian. Hum Vaccin Immunother. 2019 May 23:1-4.. Abstract
submitted by kickingbird at May, 28, 2019 from Hum Vaccin Immunother. 2019 May 23:1-4. (via https://www.tandfonline.com/doi/full/10.1080/21645515.2019.1)
When we reconsider the virology and history of the Spanish Influenza Pandemic, the science of 2018 provides us with tools which did not exist at the time. Two such tools come to mind. The first lies in ... Nguyen LT, et al. A systematic study towards evolutionary and epidemiological dynamics of currently predominant H5 highly pathogenic avian influenza viruses in Vietnam. Sci Rep. 2019 May 22;9(1):7723.. Abstract
submitted by kickingbird at May, 26, 2019 from Sci Rep. 2019 May 22;9(1):7723. (via https://www.nature.com/articles/s41598-019-42638-4)
This study aimed to elucidate virus, host and environmental dynamics of Vietnamese H5 highly pathogenic avian influenza viruses (HPAIVs) during 2014-2017. Epidemiologically, H5 HPAIVs were frequently detected ... Hu B, H?fer CT, Thiele C, Veit M. Cholesterol binding to the transmembrane region of a group 2 HA of Influenza virus is essential for virus replication affecting both virus assembly and HA´s fusion activity. J Virol. 2019 May 22.. Abstract
submitted by kickingbird at May, 26, 2019 from J Virol. 2019 May 22. (via https://www.ncbi.nlm.nih.gov/pubmed/31118253)
Hemagglutinin (HA) of Influenza virus is incorporated into cholesterol enriched, nanodomains of the plasma membrane. Phylogenetic group 2 HAs contain the conserved cholesterol consensus motif (CCM) YKLW ... Gilbert PB, et al. HAI and NAI titer correlates of inactivated and live attenuated influenza vaccine efficacy. BMC Infect Dis. 2019 May 22;19(1):453. Abstract
submitted by kickingbird at May, 26, 2019 from BMC Infect Dis. 2019 May 22;19(1):453 (via https://bmcinfectdis.biomedcentral.com/articles/10.1186/s128)
BACKGROUND: High hemagglutination inhibition (HAI) and neuraminidase inhibition (NAI) titers are generally associated with reduced influenza risk. While repeated influenza vaccination reduces seroresponse, ... Zhang Y, et al. Genetic and biological characteristics of avian influenza virus subtype H1N8 in environments related to live poultry markets in China. BMC Infect Dis. 2019 May 22;19(1):458. Abstract
submitted by kickingbird at May, 26, 2019 from BMC Infect Dis. 2019 May 22;19(1):458 (via https://bmcinfectdis.biomedcentral.com/articles/10.1186/s128)
BACKGROUND: Since 2008, avian influenza surveillance in poultry-related environments has been conducted annually in China. Samples have been collected from environments including live poultry markets, ... Leung V, et al. Thermal Stabilization of Viral Vaccines in Low-Cost Sugar Films. Sci Rep. 2019 May 21;9(1):7631. Abstract
submitted by kickingbird at May, 24, 2019 from Sci Rep. 2019 May 21;9(1):7631 (via https://www.nature.com/articles/s41598-019-44020-w)
Most currently available vaccines, particularly live vaccines, require the cold chain, as vaccine efficacy can be significantly hampered if they are not stored in a temperature range of 2-8?°C at all times. ... Yu Z, et al. PB2 and hemagglutinin mutations confer a virulent phenotype on an H1N2 avian influenza virus in mice. Arch Virol. 2019 May 20. Abstract
submitted by kickingbird at May, 23, 2019 from Arch Virol. 2019 May 20 (via https://link.springer.com/article/10.1007%2Fs00705-019-04283)
We previously obtained mouse-adapted variants of H1N2 avian influenza virus that contained PB2-L134H, PB2-I647L, PB2-D701N, HA-G228S, and M1-D231N mutations. Here, we analyzed the effects of these mutations ... Murakami S, et al. Influenza D Virus Infection in Dromedary Camels, Ethiopia. Emerg Infect Dis. 2019 Jun;25(6):1224-1226. Abstract
submitted by kickingbird at May, 22, 2019 from Emerg Infect Dis. 2019 Jun;25(6):1224-1226 (via https://wwwnc.cdc.gov/eid/article/25/6/18-1158_article)
Influenza D virus has been found to cause respiratory diseases in livestock. We surveyed healthy dromedary camels in Ethiopia and found a high seroprevalence for this virus, in contrast to animals co-existing ... Carvalho SB, et al. Membrane-based approach for the downstream processing of influenza virus-like particles. Biotechnol J. 2019 May 20:e201800570. Abstract
submitted by kickingbird at May, 22, 2019 from Biotechnol J. 2019 May 20:e201800570 (via https://onlinelibrary.wiley.com/doi/abs/10.1002/biot.2018005)
Currently marketed influenza vaccines are only efficient against homologous viruses, thus requiring a seasonal update based on circulating subtypes. This constant reformulation adds several challenges ... Nishizawa S, et al. Strong binding and off-on signaling functions of deep-red fluorescent TO-PRO-3 for influenza A virus RNA promoter region. Chembiochem. 2019 May 20.. Abstract
submitted by kickingbird at May, 22, 2019 from Chembiochem. 2019 May 20. (via https://onlinelibrary.wiley.com/doi/abs/10.1002/cbic.2019003)
Influenza A virus RNA promoter region has recently attracted much attention as RNA targets for the development of novel anti-influenza drugs. However, there are very limited reports on small RNA-binding ... Bajic G, et al. Influenza Antigen Engineering Focuses Immune Responses to a Subdominant but Broadly Protective Viral Epitope. Cell Host Microbe. 2019 May 14. Abstract
submitted by kickingbird at May, 22, 2019 from Cell Host Microbe. 2019 May 14 (via https://www.ncbi.nlm.nih.gov/pubmed/31104946)
Viral glycoproteins are under constant immune surveillance by a host's adaptive immune responses. Antigenic variation including glycan introduction or removal is among the mechanisms viruses have evolved ... Trigueiro-Louro JM, et al. To hit or not to hit: Large-scale sequence analysis and structure characterization of influenza A NS1 unlocks new antiviral target potential. Virology. 2019 Apr 27.. Abstract
submitted by kickingbird at May, 22, 2019 from Virology. 2019 Apr 27. (via https://www.sciencedirect.com/science/article/abs/pii/S00426)
Influenza NS1 protein is among the most promising novel druggable anti-influenza target, based on its structure; multiple interactions; and global function in influenza replication and pathogenesis. Notwithstanding, ... Wu JY, et al. Transmission Risk of Avian Influenza Virus along Poultry Supply Chains in Guangdong, China. J Infect. 2019 May 14.. Abstract
submitted by kickingbird at May, 20, 2019 from J Infect. 2019 May 14. (via https://www.journalofinfection.com/article/S0163-4453(19)301)
OBJECTIVES: Avian influenza viruses (AIVs) poise significant risk to human health and the poultry industry. We evaluated the transmission risk along the poultry supply chain.METHODS: During October 2015 ... Zhang W, et al. A hospital cluster combined with a family cluster of avian influenza H7N9 infection in Anhui Province, China. J Infect. 2019 May 14.. Abstract
submitted by kickingbird at May, 20, 2019 from J Infect. 2019 May 14. (via https://www.journalofinfection.com/article/S0163-4453(19)301)
OBJECTIVES: To identify human-to-human transmission of H7N9 avian influenza virus, we investigated a hospital cluster combined with family cluster in this study.METHODS: We obtained and analyzed clinical, ... Bangaru S, et al. A Site of Vulnerability on the Influenza Virus Hemagglutinin Head Domain Trimer Interface. Cell. 2019 May 16;177(5):1136-1152.e18.. Abstract
submitted by kickingbird at May, 20, 2019 from Cell. 2019 May 16;177(5):1136-1152.e18. (via https://www.cell.com/cell/fulltext/S0092-8674(19)30397-6)
Here, we describe the discovery of a naturally occurring human antibody (Ab), FluA-20, that recognizes a new site of vulnerability on the hemagglutinin (HA) head domain and reacts with most influenza A ... Watanabe A, et al. Antibodies to a Conserved Influenza Head Interface Epitope Protect by an IgG Subtype-Dependent Mechanism. Cell. 2019 May 16;177(5):1124-1135.e16. Abstract
submitted by kickingbird at May, 20, 2019 from Cell. 2019 May 16;177(5):1124-1135.e16 (via https://www.cell.com/cell/fulltext/S0092-8674(19)30349-6)
Vaccines to generate durable humoral immunity against antigenically evolving pathogens such as the influenza virus must elicit antibodies that recognize conserved epitopes. Analysis of single memory B ... Wu Y, Gao GF. "Breathing" Hemagglutinin Reveals Cryptic Epitopes for Universal Influenza Vaccine Design. Cell. 2019 May 16;177(5):1086-1088.. Abstract
submitted by kickingbird at May, 20, 2019 from Cell. 2019 May 16;177(5):1086-1088. (via https://www.cell.com/cell/fulltext/S0092-8674(19)30453-2)
A universal vaccine against influenza remains a critical target, and efforts have recently focused on the stem of the hemagglutinin glycoprotein. In this issue of Cell and a related Cell Host & Microbe ... Lambertz RLO, et al. Tmprss2 knock-out mice are resistant to H10 influenza A virus pathogenesis. J Gen Virol. 2019 May 17.. Abstract
submitted by kickingbird at May, 20, 2019 from J Gen Virol. 2019 May 17. (via https://jgv.microbiologyresearch.org/content/journal/jgv/10.)
The surface protein haemagglutinin (HA) of influenza A viruses (IAV) needs to be cleaved by a host protease to become functional. Here, we investigated if IAV of the H10 subtype also requires TMPRSS2 for ... Warfield KL, et al. Lack of selective resistance of influenza A virus in presence of host-targeted antiviral, UV-4B. Sci Rep. 2019 May 16;9(1):7484.. Abstract
submitted by kickingbird at May, 20, 2019 from Sci Rep. 2019 May 16;9(1):7484. (via https://www.nature.com/articles/s41598-019-43030-y)
Development of antiviral drug resistance is a continuous concern for viruses with high mutation rates such as influenza. The use of antiviral drugs targeting host proteins required for viral replication ... 7516 items, 20/Page, Page[152/376][|<<] [|<] [151] [152] [153] [154] [155] [156] [157] [158] [159] [160] [>|] [>>|] |
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