As an avian influenza virus panzootic is underway, the threat of a human pandemic is emerging. Infections among mammalian species in frequent contact with humans should be closely monitored. One mammalian family, the Felidae, is of particular concern. Felids, known as felines or cats, are susceptible to avian influenza virus infection. Felines prey on wild birds and may serve as a host for avian influenza virus adaptation to mammals. Feline-to-feline transmission has been demonstrated experimentally [1], and real-world outbreaks have been reported [2,3]. Domestic cats are a popular human companion animal and thus provide a potential pathway for zoonotic spillover of avian influenza viruses to humans. Here, we provide a systematic review of the scientific literature to describe the epidemiology and global distribution of avian influenza virus infections in felines reported over time. We aim to provide a comprehensive background for the assessment of the current risk, as well as bring awareness to the phenomenon of AIV infection in felines.