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COHEN S, Janicki-Deverts D, Turner RB, Casselbrant. Association between telomere length and experimentally induced upper respiratory viral infection in healthy adults. JAMA. 2013 Feb 20;309(7):699-705..  Abstract  
submitted by kickingbird at Feb, 25, 2013 from JAMA. 2013 Feb 20;309(7):699-705. (via http://www.ncbi.nlm.nih.gov/pubmed/23423415)
Abstract IMPORTANCE: Although leukocyte telomere length is associated with mortality and many chronic diseases thought to be manifestations of age-related functional decline, it is not known whether ...

PERRONE LA, Belser JA, Wadford DA, Katz JM, et al. Inducible nitric oxide contributes to viral pathogenesis following highly pathogenic influenza virus infection in mice. J Infect Dis. 2013.  Abstract  
submitted by kickingbird at Feb, 25, 2013 from J Infect Dis. 2013 (via http://www.ncbi.nlm.nih.gov/pubmed/23420903)
Highly pathogenic influenza A viruses including avian H5N1 viruses and the 1918 pandemic virus cause severe respiratory disease in humans and animals. Virus infection is followed by intense pulmonary congestion ...

CILLONIZ C, Ewig S, Menendez R, Ferrer M, et al. Bacterial co-infection with H1N1 infection in patients admitted with community acquired pneumonia. J Infect. 2012;65:223-30.  Abstract  
submitted by kickingbird at Feb, 25, 2013 from J Infect. 2012;65:223-30 (via http://www.ncbi.nlm.nih.gov/pubmed/22543245)
BACKGROUND: Bacterial co-infection is an important contributor to morbidity and mortality during influenza pandemics .We investigated the incidence, risk factors and outcome of patients with influenza ...

GAO X, Wang W, Li Y, Zhang S, et al. Enhanced Influenza VLP Vaccines Comprising Matrix-2 Ectodomain and Nucleoprotein Epitopes Protects mice from Lethal Challenge. Antiviral Res. 2013 Feb 14. pii: S0166-3542(13)000.  Abstract  
submitted by kickingbird at Feb, 25, 2013 from Antiviral Res. 2013 Feb 14. pii: S0166-3542(13)000 (via http://www.ncbi.nlm.nih.gov/pubmed/23416215)
The matrix protein 2ectodomain (M2e) of the influenza A virus is a rational target antigen candidate for the development of a universal influenza virus-like particle (VLP) vaccine. In this study, a recombinant ...

MURCIA PR, Baillie GJ, Stack JC, Jervis C, et al. Evolution of equine influenza virus in vaccinated horses. J Virol. 2013 Feb 6.  Abstract  
submitted by kickingbird at Feb, 24, 2013 from J Virol. 2013 Feb 6 (via http://www.ncbi.nlm.nih.gov/pubmed/23388708)
Influenza A viruses are characterized by their ability to evade host immunity, even in vaccinated individuals. To determine how prior immunity shapes viral diversity in vivo we studied the intra- and inter-host ...

ALFONSO R, Rodriguez A, Rodriguez P, Lutz T, et al. CHD6, a cellular repressor of influenza virus replication is degraded in human alveolar epithelial cells and mice lungs during infection. J Virol. 2013 Feb 13.  Abstract  
submitted by kickingbird at Feb, 24, 2013 from J Virol. 2013 Feb 13 (via http://www.ncbi.nlm.nih.gov/pubmed/23408615)
The influenza virus polymerase associates to an important number of transcription related proteins including the largest subunit of the RNA polymerase II complex (RNAP II). Despite this association, degradation ...

YOON SW, Kayali G, Ali MA, Webster RG, et al. A Single Amino Acid at the Hemagglutinin Cleavage Site Contributes to the Pathogenicity but not Transmission of Egyptian Highly Pathogenic H5N1 Influenza Virus in Chickens. J Virol. 2013 Feb 13..  Abstract  
submitted by kickingbird at Feb, 24, 2013 from J Virol. 2013 Feb 13. (via http://www.ncbi.nlm.nih.gov/pubmed/23408622)
Highly pathogenic avian influenza H5N1 has been enzootic in Egypt since 2008. Virus-associated mortality (but not the number of cases) in humans and poultry seems to have decreased over time, but the reason ...

FAN S, Macken CA, Li C, Ozawa M, et al. Synergistic effect of the PDZ and the p85β-binding domains of the NS1 protein in virulence of an avian H5N1 influenza A virus. J Virol. 2013 Feb 13.  Abstract  
submitted by kickingbird at Feb, 24, 2013 from J Virol. 2013 Feb 13 (via http://www.ncbi.nlm.nih.gov/pubmed/23408626)
The influenza A virus NS1 protein affects virulence through several mechanisms including the host's innate immune response and various signaling pathways. Highly pathogenic avian influenza (HPAI) viruses ...

MARGINE I, Hai R, Albrecht RA, Obermoser G, et al. H3N2 influenza virus infection induces broadly reactive hemagglutinin stalk antibodies in humans and mice. J Virol. 2013 Feb 13..  Abstract  
submitted by kickingbird at Feb, 24, 2013 from J Virol. 2013 Feb 13. (via http://www.ncbi.nlm.nih.gov/pubmed/23408625)
Broadly neutralizing antibodies directed against the conserved stalk domain of the viral hemagglutinin have attracted increasing attention in the recent years. However, only a limited number of stalk antibodies ...

ZHANG L, Guo ZW, Bridge ES, Li YM, et al. Distribution and dynamics of risk factors associated with highly pathogenic avian influenza H5N1. Epidemiol Infect. 2013 Feb 11:1-10..  Abstract  
submitted by kickingbird at Feb, 24, 2013 from Epidemiol Infect. 2013 Feb 11:1-10. (via http://www.ncbi.nlm.nih.gov/pubmed/23398949)
SUMMARY Within China's Poyang Lake region, close interactions between wild migratory birds and domestic poultry are common and provide an opportunity for the transmission and subsequent outbreaks of highly ...

CLAES G, Welby S, VAN DEN Berg T, VAN DER Stede Y,. The impact of viral tropism and housing conditions on the transmission of three H5/H7 low pathogenic avian influenza viruses in chickens. Epidemiol Infect. 2013 Feb 11:1-16.  Abstract  
submitted by kickingbird at Feb, 24, 2013 from Epidemiol Infect. 2013 Feb 11:1-16 (via http://www.ncbi.nlm.nih.gov/pubmed/23398968)
SUMMARY In this study, shedding and transmission of three H5/H7 low pathogenic avian influenza viruses (LPAIVs) in poultry was characterized and the impact of floor system on transmission was assessed. ...

Falcone V, Bierbaum S, Kern W, Kontny U, Bertz H,. Influenza virus A(H1N1)pdm09 hemagglutinin polymorphism and associated disease in southern Germany during the 2010/11 influenza season. Arch Virol. 2013 Feb 9..  Abstract  
submitted by kickingbird at Feb, 24, 2013 from Arch Virol. 2013 Feb 9. (via http://www.ncbi.nlm.nih.gov/pubmed/23397331)
A novel influenza A virus emerged in early 2009 to cause the first influenza pandemic of the 21(st) century. Understanding the evolution of influenza virus is crucial to determine pathogenesis, vaccine ...

Wang Y, Landman B, Wu C, Gelb J, Golovan S.. Comparison of vRNA and cRNA based reporters for detection of influenza replication. Antiviral Res. 2013 Feb 9..  Abstract  
submitted by kickingbird at Feb, 24, 2013 from Antiviral Res. 2013 Feb 9. (via http://www.ncbi.nlm.nih.gov/pubmed/23403209)
In this study, RNA polymerase I expressed replicons containing EGFP and luciferase reporter genes controlled by influenza vRNA or cRNA promoters were compared side-by-side in the ability to detect influenza ...

Magnusson SE, Reimer JM, Karlsson KH, Lilja L, et. Immune enhancing properties of the novel Matrix-M adjuvant leads to potentiated immune responses to an influenza vaccine in mice. Vaccine 2013 Feb 2. pii: S0264-410X(13)00107.  Abstract  
submitted by kickingbird at Feb, 14, 2013 from Vaccine 2013 Feb 2. pii: S0264-410X(13)00107 (via http://www.ncbi.nlm.nih.gov/m/pubmed/23384754/)
The novel saponin based adjuvant Matrix-M? was recently used in a Phase I study of seasonal influenza in elderly. The present study is a pre-clinical evaluation of the efficacy and mode-of-action of Matrix-M? ...

Bischoff WE, Swett K, Leng I, Peters TR, et al. Exposure to Influenza Virus Aerosols During Routine Patient Care. Bischoff WE, Swett K, Leng I, Peters TR, et al.  Abstract  
submitted by kickingbird at Feb, 14, 2013 from Bischoff WE, Swett K, Leng I, Peters TR, et al (via http://www.ncbi.nlm.nih.gov/m/pubmed/23372182/)
Background.?Defining dispersal of influenza virus via aerosol is essential for the development of prevention measures.Methods.?During the 2010-2011 influenza season, subjects with influenza-like illness ...

Zhang F, Fang F, Chang H, Peng B, et al. Comparison of protection against H5N1 influenza virus in mouse offspring provided by maternal vaccination with HA DNA and inactivated vaccine. Arch Virol 2013.  Abstract  
submitted by kickingbird at Feb, 14, 2013 from Arch Virol 2013 (via http://www.ncbi.nlm.nih.gov/m/pubmed/23385327/)
H5N1 influenza virus is one of the viruses that can potentially cause an influenza pandemic. Protection of newborns against influenza virus infection could be effectively provided by maternal immunization. ...

Lau LL, Ip DK, Nishiura H, Fang VJ, et al. Heterogeneity in virus shedding among medically-attended influenza A virus infections. J Infect Dis 2013..  Abstract  
submitted by kickingbird at Feb, 14, 2013 from J Infect Dis 2013. (via http://www.ncbi.nlm.nih.gov/m/pubmed/23382573/)
Compared with the average transmissibility of human influenza A virus infection, much less attention has been paid to its potential variability. Considering viral shedding as a proxy for infectiousness, ...

Nicola Principi, Alessia Scala, Cristina Daleno, S. Influenza C virus–associated community-acquired pneumonia in children. Influenza and Other Respiratory Viruses.  Abstract  
submitted by kickingbird at Feb, 11, 2013 from Influenza and Other Respiratory Viruses (via http://onlinelibrary.wiley.com/doi/10.1111/irv.12062/abstrac)
To evaluate the impact of influenza C (ICV) infection in children with community-acquired pneumonia (CAP), all of the children consecutively seen during 4 influenza seasons with respiratory symptoms and ...

Bragstad K, Emborg HD, K?lsen Fischer T, Voldstedl. Low vaccine effectiveness against influenza A(H3N2) virus among elderly people in Denmark in 2012/13 – a rapid epidemiological and virological assessment. Eurosurveillance, Volume 18, Issue 6, 07 February.  Abstract  
submitted by kickingbird at Feb, 11, 2013 from Eurosurveillance, Volume 18, Issue 6, 07 February (via http://www.eurosurveillance.org/ViewArticle.aspx?ArticleId=2)
In Denmark, the 2012/13 influenza season has been dominated by influenza A(H3N2). We estimated the vaccine effectiveness (VE) of the trivalent influenza vaccine by linking national registers in a test-negative ...

Kyncl J, Havlickova M, Nagy A, Jirincova H, Piskov. Early and unexpectedly severe start of influenza epidemic in the Czech Republic during influenza season 2012-13. Eurosurveillance, Volume 18, Issue 6, 07 February.  Abstract  
submitted by kickingbird at Feb, 11, 2013 from Eurosurveillance, Volume 18, Issue 6, 07 February (via http://www.eurosurveillance.org/ViewArticle.aspx?ArticleId=2)
A sudden increase in severe influenza has been registered in the Czech Republic since the end of 2012, with 264 cases requiring intensive care, including 51 deaths. Most patients had at least one risk ...

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