YOON SW, Kayali G, Ali MA, Webster RG, et al. A Single Amino Acid at the Hemagglutinin Cleavage Site Contributes to the Pathogenicity but not Transmission of Egyptian Highly Pathogenic H5N1 Influenza Virus in Chickens. J Virol. 2013 Feb 13.
Highly pathogenic avian influenza H5N1 has been enzootic in Egypt since 2008. Virus-associated mortality (but not the number of cases) in humans and poultry seems to have decreased over time, but the reason for this remains unknown. We investigated the role of a single amino acid substitution in the hemagglutinin cleavage site on virus pathogenicity and transmission in chickens. The R325G substitution significantly reduced pathogenicity without altering the transmission efficiency of HPAI H5N1 virus.
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