Jianzhong Shi,etc.,al. H7N9 virulent mutants detected in chickens in China pose an increased threat to humans. Cell Research 24 Oct, 2017. Abstract
submitted by kickingbird at Oct, 31, 2017 from Cell Research 24 Oct, 2017 (via https://www.nature.com/cr/journal/vaop/ncurrent/full/cr20171)
Certain low pathogenic avian influenza viruses can mutate to highly pathogenic viruses when they circulate in domestic poultry, at which point they can cause devastating poultry diseases and severe economic ... M Imai,etc.,al. A Highly Pathogenic Avian H7N9 Influenza Virus Isolated from A Human Is Lethal in Some Ferrets Infected via Respiratory Droplets. Cell Host & Microbe. Abstract
submitted by kickingbird at Oct, 23, 2017 from Cell Host & Microbe (via http://www.cell.com/cell-host-microbe/fulltext/S1931-3128%28)
Highly pathogenic avian influenza (HPAI) H7N9 viruses replicate efficiently in mammals HPAI H7N9 viruses are more pathogenic than low pathogenic H7N9 viruses in mammals HPAI H7N9 viruses transmit ... Bradley JS, Blumer JL, Romero JR, Michaels MG, et. Intravenous Zanamivir in Hospitalized Patients With Influenza. Pediatrics 2017 Oct 19.. Abstract
submitted by kickingbird at Oct, 22, 2017 from Pediatrics 2017 Oct 19. (via https://www.ncbi.nlm.nih.gov/m/pubmed/29051331/)
BACKGROUND: Children with severe influenza infection may require parenteral therapy if oral or inhaled therapies are ineffective or cannot be administered. Results from a study investigating intravenous ... Lion A, Richard M, Esnault E, Kut E, et al. Productive replication of avian influenza viruses in chicken endothelial cells is determined by hemagglutinin cleavability and is related to innate immune escape.. Virology 2017;513:29-42. Abstract
submitted by kickingbird at Oct, 22, 2017 from Virology 2017;513:29-42 (via https://www.ncbi.nlm.nih.gov/m/pubmed/29031164/)
Endotheliotropism is a hallmark of gallinaceous poultry infections with highly pathogenic avian influenza (HPAI) viruses and a feature that distinguishes HPAI from low pathogenic avian influenza (LPAI) ... Frabutt DA, Wang B, Riaz S, Schwartz RC, et al. Innate sensing of influenza A virus hemagglutinin glycoproteins by the host endoplasmic reticulum (ER) stress pathway triggers a potent antiviral response via ER-associated protein degradation. J Virol 2017 Oct 18.. Abstract
submitted by kickingbird at Oct, 22, 2017 from J Virol 2017 Oct 18. (via https://www.ncbi.nlm.nih.gov/m/pubmed/29046440/)
Innate immunity provides an immediate defense against infection after host cells sense "danger" signals from microbes. Endoplasmic reticulum (ER) stress arises from accumulation of misfolded/unfolded proteins ... Sutton TC, Lamirande EW, Bock KW, Moore IN, et al. In vitro neutralization is not predictive of prophylactic efficacy of broadly neutralizing monoclonal antibodies CR6261 and CR9114 against lethal H2 influenza virus challenge in mice. J Virol 2017 Oct 18. Abstract
submitted by kickingbird at Oct, 22, 2017 from J Virol 2017 Oct 18 (via https://www.ncbi.nlm.nih.gov/m/pubmed/29046448/)
Influenza viruses of the H1N1, H2N2, and H3N2 subtypes have caused previous pandemics. H2 influenza viruses represent a pandemic threat due to continued circulation in wild birds and limited immunity in ... Liu H, Grantham ML, Pekosz A. Mutations in the Influenza A virus M1 protein enhance virus budding to complement lethal mutations in the M2 cytoplasmic tail. J Virol 2017 Oct 18. Abstract
submitted by kickingbird at Oct, 22, 2017 from J Virol 2017 Oct 18 (via https://www.ncbi.nlm.nih.gov/m/pubmed/29046451/)
The influenza A virus M1 and M2 proteins play important roles in virus assembly and in the morphology of virus particles. Mutations in the distal cytoplasmic tail region of M2, and in particular a tyrosine ... Choi WS, Jeong JH, Kwon JJ, Ahn SJ, et al. Screening for Neuraminidase Inhibitor Resistance Markers among Avian Influenza Viruses of the N4, N5, N6 and N8 Neuraminidase Subtypes. J Virol 2017 Oct 18.. Abstract
submitted by kickingbird at Oct, 22, 2017 from J Virol 2017 Oct 18. (via https://www.ncbi.nlm.nih.gov/m/pubmed/29046464/)
Several subtypes of avian influenza viruses (AIVs) are emerging as novel human pathogens, and the frequency of related infections has increased in recent years. Although neuraminidase (NA) inhibitors (NAIs) ... Gordon NA, McGuire KL, Wallentine SK, Mohl GA, et. Divalent copper complexes as influenza A M2 inhibitors. Antiviral Res 2017;147:100-106. Abstract
submitted by kickingbird at Oct, 22, 2017 from Antiviral Res 2017;147:100-106 (via https://www.ncbi.nlm.nih.gov/m/pubmed/29032206/)
New M2 blockers effective against the ubiquitous amantadine-resistant S31N M2 mutation in influenza A are needed. Six copper complexes, 2, 4, 6, 8, 9, and 10, were synthesized and found to block both wild ... Duh D, Blazic B. Single mutation in the matrix gene of seasonal influenza A viruses critically affects the performance of diagnostic molecular assay. J Virol Methods 2017 Oct 6. Abstract
submitted by kickingbird at Oct, 15, 2017 from J Virol Methods 2017 Oct 6 (via https://www.ncbi.nlm.nih.gov/m/pubmed/28993123/)
Reduced intensity of the fluorescence signal in the amplification curve was observed when using a WHO recommended real time RT-PCR for influenza virus detection. A single mutation, G189T, in the conserved ... Cho J, Yi H, Jang EY, Lee MS, et al. Mycophenolic mofetil, an alternative antiviral and immunomodulator for the highly pathogenic avian influenza H5N1 virus infection. Biochem Biophys Res Commun 2017 Oct 7. Abstract
submitted by kickingbird at Oct, 15, 2017 from Biochem Biophys Res Commun 2017 Oct 7 (via https://www.ncbi.nlm.nih.gov/m/pubmed/29017920/)
Infection with the highly pathogenic avian influenza H5N1 virus results in a high incidence of mortality in humans. Severe complications from infection are often associated with hypercytokinemia. However, ... Tilmanis D, van Baalen C, Oh DY, Rossignol JF, et. The susceptibility of circulating human influenza viruses to tizoxanide, the active metabolite of nitazoxanide. Antiviral Res 2017 Oct 3. Abstract
submitted by kickingbird at Oct, 15, 2017 from Antiviral Res 2017 Oct 3 (via https://www.ncbi.nlm.nih.gov/m/pubmed/28986103/)
Nitazoxanide is a thiazolide compound that was originally developed as an anti-parasitic agent, but has recently been repurposed for the treatment of influenza virus infections. Thought to exert its anti-influenza ... Carter DM, Darby CA, Johnson SK, Carlock MA, et al. Elicitation of protective antibodies against a broad panel of H1N1 viruses in ferrets pre-immune to historical H1N1 influenza viruses. J Virol 2017 Oct 4. Abstract
submitted by kickingbird at Oct, 9, 2017 from J Virol 2017 Oct 4 (via https://www.ncbi.nlm.nih.gov/m/pubmed/28978709/)
Most pre-clinical animal studies test influenza vaccines in immunologically na?ve animal models, even though the results of vaccination may not accurately reflect the effectiveness of vaccine candidates ... Wong TM, Allen JD, Bebin-Blackwell AG, Carter DM,. COBRA HA elicits hemagglutination-inhibition antibodies against a panel of H3N2 influenza virus co-circulating variants. J Virol 2017 Oct 4. Abstract
submitted by kickingbird at Oct, 9, 2017 from J Virol 2017 Oct 4 (via https://www.ncbi.nlm.nih.gov/m/pubmed/28978710/)
Each influenza season, a set of wild-type viruses, representing one H1N1, one H3N2, 1-2 influenza B isolates, are selected for inclusion in the annual seasonal influenza vaccine. In order to develop broadly ... Yoon SW, Wong SS, Zhu H, Chen R, et al. Dysregulated T-Helper Type 1 (Th1):Th2 Cytokine Profile and Poor Immune Response in Pregnant Ferrets Infected With 2009 Pandemic Influenza A(H1N1) Virus. J Infect Dis 2017 Jul 18. Abstract
submitted by kickingbird at Oct, 9, 2017 from J Infect Dis 2017 Jul 18 (via https://www.ncbi.nlm.nih.gov/m/pubmed/28973317/)
Pregnancy has been associated with severe influenza, an association highlighted during the 2009 pandemic of influenza A(H1N1) virus (A[H1N1]pdm09) infection. To assess the underlying mechanism, we infected ... Wu Y, Yang D, Xu B, Liang W, et al.. Immune efficacy of an adenoviral vector-based swine influenza vaccine against antigenically distinct H1N1 strains in mice. Antiviral Res 2017 Sep 20. Abstract
submitted by kickingbird at Oct, 3, 2017 from Antiviral Res 2017 Sep 20 (via https://www.ncbi.nlm.nih.gov/m/pubmed/28941982/)
Avian-like H1N1 swine influenza viruses are prevalent in pigs and have occasionally crossed the species barrier and infected humans, which highlights the importance of preventing swine influenza. Human ... Andersen TK, Zhou F, Cox R, Bogen B, et al. A DNA vaccine that targets hemagglutinin to antigen presenting cells protects mice against H7 influenza. J Virol 2017 Sep 20. Abstract
submitted by kickingbird at Sep, 25, 2017 from J Virol 2017 Sep 20 (via https://www.ncbi.nlm.nih.gov/m/pubmed/28931687/)
Zoonotic influenza H7 viral infections have a case fatality rate of about 40%. Currently no or limited human to human spread has occurred, but we may be facing a severe pandemic threat if the virus acquires ... Naguib MM, Ulrich R, Kasbohm E, Eng CLP, et al. Natural reassortants between potentially zoonotic avian influenza viruses H5N1 and H9N2 from Egypt display distinct pathogenic phenotypes in experimentally infected chickens and ferrets. J Virol 2017 Sep 20. Abstract
submitted by kickingbird at Sep, 25, 2017 from J Virol 2017 Sep 20 (via https://www.ncbi.nlm.nih.gov/m/pubmed/28931674/)
Co-circulation of zoonotic highly pathogenic avian influenza virus (HPAIV) H5N1 and AIV of subtype H9N2 among poultry in Egypt for at least six years should render this country a hypothetical hotspot for ... Kiso M, Iwatsuki-Horimoto K, Yamayoshi S, Uraki R,. Emergence of Oseltamivir-Resistant H7N9 Influenza Viruses in Immunosuppressed Cynomolgus Macaques. J Infect Dis 2017;216:582-593. Abstract
submitted by kickingbird at Sep, 25, 2017 from J Infect Dis 2017;216:582-593 (via https://www.ncbi.nlm.nih.gov/m/pubmed/28931216/)
Antiviral compounds (eg, the neuraminidase inhibitor oseltamivir) are invaluable for the treatment of individuals infected with influenza A viruses of the H7N9 subtype (A[H7N9]), which have infected and ... Skowronski DM, Chambers C, De Serres G, Sabaiduc S. Age-Related Differences in Influenza B Infection by Lineage in a Community-Based Sentinel System, 2010-2011 to 2015-2016, Canada. J Infect Dis 2017;216:697-702.. Abstract
submitted by kickingbird at Sep, 25, 2017 from J Infect Dis 2017;216:697-702. (via https://www.ncbi.nlm.nih.gov/m/pubmed/28934439/)
Age-related differences in influenza B lineage detection were explored in the community-based Canadian Sentinel Practitioner Surveillance Network (SPSN) from 2010-2011 to 2015-2016. Whereas >80% of B(Victoria) ... 5172 items, 20/Page, Page[153/259][|<<] [|<] [151] [152] [153] [154] [155] [156] [157] [158] [159] [160] [>|] [>>|] |
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