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2026-3-5 6:24:03
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Zhong JC, Zhong S, Touyon L, Ho F, Au NYM, Cheng S. Repeat influenza vaccination effects in 2021/22 and 2022/23 in a community-based cohort in Hong Kong. J Infect Dis. 2026 Jan 28:jiag051.  Abstract  
submitted by kickingbird at Jan, 29, 2026 from J Infect Dis. 2026 Jan 28:jiag051 (via https://academic.oup.com/jid/advance-article/doi/10.1093/inf)
Background: Repeated annual influenza vaccination has been associated with attenuated immune responses and reduced clinical effectiveness. Most studies of repeat vaccination immunogenicity have focused ...

Ye, Y., Shuai, H., Song, Y. et al. Genomic features associated with sustained mammalian transmission of avian influenza A viruses. Nat Microbiol (2026).  Abstract  
submitted by kickingbird at Jan, 28, 2026 from Nat Microbiol (2026) (via https://link.springer.com/article/10.1038/s41564-025-02257-4)
Comparably few lineages of influenza A virus (IAV) have evolved long-term sustained transmission in mammals. The reasons remain largely unknown, and the possibility of avian IAVs evolving sustained mammalian ...

Morel, G., Pham, A., Morgenstern, C. et al. An outbreak of highly pathogenic avian influenza H5N1 could impact the dairy cattle sector and the broader economy in the United States. Commun Earth Environ (2026).  Abstract  
submitted by kickingbird at Jan, 28, 2026 from Commun Earth Environ (2026) (via https://link.springer.com/article/10.1038/s43247-025-03153-9)
The outbreak of Highly Pathogenic Avian Influenza H5N1 in U.S. dairy cattle poses substantial risks to public health, economic sustainability of farming, and global food systems. Using a Computable General ...

Zorian T Thornton, etc.,al. [preprint]antigen-prime: Simulating coupled genetic and antigenic evolution of influenza virus. https://doi.org/10.64898/2026.01.23.701420.  Abstract  
submitted by kickingbird at Jan, 27, 2026 from https://doi.org/10.64898/2026.01.23.701420 (via https://www.biorxiv.org/content/10.64898/2026.01.23.701420v1)
Seasonal influenza virus undergoes rapid antigenic drift to escape population immunity. Computational methods can be used to organize viral genetic diversity into antigenically similar variants and estimate ...

Belser, J.A., Brock, N., Sun, X. et al. Oseltamivir and baloxavir monotherapy and combination therapy efficacy against clade 2.3.4.4b A(H5N1) influenza virus infection in ferrets. Commun Biol (2026).  Abstract  
submitted by kickingbird at Jan, 27, 2026 from Commun Biol (2026) (via https://link.springer.com/article/10.1038/s42003-026-09607-w)
Neuraminidase inhibitors (NAIs) and cap-dependent endonuclease inhibitors (CENIs) represent two classes of antiviral drugs recommended for early treatment of patients with seasonal influenza A virus (IAV) ...

Arata Hidano, etc.,al. Epidemiology and Risk Modelling of Influenza A Virus Within and Between Pig Herds in Northern Lao PDR. Transboundary and Emerging Diseases.  Abstract  
submitted by kickingbird at Jan, 26, 2026 from Transboundary and Emerging Diseases (via https://onlinelibrary.wiley.com/doi/10.1155/tbed/2407533)
Animal-origin influenza A virus (IAV) is a perennial candidate for causing the next pandemic. With high risk for interspecies IAV transmission but limited resources for surveillance, particularly in rural ...

Marco Falchieri, etc.,al. Detection of Two High Pathogenicity Avian Influenza Virus (HPAIV) Subtypes, H5N1 and H5N5, in a Mass Mortality Event in Wild Seabirds and Co-Location With Dead Seals. Transboundary and Emerging Diseases.  Abstract  
submitted by kickingbird at Jan, 26, 2026 from Transboundary and Emerging Diseases (via https://onlinelibrary.wiley.com/doi/10.1155/tbed/4680980)
H5Nx Clade 2.3.4.4b high pathogenicity avian influenza viruses (HPAIVs) have been detected repeatedly in Great Britain (GB) since autumn 2020, with H5N1 dominating detections but with low level detection ...

Teitelbaum CS, Prosser DJ, Ackerman JT, Ahmed S, A. Waterfowl Move Less in Heterogeneous and Human-Populated Landscapes, With Implications for Spread of Avian Influenza Viruses. Ecol Lett. 2026 Jan;29(1):e70265.  Abstract  
submitted by kickingbird at Jan, 25, 2026 from Ecol Lett. 2026 Jan;29(1):e70265 (via https://onlinelibrary.wiley.com/doi/10.1111/ele.70265)
Animal movements contribute to the spread of infectious diseases and are driven in part by environmental conditions. We investigated the links among the environment, animal movement, and infectious disease ...

Kai Sha, etc.,al. High-Throughput Neutralizing Antibody (nAb) Assay Using a Pseudovirus Platform for Seasonal and Pandemic Influenza Studies. Open Forum Infectious Diseases.  Abstract  
submitted by kickingbird at Jan, 25, 2026 from Open Forum Infectious Diseases (via https://academic.oup.com/ofid/article/13/Supplement_1/ofaf69)
In early 2024, a high-pathogenicity avian influenza (HPAI) H5N1 began spreading from wild birds to domestic fowl and eventually livestock and wildlife in the United States. Human infections have been limited ...

Anuradha Rao, etc.,al. Detection of highly pathogenic avian influenza A(H5N1) in contrived nasal swab specimens using commercial molecular influenza A tests. Open Forum Infectious Diseases.  Abstract  
submitted by kickingbird at Jan, 25, 2026 from Open Forum Infectious Diseases (via https://academic.oup.com/ofid/article/13/Supplement_1/ofaf69)
At least 70 human cases of highly pathogenic avian influenza (HPAI) A H5N1 (i.e., "bird flu") have been reported in the U.S. since 2024, primarily among individuals with exposure to dairy cattle or poultry. ...

Yohei Watanabe, etc.,al. Intra-patient neuraminidase mutations in avian H5N1 influenza virus reduce sialidase activity to complement weaker hemagglutinin binding and facilitate human infection. PLOS Pathogens.  Abstract  
submitted by kickingbird at Jan, 25, 2026 from PLOS Pathogens (via https://journals.plos.org/plospathogens/article?id=10.1371/j)
Clade 2.2 H5N1 influenza viruses have caused an unusually high number of human infections, providing a unique opportunity to investigate early molecular steps associated with host adaptation. Although ...

Mana Esaki, etc.,al. Genetically distinct H5N2 high pathogenicity avian influenza virus isolated from a peregrine falcon on Amami-Oshima Island, Japan, harboring enhanced pathogenicity-associated amino acids in the PA pro. Virology.  Abstract  
submitted by kickingbird at Jan, 24, 2026 from Virology (via https://www.sciencedirect.com/science/article/abs/pii/S00426)
We report the first confirmed case of high pathogenicity avian influenza virus (HPAIV) infection in a peregrine falcon (Falco peregrinus) on Amami-Oshima Island, a region known for its unique biodiversity. ...

Liang Gong, etc.,al. Development of a dually-amplified analytical method for rapid, specific and ultrasensitive detection of avian influenza virus H5N1 DNA. Microchemical Journal.  Abstract  
submitted by kickingbird at Jan, 24, 2026 from Microchemical Journal (via https://www.sciencedirect.com/science/article/abs/pii/S00262)
Influenza virus infections, particularly those caused by the Avian influenza virus, result in millions of deaths and substantial economic losses annually. Early diagnosis of the pathogen during the initial ...

Jonathan E. Pekar, etc.,al. Can H5N1 avian influenza in dairy cattle be contained in the US?. Cell.  Abstract  
submitted by kickingbird at Jan, 24, 2026 from Cell (via https://www.sciencedirect.com/science/article/abs/pii/S00928)
The emergence and sustained spread of H5N1 in US dairy cattle since 2024 have demonstrated that highly pathogenic avian influenza (HPAI) is capable of establishing long-term transmission in livestock. ...

Brigleb PH, Sharp B, Lazure L, Livingston B, Patri. Immune history confers antibody- and T cell-dependent cross-protection against highly pathogenic avian influenza H5N1 viruses. J Virol 0:e02088-25.  Abstract  
submitted by kickingbird at Jan, 24, 2026 from J Virol 0:e02088-25 (via https://journals.asm.org/doi/10.1128/jvi.02088-25)
The outbreak of highly pathogenic avian H5 influenza (HPAI) clade 2.3.4.4b in cattle has spread across the United States. Mice with pre-existing immunity to H1N1 virus or with a live-attenuated influenza ...

Puente-Massaguer, E., Galdino Andrade, T., Scherm,. An H5N1 clade 2.3.4.4b virus vaccine that elicits cross-protective antibodies against conserved domains of H5 and N1 glycoproteins. Nat Commun (2026).  Abstract  
submitted by kickingbird at Jan, 24, 2026 from Nat Commun (2026) (via https://link.springer.com/article/10.1038/s41467-026-68457-6)
The continuous evolution and global spread of highly pathogenic avian influenza (HPAI) H5N1 viruses, particularly clade 2.3.4.4b, pose major challenges for pandemic preparedness. This study evaluates a ...

Nemeth, N.M., Andreasen, V.A., Weyna, A.A.W. et al. Disease susceptibility and biological vulnerability of black vultures to fatal clade 2.3.4.4b highly pathogenic avian influenza A(H5N1) virus infection. Sci Rep (2026).  Abstract  
submitted by kickingbird at Jan, 24, 2026 from Sci Rep (2026) (via https://link.springer.com/article/10.1038/s41598-026-36912-5)
High numbers of black vultures (Coragyps atratus) have died from clade 2.3.4.4b highly pathogenic (HP) avian influenza A(H5N1) virus (IAV) since its initial detection in North America in November 2021. ...

Zhai, S., Dou, Y., Cui, Z. et al. Emerging trends and hotspots in Oseltamivir resistance: insights from a bibliometric investigation. Naunyn-Schmiedeberg´s Arch Pharmacol (2026).  Abstract  
submitted by kickingbird at Jan, 24, 2026 from Naunyn-Schmiedeberg´s Arch Pharmacol (2026) (via https://link.springer.com/article/10.1007/s00210-026-04977-8)
Influenza has long been a serious global public health problem, and the risk of drug resistance to Oseltamivir, as a first-line antiviral drug, cannot be ignored. Although some research findings have been ...

Hew, Y.L., Isoda, N., Miura, T. et al. Evaluation of the Efficacy of Low-Concentration Gaseous Chlorine Dioxide in Inactivating Airborne H5 High Pathogenicity Avian Influenza Virus in Vivo Model. Food Environ Virol 18, 4 (2026).  Abstract  
submitted by kickingbird at Jan, 24, 2026 from Food Environ Virol 18, 4 (2026) (via https://link.springer.com/article/10.1007/s12560-026-09677-3)
H5 high pathogenicity avian influenza virus (HPAIV) continues to spread globally, causing several high pathogenicity avian influenza (HPAI) outbreaks in poultry and significant economic losses. Biosecurity ...

Joshua Mack, Amy Hurford. [preprint]Using an evolutionary epidemiological model of pandemics to estimate the infection fatality ratio for humans infected with avian influenza viruses. https://doi.org/10.64898/2026.01.21.26344526.  Abstract  
submitted by kickingbird at Jan, 24, 2026 from https://doi.org/10.64898/2026.01.21.26344526 (via https://www.medrxiv.org/content/10.64898/2026.01.21.26344526)
The risk of highly pathogenic avian influenza infection to humans is challenging to estimate because many human avian influenza virus (AIV) infections are undetected as they may be asymptomatic, symptomatic ...

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