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2025-12-5 22:08:40
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Kobayashi D, Hiono T, Arakawa H, Kaji H, Ohkawara. Deglycosylation and truncation in the neuraminidase stalk are functionally equivalent in enhancing the pathogenicity of a high pathogenicity avian influenza virus in chickens. J Virol. 2025 Feb 14:e0147824.  Abstract  
submitted by kickingbird at Feb, 15, 2025 from J Virol. 2025 Feb 14:e0147824 (via https://journals.asm.org/doi/10.1128/jvi.01478-24)
Influenza A viruses with fewer amino acids in the neuraminidase (NA) stalk domain are primarily isolated from chickens rather than wild ducks, indicating that a shortened NA stalk is considered an adaptation ...

Liu J, An T, Peng J, Zhu Q, Zhao H, Liang Z, Mo K,. An amplification-free digital droplet assay for influenza A viral RNA based on CRISPR/Cas13a. Analyst. 2025 Feb 14.  Abstract  
submitted by kickingbird at Feb, 15, 2025 from Analyst. 2025 Feb 14 (via https://pubs.rsc.org/en/content/articlelanding/2025/an/d4an0)
Most of the CRISPR-based RNA detection methods are combined with amplification to improve sensitivity, which lead to some drawbacks such as aerosol pollution, complicated operation, and amplification bias. ...

Kaitlyn M. Sarlo Davila, etc.,al. [preprint]Transmission of highly pathogenic avian influenza H5N1 to calves fed unpasteurized milk from experimentally infected cows. https://doi.org/10.31220/agriRxiv.2025.0030.  Abstract  
submitted by kickingbird at Feb, 14, 2025 from https://doi.org/10.31220/agriRxiv.2025.0030 (via https://www.cabidigitallibrary.org/doi/10.31220/agriRxiv.202)
Highly pathogenic avian influenza (HPAI) H5N1 clade 2.3.4.4b genotype B3.13 was confirmed in a dairy cow in Texas on March 25, 2024, by the US Department of Agriculture (USDA) National Veterinary Services ...

Peter Cronin, Jurre Siegers, Vireak Heang et al. [preprint]Air sampling accurately captures circulating zoonotic viral diversity emerging from poultry live-animal markets. https://doi.org/10.21203/rs.3.rs-5682962/v1.  Abstract  
submitted by kickingbird at Feb, 14, 2025 from https://doi.org/10.21203/rs.3.rs-5682962/v1 (via https://www.researchsquare.com/article/rs-5682962/v1)
Environmental surveillance has emerged as a pivotal strategy for early detection of pathogens that pose threats to humans (1) but has not been utilized for zoonotic agents. In Asia, live-bird markets (LBMs) ...

Liang Wang, George F. Gao. A brief history of human infections with H5Ny avian influenza viruses. Cell Host & Microbe, Volume 33, Issue 2, 176 - 181.  Abstract  
submitted by kickingbird at Feb, 14, 2025 from Cell Host & Microbe, Volume 33, Issue 2, 176 - 181 (via https://www.cell.com/cell-host-microbe/abstract/S1931-3128(2)
The H5 subtype of avian influenza viruses (AIVs) presents a continued threat to human health, intensifying with the H5N1 outbreak in cattle herds and onward transmission to humans. In this commentary, ...

Chi M, Liu F, Chi H, Liu P, Xu B, Zhang D. Nomogram construction based on characteristic genes and clinical variables to predict the risk of multiple organ dysfunction syndrome caused by influenza in children. Transl Pediatr. 2025 Jan 24;14(1):25-41.  Abstract  
submitted by kickingbird at Feb, 14, 2025 from Transl Pediatr. 2025 Jan 24;14(1):25-41 (via https://tp.amegroups.org/article/view/133690/html)
Background: Screening for risk factors for the occurrence of multiple organ dysfunction syndrome (MODS) caused by pediatric influenza is an essential approach to improving treatment interventions and stratifying ...

Ryt-Hansen P, George S, Hjulsager CK, Trebbien R,. Rapid Surge of Reassortant A(H1N1) Influenza Viruses in Danish Swine and their Zoonotic Potential. Emerg Microbes Infect. 2025 Feb 13:2466686.  Abstract  
submitted by kickingbird at Feb, 14, 2025 from Emerg Microbes Infect. 2025 Feb 13:2466686 (via https://www.tandfonline.com/doi/full/10.1080/22221751.2025.2)
In 2018, a single detection of a novel reassortant swine influenza A virus (swIAV) was made in Denmark. The hemagglutinin (HA) of the virus was from the H1N1 pandemic 2009 (H1N1pdm09) lineage and the neuraminidase ...

Leonard J, Harker EJ, Szablewski CM, et al. Seroprevalence of Highly Pathogenic Avian Influenza A(H5) Virus Infections Among Bovine Veterinary Practitioners - United States, September 2024. MMWR Morb Mortal Wkly Rep 2025;74:50–52.  Abstract  
submitted by kickingbird at Feb, 14, 2025 from MMWR Morb Mortal Wkly Rep 2025;74:50–52 (via https://www.cdc.gov/mmwr/volumes/74/wr/mm7404a2.htm)
SummaryWhat is already known about this topic?Highly pathogenic avian influenza (HPAI) A(H5) virus infections have been detected in humans exposed to infected dairy cattle.What is added by this report?Public ...

Alexander Nagy, Lenka ?erníková, Kamil Sedlák. [preprint]Genetic data and meteorological conditions: unravelling the windborne transmission of H5N1 high-pathogenicity avian influenza between commercial poultry outbreaks. https://doi.org/10.1101/2025.02.12.637829.  Abstract  
submitted by kickingbird at Feb, 13, 2025 from https://doi.org/10.1101/2025.02.12.637829 (via https://www.biorxiv.org/content/10.1101/2025.02.12.637829v1)
Understanding the transmission routes of high-pathogenicity avian influenza (HPAI) is crucial for developing effective control measures to prevent its spread. In this context, windborne transmission, the ...

Kaler L, Engle EM, Corkran M, Iverson E, Boboltz A. Mucus Physically Restricts Influenza A Viral Particle Access to the Epithelium. Adv Biol (Weinh). 2025 Feb 12:e2400329.  Abstract  
submitted by kickingbird at Feb, 13, 2025 from Adv Biol (Weinh). 2025 Feb 12:e2400329 (via https://onlinelibrary.wiley.com/doi/10.1002/adbi.202400329)
Prior work suggests influenza A virus (IAV) crosses the airway mucus barrier in a sialic acid-dependent manner through the actions of the viral envelope proteins, hemagglutinin, and neuraminidase. However, ...

Sun Y, Wei Y, Han X, Wang Y, Yin Q, Zhang Y, Yang. Effect of Inoculation Volume on a Mouse Model of Influenza Virus Infected with the Same Viral Load. Vaccines. 2025; 13(2):173.  Abstract  
submitted by kickingbird at Feb, 13, 2025 from Vaccines. 2025; 13(2):173 (via https://www.mdpi.com/2076-393X/13/2/173)
Background: Influenza is a highly contagious respiratory disease that poses significant health and economic burdens. Mice are commonly used as animal models for studying influenza virus pathogenesis and ...

Goujgoulova G, Koev K. Risk Assessment of Spread of the Influenza A Virus in Cows in South Bulgaria. Viruses. 2025; 17(2):246.  Abstract  
submitted by kickingbird at Feb, 13, 2025 from Viruses. 2025; 17(2):246 (via https://www.mdpi.com/1999-4915/17/2/246)
In this article, we present an assessment of the risk of the potential introduction and spread of highly pathogenic avian influenza (HPAI) in cows in Bulgaria. In the spring of 2024, we witnessed an unprecedented ...

Dhagat P, Coan J, Ganguly A, Puetz C, Silvestri D,. Enhancing Healthcare Preparedness: Lessons from a Tabletop Exercise on Highly Pathogenic Avian Influenza (HPAI). Tropical Medicine and Infectious Disease. 2025; 10.  Abstract  
submitted by kickingbird at Feb, 13, 2025 from Tropical Medicine and Infectious Disease. 2025; 10 (via https://www.mdpi.com/2414-6366/10/2/47)
Tabletop exercises offer a structured opportunity to assess strengths and potential gaps in preparedness and response plans in a safe learning environment. The New York City Health + Hospitals System-Wide ...

Partlow EA, Jaeggi-Wong A, Planitzer SD, Berg N, L. Influenza A virus rapidly adapts particle shape to environmental pressures. Nat Microbiol. 2025 Feb 10.  Abstract  
submitted by kickingbird at Feb, 12, 2025 from Nat Microbiol. 2025 Feb 10 (via https://www.nature.com/articles/s41564-025-01925-9)
Enveloped viruses such as influenza A virus (IAV) often produce a mixture of virion shapes, ranging from 100 nm spheres to micron-long filaments. Spherical virions use fewer resources, while filamentous ...

Soto G, Romero C, Gonzales M, La Rosa S, Ponce D,. Influenza Virus Surveillance in Healthcare Personnel in Peru: NAMRU SOUTH Experience and Perspective. J Infect Dis. 2025 Feb 10;231(Supplement_1):S25-S3.  Abstract  
submitted by kickingbird at Feb, 12, 2025 from J Infect Dis. 2025 Feb 10;231(Supplement_1):S25-S3 (via https://academic.oup.com/jid/article-abstract/231/Supplement)
Vaccinating healthcare personnel (HCP) is a top priority for public health globally. This strategy aims not only to protect HCP but also patients, reducing transmission of infections in healthcare services. ...

Campbell AJ, Brizuela K, Lakdawala SS. Transmission and exposure risks of dairy cow H5N1 influenza virus. mBio. 2025 Feb 11:e0294424.  Abstract  
submitted by kickingbird at Feb, 12, 2025 from mBio. 2025 Feb 11:e0294424 (via https://journals.asm.org/doi/10.1128/mbio.02944-24)
In March 2024, highly pathogenic H5N1 was detected in dairy cows; as of 12 December 2024, it had spread to over 800 herds in 16 states. The ongoing outbreak is a public health crisis affecting both humans ...

Yang, F., Cheng, L., Liu, F. et al. Genetic and molecular characterization of a novel reassortant H3N2 influenza virus from a sick pig in Eastern China in 2019. Vet Res 56, 38 (2025).  Abstract  
submitted by kickingbird at Feb, 11, 2025 from Vet Res 56, 38 (2025) (via https://link.springer.com/article/10.1186/s13567-025-01462-7)
Swine influenza viruses (SIVs) cause clinical respiratory symptoms associated with high mortality rates among pigs. Because pigs can be a “mixing vessel” for influenza viruses, the SIV might pose a serious ...

Andrew, C. L., L. McPhee, K. S. Kuchinski, J. Wigh. Bait trapping of waterfowl increases the environmental contamination of avian influenza virus (AIV). Journal of Wildlife Management e22720.  Abstract  
submitted by kickingbird at Feb, 11, 2025 from Journal of Wildlife Management e22720 (via https://wildlife.onlinelibrary.wiley.com/doi/10.1002/jwmg.22)
Highly pathogenic avian influenza virus (HPAIV) H5Nx clade 2.3.4.4b has circulated in North America since late 2021, resulting in higher rates of morbidity and mortality in wild birds than observed in ...

Okano S, Kimura A, Ogasawara T, Tagawa K, Oshima M. A Case of Autoimmune Glial Fibrillary Acidic Protein Astrocytopathy Caused by Influenza A Infection. Intern Med. 2025 Feb 8.  Abstract  
submitted by kickingbird at Feb, 11, 2025 from Intern Med. 2025 Feb 8 (via https://www.jstage.jst.go.jp/article/internalmedicine/advpub)
Autoimmune glial fibrillary acidic protein (GFAP) astrocytopathy is a new spectrum of autoimmune inflammatory nervous system disorders associated with infection, neoplasm, or drug use. We present the first ...

Sergio M. Qui?ones-Parra et al. Molecular determinants of cross-strain influenza A virus recognition by αβ T cell receptors. Sci. Immunol.10,eadn3805(2025).  Abstract  
submitted by kickingbird at Feb, 10, 2025 from Sci. Immunol.10,eadn3805(2025) (via https://www.science.org/doi/10.1126/sciimmunol.adn3805)
Cross-reactive αβ T cell receptors (TCRs) recognizing multiple peptide variants can provide effective control of rapidly evolving viruses yet remain understudied. By screening 12 naturally occurring influenza-derived ...

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