CHAMBERS BS, Li Y, Hodinka RL, Hensley SE, et al. Recent H3N2 influenza virus clinical isolates rapidly acquire hemagglutinin or neuraminidase mutations when propagated for antigenic analyses. J Virol. 2014 Jul 2. pii: JVI.01077-14.. Abstract
submitted by kickingbird at Jul, 13, 2014 from J Virol. 2014 Jul 2. pii: JVI.01077-14. (via http://www.ncbi.nlm.nih.gov/pubmed/24991002)
Prior to serological testing, influenza viruses are typically propagated in eggs or cell culture. Recent human H3N2 strains bind to cells with low avidity. Here, we isolated 9 primary H3N2 viral isolates ... MORRISON J, Josset L, Tchitchek N, Chang J, et al. H7N9 and other pathogenic avian influenza viruses elicit a three-pronged transcriptomic signature that is reminiscent of 1918 influenza and associated with lethal outcome in mice. J Virol. 2014 Jul 2. pii: JVI.00570-14. Abstract
submitted by kickingbird at Jul, 13, 2014 from J Virol. 2014 Jul 2. pii: JVI.00570-14 (via http://www.ncbi.nlm.nih.gov/pubmed/24991006)
Modulating the host response is a promising approach to treating influenza, a virus whose pathogenesis is determined in part by the reaction it elicits within the host. Though the pathogenicity of emerging ... HUANG SS, Banner D, Paquette SG, Leon AJ, et al. Pathogenic Influenza B Virus in the Ferret Model Establishes Lower Respiratory Tract Infection. J Gen Virol. 2014 Jul 2. pii: vir.0.064352-0. Abstract
submitted by kickingbird at Jul, 13, 2014 from J Gen Virol. 2014 Jul 2. pii: vir.0.064352-0 (via http://www.ncbi.nlm.nih.gov/pubmed/24989173)
Influenza B viruses have become increasingly more prominent during influenza seasons. Influenza B species is typically considered a mild disease that receives less attention than influenza A species, but ... GARCIA-BARRENO B, Delgado T, Benito S, Casas I, et. Exploring the antigenic relatedness of influenza virus hemagglutinins with strain-specific polyclonal antibodies. J Gen Virol. 2014 Jul 7. pii: vir.0.067413-0. Abstract
submitted by kickingbird at Jul, 13, 2014 from J Gen Virol. 2014 Jul 7. pii: vir.0.067413-0 (via http://www.ncbi.nlm.nih.gov/pubmed/25000959)
Alternative methods to the standard hemagglutination inhibition (HI) and neutralization tests to probe the antigenic properties of the influenza virus hemagglutinin (HA) were developed in this study. Vaccinia ... KANDEIL A, El-Shesheny R, Maatouq AM, Moatasim Y,. Genetic and antigenic evolution of H9N2 avian influenza viruses circulating in Egypt between 2011 and 2013. Arch Virol. 2014 Jul 3.. Abstract
submitted by kickingbird at Jul, 13, 2014 from Arch Virol. 2014 Jul 3. (via http://www.ncbi.nlm.nih.gov/pubmed/24990416)
Avian influenza virus subtype H9N2 has been circulating in the Middle East since the 1990s. For uncertain reasons, H9N2 was not detected in Egyptian farms until the end of 2010. Circulation of H9N2 viruses ... PRABAKARAN M, Rajesh Kumar S, Ashok Raj KV, Wu X,. Cross-protective efficacy of baculovirus displayed hemagglutinin against highly pathogenic influenza H7 subtypes. Antiviral Res. 2014 Jul 2. pii: S0166-3542. Abstract
submitted by kickingbird at Jul, 13, 2014 from Antiviral Res. 2014 Jul 2. pii: S0166-3542 (via http://www.ncbi.nlm.nih.gov/pubmed/24997413)
The outbreak of human infections with avian-origin H7N9 influenza has raised global concerns about a potential human pandemic. Therefore, the generation of simple and reliable newer vaccines is high priority ... Donis RO; The Influenza Cell Culture Working Group. Performance characteristics of qualified cell lines for isolation and propagation of influenza viruses for vaccine manufacturing.. Vaccine. 2014 Jun 24. pii: S0264-410X(14)00846-9.. Abstract
submitted by kickingbird at Jul, 7, 2014 from Vaccine. 2014 Jun 24. pii: S0264-410X(14)00846-9. (via http://www.ncbi.nlm.nih.gov/pubmed/24975811)
Cell culture is now available as a method for the production of influenza vaccines in addition to eggs. In accordance with currently accepted practice, viruses recommended as candidates for vaccine manufacture ... AXELSEN JB, Yaari R, Grenfell BT, Stone L, et al. Multiannual forecasting of seasonal influenza dynamics reveals climatic and evolutionary drivers. Proc Natl Acad Sci U S A. 2014;111:9538-42. Abstract
submitted by kickingbird at Jul, 7, 2014 from Proc Natl Acad Sci U S A. 2014;111:9538-42 (via http://www.ncbi.nlm.nih.gov/pubmed/24979763)
Human influenza occurs annually in most temperate climatic zones of the world, with epidemics peaking in the cold winter months. Considerable debate surrounds the relative role of epidemic dynamics, viral ... KANG HM, Lee EK, Song BM, Jeong J, et al. Genetic and pathogenic characteristics of H1 avian and swine influenza A viruses. J Gen Virol. 2014 Jun 27. Abstract
submitted by kickingbird at Jul, 7, 2014 from J Gen Virol. 2014 Jun 27 (via http://www.ncbi.nlm.nih.gov/pubmed/24973238)
This study examined the potential for cross-species transmission of influenza viruses by comparing the genetic and pathogenic characteristics of H1 avian influenza viruses (AIVs) with different host origins ... MOON H, Hong M, Kim JK, Seon B, et al. H3N2 canine influenza virus with the matrix gene from the pandemic A/H1N1 virus: infection dynamics in dogs and ferrets. Epidemiol Infect. 2014 Jun 30:1-9. Abstract
submitted by kickingbird at Jul, 7, 2014 from Epidemiol Infect. 2014 Jun 30:1-9 (via http://www.ncbi.nlm.nih.gov/pubmed/24977303)
After an outbreak of pandemic influenza A/H1N1 (pH1N1) virus, we had previously reported the emergence of a recombinant canine influenza virus (CIV) between the pH1N1 virus and the classic H3N2 CIV. Our ... HAMILTON BS, Chung C, Cyphers SY, Rinaldi VD, et a. Inhibition of influenza virus infection and hemagglutinin cleavage by the protease inhibitor HAI-2. Biochem Biophys Res Commun. 2014 Jun 27. Abstract
submitted by kickingbird at Jul, 7, 2014 from Biochem Biophys Res Commun. 2014 Jun 27 (via http://www.ncbi.nlm.nih.gov/pubmed/24978308)
Influenza virus remains a significant concern to public health, with the continued potential for a high fatality pandemic. Vaccination and antiviral therapeutics are effective measures to circumvent influenza ... SYED MUSTHAQ S, Kumar SR, Szyporta M, Kwang J, et. Immunization with baculovirus displayed H6 hemagglutinin vaccine protects mice against lethal H6 influenza virus challenge. Antiviral Res. 2014 Jun 25. pii: S0166-3542(14)001. Abstract
submitted by kickingbird at Jul, 7, 2014 from Antiviral Res. 2014 Jun 25. pii: S0166-3542(14)001 (via http://www.ncbi.nlm.nih.gov/pubmed/24973759)
Low pathogenic influenza viruses of H6 hemagglutinin (HA) subtype have a high prevalence among aquatic and domestic birds and have caused outbreaks in poultry worldwide. The first human infection with ... Ren L, Yu X, Zhao B, Wu F, Jin Q, Zhang X, et al. Infection with Possible Precursor of Avian Influenza A(H7N9) Virus in a Child, China, 2013. Emerg Infect Dis. 2014 Aug. Abstract
submitted by kickingbird at Jul, 4, 2014 from Emerg Infect Dis. 2014 Aug (via http://dx.doi.org/10.3201/eid2008.140325)
During the early stage of the avian influenza A(H7N9) epidemic in China in March 2013, a strain of the virus was identified in a 4-year-old boy with mild influenza symptoms. Phylogenetic analysis indicated ... WIKRAMARATNA PS, Pybus OG, Gupta S. Contact between bird species of different lifespans can promote the emergence of highly pathogenic avian influenza strains. Proc Natl Acad Sci U S A. 2014 Jun 23.. Abstract
submitted by kickingbird at Jun, 29, 2014 from Proc Natl Acad Sci U S A. 2014 Jun 23. (via http://www.ncbi.nlm.nih.gov/pubmed/24958867)
Outbreaks of highly pathogenic strains of avian influenza viruses (AIVs) cause considerable economic losses to the poultry industry and also pose a threat to human life. The possibility that one of these ... AEFFNER F, Woods PS, Davis IC. Activation of A1-adenosine Receptors Promotes Leukocyte Recruitment to the Lung and Attenuates Acute Lung Injury in Mice Infected with Influenza A/WSN/33 (H1N1) Virus. J Virol. 2014 Jun 25. pii: JVI.01068-14. Abstract
submitted by kickingbird at Jun, 29, 2014 from J Virol. 2014 Jun 25. pii: JVI.01068-14 (via http://www.ncbi.nlm.nih.gov/pubmed/24965449)
We have shown that bronchoalveolar epithelial A1-adenosine receptors (A1-AdoR) are activated in influenza A virus-infected mice. Alveolar macrophages and neutrophils also express A1-AdoRs and we hypothesized ... OHKURA T, Momose F, Ichikawa R, Takeuchi K, et al. Influenza A virus hemagglutinin and neuraminidase mutually accelerate their apical targeting through clustering of lipid rafts. J Virol. 2014 Jun 25. pii: JVI.00586-14. Abstract
submitted by kickingbird at Jun, 29, 2014 from J Virol. 2014 Jun 25. pii: JVI.00586-14 (via http://www.ncbi.nlm.nih.gov/pubmed/24965459)
In polarized epithelial cells, influenza A virus hemagglutinin (HA) and neuraminidase (NA) are intrinsically associated with lipid rafts and target the apical plasma membrane for viral assembly and budding. ... WU NC, Young AP, Al-Mawsawi LQ, Olson CA, et al. High-throughput identification of loss-of-function mutations for anti-interferon activity in influenza A virus NS segment. J Virol. 2014 Jun 25. pii: JVI.01494-14.. Abstract
submitted by kickingbird at Jun, 29, 2014 from J Virol. 2014 Jun 25. pii: JVI.01494-14. (via http://www.ncbi.nlm.nih.gov/pubmed/24965464)
Viral proteins often display several functions which require multiple assays to dissect their genetic basis. Here, we describe a systematic approach to screen for loss-of-function mutations that confer ... NELSON MI, Wentworth DE, Culhane MR, Vincent AL, e. Introductions and evolution of human-origin seasonal influenza A viruses in multinational swine populations. J Virol. 2014 Jun 25. pii: JVI.01080-14. Abstract
submitted by kickingbird at Jun, 29, 2014 from J Virol. 2014 Jun 25. pii: JVI.01080-14 (via http://www.ncbi.nlm.nih.gov/pubmed/24965467)
The capacity of influenza A viruses to cross species barriers presents a continual threat to human and animal health. Knowledge of the human-swine interface is particularly important for understanding ... YEN HL, Zhou J, Choy KT, Sia SF, et al. The R292 K mutation that confers resistance to neuraminidase inhibitors leads to competitive fitness loss of A/Shanghai/1/2013 (H7N9) influenza virus in ferrets.. J Infect Dis. 2014 Jun 20. pii: jiu353. Abstract
submitted by kickingbird at Jun, 29, 2014 from J Infect Dis. 2014 Jun 20. pii: jiu353 (via http://www.ncbi.nlm.nih.gov/pubmed/24951824)
BACKGROUND:
?The neuraminidase (NA) inhibitors are the only licensed therapeutic option for human zoonotic H7N9 infections. An NA-R292 K mutation that confers broad-spectrum resistance to NA inhibitors ... WANG J, Li F, Sun R, Gao X, et al. Klebsiella pneumoniae Alleviates Influenza-Induced Acute Lung Injury via Limiting NK Cell Expansion. J Immunol. 2014 Jun 20. pii: 1303303.. Abstract
submitted by kickingbird at Jun, 29, 2014 from J Immunol. 2014 Jun 20. pii: 1303303. (via http://www.ncbi.nlm.nih.gov/pubmed/24951819)
A protective effect induced by bacterial preinfection upon a subsequent lethal influenza virus infection has been observed, but the underlying immune mechanisms have not yet been fully elucidated. In this ... 9876 items, 20/Page, Page[375/494][|<<] [|<] [371] [372] [373] [374] [375] [376] [377] [378] [379] [380] [>|] [>>|] |
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