HUANG SS, Banner D, Paquette SG, Leon AJ, et al. Pathogenic Influenza B Virus in the Ferret Model Establishes Lower Respiratory Tract Infection. J Gen Virol. 2014 Jul 2. pii: vir.0.064352-0
Influenza B viruses have become increasingly more prominent during influenza seasons. Influenza B species is typically considered a mild disease that receives less attention than influenza A species, but has been causing 20% to 50% of the total influenza incidence in several regions around the world. Although there is increasing evidence of mid to lower respiratory tract diseases such as bronchitis and pneumonia in influenza B patients, little is known about the pathogenesis of recent influenza B viruses. Here we investigated the clinical and pathological profiles of infection with strains representing the two current co-circulating B lineages (B/Yamagata and B/Victoria) in the ferret model. Specifically, we studied two B/Victoria (B/Brisbane/60/2008 and B/Bolivia/1526/2010) and two B/Yamagata (B/Florida/04/2006 and B/Wisconsin/01/2010) strain infections in ferrets and observed strain-specific but not lineage-specific pathogenicity. We found B/Brisbane/60/2008 caused the most severe clinical illness and B/Brisbane/60/2008 and the B/Yamagata strains instigated pathology in the middle to lower respiratory tract. Importantly, B/Brisbane/60/2008 established efficient lower respiratory tract infection with high viral burden. Phylogenetic analyses demonstrated profound reassortment among recent influenza B viruses which indicated the genetic make-up of B/Brisbane/60/2008 differed from the other strains and resembled the 2002-2003 influenza B global outbreak strain, B/Brisbane/32/2002. This may explain the pathogenicity difference post infection in ferrets. Our study characterized influenza B infections in ferrets and this model may aid in the future development of effective influenza therapeutic treatment.
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