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2026-3-18 9:09:49
Article

Jenny J. Ahn, etc.,al. [preprint]Influenza hemagglutinin subtypes have different sequence constraints despite sharing extremely similar structures. https://doi.org/10.64898/2026.01.05.697808.  Abstract  
submitted by kickingbird at Jan, 9, 2026 from https://doi.org/10.64898/2026.01.05.697808 (via https://www.biorxiv.org/content/10.64898/2026.01.05.697808v1)
Hemagglutinins (HA) from different influenza A virus subtypes share as little as ~40% amino acid identity, yet their protein structure and cell entry function are highly conserved. Here we examine the ...

Mei M, Zhang X, Wu Q, Xu M, Zhao Y. Virulence and transmission characteristic of H3N8 avian influenza virus circulating in chickens in China. Virulence. 2026 Jan 7:2613516.  Abstract  
submitted by kickingbird at Jan, 9, 2026 from Virulence. 2026 Jan 7:2613516 (via https://www.tandfonline.com/doi/full/10.1080/21505594.2026.2)
Influenza H3N8 viruses have been frequently isolated from chicken farms. However, comprehensive characterization of their virological properties, molecular evolution, virulence, and risk of spillover into ...

Lucas M. Ferreri, etc.,al. [preprint]Within-host adaptive evolution is limited by genetic drift in experimental human influenza A virus infections. https://doi.org/10.64898/2026.01.07.698006.  Abstract  
submitted by kickingbird at Jan, 9, 2026 from https://doi.org/10.64898/2026.01.07.698006 (via https://www.biorxiv.org/content/10.64898/2026.01.07.698006v1)
Selection of advantageous mutations drives the emergence of dominant variants during seasonal influenza epidemics. However, within-host detection of such variants remains rare, limiting our understanding ...

Claudia Trombetta, etc.,al. [preprint]Serological investigation of influenza D virus in cats and dogs in Europe. https://doi.org/10.64898/2026.01.03.697426.  Abstract  
submitted by kickingbird at Jan, 9, 2026 from https://doi.org/10.64898/2026.01.03.697426 (via https://www.biorxiv.org/content/10.64898/2026.01.03.697426v1)
A multicentric European study investigated the seroprevalence of influenza D virus (IDV) in domestic cats and dogs. Serum samples from Italy, France and Ukraine (2015-2018, 2020, 2023- 2024) showed no ...

Ishida, H., Murakami, H., Mizuno, S. et al. Development of an influenza D virus with an eight- or nine-segment genome. Sci Rep (2026).  Abstract  
submitted by kickingbird at Jan, 9, 2026 from Sci Rep (2026) (via https://link.springer.com/article/10.1038/s41598-025-34838-y)
Influenza D virus (IDV) contains seven genome segments. The M and NS segments are regulated via splicing to express two proteins each (P42 and M1 from the M segment and NS1 and NS2 from the NS segment). ...

Jiaojiao Liu, etc.,al. [preprint]Antibodies elicited by the 2025-2026 influenza vaccine in humans. https://doi.org/10.64898/2026.01.05.26343449.  Abstract  
submitted by kickingbird at Jan, 8, 2026 from https://doi.org/10.64898/2026.01.05.26343449 (via https://www.medrxiv.org/content/10.64898/2026.01.05.26343449)
A new H3N2 variant (named subclade K) possesses several key hemagglutinin substitutions and is circulating widely during the 2025-2026 influenza season. In this report, we completed experiments to determine ...

Natalie N Tarbuck, etc.,al. [preprint]Natural H5N1 immunity in dairy cows is durable and cross-protective but non-sterilizing. https://doi.org/10.64898/2026.01.06.697911.  Abstract  
submitted by kickingbird at Jan, 8, 2026 from https://doi.org/10.64898/2026.01.06.697911 (via https://www.biorxiv.org/content/10.64898/2026.01.06.697911v1)
Ongoing transmission of influenza A virus (H5N1) in U.S. dairy cattle threatens both animal and human health, underscoring the need to understand the durability of host immunity against reinfection with ...

Couty, M., Guinat, C., Fornasiero, D. et al. The role of wild birds in the global highly pathogenic avian influenza H5 panzootic, 2020–2023. npj biodivers 5, 1 (2026).  Abstract  
submitted by kickingbird at Jan, 8, 2026 from npj biodivers 5, 1 (2026) (via https://link.springer.com/article/10.1038/s44185-025-00114-5)
The emergence of Highly Pathogenic Avian Influenza (HPAI) H5 clade 2.3.4.4b has triggered an unprecedented global panzootic in recent years. As the frequency and scale of HPAI H5 outbreaks continue to ...

Cruziniani, F.E., Gabrick, E.C., Moraes, A.L.R. et. Epidemic model with seasonality for avian influenza waves in humans. Eur. Phys. J. Spec. Top. (2026).  Abstract  
submitted by kickingbird at Jan, 8, 2026 from Eur. Phys. J. Spec. Top. (2026) (via https://link.springer.com/article/10.1140/epjs/s11734-025-02)
Control strategies and prevention of infectious illnesses are challenges faced by the healthcare systems. Infectious diseases are caused by organisms and can be transmitted through different ways, such ...

Alcocer Bonifaz, M., Bhavsar, D., Siegrist, CA. et. Adjuvanted influenza vaccination increases pre-existing H5N1 cross-reactive antibodies. Nat Commun (2026).  Abstract  
submitted by kickingbird at Jan, 8, 2026 from Nat Commun (2026) (via https://link.springer.com/article/10.1038/s41467-025-68137-x)
Highly pathogenic H5N1 avian influenza viruses of clade 2.3.4.4b cause sporadic human infections and currently raise concerns about a new influenza pandemic. Heterogeneities in disease severity have been ...

Eales O, McCaw JM, Shearer FM. Modeling of H5N1 influenza virus kinetics during dairy cattle infection suggests the timing of infectiousness. PLoS Biol. 2026 Jan 5;24(1):e3003586.  Abstract  
submitted by kickingbird at Jan, 7, 2026 from PLoS Biol. 2026 Jan 5;24(1):e3003586 (via https://journals.plos.org/plosbiology/article?id=10.1371/jou)
Since early-2024 unprecedented outbreaks of highly pathogenic avian influenza H5N1 clade 2.3.4.4b have been ongoing in dairy cattle in the United States with significant consequences for the dairy industry ...

Davis CN, Hill EM, Jewell CP, Rysava K, Thompson R. A modelling assessment of the impact of control measures on highly pathogenic avian influenza transmission in poultry in Great Britain. PLoS Comput Biol. 2026 Jan 5;22(1):e1013874.  Abstract  
submitted by kickingbird at Jan, 7, 2026 from PLoS Comput Biol. 2026 Jan 5;22(1):e1013874 (via https://journals.plos.org/ploscompbiol/article?id=10.1371/jo)
Since 2020, large-scale outbreaks of highly pathogenic avian influenza (HPAI) H5N1 in Great Britain have resulted in substantial poultry mortality and economic losses. Alongside the costs, the risk of ...

Tamao K, Noji H, Tabata K. Heterogeneity of genetic sequence within quasi-species of influenza virus revealed by single-molecule sequencing. Elife. 2026 Jan 6;14:RP108882.  Abstract  
submitted by kickingbird at Jan, 7, 2026 from Elife. 2026 Jan 6;14:RP108882 (via https://elifesciences.org/articles/108882)
Influenza viruses exhibit high mutation rates and extensive genetic diversity, which hinder effective vaccine development and facilitate immune evasion (Taubenberger and Morens, 2006; Barr et al., 2010). ...

Tobias A. Ross, etc.,al. AviFluMap: An interactive tool to assess H5N1 avian influenza incursion risk in Australia via migratory birds. Ecological Informatics.  Abstract  
submitted by kickingbird at Jan, 7, 2026 from Ecological Informatics (via https://www.sciencedirect.com/science/article/pii/S157495412)
The current panzootic of clade 2.3.4.4b H5Nx high pathogenicity avian influenza (H5 HPAI bird flu) has resulted in unprecedented global impacts on both wild bird populations and poultry industries. Despite ...

Andrea Aebischer, etc.,al. [preprint]Development of a multi-species luciferase-based double antigen ELISA for the detection of antibodies against Influenza A virus H5 clade 2.3.4.4b. https://doi.org/10.64898/2026.01.05.697617.  Abstract  
submitted by kickingbird at Jan, 6, 2026 from https://doi.org/10.64898/2026.01.05.697617 (via https://www.biorxiv.org/content/10.64898/2026.01.05.697617v1)
The highly pathogenic avian influenza viruses (HPAIV) of subtype H5N1 represent a major threat to animal and public health. The current panzootic with H5 clade 2.3.4.4b has caused numerous, widespread ...

Jane L. Younger, etc.,al. [preprint]High pathogenicity avian influenza virus H5N1 clade 2.3.4.4b in Antarctica: Multiple Introductions and the First Confirmed Infection of Ice-Dependent Seals. https://doi.org/10.64898/2026.01.04.697571.  Abstract  
submitted by kickingbird at Jan, 6, 2026 from https://doi.org/10.64898/2026.01.04.697571 (via https://www.biorxiv.org/content/10.64898/2026.01.04.697571v1)
Highly pathogenic avian influenza (HPAI) H5N1 clade 2.3.4.4b has expanded rapidly across the Southern Ocean since 2023, causing extensive mortality in sub-Antarctic wildlife. Yet its penetration into Antarctica ...

Disha Bhavsar, etc.,al. Structural and functional characterization of the antigenicity of influenza A virus hemagglutinin subtype H15. Cell Reports, 27 January 2026.  Abstract  
submitted by kickingbird at Jan, 5, 2026 from Cell Reports, 27 January 2026 (via https://www.sciencedirect.com/science/article/pii/S221112472)
Avian H15 influenza viruses are closely related to H7 viruses, but only 22 H15 sequences have been reported since 1987, suggesting both rarity and minimal antigenic variation. Here, we characterized a ...

Kaitlyn Sarlo Davila, etc.,al. [preprint]Inoculation with highly pathogenic avian influenza H5N1 genotype D1.1 in naive dairy cows and dairy cows previously exposed to genotype B3.13. https://doi.org/10.21203/rs.3.rs-8339573/v1.  Abstract  
submitted by kickingbird at Jan, 4, 2026 from https://doi.org/10.21203/rs.3.rs-8339573/v1 (via https://www.researchsquare.com/article/rs-8339573/v1)
USDA confirmed by whole genome sequence the first detection of HPAI H5N1 clade 2.3.4.4b genotype D1.1 in dairy cattle. While genotype D1.1 has been the dominant strain circulating in migratory birds in ...

Ying Zeng, Tianqi Wang, Aijia Sun, Chuan Xia. Roles of Cellular Noncoding RNAs in Productive Infection of Influenza A Virus. The FASEB Journal.  Abstract  
submitted by kickingbird at Jan, 3, 2026 from The FASEB Journal (via https://faseb.onlinelibrary.wiley.com/doi/10.1096/fj.2025025)
Influenza A virus (IAV) causes annual epidemics and occasional pandemics, remaining a threat to public health and economy worldwide. It has been established that many cellular noncoding RNAs (ncRNAs) are ...

Enkhbat M, Batzorig U, Dashdondog N, Trujillo-Varg. The Highly Interrelated Morbidity Respiratory Viruses Cause Among Humans and Animals in Mongolia. Viruses. 2025 Nov 28;17(12):1557.  Abstract  
submitted by kickingbird at Jan, 3, 2026 from Viruses. 2025 Nov 28;17(12):1557 (via https://www.mdpi.com/1999-4915/17/12/1557)
Mongolia is unique for its cold climate, its large populations of free-roaming livestock, its dense populations of people living in often crowded cities with high air pollution, and its subsequent elevated ...

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