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2024-4-18 15:27:21
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Cogdale J, Kele B, Myers R, Harvey R, Lofts A, Mik. A case of swine influenza A(H1N2)v in England, November 2023. Euro Surveill. 2024 Jan;29(3).  Abstract  
submitted by kickingbird at Jan, 20, 2024 from Euro Surveill. 2024 Jan;29(3) (via https://www.eurosurveillance.org/content/10.2807/1560-7917.E)
Under International Health Regulations from 2005, a human infection caused by a novel influenza A virus variant is considered an event that has potential for high public health impact and is immediately ...

Hamza H, Ghosh M, L?ffler MW, Rammensee HG, Planz. Identification and Relative Abundance of Naturally Presented and Cross-reactive Influenza A virus MHC class I-restricted T Cell Epitopes. Emerg Microbes Infect. 2024 Jan 19:2306959.  Abstract  
submitted by kickingbird at Jan, 20, 2024 from Emerg Microbes Infect. 2024 Jan 19:2306959 (via https://www.tandfonline.com/doi/full/10.1080/22221751.2024.2)
Cytotoxic T lymphocytes are key for controlling viral infection. Unraveling CD8+ T cell-mediated immunity to distinct influenza virus strains and subtypes across prominent HLA types is relevant for combating ...

Kieran TJ, Sun X, Maines TR, Beauchemin CAA, Belse. Exploring associations between viral titer measurements and disease outcomes in ferrets inoculated with 125 contemporary influenza A viruses. J Virol. 2024 Jan 19:e0166123.  Abstract  
submitted by kickingbird at Jan, 20, 2024 from J Virol. 2024 Jan 19:e0166123 (via https://journals.asm.org/doi/10.1128/jvi.01661-23)
As use of the ferret model to study influenza A virus (IAV) pathogenicity increases, periodic assessment of data generated in this model is warranted, to identify features associated with virus replication ...

Taniguchi K, Noshi T, Omoto S, Sato A, Shishido T,. The impact of PA/I38 substitutions and PA polymorphisms on the susceptibility of zoonotic influenza A viruses to baloxavir. Arch Virol. 2024 Jan 12;169(2):29.  Abstract  
submitted by kickingbird at Jan, 18, 2024 from Arch Virol. 2024 Jan 12;169(2):29 (via https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10786730/)
Genetic reassortment of avian, swine, and human influenza A viruses (IAVs) poses potential pandemic risks. Surveillance is important for influenza pandemic preparedness, but the susceptibility of zoonotic ...

Kwasnik M, Rola J, Rozek W. Influenza D in Domestic and Wild Animals. Viruses. 2023 Dec 15;15(12):2433.  Abstract  
submitted by kickingbird at Jan, 17, 2024 from Viruses. 2023 Dec 15;15(12):2433 (via https://www.mdpi.com/1999-4915/15/12/2433)
Influenza D virus (IDV) infections have been observed in animals worldwide, confirmed through both serological and molecular tests, as well as virus isolation. IDV possesses unique properties that distinguish ...

Chen B, Guo G, Wang G, Zhu Q, Wang L, Shi W, Wang. ATG7/GAPLINC/IRF3 axis plays a critical role in regulating pathogenesis of influenza A virus. PLoS Pathog. 2024 Jan 16;20(1):e1011958.  Abstract  
submitted by kickingbird at Jan, 17, 2024 from PLoS Pathog. 2024 Jan 16;20(1):e1011958 (via https://journals.plos.org/plospathogens/article?id=10.1371/j)
Autophagy-related protein 7 (ATG7) is an essential autophagy effector enzyme. Although it is well known that autophagy plays crucial roles in the infections with various viruses including influenza A virus ...

Yang H, Lei G, Deng Z, Sun F, Tian Y, Cheng J, Yu. An Engineered Influenza a Virus Expressing the Co-Stimulator OX40L as an Oncolytic Agent Against Hepatocellular Carcinoma. J Hepatocell Carcinoma. 2024 Jan 9;11:1-13.  Abstract  
submitted by kickingbird at Jan, 16, 2024 from J Hepatocell Carcinoma. 2024 Jan 9;11:1-13 (via https://www.dovepress.com/getfile.php?fileID=95852)
Background: Oncolytic virus (OV) therapy has emerged as a promising novel form of immunotherapy. Moreover, an increasing number of studies have shown that the therapeutic efficacy of OV can be further ...

Ortigoza MB, Mobini CL, Rocha HL, Bartlett S, Loom. Inhibiting influenza virus transmission using a broadly acting neuraminidase that targets host sialic acids in the upper respiratory tract. mBio. 2024 Jan 11:e0220323.  Abstract  
submitted by kickingbird at Jan, 12, 2024 from mBio. 2024 Jan 11:e0220323 (via https://journals.asm.org/doi/10.1128/mbio.02203-23)
Influenza virus transmission studies have historically focused on viral mutations that alter hemagglutinin binding to sialic acid (SA) receptors in vitro. However, SA binding preference does not fully ...

Lyashko AV, Timofeeva TA, Rudneva IA, Lomakina NF,. Antigenic Architecture of the H7N2 Influenza Virus Hemagglutinin Belonging to the North American Lineage. Int J Mol Sci. 2023 Dec 22;25(1):212.  Abstract  
submitted by kickingbird at Jan, 12, 2024 from Int J Mol Sci. 2023 Dec 22;25(1):212 (via https://www.mdpi.com/1422-0067/25/1/212)
The North American low pathogenic H7N2 avian influenza A viruses, which lack the 220-loop in the hemagglutinin (HA), possess dual receptor specificity for avian- and human-like receptors. The purpose of ...

Maya-Badillo BA, Orta-Pineda G, Zavala-Vasco D, Ri. Influenza A virus antibodies in dogs, hunting dogs, and backyard pigs in Campeche, Mexico. Zoonoses Public Health. 2024 Jan 9.  Abstract  
submitted by kickingbird at Jan, 11, 2024 from Zoonoses Public Health. 2024 Jan 9 (via https://onlinelibrary.wiley.com/doi/10.1111/zph.13110)
Aims: This study aimed to identify exposure to human, swine, and avian influenza A virus subtypes in rural companion and hunting dogs, backyard pigs, and feral pigs.Methods and results: The study took ...

Jang SG, Kim YI, Casel MAB, Choi JH, Gil JR, Rollo. HA N193D substitution in the HPAI H5N1 virus alters receptor binding affinity and enhances virulence in mammalian hosts. Emerg Microbes Infect. 2024 Jan 8:2302854.  Abstract  
submitted by kickingbird at Jan, 9, 2024 from Emerg Microbes Infect. 2024 Jan 8:2302854 (via https://www.tandfonline.com/doi/full/10.1080/22221751.2024.2)
During the 2021/2022 winter season, we isolated highly pathogenic avian influenza (HPAI) H5N1 viruses harboring an amino acid substitution from Asparagine(N) to Aspartic acid (D) at residue 193 of the ...

Wang Q, Liu Z, Zeng X, Zheng Y, Lan L, Wang X, Lai. Integrated analysis of miRNA-mRNA expression of newly emerging swine H3N2 influenza virus cross-species infection with tree shrews. Virol J. 2024 Jan 4;21(1):4.  Abstract  
submitted by kickingbird at Jan, 5, 2024 from Virol J. 2024 Jan 4;21(1):4 (via https://virologyj.biomedcentral.com/articles/10.1186/s12985-)
Background: Cross-species transmission of zoonotic IAVs to humans is potentially widespread and lethal, posing a great threat to human health, and their cross-species transmission mechanism has attracted ...

Elli S, Raffaini G, Guerrini M, Kosakovsky Pond S,. Molecular modeling and phylogenetic analyses highlight the role of amino acid 347 of the N1 subtype neuraminidase in influenza virus host range and interspecies adaptation. Front Microbiol. 2023 Dec 19;14:1309156.  Abstract  
submitted by kickingbird at Jan, 5, 2024 from Front Microbiol. 2023 Dec 19;14:1309156 (via https://www.frontiersin.org/articles/10.3389/fmicb.2023.1309)
The N1 neuraminidases (NAs) of avian and pandemic human influenza viruses contain tyrosine and asparagine, respectively, at position 347 on the rim of the catalytic site; the biological significance of ...

Nu?ez IA, Jang H, Huang Y, Kelvin A, Ross TM. Influenza virus immune imprinting dictates the clinical outcomes in ferrets challenged with highly pathogenic avian influenza virus H5N1. Front Vet Sci. 2023 Dec 19;10:1286758.  Abstract  
submitted by kickingbird at Jan, 5, 2024 from Front Vet Sci. 2023 Dec 19;10:1286758 (via https://www.frontiersin.org/articles/10.3389/fvets.2023.1286)
Zoonotic transmission of H5N1 highly pathogenic avian influenza virus (HPAIV) into the human population is an increasing global threat. The recent 2022 HPAIV outbreak significantly highlighted this possibility, ...

Hohensee L, Scheibner D, Sch?fer A, Shelton H, Met. The role of PB1-F2 in adaptation of high pathogenicity avian influenza virus H7N7 in chickens. Vet Res. 2024 Jan 3;55(1):5.  Abstract  
submitted by kickingbird at Jan, 5, 2024 from Vet Res. 2024 Jan 3;55(1):5 (via https://veterinaryresearch.biomedcentral.com/articles/10.118)
Avian influenza viruses (AIV) of the H7N7 subtype are enzootic in the wild bird reservoir in Europe, cause infections in poultry, and have sporadically infected humans. The non-structural protein PB1-F2 ...

El-Kafrawy SA, Alsayed SM, Faizo AA, Bajrai LH, Ut. Genetic diversity and molecular analysis of human influenza virus among pilgrims during Hajj. Heliyon. 2023 Dec 2;10(1):e23027.  Abstract  
submitted by kickingbird at Jan, 3, 2024 from Heliyon. 2023 Dec 2;10(1):e23027 (via https://www.cell.com/heliyon/fulltext/S2405-8440(23)10235-0)
The risk of transmission of respiratory tract infections is considerably enhanced at mass gathering (MG) religious events. Hajj is an annual Islamic MG event with approximately 3 million Muslim pilgrims ...

Li H, Sun Z, Zheng T, Chen M, Lei X, Yu X, Ning Z. CD46 inhibits the replication of swine influenza viruses by promoting the production of type I IFNs in PK-15 cells. Vet Res Commun. 2023 Dec 28.  Abstract  
submitted by kickingbird at Dec, 29, 2023 from Vet Res Commun. 2023 Dec 28 (via https://link.springer.com/article/10.1007/s11259-023-10289-6)
Swine flu caused by swine influenza A virus (swIAV) is an acute respiratory viral disease that is spreading in swine herds worldwide. Although the effect of some host factors on replication of swIAV has ...

Rashid F, Xie Z, Li M, Xie Z, Luo S, Xie L. Roles and functions of IAV proteins in host immune evasion. Front Immunol. 2023 Dec 13;14:1323560.  Abstract  
submitted by kickingbird at Dec, 28, 2023 from Front Immunol. 2023 Dec 13;14:1323560 (via https://www.frontiersin.org/articles/10.3389/fimmu.2023.1323)
Influenza A viruses (IAVs) evade the immune system of the host by several regulatory mechanisms. Their genomes consist of eight single-stranded segments, including nonstructural proteins (NS), basic polymerase ...

Finney J, Moseman AP, Kong S, Watanabe A, Song S,. Protective human antibodies against a conserved epitope in pre- and postfusion influenza hemagglutinin. Proc Natl Acad Sci U S A. 2024 Jan 2;121(1):e23169.  Abstract  
submitted by kickingbird at Dec, 27, 2023 from Proc Natl Acad Sci U S A. 2024 Jan 2;121(1):e23169 (via https://www.pnas.org/doi/10.1073/pnas.2316964120)
Phylogenetically and antigenically distinct influenza A and B viruses (IAV and IBV) circulate in human populations, causing widespread morbidity. Antibodies (Abs) that bind epitopes conserved in both IAV ...

Daulagala P, Cheng SMS, Chin A, Luk LLH, Leung K,. Avian Influenza A(H5N1) Neuraminidase Inhibition Antibodies in Healthy Adults after Exposure to Influenza A(H1N1)pdm09. Emerg Infect Dis. 2024 Jan;30(1):168-171.  Abstract  
submitted by kickingbird at Dec, 27, 2023 from Emerg Infect Dis. 2024 Jan;30(1):168-171 (via https://wwwnc.cdc.gov/eid/article/30/1/23-0756_article)
We detected high titers of cross-reactive neuraminidase inhibition antibodies to influenza A(H5N1) virus clade 2.3.4.4b in 96.8% (61/63) of serum samples from healthy adults in Hong Kong in 2020. In contrast, ...

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