Influenza has long been a serious global public health problem, and the risk of drug resistance to Oseltamivir, as a first-line antiviral drug, cannot be ignored. Although some research findings have been published, a systematic review of current research on Oseltamivir resistance is lacking. Therefore, we employed a bibliometric method to conduct comprehensive search and to present current trends. Based on the screening criteria, literature related to Oseltamivir resistance from 2000 To 2024 was retrieved from the Web of Science Core Collection (WOSCC). Citespace and Bibliometrix were used to analyze and visualize the indicators (country, institution, journal, author, keywords, references) of the included literature. This study compiled 5159 articles from 1996 To 2024. The number of publications has shown a fluctuating upward trend, with the most research published in 2011, followed by a slight decline and then another increase. The United States and China have the highest number of publications, and the Centers for Disease Control and Prevention (CDC) has the highest number of institutions publishing. Hurt, AC, and Hayden, FG are the most influential authors and co-cited authors in this field. Antiviral Research and the New England Journal of Medicine are the journals with the highest output and citation frequency, respectively. The reference with the highest outbreak intensity is HAYDEN FG, 1999, NEW ENGL J MED, V341, P1336. Influenza virus subtypes, including H1N1 and H5N1, neuraminidase inhibitors, and drug safety are currently hot and cutting-edge research topics in this field. Based on the comprehensive literature analysis, this study summarizes the current status of Oseltamivir resistance and identifies emerging trends. These discoveries provide a reference for exploring the mechanisms, epidemiological patterns, clinical impacts, and response strategies of Oseltamivir resistance. Future research could strengthen international collaboration and cooperation to reveal and propose innovative solutions or recommendations from multiple perspectives, contributing to the development of global public health.