Richard J Sugrue, Richard Sutejo, Boon Huan Tan. [preprint]Evaluating the use of siRNA to silence the expression of the H5N2 virus polymerase genes as strategy to block the transmission of the avian H5N2 virus in mammalian cells. https://doi.org/10.64898/2026.05.04.722578. Abstract
submitted by kickingbird at May, 9, 2026 from https://doi.org/10.64898/2026.05.04.722578 (via https://www.biorxiv.org/content/10.64898/2026.05.04.722578v1)
We prepared siRNA libraries against the H5N2 virus NP gene, and the PA, PB1 and PB2 genes that express the proteins that form the virus polymerase complex. The antiviral activity of the siRNA libraries ... Josephine von Kempis, etc.,al. [preprint]Opposing cell type preferences for binding and replication shape influenza A virus infection in human airways. https://doi.org/10.64898/2026.05.04.722582. Abstract
submitted by kickingbird at May, 9, 2026 from https://doi.org/10.64898/2026.05.04.722582 (via https://www.biorxiv.org/content/10.64898/2026.05.04.722582v1)
Influenza A viruses (IAVs) pose a persistent threat to human health through seasonal epidemics and zoonotic spillover from avian reservoirs. As respiratory pathogens, they primarily target the airway epithelium. ... Tamiru N. Alkie et al. Mammary and respiratory infection of sheep with H5Nx clade 2.3.4.4b viruses with milk-mediated transmission to lambs. Sci. Adv.12,eaed1287(2026). Abstract
submitted by kickingbird at May, 9, 2026 from Sci. Adv.12,eaed1287(2026) (via https://www.science.org/doi/10.1126/sciadv.aed1287)
H5Nx clade 2.3.4.4b viruses are evolving rapidly, expanding host ranges and threatening animal and public health. In the US, genotype B3.13 dominates dairy outbreaks, while D1.1 is linked to fewer cases. ... Kieran TJ, Maines TR, Belser JA. Limited ´heft´ of weight-based outcomes in predicting influenza A virus disease severity in ferrets. PLoS Comput Biol. 2026 May 8;22(5):e1014210. Abstract
submitted by kickingbird at May, 9, 2026 from PLoS Comput Biol. 2026 May 8;22(5):e1014210 (via https://journals.plos.org/ploscompbiol/article?id=10.1371/jo)
Studies evaluating viral pathogenicity in small mammalian models often quantify disease severity using the magnitudes of temperature rise and weight loss post-challenge. However, no rigorous assessment ... Mengdan Fei, etc.,al. Migration of Brown-headed Gulls on the Qinghai-Tibet Plateau: Potential transmission routes for highly pathogenic H5Nx virus. Avian Research. Abstract
submitted by kickingbird at May, 9, 2026 from Avian Research (via https://www.sciencedirect.com/science/article/pii/S205371662)
The Qinghai-Tibet Plateau serves as a critical hub along the Central Asian Flyway (CAF) and a recognized hotspot for the emergence of highly pathogenic avian influenza (HPAI) viruses. Despite recurrent ... Bhat S, Sadeyen JR, Yang J, Chrzastek K, Karunarat. A G57 (BJ/94-like) H9N2 avian influenza virus exhibits enhanced replication and tissue dissemination in chickens compared with a G1-B virus. J Gen Virol. 2026 May;107(5). Abstract
submitted by kickingbird at May, 9, 2026 from J Gen Virol. 2026 May;107(5) (via https://www.microbiologyresearch.org/content/journal/jgv/10.)
Avian influenza H9N2 viruses cause economic losses to the poultry industry and pose a public health risk. Two major H9N2 lineages dominate globally: the G1 lineage (genotype G1-B), prevalent in the Middle ... Lemaitre J, Lessler J. [preprint]Generative diffusion models for spatiotemporal influenza forecasting. ArXiv [Preprint]. 2026 Apr 27:arXiv:2604.24913v1. Abstract
submitted by kickingbird at May, 8, 2026 from ArXiv [Preprint]. 2026 Apr 27:arXiv:2604.24913v1 (via https://arxiv.org/abs/2604.24913v1)
Forecasting infectious disease incidence can provide important information to guide public health planning, yet is difficult because epidemic dynamics are complex. Current mechanistic and statistical approaches ... Ries HJ, Lalli J, Florek KR, Barlow S, Goss M, et. Weak selection and stochastic processes limit the emergence of antigenic variants during household transmission of influenza A viruses. PLOS Pathogens 22(5): e1013689. Abstract
submitted by kickingbird at May, 8, 2026 from PLOS Pathogens 22(5): e1013689 (via https://journals.plos.org/plospathogens/article?id=10.1371/j)
Influenza viruses undergo antigenic drift, the gradual accumulation of mutations that cause antigenic changes in the viral surface proteins hemagglutinin (HA) and neuraminidase (NA). Although selection ... Linxi He, Daihai He. Sensitivity of Convergent Cross Mapping to temporal discontinuities: A case study of seasonal influenza in Hong Kong. Infectious Disease Modelling. Abstract
submitted by kickingbird at May, 8, 2026 from Infectious Disease Modelling (via https://www.sciencedirect.com/science/article/pii/S246804272)
Convergent cross mapping (CCM) method has been widely applied to investigate environmental drivers of infectious disease dynamics, particularly for seasonal influenza. However, its robustness to temporal ... Schafers J, Warren CJ, Yang J, Zhang J, Cole SJ, C. Stability of influenza viruses in the milk of cows and sheep. J Gen Virol. 2026 May;107(5). Abstract
submitted by kickingbird at May, 8, 2026 from J Gen Virol. 2026 May;107(5) (via https://www.microbiologyresearch.org/content/journal/jgv/10.)
In late 2023, H5N1 high-pathogenicity avian influenza virus (HPAIV) started circulating in dairy cattle in the USA. High viral titres were detected in milk from infected cows, raising concerns about onward ... Manoj S Nair, etc., al. Serum neutralisation of H5N1 clade 2.3.4.4b influenza is largely mediated by neuraminidase-directed antibodies. The Lancet Microbe. Abstract
submitted by kickingbird at May, 7, 2026 from The Lancet Microbe (via https://www.sciencedirect.com/science/article/pii/S266652472)
Highly pathogenic avian influenza A (H5N1) continues to circulate globally in avian and mammalian species. Since its emergence in 1997, over 1000 confirmed human infections with H5N1 have been reported, ... Megan R. Miller, etc., al. Evaluation of PCR-Based H5N1 Influenza Detection Methods in Milk from an Inter-laboratory Comparison Study Demonstrating Method-Dependent Sensitivity Variability. Journal of Food Protection. Abstract
submitted by kickingbird at May, 7, 2026 from Journal of Food Protection (via https://www.sciencedirect.com/science/article/pii/S0362028X2)
Since March 2024, H5N1 highly pathogenic avian influenza (HPAI) has been detected in U.S. dairy cattle. Infectious virus shed in unpasteurized milk, a matrix not previously evaluated for H5N1 detection, ... Kun Xiao, Yan Cao, Zhihai Han, Qian Da, Yun Feng,. A large-scale single-cell atlas reveals the pulmonary immune panorama in adult patients with influenza. Am J Respir Crit Care Med. 2026 Mar 16:aamag122. Abstract
submitted by kickingbird at May, 6, 2026 from Am J Respir Crit Care Med. 2026 Mar 16:aamag122 (via https://academic.oup.com/ajrccm/advance-article-abstract/doi)
Rationale: The host immune determinants that distinguish protective from life-threatening responses to influenza are poorly understood. Identifying drivers of immunopathology in the human lung is critical ... Campbell AJ, Shephard M, Paulos AP, Pauly MD, Vu M. Surveillance on California dairy farms reveals multiple possible sources of H5N1 influenza virus transmission. PLoS Biol . 2026 May 5;24(5):e3003761. Abstract
submitted by kickingbird at May, 6, 2026 from PLoS Biol . 2026 May 5;24(5):e3003761 (via https://journals.plos.org/plosbiology/article?id=10.1371/jou)
Transmission routes of highly pathogenic H5N1 between cows or to humans remain unclear due to limited data from affected dairy farms. We performed air, farm wastewater, and milk sampling on 14 H5N1-positive ... Xingyi Li, etc.,al. FluNexus: A versatile web platform for antigenic prediction and visualization of influenza A viruses. iMeta. Abstract
submitted by kickingbird at May, 5, 2026 from iMeta (via https://onlinelibrary.wiley.com/doi/10.1002/imt2.70127)
Influenza A viruses pose a major global health threat due to their high mutation rates, broad host ranges, and pandemic potential. Human seasonal influenza is primarily driven by H1 and H3 subtypes, which ... Liu, H., Li, X., Sun, N. et al. Spatiotemporal instability of influenza seasonality during viral co-circulation. npj Syst Biol Appl (2026). Abstract
submitted by kickingbird at May, 5, 2026 from npj Syst Biol Appl (2026) (via https://www.nature.com/articles/s41540-026-00729-9)
Co-circulation of multiple influenza subtypes poses a major challenge to global public health. However, its specific impact on non-stationary epidemic sequences and coupling relationships with environmental ... Flagg M, Winski CJ, Brackney BG, Lutterman TR, Ort. Replication Efficiency of Contemporary Highly Pathogenic Avian Influenza A(H5N1) Virus Isolates in Human Nasal Epithelium Model. Emerg Infect Dis. 2026 May. Abstract
submitted by kickingbird at May, 4, 2026 from Emerg Infect Dis. 2026 May (via https://wwwnc.cdc.gov/eid/article/32/5/26-0053_article)
Replication of influenza A virus in human nasal epithelium affects transmissibility and disease. We compared virus replication and immune responses in human nasal epithelium infected with seasonal and ... Fathelrahman E, Mohamed Ali M, Challa TG, Osman R,. Modeling and assessing Highly Pathogenic Avian Influenza (HPAI) spread, epidemiological control measures, and cost. PLoS One. 2026 Apr 30;21(4):e0340004. Abstract
submitted by kickingbird at May, 1, 2026 from PLoS One. 2026 Apr 30;21(4):e0340004 (via https://journals.plos.org/plosone/article?id=10.1371/journal)
Highly Pathogenic Avian Influenza (HPAI) is a highly contagious, transboundary disease that can affect animals and humans, posing significant health risks to both. This study aimed to prepare for a potential ... Wang M, Laison EKE, Philippsen T, Ghaemi S, Liu J,. Mechanistic modelling of highly pathogenic avian influenza: A scoping review revealing critical gaps in cross-species transmission models. PLoS One. 2026 Apr 30;21(4):e0347929. Abstract
submitted by kickingbird at May, 1, 2026 from PLoS One. 2026 Apr 30;21(4):e0347929 (via https://journals.plos.org/plosone/article?id=10.1371/journal)
Background: Highly pathogenic avian influenza (HPAI) viruses, particularly subtypes such as H5N1 and H7N9, have caused widespread outbreaks in wild birds, poultry, livestock and occasionally humans, raising ... Daines R, Sadeyen J, Chang P, Iqbal M. 0. Mapping hemagglutinin residues driving antigenic diversity in H5Nx avian influenza viruses. J Virol 0:e00095-26. Abstract
submitted by kickingbird at May, 1, 2026 from J Virol 0:e00095-26 (via https://journals.asm.org/doi/10.1128/jvi.00095-26)
Since its emergence in 1996, the H5 avian influenza virus (AIV) A/Goose/Guangdong/1/1996 (Gs/GD) hemagglutinin (HA) has evolved into over 30 genetically and antigenically distinct clades, including the ... 6878 items, 20/Page, Page[4/344][|<<] [|<] [1] [2] [3] [4] [5] [6] [7] [8] [9] [10] [>|] [>>|] |
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