Ford, Colby T. et al. Large-scale computational modelling of H5 influenza variants against HA1-neutralising antibodies. eBioMedicine, Volume 114, 105632. Abstract
submitted by kickingbird at Mar, 21, 2025 from eBioMedicine, Volume 114, 105632 (via https://www.thelancet.com/journals/ebiom/article/PIIS2352-39)
BackgroundThe United States Department of Agriculture has recently released reports that show samples collected from 2022 to 2025 of highly pathogenic avian influenza (H5N1) have been detected in mammals ... Mingsheng Zhao, etc.,al. Genetic Evolution and Molecular Characteristics of Avian Influenza Viruses in Jining from 2018 to 2023. Front. Microbiol. Volume 16, 2025. Abstract
submitted by kickingbird at Mar, 21, 2025 from Front. Microbiol. Volume 16, 2025 (via https://www.frontiersin.org/journals/microbiology/articles/1)
Objective This study aimed to analyze the genetic evolution and molecular characteristics of H5, H7, and H9 subtypes of avian influenza viruses in the external environment of poultry in Jining from 2018 ... Sebastian Bittrich, etc.,al. Visualizing and analyzing 3D biomolecular structures using Mol* at RCSB.org: Influenza A H5N1 virus proteome case study. TOOLS FOR PROTEIN SCIENCE. Abstract
submitted by kickingbird at Mar, 21, 2025 from TOOLS FOR PROTEIN SCIENCE (via https://onlinelibrary.wiley.com/doi/10.1002/pro.70093)
The easiest and often most useful way to work with experimentally determined or computationally predicted structures of biomolecules is by viewing their three-dimensional (3D) shapes using a molecular ... David J Bacsik, etc.,al. [preprint]Validation of H5 influenza virus subtyping RT-qPCR assay and low prevalence of H5 detection in 2024-2025 influenza virus season. https://doi.org/10.1101/2025.03.17.25324122. Abstract
submitted by kickingbird at Mar, 21, 2025 from https://doi.org/10.1101/2025.03.17.25324122 (via https://www.medrxiv.org/content/10.1101/2025.03.17.25324122v)
A sustained outbreak of H5N1 influenza virus among wild fowl and domestic livestock has caused more than 70 zoonotic infections in humans in the United States, including one death. The Centers for Disease ... Daniel Janies, etc.,al. [preprint]Analyses of phylogenetics, natural selection, and protein structure of clade 2.3.4.4b H5N1 Influenza A reveal that recent viral lineages have evolved promiscuity in host range and improved r. https://doi.org/10.1101/2025.03.15.641219. Abstract
submitted by kickingbird at Mar, 21, 2025 from https://doi.org/10.1101/2025.03.15.641219 (via https://www.biorxiv.org/content/10.1101/2025.03.15.641219v1)
H5N1 influenza has been circulating in birds from Eurasia and Africa for more than 146 years, but human infection has been sporadic. H5N1 (clade 2.3.4.4b) has recently infected hundreds of species of wild ... David Scheibner, etc.,al. [preprint]Different genetic determinants for high virulence, transmission and replication of high pathogenicity H7N7 avian influenza virus in turkeys and chickens. https://doi.org/10.1101/2025.03.18.643940. Abstract
submitted by kickingbird at Mar, 21, 2025 from https://doi.org/10.1101/2025.03.18.643940 (via https://www.biorxiv.org/content/10.1101/2025.03.18.643940v1)
High pathogenicity (HP) avian influenza viruses (AIV) generally evolve from low pathogenicity (LP) precursors after transmission from wild birds to chickens (Gallus gallus domesticus) and turkeys (Meleagris ... Jessica A Belser, etc.,al. Ocular infectivity and replication of a clade 2.3.4.4b A(H5N1) influenza virus associated with human conjunctivitis in a dairy farm worker in the USA: an in-vitro and ferret study. The Lancet Microbe. Abstract
submitted by kickingbird at Mar, 21, 2025 from The Lancet Microbe (via https://www.sciencedirect.com/science/article/pii/S266652472)
SummaryBackgroundThe human eye represents a potential site of influenza A virus (IAV) replication, and an entry point for the virus to reach the respiratory tract. The frequent detection of conjunctivitis ... Zhao C, Huang J, Zhang C, Wang Y, Zhang X, Liu S,. Characteristics of the First Domestic Duck-Origin H12N8 Avian Influenza Virus in China. International Journal of Molecular Sciences. 2025;. Abstract
submitted by kickingbird at Mar, 21, 2025 from International Journal of Molecular Sciences. 2025; (via https://www.mdpi.com/1422-0067/26/6/2740)
The H12 subtypes of avian influenza viruses (AIVs) are globally prevalent in wild birds, occasionally spilling over into poultry. In this study, we isolated an H12N8 virus from ducks in a live poultry ... Jones JC, Andreev K, Fabrizio TP, Bowman AS, Govor. Baloxavir improves disease outcomes in mice after intranasal or ocular infection with Influenza A virus H5N1-contaminated cow´s milk. Nat Microbiol. 2025 Mar 17. Abstract
submitted by kickingbird at Mar, 20, 2025 from Nat Microbiol. 2025 Mar 17 (via https://www.nature.com/articles/s41564-025-01961-5)
Testing approved antivirals against A(H5N1) influenza viruses circulating in peridomestic species, including dairy cows, is critical to public health and pre-pandemic planning. It cannot be tested in humans ... Mohammed Nooruzzaman, etc.,al. [preprint]Stability of influenza A H5N1 virus in raw milk cheese. https://doi.org/10.1101/2025.03.13.643009. Abstract
submitted by kickingbird at Mar, 14, 2025 from https://doi.org/10.1101/2025.03.13.643009 (via https://www.biorxiv.org/content/10.1101/2025.03.13.643009v1)
We evaluated the stability of highly pathogenic avian influenza (HPAI) H5N1 virus in raw milk cheeses using a mini cheese model prepared with HPAI-spiked raw milk under varying pH levels (pH 6.6, 5.8 and ... Octaviani, C.P., Huang, P., Bi-Hung, P. et al. Superior replication, pathogenicity, and immune evasion of a Texas dairy cattle H5N1 virus compared to a historical avian isolate. Sci Rep 15, 8797 (2025). Abstract
submitted by kickingbird at Mar, 14, 2025 from Sci Rep 15, 8797 (2025) (via https://link.springer.com/article/10.1038/s41598-025-93493-5)
The current outbreak of highly pathogenic avian influenza (HPAI) viruses of the H5N1 subtype clade 2.3.4.4b in dairy cattle in the United States has affected nearly 900 dairy farms and resulted in at least ... Smith VA, Schall AR, Tomsho JW. Nonstructural Protein 1 of Influenza A (NS1A) Demonstrates Strain-Specific dsRNA Binding Capabilities. ACS Infect Dis. 2025 Mar 13. Abstract
submitted by kickingbird at Mar, 14, 2025 from ACS Infect Dis. 2025 Mar 13 (via https://pubs.acs.org/doi/10.1021/acsinfecdis.4c00882)
Nonstructural protein 1 of influenza A (NS1A) is a key virulence factor produced inside host cells infected with Influenza A Virus (IAV) and consists of an N-terminal dsRNA binding domain (RBD) and a C-terminal ... Garretson, T.A., Liu, J., Li, S.H. et al. Immune history shapes human antibody responses to H5N1 influenza viruses. Nat Med (2025). Abstract
submitted by kickingbird at Mar, 13, 2025 from Nat Med (2025) (via https://www.nature.com/articles/s41591-025-03599-6)
Avian H5N1 influenza viruses are circulating widely in cattle and other mammals and pose a risk for a human pandemic. Previous studies suggest that older humans are more resistant to H5N1 infections due ... Edoardo Giussani, Alessandro Sartori, Angela Salom. FluMut: a tool for mutation surveillance in highly pathogenic H5N1 genomes. Virus Evolution, 2025; veaf011. Abstract
submitted by kickingbird at Mar, 13, 2025 from Virus Evolution, 2025; veaf011 (via https://academic.oup.com/ve/advance-article/doi/10.1093/ve/v)
Over the past century, Influenza A virus (IAV) has caused four of the five reported pandemics, all of which originated from viruses possessing genome segments of avian origin. The recent spread of highly ... He F, Yu H, Liu L, Li X, Xing Y, Yang L, Yang P, Z. Antigenicity and genetic properties of an Eurasian avian-like H1N1 swine influenza virus in Jiangsu Province, China. Biosaf Health. 2024 Nov 20;6(6):319-326. Abstract
submitted by kickingbird at Mar, 13, 2025 from Biosaf Health. 2024 Nov 20;6(6):319-326 (via https://www.sciencedirect.com/science/article/pii/S259005362)
Pigs are vital genetic mixing vessels for human and avian influenza viruses because their tracheal epitheliums possess both sialic acid α-2,6-Gal and α-2,3-Gal receptors. Cross-species transmission of ... Liang Y, Guo J, Li Z, Liu S, Zhang T, Sun S, Lu F,. A novel method to assess antibody-dependent cell-mediated cytotoxicity against influenza A virus M2 in immunized murine models. Biosaf Health. 2024 Apr 17;6(3):178-185. Abstract
submitted by kickingbird at Mar, 13, 2025 from Biosaf Health. 2024 Apr 17;6(3):178-185 (via https://www.sciencedirect.com/science/article/pii/S259005362)
The matrix protein 2 (M2) is a preferred target for developing a universal vaccine against the influenza A virus (IAV). This study aimed to develop a method for assessing antibody-dependent cell-mediated ... Wang X, Wang X, Hao X, Gao R, Lu X, Yang W, Chen Y. The Novel H10N3 Avian Influenza Virus Triggers Lethal Cytokine Storm by Activating Multiple Forms of Programmed Cell Death in Mammalian Lungs. Int J Mol Sci. 2025 Feb 25;26(5):1977. Abstract
submitted by kickingbird at Mar, 13, 2025 from Int J Mol Sci. 2025 Feb 25;26(5):1977 (via https://www.mdpi.com/1422-0067/26/5/1977)
The novel H10N3 avian influenza virus (AIV) has infected four individuals since 2021 and caused severe respiratory damage, posing a significant threat to public health. However, its pathogenic mechanisms ... Ospina-Jimenez AF, Gomez AP, Rincon-Monroy MA, Per. A novel reassorted swine H3N2 influenza virus demonstrates an undetected human-to-swine spillover in Latin America and highlights zoonotic risks. Virology. 2025 Mar 5;606:110483. Abstract
submitted by kickingbird at Mar, 13, 2025 from Virology. 2025 Mar 5;606:110483 (via https://www.sciencedirect.com/science/article/abs/pii/S00426)
Influenza A virus (FLUAV) affects a wide range of hosts, including humans and animals, posing a threat to public health. In swine, H3N2 subtype is associated with human-to-swine spillovers of seasonal ... Pawar SD, Keng SS, Tare DS, Balakrishnan A, S S, K. Evidence of novel reassortment in clade 2.3.4.4b avian influenza H5N1 viruses, India, 2024. Virology. 2025 Mar 5;606:110482. Abstract
submitted by kickingbird at Mar, 13, 2025 from Virology. 2025 Mar 5;606:110482 (via https://www.sciencedirect.com/science/article/abs/pii/S00426)
H5N1 viruses belonging to clade 2.3.4.4b have caused unprecedented outbreaks globally. Outbreaks of H5N1 virus were reported in poultry and wild birds from Kerala (India) in the year 2024. Samples from ... Caroline Kikawa, etc.,al. [preprint]High-throughput neutralization measurements correlate strongly with evolutionary success of human influenza strains. https://doi.org/10.1101/2025.03.04.641544. Abstract
submitted by kickingbird at Mar, 13, 2025 from https://doi.org/10.1101/2025.03.04.641544 (via https://www.biorxiv.org/content/10.1101/2025.03.04.641544v1)
Human influenza viruses rapidly acquire mutations in their hemagglutinin (HA) protein that erode neutralization by antibodies from prior exposures. Here, we use a sequencing-based assay to measure neutralization ... 6469 items, 20/Page, Page[33/324][|<<] [|<] [31] [32] [33] [34] [35] [36] [37] [38] [39] [40] [>|] [>>|] |
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