Gorden PJ, Magstadt DR, Baker AL, Arruda BL, Bell. Viral Mastitis Associated with Influenza A in Dairy Cattle. Vet Clin North Am Food Anim Pract. 2025 Apr 7:S074. Abstract
submitted by kickingbird at Apr, 10, 2025 from Vet Clin North Am Food Anim Pract. 2025 Apr 7:S074 (via https://www.sciencedirect.com/science/article/abs/pii/S07490)
n early 2024, farmers in the southwestern United States described a mysterious disease outbreak causing acute illness and milk drop. Diagnostic investigations determined this syndrome to result from H5N1 ... Tan WX, Qin SY, Yang X, Li XM, Li JH, Cao H, Jiang. Global Prevalence and Distribution of H9 Subtype of Avian Influenza Viruses in Wild Birds: Literature Review with Meta-Analysis. Vector Borne Zoonotic Dis. 2025 Apr 9. Abstract
submitted by kickingbird at Apr, 10, 2025 from Vector Borne Zoonotic Dis. 2025 Apr 9 (via https://www.liebertpub.com/doi/10.1089/vbz.2024.0111)
Background: As a natural accelerator of highly pathogenic avian influenza in wild birds, the H9 subtype of avian influenza poses a substantial threat to both humans and the poultry industry. A comprehensive ... Liu X, Balligand T, Le Gall C, Ploegh HL. A monoclonal anti-hemagglutinin stem antibody modified with zanamivir protects against both influenza A and B viruses. Proc Natl Acad Sci U S A. 2025 Apr 15;122(15):e242. Abstract
submitted by kickingbird at Apr, 9, 2025 from Proc Natl Acad Sci U S A. 2025 Apr 15;122(15):e242 (via https://www.pnas.org/doi/10.1073/pnas.2424889122)
Influenza remains a significant public health threat. Both monoclonal antibodies and small-molecule inhibitors can target the influenza surface glycoproteins hemagglutinin (HA) or neuraminidase (NA) for ... Xu S, Liu Y, Luo C, Zhou M, Wang K, Xie Q, Zhang Q. Identification and characterization of a broadly neutralizing and protective nanobody against the HA1 domain of H5 avian influenza virus hemagglutinin. J Virol. 2025 Apr 7:e0209024. Abstract
submitted by kickingbird at Apr, 8, 2025 from J Virol. 2025 Apr 7:e0209024 (via https://journals.asm.org/doi/10.1128/jvi.02090-24)
The highly pathogenic avian influenza viruses (HPAIVs) of subtype H5, particularly those of the currently circulating clades 2.3.2.1 and 2.3.4.4, are largely responsible for the sporadic human infections ... Zhang H, Chen X, Liu D, Liu X, Ge Y, Sun Y, Zhang. Immunogenicity and protective efficacy of an inactivated bivalent vaccine containing two recombinant H1N1 and H3N2 swine influenza virus strains. Cell Mol Life Sci. 2025 Apr 7;82(1):150. Abstract
submitted by kickingbird at Apr, 8, 2025 from Cell Mol Life Sci. 2025 Apr 7;82(1):150 (via https://link.springer.com/article/10.1007/s00018-025-05674-0)
The wild-type H1N1 and H3N2 swine influenza virus (SIV) strains are unsuitable for vaccine production because of high lethality in chicken embryos and low reproductive titers. This study developed recombinant ... Wang, P., Fu, J., Cheng, L. et al. Neutralizing monoclonal antibodies as effective therapeutics and prophylactics against lethal H10N7 avian influenza infection in a mouse model. Vet Res 56, 75 (2025). Abstract
submitted by kickingbird at Apr, 7, 2025 from Vet Res 56, 75 (2025) (via https://link.springer.com/article/10.1186/s13567-025-01504-0)
The H10 subtype of avian influenza virus (AIV) is widespread in poultry worldwide and poses a significant threat to animal health. With the emergence of sporadic and fatal cases in humans infected with ... Hu Z, Ai H, Wang Z, Huang S, Sun H, Xuan X, Chen M. Impact of inactivated vaccine on transmission and evolution of H9N2 avian influenza virus in chickens. NPJ Vaccines. 2025 Apr 4;10(1):67. Abstract
submitted by kickingbird at Apr, 7, 2025 from NPJ Vaccines. 2025 Apr 4;10(1):67 (via https://www.nature.com/articles/s41541-025-01115-y)
H9N2 avian influenza virus (AIV) is endemic in poultry worldwide and increasingly zoonotic. Despite the long-term widespread use of inactivated vaccines, H9N2 AIVs remain dominant in chicken flocks. We ... Chen PL, Richardson RA, Rovito S, Yang G, Writt HN. Live-attenuated pandemic H1N1 influenza vaccines expressing computationally optimized broadly reactive antigens (COBRAs) are immunogenic and protective in mice and ferrets. Vaccine. 2025 Apr 4;53:127090. Abstract
submitted by kickingbird at Apr, 7, 2025 from Vaccine. 2025 Apr 4;53:127090 (via https://www.sciencedirect.com/science/article/abs/pii/S02644)
Computationally optimized broadly reactive antigens (COBRAs) induce broad and protective immune responses across multiple viral vaccine platforms. However, their suitability for incorporation into live ... Wagoner, Zachary W. et al.. Systems immunology analysis of human immune organoids identifies host-specific correlates of protection to different influenza vaccines. Cell Stem Cell, Volume 32, Issue 4, 529 - 546.e6. Abstract
submitted by kickingbird at Apr, 6, 2025 from Cell Stem Cell, Volume 32, Issue 4, 529 - 546.e6 (via https://www.cell.com/cell-stem-cell/fulltext/S1934-5909(25)0)
Vaccines are an essential tool to significantly reduce pathogen-related morbidity and mortality. However, our ability to rationally design vaccines and identify correlates of protection remains limited. ... Xiao X, Wang X, Xu F, Liang Y, Luo Y, Li S, Zhou P. Synergistic effects of PA (S184N) and PB2 (E627K) mutations on the increased pathogenicity of H3N2 canine influenza virus infections in mice and dogs. J Virol. 2025 Apr 4:e0198424. Abstract
submitted by kickingbird at Apr, 5, 2025 from J Virol. 2025 Apr 4:e0198424 (via https://journals.asm.org/doi/10.1128/jvi.01984-24)
As companion animals, dogs are susceptible to various subtypes of influenza A virus (IAV), with the H3N2 and H3N8 subtypes of canine influenza virus (CIV) stably circulating among canines. Compared to ... Arbani O, Ducatez MF, Kadja-Wonou M, Salamat F, Ki. Development of an experimental model using cold stress to assess the pathogenicity of two Moroccan AI H9N2 isolates from 2016 and 2022 in commercial broiler chickens. PLoS One. 2025 Apr 4;20(4):e0320666. Abstract
submitted by kickingbird at Apr, 5, 2025 from PLoS One. 2025 Apr 4;20(4):e0320666 (via https://journals.plos.org/plosone/article?id=10.1371/journal)
Since 2016, low pathogenic avian influenza virus (LPAIV) H9N2 became a major issue for poultry production in Morocco. Even though the agent was classified as low pathogenic, AI H9N2 cause significant economic ... Lindsey R Robinson-McCarthy, etc.,al. [preprint]Dairy cattle herds mount a characteristic antibody response to highly pathogenic H5N1 avian influenza viruses. https://doi.org/10.1101/2025.04.01.646587. Abstract
submitted by kickingbird at Apr, 2, 2025 from https://doi.org/10.1101/2025.04.01.646587 (via https://www.biorxiv.org/content/10.1101/2025.04.01.646587v1)
An unprecedented outbreak of a highly pathogenic avian influenza virus, H5 clade 2.3.4.4b, was reported in United States dairy cattle during the spring of 2024. It has now spread to hundreds of herds across ... Liu, Y., Deng, S., Ren, S. et al. Intranasal influenza virus-vectored vaccine offers protection against clade 2.3.4.4b H5N1 infection in small animal models. Nat Commun 16, 3133 (2025). Abstract
submitted by kickingbird at Apr, 2, 2025 from Nat Commun 16, 3133 (2025) (via https://link.springer.com/article/10.1038/s41467-025-58504-z)
The highly pathogenic avian influenza (HPAI) H5N1 virus has been endemic in aquatic birds since 1997, causing outbreaks in domestic poultry and occasional human infections worldwide. Recently, the cross-species ... zhu-nan Li, etc.,al. [preprint]Population Immunity to Hemagglutinin Head, Stalk and Neuraminidase of Highly Pathogenic Avian Influenza 2.3.4.4b A(H5N1) viruses in the United States and the Impact of Seasonal Influenza on. https://doi.org/10.1101/2025.03.30.25323419. Abstract
submitted by kickingbird at Apr, 1, 2025 from https://doi.org/10.1101/2025.03.30.25323419 (via https://www.medrxiv.org/content/10.1101/2025.03.30.25323419v)
The unprecedented 2.3.4.4b A(H5N1) outbreak in dairy cattle, poultry, and spillover to humans in the United States (US) poses a major public health threat. Population immunity is a critical component of ... Ramya S Barre, etc.,al. [preprint]A Human H5N1 Influenza Virus Expressing Bioluminescence for Evaluating Viral Infection and Identifying Therapeutic Interventions. https://doi.org/10.1101/2025.03.28.646035. Abstract
submitted by kickingbird at Mar, 31, 2025 from https://doi.org/10.1101/2025.03.28.646035 (via https://www.biorxiv.org/content/10.1101/2025.03.28.646035v1)
A multistate outbreak of highly pathogenic avian influenza virus (HPAIV) H5N1 in dairy cows was first reported on March 25, 2024, in the United States (US), marking the first discovery of HPAIV H5N1 in ... Ahmed Mostafa, etc.,al. [preprint]A Live Attenuated Vaccine Candidate against Emerging Highly Pathogenic Cattle-Origin 2.3.4.4b H5N1 Viruses. https://doi.org/10.1101/2025.03.28.646033. Abstract
submitted by kickingbird at Mar, 31, 2025 from https://doi.org/10.1101/2025.03.28.646033 (via https://www.biorxiv.org/content/10.1101/2025.03.28.646033v1)
Influenza viruses present a significant public health risk, causing substantial illness and death in humans each year. Seasonal flu vaccines must be updated regularly, and their effectiveness often decreases ... Jia Li, Tangqi Wang, Xiaojuan Guo, Yujie Jiang,etc. Broad Mucosal and Systemic Immunity in Mice Induced by Intranasal Booster With a Novel Recombinant Adenoviral Based Vaccine Protects Against Divergent Influenza A Virus. Journal of Medical Virology. Abstract
submitted by kickingbird at Mar, 31, 2025 from Journal of Medical Virology (via https://onlinelibrary.wiley.com/doi/10.1002/jmv.70326)
The development of broad-spectrum universal influenza vaccines and optimization of vaccination strategies to address the threats posed by pandemics and emerging influenza viruses are critical for public ... Phrutsamon Wongnak, etc.,al. [preprint]Characterising viral clearance kinetics in acute influenza. https://doi.org/10.1101/2025.03.07.25323547. Abstract
submitted by kickingbird at Mar, 31, 2025 from https://doi.org/10.1101/2025.03.07.25323547 (via https://www.medrxiv.org/content/10.1101/2025.03.07.25323547v)
Pharmacometric assessment of antiviral efficacy in acute influenza informs treatment decisions and pandemic preparedness. We assessed natural viral clearance in untreated acute influenza to guide clinical ... Poulami Basu Thakur, etc.,al. [preprint]Heterogeneity across mammalian- and avian-origin A(H1N1) influenza viruses influences viral infectivity following incubation with host bacteria from the human respiratory tract. https://doi.org/10.1101/2025.03.28.645935. Abstract
submitted by kickingbird at Mar, 31, 2025 from https://doi.org/10.1101/2025.03.28.645935 (via https://www.biorxiv.org/content/10.1101/2025.03.28.645935v1)
Influenza A viruses (IAV) are primarily transmitted between mammals by the respiratory route, and encounter bacteria in the respiratory tract before infecting susceptible epithelial cells. Previous studies ... Li L, Chen R, Yan Z, Cai Q, Guan Y, Zhu H. Experimental Infection of Rats with Influenza A Viruses: Implications for Murine Rodents in Influenza A Virus Ecology. Viruses. 2025; 17(4):495. Abstract
submitted by kickingbird at Mar, 31, 2025 from Viruses. 2025; 17(4):495 (via https://www.mdpi.com/1999-4915/17/4/495)
Rattus norvegicus (brown rat), a widely distributed rodent and common biomedical model, is a known reservoir for many zoonotic pathogens but has not been traditionally recognized as a host for influenza ... 6469 items, 20/Page, Page[31/324][|<<] [|<] [31] [32] [33] [34] [35] [36] [37] [38] [39] [40] [>|] [>>|] |
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