Miotto O, Heiny A, Tan TW, August JT, Brusic V. Identification of human-to-human transmissibility factors in PB2 proteins of influenza A by large-scale mutual information analysis. BMC Bioinformatics. 2008;9 Suppl 1:S18.. Full Text
submitted by kickingbird at Mar, 25, 2008 from BMC Bioinformatics. 2008;9 Suppl 1:S18. (via http://www.biomedcentral.com/1471-2105/9/S1/S18)
BACKGROUND: The identification of mutations that confer unique properties to a pathogen, such as host range, is of fundamental importance in the fight against disease. This paper describes a novel method ... Singh DT, Trehan R, Schmidt B, Bretschneider T.. Comparative phyloinformatics of virus genes at micro and macro levels in a distributed computing environment. BMC Bioinformatics. 2008;9 Suppl 1:S23. Full Text
submitted by kickingbird at Mar, 25, 2008 from BMC Bioinformatics. 2008;9 Suppl 1:S23 (via http://www.biomedcentral.com/1471-2105/9/S1/S23)
BACKGROUND: Preparedness for a possible global pandemic caused by viruses such as the highly pathogenic influenza A subtype H5N1 has become a global priority. In particular, it is critical to monitor the ... Miotto O, Tan TW, Brusic V. Rule-based knowledge aggregation for large-scale protein sequence analysis of influenza A viruses. BMC Bioinformatics. 2008;9 Suppl 1:S7. Full Text
submitted by kickingbird at Mar, 25, 2008 from BMC Bioinformatics. 2008;9 Suppl 1:S7 (via http://www.biomedcentral.com/1471-2105/9/S1/S7)
BACKGROUND: The explosive growth of biological data provides opportunities for new statistical and comparative analyses of large information sets, such as alignments comprising tens of thousands of sequences. ... Moghadas SM, Bowman CS, R?st G, Wu J.. Population-wide emergence of antiviral resistance during pandemic influenza. PLoS ONE. 2008 Mar 19;3(3):e1839.. Full Text
submitted by kickingbird at Mar, 25, 2008 from PLoS ONE. 2008 Mar 19;3(3):e1839. (via http://www.plosone.org/article/info:doi/10.1371/journal.pone)
BACKGROUND: The emergence of neuraminidase inhibitor resistance has raised concerns about the prudent use of antiviral drugs in response to the next influenza pandemic. While resistant strains may initially ... Vana G, Westover KM.. Origin of the 1918 Spanish influenza virus: A comparative genomic analysis.. Mol Phylogenet Evol. 2008 Feb 14. Abstract
submitted by kickingbird at Mar, 25, 2008 from Mol Phylogenet Evol. 2008 Feb 14 (via http://www.ncbi.nlm.nih.gov/pubmed/18353690?ordinalpos=15&it)
To test the avian-origin hypothesis of the 1918 Spanish influenza virus we surveyed influenza sequences from a broad taxonomic distribution and collected 65 full-length genomes representing avian, human ... Gyarmati P, Conze T, Zohari S, Leblanc N, Nilsson. Simultaneous genotyping of all hemagglutinin and neuraminidase subtypes of avian influenza viruses using padlock probes. J Clin Microbiol. 2008 Mar 19. Abstract
submitted by kickingbird at Mar, 25, 2008 from J Clin Microbiol. 2008 Mar 19 (via http://jcm.asm.org/cgi/content/abstract/JCM.02292-07v1)
A subtyping assay for both the hemagglutinin (HA) and neuraminidase (NA) surface antigens of the Avian Influenza virus (AIV) has been developed. The method uses padlock probe chemistry combined with a ... Boni MF, Zhou Y, Taubenberger JK, Holmes EC.. Homologous Recombination is Very Rare or Absent in Human Influenza A Virus. J Virol. 2008 Mar 19. Abstract
submitted by kickingbird at Mar, 25, 2008 from J Virol. 2008 Mar 19 (via http://jvi.asm.org/cgi/content/abstract/JVI.02683-07v1)
To determine the extent of homologous recombination in human influenza A virus we assembled a data set of 13,852 sequences representing all eight segments and of both major circulating subtypes, H3N2 and ... Hao X, Kim TS, Braciale TJ.. Differential response of respiratory dendritic cell subsets to influenza virus infection. J Virol. 2008 Mar 19. Abstract
submitted by kickingbird at Mar, 25, 2008 from J Virol. 2008 Mar 19 (via http://jvi.asm.org/cgi/content/abstract/JVI.02367-07v1)
Dendritic cells (DC) are believed to play an important role in the initiation of innate and adaptive immune responses to infection - including respiratory tract infections where respiratory dendritic cells ... Kreijtz J, de Mutsert G, van Baalen C, Fouchier R,. Cross-recognition of avian H5N1 influenza virus by human cytotoxic T lymphocyte populations directed to human influenza A virus. J Virol. 2008 Mar 19. Abstract
submitted by kickingbird at Mar, 25, 2008 from J Virol. 2008 Mar 19 (via http://jvi.asm.org/cgi/content/abstract/JVI.02694-07v1)
Since the number of human cases of infection with avian H5N1 influenza viruses is ever increasing, a pandemic outbreak caused by these viruses is feared. Therefore, in addition to virus-specific antibodies, ... Castiglioni P, Hall de S, Jacovetty EL, Ingulli E,. Protection against Influenza A Virus by Memory CD8 T Cells Requires Reactivation by Bone Marrow-Derived Dendritic Cells. J Immunol. 2008 Apr 1;180(7):4956-64. Abstract
submitted by kickingbird at Mar, 25, 2008 from J Immunol. 2008 Apr 1;180(7):4956-64 (via http://www.jimmunol.org/cgi/content/abstract/180/7/4956)
Influenza A virus is the causative agent of an acute inflammatory disease of the airway. Although Abs can prevent infection, disease and death can be prevented by T cell-mediated immunity. Recently, we ... Meisner J, Szretter KJ, Bradley KC, Langley WA, Li. Infectivity Studies of Influenza Virus Hemagglutinin Receptor Binding-Site Mutants in Mice. J Virol. 2008 Mar 19. Abstract
submitted by kickingbird at Mar, 25, 2008 from J Virol. 2008 Mar 19 (via http://jvi.asm.org/cgi/content/abstract/JVI.01958-07v1)
The replicative properties of influenza hemagglutinin (HA) mutants with altered receptor binding characteristics were analyzed following intranasal inoculation of mice. Among the mutants examined was a ... Straight TM, Ottolini MG, Prince GA, Eichelberger. Antibody contributes to heterosubtypic protection against influenza A-induced tachypnea in cotton rats.. Virol J. 2008 Mar 20;5(1):44. Abstract
submitted by kickingbird at Mar, 25, 2008 from Virol J. 2008 Mar 20;5(1):44 (via http://www.virologyj.com/content/5/1/44)
Influenza virus infection or vaccination evokes an antibody response to viral hemagglutinin (HA) and neuraminidase (NA) surface glycoproteins, which results in immunity against influenza A viruses ... Nicas M, Best D.. A study quantifying the hand-to-face contact rate and its potential application to predicting respiratory tract infection.. J Occup Environ Hyg. 2008 Jun;5(6):347-52. Abstract
submitted by kickingbird at Mar, 25, 2008 from J Occup Environ Hyg. 2008 Jun;5(6):347-52 (via http://www.informaworld.com/smpp/content?content=10.1080/154)
A substantial portion of human respiratory tract infection is thought to be transmitted via contaminated hand contact with the mouth, eyes, and/or nostrils. Thus, a key risk factor for infection transmission ... Wang J, Vijaykrishna D, Duan L, Bahl J, Zhang JX,. Identification of the progenitors of Indonesian and Vietnamese avian influenza A (H5N1) viruses from southern China. J Virol. 2008 Apr;82(7):3405-14. Abstract
submitted by kickingbird at Mar, 19, 2008 from J Virol. 2008 Apr;82(7):3405-14 (via http://www.ncbi.nlm.nih.gov/pubmed/18216109?ordinalpos=1)
The transmission of highly pathogenic avian influenza H5N1 virus to Southeast Asian countries triggered the first major outbreak and transmission wave in late 2003, accelerating the pandemic threat to ... Roussan DA, Haddad R, Khawaldeh G.. Molecular survey of avian respiratory pathogens in commercial broiler chicken flocks with respiratory diseases in jordan. Poult Sci. 2008 Mar;87(3):444-8. Abstract
submitted by kickingbird at Mar, 19, 2008 from Poult Sci. 2008 Mar;87(3):444-8 (via http://www.ncbi.nlm.nih.gov/pubmed/18281569?dopt=Abstract)
Acute respiratory tract infections are of paramount importance in the poultry industry. Avian influenza virus (AIV), infectious bronchitis virus (IBV), Newcastle disease virus (NDV), avian pneumovirus ... Raviv Y, Blumenthal R, Tompkins SM, Humberd J, Hog. Hydrophobic Inactivation of Influenza Viruses confers Preservation of Viral Structure with Enhanced Immunogenicity. J Virol. 2008 Feb 27. Abstract
submitted by kickingbird at Mar, 19, 2008 from J Virol. 2008 Feb 27 (via http://www.ncbi.nlm.nih.gov/pubmed/18305038?dopt=Abstract)
The use of inactivated influenza virus for the development of vaccines with broad heterosubtypic protection requires selective inactivation techniques that eliminate viral infectivity while preserving ... Gabriel G, Herwig A, Klenk HD.. Interaction of Polymerase Subunit PB2 and NP with Importin alpha1 Is a Determinant of Host Range of Influenza A Virus. PLoS Pathog. 2008 Feb 1;4(2):e11. Full Text
submitted by kickingbird at Mar, 19, 2008 from PLoS Pathog. 2008 Feb 1;4(2):e11 (via http://www.plospathogens.org/article/info:doi/10.1371/journa)
We have previously reported that mutations in the polymerase proteins PB1, PB2, PA, and the nucleocapsid protein NP resulting in enhanced transcription and replication activities in mammalian cells are ... Srinivasan A, Viswanathan K, Raman R, Chandrasekar. Quantitative biochemical rationale for differences in transmissibility of 1918 pandemic influenza A viruses. Proc Natl Acad Sci U S A. 2008 Feb 26;105(8):2800-. Full Text
submitted by kickingbird at Mar, 19, 2008 from Proc Natl Acad Sci U S A. 2008 Feb 26;105(8):2800- (via http://www.pnas.org/cgi/content/full/105/8/2800)
The human adaptation of influenza A viruses is critically governed by the binding specificity of the viral surface hemagglutinin (HA) to long (chain length) alpha2-6 sialylated glycan (alpha2-6) receptors ... Jackson D, Hossain MJ, Hickman D, Perez DR, Lamb R. A new influenza virus virulence determinant: The NS1 protein four C-terminal residues modulate pathogenicity. Proc Natl Acad Sci U S A. 2008 Mar 11. Full Text
submitted by kickingbird at Mar, 18, 2008 from Proc Natl Acad Sci U S A. 2008 Mar 11 (via http://www.pnas.org/cgi/reprint/0800482105v1)
The virulence of influenza virus is a multigenic trait. One determinant of virulence is the multifunctional NS1 protein that functions in several ways to defeat the cellular innate immune response. Recent ... Vanlaere I, Vanderrijst A, Guénet JL, De Filette M. Mx1 causes resistance against influenza A viruses in the Mus spretus-derived inbred mouse strain SPRET/Ei. Cytokine. 2008 Mar 9. Abstract
submitted by kickingbird at Mar, 18, 2008 from Cytokine. 2008 Mar 9 (via http://www.ncbi.nlm.nih.gov/pubmed/18334301?ordinalpos=22&it)
Inbred SPRET/Ei mice, derived from Mus spretus, were found to be extremely resistant to infection with a mouse adapted influenza A virus. The resistance was strongly linked to distal chromosome 16, where ... 5165 items, 20/Page, Page[218/259][|<<] [|<] [211] [212] [213] [214] [215] [216] [217] [218] [219] [220] [>|] [>>|] |
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