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2026-2-1 14:38:48
Article

Minxi Jiang, etc.,al. [preprint]Developing and Benchmarking One Health Genomic Surveillance Tools for Influenza A Virus in Wastewater. https://doi.org/10.1101/2025.09.19.676942.  Abstract  
submitted by kickingbird at Sep, 22, 2025 from https://doi.org/10.1101/2025.09.19.676942 (via https://www.biorxiv.org/content/10.1101/2025.09.19.676942v1)
Influenza A viruses (IAV) remain a persistent One Health threat, and whole-genome sequencing from wastewater offers a promising surveillance tool. However, IAV is at low abundance in wastewater, making ...

Indr? Blagnyt?, etc.,al. [preprint]Phylogeographic analysis of Influenza D virus evolution. https://doi.org/10.1101/2025.09.19.677308.  Abstract  
submitted by kickingbird at Sep, 22, 2025 from https://doi.org/10.1101/2025.09.19.677308 (via https://www.biorxiv.org/content/10.1101/2025.09.19.677308v1)
Influenza D virus (IDV), first identified in 2011 and primarily affecting cattle, has since been detected in a wide range of mammalian hosts and geographic regions. Despite widespread circulation in domestic ...

Rebecca M. Schneider, etc.,al. [preprint]The structures of tetrameric Avian Immunoglobulin A are uniquely structured to support mucosal immunity. https://doi.org/10.1101/2025.09.19.677352.  Abstract  
submitted by kickingbird at Sep, 22, 2025 from https://doi.org/10.1101/2025.09.19.677352 (via https://www.biorxiv.org/content/10.1101/2025.09.19.677352v1)
Birds and mammals assemble polymeric (p) forms of immunoglobulin (Ig) A, which are transported to mucosal surfaces and released as secretory (S) IgA, the predominant mucosal antibody. Mammalian SIgA, which ...

Harit D, Sawant S, Spreng RL, Gurley S, Schechter. Qualification of a reporter virus microneutralization assay for evaluation of influenza specific antibodies in human clinical trials. Vaccine. 2025 Sep 19;64:127699.  Abstract  
submitted by kickingbird at Sep, 22, 2025 from Vaccine. 2025 Sep 19;64:127699 (via https://www.sciencedirect.com/science/article/abs/pii/S02644)
Neutralizing antibodies can block the entry of viruses into host cells. Next-generation influenza vaccines should stimulate the production of high levels of neutralizing antibodies capable of preventing ...

Danuta M Skowronski, etc.,al. [preprint]Cross-reactive neuraminidase inhibition antibodies against H5N1 by consecutive influenza A imprinting cohorts of the past century: population-based serosurvey, British Columbia, Canada. https://doi.org/10.1101/2025.09.19.25336209.  Abstract  
submitted by kickingbird at Sep, 22, 2025 from https://doi.org/10.1101/2025.09.19.25336209 (via https://www.medrxiv.org/content/10.1101/2025.09.19.25336209v)
Background: Avian influenza of the H5N1 subtype shares substantial relatedness in its neuraminidase (NA) surface protein with human influenza A H1N1 viruses of the past century. Understanding variation ...

Jun-Qing Wei, Sen Zhang, Ya- Dan Li, Shu-Yang Jian. Deep learning predicts potential reassortments of avian H5N1 with human influenza viruses. National Science Review, 2025;, nwaf396.  Abstract  
submitted by kickingbird at Sep, 22, 2025 from National Science Review, 2025;, nwaf396 (via https://academic.oup.com/nsr/advance-article/doi/10.1093/nsr)
Frequent infection cases with avian H5N1 influenza A viruses (IAVs) are posing pandemic risks of human/avian-reassorted IAVs. We aimed to build an attentional deep learning model named HAIRANGE, for predicting ...

Hoang-Hai Nguyen, Josip Rudar, Nathaniel Lesperanc. WaveSeekerNet: accurate prediction of influenza A virus subtypes and host source using attention-based deep learning. GigaScience, Volume 14, 2025, giaf089.  Abstract  
submitted by kickingbird at Sep, 22, 2025 from GigaScience, Volume 14, 2025, giaf089 (via https://academic.oup.com/gigascience/article/doi/10.1093/gig)
BackgroundInfluenza A virus (IAV) poses a significant threat to animal health globally, with its ability to overcome species barriers and cause pandemics. Rapid and accurate IAV subtypes and host source ...

Liu, L., Xia, L., Wu, B. et al. Preparation and characterization of a Llama VHH-hFc chimeric antibody recognizing conserved neutralization epitope of H5N1 hemagglutinin with high affinity. Arch Microbiol 207, 252 (2025).  Abstract  
submitted by kickingbird at Sep, 22, 2025 from Arch Microbiol 207, 252 (2025) (via https://link.springer.com/article/10.1007/s00203-025-04460-7)
Highly pathogenic avian influenza (HPAI) H5N1 virus poses a continuing global public health threat due to its outbreaks in poultry farms and zoonotic transmission from birds to humans. In the quest of ...

Colombo RE, Richard SA, Schmidt K, Schofield C, Ga. Randomized pragmatic trial of the comparative effectiveness of chicken egg-based inactivated, mammalian cell-culture-based inactivated, and recombinant protein quadrivalent seasonal influenza vaccines. Clin Infect Dis. 2025 Sep 18:ciaf503.  Abstract  
submitted by kickingbird at Sep, 21, 2025 from Clin Infect Dis. 2025 Sep 18:ciaf503 (via https://academic.oup.com/cid/advance-article-abstract/doi/10)
Background: Influenza is a major cause of morbidity and mortality worldwide. The Pragmatic Assessment of Influenza Vaccine Effectiveness (VE) in the Department of Defense (PAIVED) study compared the relative ...

Chrzastek K, Lieber CM, Plemper RK. H5N1 Clade 2.3.4.4b: Evolution, Global Spread, and Host Range Expansion. Pathogens. 2025; 14(9):929.  Abstract  
submitted by kickingbird at Sep, 20, 2025 from Pathogens. 2025; 14(9):929 (via https://www.mdpi.com/2076-0817/14/9/929)
Highly pathogenic avian influenza viruses (HPAIVs) of the H5 subtype pose a continuous threat to animal and public health due to their zoonotic potential, rapid evolution, and ability to spread across ...

Soni S, Mebratu YA. Polymorphism of BIK as a Host Risk Factor for Severe Influenza. DNA Cell Biol. 2025 Sep 19.  Abstract  
submitted by kickingbird at Sep, 20, 2025 from DNA Cell Biol. 2025 Sep 19 (via https://www.liebertpub.com/doi/10.1177/10445498251379681)
This essay focuses on a key host factor, the protein BIK (Bcl-2-interacting killer), that influences the severity of influenza A virus (IAV) infections. Our recent research published in Proceedings of ...

Allison K Miller, etc.,al. [preprint]Evaluating sampling strategies for the detection of avian influenza viruses in the environment. https://doi.org/10.1101/2025.09.18.677014.  Abstract  
submitted by kickingbird at Sep, 19, 2025 from https://doi.org/10.1101/2025.09.18.677014 (via https://www.biorxiv.org/content/10.1101/2025.09.18.677014v1)
Highly pathogenic avian influenza (HPAI) viruses threaten humans, livestock and wildlife, highlighting the urgent need for early warning surveillance. Environmental RNA (eRNA) monitoring provides a safer, ...

Clément Castille, etc.,al. [preprint]Duck Slurry as a Matrix for Avian Influenza Virus Surveillance and Genetic Characterization in Domestic Flocks. https://doi.org/10.1101/2025.09.18.677031.  Abstract  
submitted by kickingbird at Sep, 19, 2025 from https://doi.org/10.1101/2025.09.18.677031 (via https://www.biorxiv.org/content/10.1101/2025.09.18.677031v1)
Avian influenza viruses (AIVs) circulate widely in domestic and wild birds and continue to pose major risks to animal and public health, in particular those of high pathogenicity (HP). Ducks play a key ...

Yu J, Kong M, Bai H, Fang W, Zhou X, Luo W, Gui H,. Genetic and biological features of avian influenza virus subtype H10N5 in environmental samples related to a case of dual infection by H10N5 and H3N2. Diagn Microbiol Infect Dis. 2025 Aug 6;114(1):1170.  Abstract  
submitted by kickingbird at Sep, 19, 2025 from Diagn Microbiol Infect Dis. 2025 Aug 6;114(1):1170 (via https://www.sciencedirect.com/science/article/abs/pii/S07328)
In 2023, the first case of dual infection with H10N5 avian influenza virus and seasonal H3N2 influenza virus in humans was reported in Anhui Province, China, marking the first documented cross-species ...

Liam Brierley, Joaquin Mould-Quevedo, Matthew Bayl. [preprint]An AI for an AI: identifying zoonotic potential of avian influenza viruses via genomic machine learning. https://doi.org/10.1101/2025.09.16.676011.  Abstract  
submitted by kickingbird at Sep, 18, 2025 from https://doi.org/10.1101/2025.09.16.676011 (via https://www.biorxiv.org/content/10.1101/2025.09.16.676011v1)
Avian influenza remains a serious risk to human health via zoonotic transmission, as well as a feasible pandemic threat. Although limited zoonotic cases have resulted from the current epizootic outbreak, ...

Pappas C, Brock N, Belser JA, Kieran TJ, Pulit-Pen. Identification of clinical and virological correlates associated with influenza A candidate vaccine virus (CVV) attenuation in a ferret model. J Virol 0:e01023-25.  Abstract  
submitted by kickingbird at Sep, 18, 2025 from J Virol 0:e01023-25 (via https://journals.asm.org/doi/10.1128/jvi.01023-25)
Influenza A viruses continuously circulate among avian and swine species, posing a persistent threat to public health. The development of influenza candidate vaccine viruses (CVVs) plays a pivotal role ...

Ito Toshihiro. Pathogenicity and host range of avian influenza viruses: molecular determinants and virological perspectives. J Vet Med Sci. 2025 Sep 16.  Abstract  
submitted by kickingbird at Sep, 18, 2025 from J Vet Med Sci. 2025 Sep 16 (via https://www.jstage.jst.go.jp/article/jvms/advpub/0/advpub_25)
The pathogenicity of avian influenza virus (AIV) is governed primarily by the hemagglutinin (HA) glycoprotein. Highly pathogenic avian influenza viruses contain a highly cleavable HA molecule susceptible ...

Di Genova C, Warren CJ, Johnson S, Riccio S, Roper. Pigeons exhibit low susceptibility and poor transmission capacity for H5N1 clade 2.3.4.4b high pathogenicity avian influenza virus. J Gen Virol. 2025 Sep;106(9).  Abstract  
submitted by kickingbird at Sep, 18, 2025 from J Gen Virol. 2025 Sep;106(9) (via https://www.microbiologyresearch.org/content/journal/jgv/10.)
The ongoing panzootic of H5N1 high pathogenicity avian influenza virus (HPAIV) has caused the deaths of over half a billion wild birds and poultry and has led to spillover events in both wild and domestic ...

Sun X, Subbiah J, Belser JA, Brock N, Gansebom S,. Effect of Seasonal Influenza Vaccines on Avian Influenza A(H5N1) Clade 2.3.4.4b Virus Infection in Ferrets. Emerg Infect Dis. 2025 Oct.  Abstract  
submitted by kickingbird at Sep, 18, 2025 from Emerg Infect Dis. 2025 Oct (via https://wwwnc.cdc.gov/eid/article/31/10/25-0668_article)
Highly pathogenic avian influenza A(H5N1) clade 2.3.4.4b viruses have infected >1,000 herds of dairy cattle and hundreds of poultry flocks in the United States since the beginning of 2024. Seventy human ...

Banyard AC, Coombes H, Terrey J, McGinn N, Seeking. Detection of clade 2.3.4.4b H5N1 high pathogenicity avian influenza virus in a sheep in Great Britain, 2025. Emerg Microbes Infect. 2025 Dec;14(1):2547730.  Abstract  
submitted by kickingbird at Sep, 16, 2025 from Emerg Microbes Infect. 2025 Dec;14(1):2547730 (via https://www.tandfonline.com/doi/full/10.1080/22221751.2025.2)
Clade 2.3.4.4b H5N1 high pathogenicity avian influenza virus (HPAIV) continues to pose a significant global threat, affecting wild and domestic avian, and mammalian species. In early 2024, H5N1 HPAIV was ...

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