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2024-4-28 1:02:14
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Kwon JH, Bertran K, Lee DH, Criado MF, Killmaster. Diverse infectivity, transmissibility, and pathobiology of clade 2.3.4.4 H5Nx highly pathogenic avian influenza viruses in chickens. Emerg Microbes Infect. 2023 Dec;12(1):2218945.  Abstract  
submitted by kickingbird at Jun, 14, 2023 from Emerg Microbes Infect. 2023 Dec;12(1):2218945 (via https://www.tandfonline.com/doi/full/10.1080/22221751.2023.2)
Clade 2.3.4.4 Eurasian lineage H5Nx highly pathogenic avian influenza virus (HPAIV) has become the globally dominant clade and caused global outbreaks since 2014. The clade 2.3.4.4 viruses have evolved ...

Hanula R, Bortolussi-Courval é, Mendel A, Ward BJ,. Evaluation of Oseltamivir Used to Prevent Hospitalization in Outpatients With Influenza: A Systematic Review and Meta-analysis. JAMA Intern Med. 2023 Jun 12..  Abstract  
submitted by kickingbird at Jun, 13, 2023 from JAMA Intern Med. 2023 Jun 12. (via https://jamanetwork.com/journals/jamainternalmedicine/fullar)
Importance: Despite widespread use, summary evidence from prior meta-analyses has contradictory conclusions regarding whether oseltamivir decreases the risk of hospitalization when given to outpatients. ...

Tosheva II, Saygan KS, Mijnhardt SM, Russell CJ, F. Hemagglutinin stability as a key determinant of influenza A virus transmission via air. Curr Opin Virol. 2023 Jun 10;61:101335.  Abstract  
submitted by kickingbird at Jun, 13, 2023 from Curr Opin Virol. 2023 Jun 10;61:101335 (via https://www.sciencedirect.com/science/article/pii/S187962572)
To cause pandemics, zoonotic respiratory viruses need to adapt to replication in and spread between humans, either via (indirect or direct) contact or through the air via droplets and aerosols. To render ...

Wang K, Gong M, Zhao S, Lai C, Zhao L, Cheng S, Xi. A novel lncRNA DFRV plays a dual function in influenza A virus infection. Front Microbiol. 2023 May 25;14:1171423.  Abstract  
submitted by kickingbird at Jun, 12, 2023 from Front Microbiol. 2023 May 25;14:1171423 (via https://www.frontiersin.org/articles/10.3389/fmicb.2023.1171)
Long noncoding RNAs (lncRNAs) have been associated with a variety of biological activities, including immune responses. However, the function of lncRNAs in antiviral innate immune responses are not fully ...

Gass JD Jr, Hill NJ, Damodaran L, Naumova EN, Nutt. Ecogeographic Drivers of the Spatial Spread of Highly Pathogenic Avian Influenza Outbreaks in Europe and the United States, 2016-Early 2022. Int J Environ Res Public Health. 2023 Jun 1;20(11).  Abstract  
submitted by kickingbird at Jun, 11, 2023 from Int J Environ Res Public Health. 2023 Jun 1;20(11) (via https://www.mdpi.com/1660-4601/20/11/6030)
H5Nx highly pathogenic avian influenza (HPAI) viruses of clade 2.3.4.4 have caused outbreaks in Europe among wild and domestic birds since 2016 and were introduced to North America via wild migratory birds ...

Chen P, Jin Z, Peng L, Zheng Z, Cheung YM, Guan J,. Characterization of an Emergent Chicken H3N8 Influenza Virus in Southern China: a Potential Threat to Public Health. J Virol. 2023 Jun 8:e0043423.  Abstract  
submitted by kickingbird at Jun, 9, 2023 from J Virol. 2023 Jun 8:e0043423 (via https://journals.asm.org/doi/10.1128/jvi.00434-23)
Although influenza A viruses of several subtypes have occasionally infected humans, to date only those of the H1, H2, and H3 subtypes have led to pandemics and become established in humans. The detection ...

Zhou Y, Zhang S, Wang B, Ran Y, Tu S, Lin Z, Jin M. Proliferating cell nuclear antigen impairs the nuclear import of influenza A virus PB2 and suppresses virus replication. J Med Virol. 2023 Jun;95(6):e28849.  Abstract  
submitted by kickingbird at Jun, 8, 2023 from J Med Virol. 2023 Jun;95(6):e28849 (via https://pubmed.ncbi.nlm.nih.gov/37282768/)
The genome of Influenza A virus (IAV) transcribes and replicates in the nucleus of cells and the viral ribonucleoprotein (vRNP) complex plays an important role in viral replication. As a major component ...

Stevens L, de Buyl S, Mognetti BM. The sliding motility of the bacilliform virions of Influenza A viruses. Soft Matter. 2023 Jun 6.  Abstract  
submitted by kickingbird at Jun, 7, 2023 from Soft Matter. 2023 Jun 6 (via https://pubs.rsc.org/en/content/articlelanding/2023/SM/D3SM0)
Influenza A virus (IAV) infection relies on the action of the hemagglutinin (HA) and neuraminidase (NA) membrane proteins. The HA ligands anchor the IAV virion to the cell's surface by binding the sialic ...

Yehia N, Rabie N, Adel A, Mossad Z, Nagshabandi MK. Differential replication characteristic of reassortant avian influenza A viruses H5N8 clade 2.3.4.4b in Madin-Darby canine kidney cell. Poult Sci. 2023 Mar 29;102(7):102685.  Abstract  
submitted by kickingbird at Jun, 4, 2023 from Poult Sci. 2023 Mar 29;102(7):102685 (via https://www.sciencedirect.com/science/article/pii/S003257912)
Late in 2016, multiple reassortant highly pathogenic (HP) avian influenza virus (AIVs) H5N8 was detected. AIVs infect different isolated hosts with a specific viral tropism. In the current study, the whole ...

Wang C, Honce R, Salvatore M, Chow D, Randazzo D,. Influenza Defective Interfering Virus Promotes Multiciliated Cell Differentiation and Reduces the Inflammatory Response in Mice. J Virol. 2023 May 31:e0049323.  Abstract  
submitted by kickingbird at Jun, 2, 2023 from J Virol. 2023 May 31:e0049323 (via https://journals.asm.org/doi/10.1128/jvi.00493-23)
Influenza defective interfering (DI) viruses have long been considered promising antiviral candidates because of their ability to interfere with replication-competent viruses and induce antiviral immunity. ...

Meng B, Li H, Feng C, Guo W, Feng Y, Zhu D, Chen H. Emergence of a novel reassortant H3N6 canine influenza virus. Front Microbiol. 2023 May 11;14:1186869.  Abstract  
submitted by kickingbird at May, 31, 2023 from Front Microbiol. 2023 May 11;14:1186869 (via https://www.frontiersin.org/articles/10.3389/fmicb.2023.1186)
Although the natural hosts of avian influenza viruses (AIVs) are wild birds, multiple subtypes of AIVs have established epidemics in numerous mammals due to their cross-species spillover. Replication and ...

Nico Halwe, etc al. The bat-borne influenza A virus H9N2 exhibits a set of unexpected pre-pandemic features. Research Square.  Abstract  
submitted by kickingbird at May, 29, 2023 from Research Square (via https://www.researchsquare.com/article/rs-2937503/v1)
An Old-World bat H9N2 influenza A virus (IAV) identified in Egypt exhibits high replication and transmission potential in ferrets, efficient infection of human lung explant cultures and marked escape from ...

Schuele C, Schmeisser F, Orr M, Meseda CA, Vasudev. Neutralizing and protective murine monoclonal antibodies to the hemagglutinin of influenza H5 clades 2.3.2.1 and 2.3.4.4. Influenza Other Respir Viruses. 2023 May;17(5):e13.  Abstract  
submitted by kickingbird at May, 29, 2023 from Influenza Other Respir Viruses. 2023 May;17(5):e13 (via https://onlinelibrary.wiley.com/doi/10.1111/irv.13152)
Background: Highly pathogenic avian H5 influenza viruses have spread and diversified genetically and antigenically into multiple clades and subclades. Most isolates of currently circulating H5 viruses ...

Liu Y, Wang Y, Wang Y, Mai H, Chen Y, Zhang Y, Ji. Phylogenetic analysis of HA and NA genes of influenza A viruses in immunosuppressed inpatients in Beijing during the 2018-2020 influenza seasons. Virol J. 2023 May 26;20(1):101.  Abstract  
submitted by kickingbird at May, 29, 2023 from Virol J. 2023 May 26;20(1):101 (via https://virologyj.biomedcentral.com/articles/10.1186/s12985-)
Background: Influenza A viruses have undergone rapid evolution with virulent; however, complete and comprehensive data on gene evolution and amino acid variation of HA and NA in immunosuppressed patients ...

Ning H, Chiu SH, Xu X, Ma Y, Chen JL, Yang G. The Immunosuppressive Roles of PD-L1 during Influenza A Virus Infection. Int J Mol Sci. 2023 May 11;24(10):8586.  Abstract  
submitted by kickingbird at May, 29, 2023 from Int J Mol Sci. 2023 May 11;24(10):8586 (via https://www.mdpi.com/1422-0067/24/10/8586)
The clinical benefits of targeting programmed death-ligand 1 (PD-L1) in various cancers represent a strategy for the treatment of immunosuppressive diseases. Here, it was demonstrated that the expression ...

An SH, Hong SM, Song JH, Son SE, Lee CY, Choi KS,. Engineering an Optimal Y280-Lineage H9N2 Vaccine Strain by Tuning PB2 Activity. Int J Mol Sci. 2023 May 16;24(10):8840.  Abstract  
submitted by kickingbird at May, 29, 2023 from Int J Mol Sci. 2023 May 16;24(10):8840 (via https://www.mdpi.com/1422-0067/24/10/8840)
H9N2 avian influenza A viruses (AIVs) cause economic losses in the poultry industry and provide internal genomic segments for the evolution of H5N1 and H7N9 AIVs into more detrimental strains for poultry ...

Agustiningsih A, Indalao IL, Pangesti KA, Sukowati. Molecular Characterization of Influenza A/H3N2 Virus Isolated from Indonesian Hajj and Umrah Pilgrims 2013 to 2014. Life (Basel). 2023 Apr 27;13(5):1100.  Abstract  
submitted by kickingbird at May, 29, 2023 from Life (Basel). 2023 Apr 27;13(5):1100 (via https://www.mdpi.com/2075-1729/13/5/1100)
The Hajj and Umrah are the annual mass gatherings of Muslims in Saudi Arabia and increase the transmission risk of acute respiratory infection. This study describes influenza infection among pilgrims upon ...

Guan L, Zhong G, Fan S, Plisch EM, Presler R, Gu C. Highly Pathogenic H5 Influenza Viruses Isolated between 2016 and 2017 in Vietnamese Live Bird Markets. Viruses. 2023 Apr 29;15(5):1093.  Abstract  
submitted by kickingbird at May, 29, 2023 from Viruses. 2023 Apr 29;15(5):1093 (via https://www.mdpi.com/1999-4915/15/5/1093)
Routine surveillance in live poultry markets in the northern regions of Vietnam from 2016 to 2017 resulted in the isolation of 27 highly pathogenic avian H5N1 and H5N6 viruses of 3 different clades (2.3.2.1c, ...

Sharshov K, Dubovitskiy N, Derko A, Loginova A, Ko. Does Avian Coronavirus Co-Circulate with Avian Paramyxovirus and Avian Influenza Virus in Wild Ducks in Siberia?. Viruses. 2023 May 7;15(5):1121.  Abstract  
submitted by kickingbird at May, 29, 2023 from Viruses. 2023 May 7;15(5):1121 (via https://www.mdpi.com/1999-4915/15/5/1121)
Avian coronaviruses (ACoV) have been shown to be highly prevalent in wild bird populations. More work on avian coronavirus detection and diversity estimation is needed for the breeding territories of migrating ...

Jakob C, Lovate GL, Desirò D, Gie?ler L, Smyth RP,. Sequential disruption of SPLASH-identified vRNA-vRNA interactions challenges their role in influenza A virus genome packaging. Nucleic Acids Res. 2023 May 24:gkad442.  Abstract  
submitted by kickingbird at May, 26, 2023 from Nucleic Acids Res. 2023 May 24:gkad442 (via https://academic.oup.com/nar/advance-article/doi/10.1093/nar)
A fundamental step in the influenza A virus (IAV) replication cycle is the coordinated packaging of eight distinct genomic RNA segments (i.e. vRNAs) into a viral particle. Although this process is thought ...

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