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GOTO H, Muramoto Y, Noda T, Kawaoka Y, et al. The genome packaging signal of the influenza A virus genome comprises a genome incorporation signal and a genome bundling signal. J Virol. 2013 Aug 7.  Abstract  
submitted by kickingbird at Aug, 11, 2013 from J Virol. 2013 Aug 7 (via http://www.ncbi.nlm.nih.gov/pubmed/23926345)
The influenza A virus genome comprises eight single-stranded negative-sense RNA segments (vRNAs). All eight vRNAs are selectively packaged into each progeny virion via so-called segment-specific genome ...

LOHRMANN F, Dijkman R, Stertz S, Thiel V, et al. Emergence of a C-terminal seven amino acid elongation of NS1 around 1950 conferred a minor growth advantage to former seasonal influenza A viruses. J Virol. 2013 Aug 7..  Abstract  
submitted by kickingbird at Aug, 11, 2013 from J Virol. 2013 Aug 7. (via http://www.ncbi.nlm.nih.gov/pubmed/23926347)
Influenza A viruses circulating in humans from ~1950 to ~1987 featured a non-structural (NS1) protein with a C-terminal extension of seven amino acids. The biological significance of this NS1 elongation ...

NG S, Fang VJ, Ip DK, Chan KH, et al. Estimation of the association between antibody titers and protection against confirmed influenza virus infection in children. J Infect Dis. 2013 Aug 1..  Abstract  
submitted by kickingbird at Aug, 11, 2013 from J Infect Dis. 2013 Aug 1. (via http://www.ncbi.nlm.nih.gov/pubmed/23908481)
Antibody titers measured by hemagglutination inhibition (HAI) correlate with protection against influenza virus infection, and are used to specify criteria for vaccine licensure. In a randomized controlled ...

Xian Qi, etc.,al. Probable person to person transmission of novel avian influenza A (H7N9) virus in Eastern China, 2013: epidemiological investigation. BMJ 2013;347:f4752.  Abstract  
submitted by kickingbird at Aug, 9, 2013 from BMJ 2013;347:f4752 (via http://www.bmj.com/content/347/bmj.f4752)
Abstract Objective To determine whether the novel avian influenza H7N9 virus can transmit from person to person and its efficiency. Design Epidemiological investigations conducted after a family cluster ...

KOHIO HP, Adamson AL. Glycolytic control of vacuolar-type ATPase activity: A mechanism to regulate influenza viral infection. Virology. 2013 Jul 19.  Abstract  
submitted by kickingbird at Jul, 30, 2013 from Virology. 2013 Jul 19 (via http://www.ncbi.nlm.nih.gov/pubmed/23876457)
As new influenza virus strains emerge, finding new mechanisms to control infection is imperative. In this study, we found that we could control influenza infection of mammalian cells by altering the level ...

SZURGOT I, Szolajska E, Laurin D, Lambrecht B, et. Self-adjuvanting influenza candidate vaccine presenting epitopes for cell-mediated immunity on a proteinaceous multivalent nanoplatform. Vaccine. 2013 Jul 20.  Abstract  
submitted by kickingbird at Jul, 30, 2013 from Vaccine. 2013 Jul 20 (via http://www.ncbi.nlm.nih.gov/pubmed/23880363)
We exploit the features of a virus-like particle, adenoviral dodecahedron (Ad Dd), for engineering a multivalent vaccination platform carrying influenza epitopes for cell-mediated immunity. The delivery ...

HERTZ T, Oshansky CM, Roddam PL, Devincenzo JP, et. HLA targeting efficiency correlates with human T-cell response magnitude and with mortality from influenza A infection. Proc Natl Acad Sci U S A. 2013 Jul 22.  Abstract  
submitted by kickingbird at Jul, 30, 2013 from Proc Natl Acad Sci U S A. 2013 Jul 22 (via http://www.ncbi.nlm.nih.gov/pubmed/23878211)
Experimental and computational evidence suggests that HLAs preferentially bind conserved regions of viral proteins, a concept we term "targeting efficiency," and that this preference may provide improved ...

SHCHERBIK S, Sergent SB, Davis WG, Shu B, et al. Application of real time RT-PCR for the genetic homogeneity and stability tests of the seed candidates for live attenuated influenza vaccine production. J Virol Methods. 2013 Jul 18. pii: S0166-0934.  Abstract  
submitted by kickingbird at Jul, 30, 2013 from J Virol Methods. 2013 Jul 18. pii: S0166-0934 (via http://www.ncbi.nlm.nih.gov/pubmed/23872266)
Development and improvement of quality control tests for live attenuated vaccines are a high priority because of safety concerns. Live Attenuated Influenza Vaccine (LAIV) viruses are 6:2 reassortants containing ...

BUEHLER J, Navi D, Lorusso A, Vincent A, et al. Influenza A virus PB1-F2 protein expression is regulated in a strain-specific manner by sequences located downstream of the PB1-F2 initiation codon. J Virol. 2013 Jul 24.  Abstract  
submitted by kickingbird at Jul, 30, 2013 from J Virol. 2013 Jul 24 (via http://www.ncbi.nlm.nih.gov/pubmed/23885074)
Translation of influenza A virus PB1-F2 occurs in a second open reading frame (ORF) of the PB1 gene segment. PB1-F2 has been implicated in regulation of polymerase activity, immunopathology, susceptibility ...

SULLI C, Banik SS, Schilling J, Moser A, et al. Detection of proton movement directly across viral membranes to identify novel influenza M2 inhibitors. J Virol. 2013 Jul 24.  Abstract  
submitted by kickingbird at Jul, 30, 2013 from J Virol. 2013 Jul 24 (via http://www.ncbi.nlm.nih.gov/pubmed/23885079)
The influenza M2 protein is a well-validated yet underexploited proton-selective ion channel essential for influenza virus infectivity. Because M2 is a toxic viral ion channel, existing M2 inhibitors have ...

DU L, Li Y, Zhao G, Wang L, et al. Highly pathogenic avian influenza H5N1 mutants with air-transmissibility are susceptible to human and animal neutralizing antibodies. J Infect Dis. 2013 Jul 18..  Abstract  
submitted by kickingbird at Jul, 30, 2013 from J Infect Dis. 2013 Jul 18. (via http://www.ncbi.nlm.nih.gov/pubmed/23868877)
A laboratory-generated reassortant H5 hemagglutinin (HA)/H1N1 virus containing four mutations in H5N1 HA become airborne transmissible among mammals. Here we constructed 15 H5N1 pseudoviruses containing ...

NOH JY, Song JY, Hwang SY, Choi WS, et al. Viral load dynamics in adult patients with A(H1N1)pdm09 influenza. Epidemiol Infect. 2013 Jul 18:1-6.  Abstract  
submitted by kickingbird at Jul, 30, 2013 from Epidemiol Infect. 2013 Jul 18:1-6 (via http://www.ncbi.nlm.nih.gov/pubmed/23866846)
SUMMARY The dynamics of influenza A viral load in respiratory samples collected from adult A(H1N1)pdm09 influenza patients were investigated. Three respiratory specimens were obtained every 2-4 days and ...

L. Zhang et al.. Protection by Face Masks against Influenza A(H1N1)pdm09 Virus on Trans-Pacific Passenger Aircraft, 2009. EID Volume 19, Number 9 September 2013.  Abstract  
submitted by kickingbird at Jul, 29, 2013 from EID Volume 19, Number 9 September 2013 (via http://wwwnc.cdc.gov/eid/article/19/9/12-1765_article.htm)
In response to several influenza A(H1N1)pdm09 infections that developed in passengers after they traveled on the same 2 flights from New York, New York, USA, to Hong Kong, China, to Fuzhou, China, we assessed ...

K. Shanmuganatham et al. Antigenic and Molecular Characterization of Avian Influenza A(H9N2) Viruses, Bangladesh. EID Volume 19, Number 9 September 2013.  Abstract  
submitted by kickingbird at Jul, 29, 2013 from EID Volume 19, Number 9 September 2013 (via http://wwwnc.cdc.gov/eid/article/19/9/13-0336_article.htm)
Human infection with avian influenza A(H9N2) virus was identified in Bangladesh in 2011. Surveillance for influenza viruses in apparently healthy poultry in live-bird markets in Bangladesh during 2008–2011 ...

MIN JY, Santos C, Fitch A, Twaddle A, et al. Mammalian adaptation in the PB2 gene of avian H5N1 influenza virus. J Virol. 2013 Jul 17..  Abstract  
submitted by kickingbird at Jul, 29, 2013 from J Virol. 2013 Jul 17. (via http://www.ncbi.nlm.nih.gov/pubmed/23864613)
The substitution of glutamic acid (E) for lysine (K) at position 627 of the PB2 protein of avian H5N1 viruses has been identified as a virulence and host-range determinant for infection of mammals. Here, ...

BLUMENKRANTZ D, Roberts KL, Shelton H, Lycett S, e. The short stalk length of HPAI H5N1 influenza neuraminidase limits transmission of pandemic H1N1 virus in ferrets. J Virol. 2013 Jul 17.  Abstract  
submitted by kickingbird at Jul, 29, 2013 from J Virol. 2013 Jul 17 (via http://www.ncbi.nlm.nih.gov/pubmed/23864615)
H5N1 influenza viruses pose a pandemic threat but have not acquired the ability to support sustained transmission between mammals in nature. The restrictions to transmissibility of avian influenza viruses ...

TE VELTHUIS AJ, Turrell L, Vreede FT, Fodor E, et. Uncoupling of influenza A virus transcription and replication through mutation of the unpaired adenosine in the vRNA promoter. J Virol. 2013 Jul 17..  Abstract  
submitted by kickingbird at Jul, 29, 2013 from J Virol. 2013 Jul 17. (via http://www.ncbi.nlm.nih.gov/pubmed/23864616)
Transcription and replication of the influenza A virus RNA genome are mediated by the viral RNA polymerase from a promoter consisting of the partially base-paired 3' and 5' termini of viral genome segments. ...

VIJAYKRISHNA D, Deng YM, Su YC, Fourment M, et al. The recent establishment of North American H10 lineage influenza viruses in Australian wild waterfowl and the evolution of Australian avian influenza viruses. J Virol. 2013 Jul 17.  Abstract  
submitted by kickingbird at Jul, 29, 2013 from J Virol. 2013 Jul 17 (via http://www.ncbi.nlm.nih.gov/pubmed/23864623)
Influenza A H10N7 virus with a hemagglutinin gene of North American origin was detected in Australian chickens and poultry abattoir workers in New South Wales in 2010 and in chickens in Queensland on a ...

PASCUA PN, Song MS, Kwon HI, Lim GJ, et al. The homologous tripartite viral RNA polymerase of A/swine/Korea/CT1204/2009(H1N2) influenza virus synergistically drives efficient replication and promotes respiratory-droplet transmission in ferrets. J Virol. 2013 Jul 17..  Abstract  
submitted by kickingbird at Jul, 29, 2013 from J Virol. 2013 Jul 17. (via http://www.ncbi.nlm.nih.gov/pubmed/23864624)
We previously reported that A/swine/Korea/1204/2009(H1N2) virus was virulent and transmissible in ferrets in which the respiratory droplet'transmissible virus (CT-Sw/1204) had acquired simultaneous HAD225G ...

CHAVES SS, Aragon D, Bennett N, Cooper T, et al. Patients hospitalized with laboratory-confirmed influenza during the 2010-2011 influenza season: exploring disease severity by virus type and subtype. J Infect Dis. 2013 Jul 17..  Abstract  
submitted by kickingbird at Jul, 29, 2013 from J Infect Dis. 2013 Jul 17. (via http://www.ncbi.nlm.nih.gov/pubmed/23863950)
Background.?The 2010-11 influenza season was dominated by influenza A(H3N2) virus, but influenza A(H1N1)pdm09 (pH1N1) and B viruses co-circulated. This provided an opportunity to explore within-season ...

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