Yang Xue, Yuki Tai, Hiromi Yamamoto, Daiki Mori, K. T cell help is a limiting factor for rare anti-influenza memory B cells to reenter germinal centers and generate potent broadly neutralizing antibodies. International Immunology, 2026;, dxag003. Abstract
submitted by kickingbird at 20 hours ago from International Immunology, 2026;, dxag003 (via https://academic.oup.com/intimm/advance-article-abstract/doi)
Development of vaccines eliciting broadly neutralizing influenza antibodies (bnAbs) is an extraordinary challenge. One hypothetical proposal is that CD4+ T cell help to rare immuno-subdominant bnAb class ... Andrew Y Cho, Dong-Hun Lee, Alice Fusaro, Edoardo. Wild birds drive the introduction, maintenance, and spread of H5N1 clade 2.3.4.4b high pathogenicity avian influenza viruses in Spain, 2021-2022. Virus Evolution, 2026;, veag006. Abstract
submitted by kickingbird at 20 hours ago from Virus Evolution, 2026;, veag006 (via https://academic.oup.com/ve/advance-article/doi/10.1093/ve/v)
The 2021-2022 high pathogenicity avian influenza (HPAI) epizootic was the worst ever recorded in Europe in general and in Spain in particular. Between December 2021 and November 2022, H5N1 clade 2.3.4.4b ... Xingyi Li, etc.,al. [preprint]FluNexus: a versatile web platform for antigenic prediction and visualization of influenza A viruses. https://doi.org/10.64898/2026.01.29.702696. Abstract
submitted by kickingbird at 21 hours ago from https://doi.org/10.64898/2026.01.29.702696 (via https://www.biorxiv.org/content/10.64898/2026.01.29.702696v1)
Influenza A viruses continuously undergo antigenic evolution to escape host immunity induced by previous infections or vaccinations, consequently causing seasonal epidemics and occasional pandemics. Antigenic ... Ying, Baoling et al. An intranasal adenoviral-vectored vaccine protects against highly pathogenic avian influenza H5N1 in naive and antigen-experienced animals. Cell Reports Medicine, January 30, 2026. Abstract
submitted by kickingbird at 21 hours ago from Cell Reports Medicine, January 30, 2026 (via https://www.cell.com/cell-reports-medicine/fulltext/S2666-37)
The emergence of highly pathogenic avian H5N1 influenza viruses in dairy cows and humans has increased the potential for another pandemic. To address this risk, we developed chimpanzee adenoviral (ChAd)-vectored ... Daniel, Katharina et al. Pre-existing neutralizing antibodies against cattle-transmitted influenza A virus H5N1 are detectable in unexposed individuals. Immunity, January 30, 2026. Abstract
submitted by kickingbird at 21 hours ago from Immunity, January 30, 2026 (via https://www.cell.com/immunity/fulltext/S1074-7613(25)00569-2)
The transmission of influenza A virus H5N1 clade 2.3.4.4b from cattle to humans highlights the risk of an H5N1 pandemic. Pre-existing immunity strongly impacts the course and severity of viral infections, ... Xiaolong Lu, etc.,al. The host RNA helicase DDX6 restricts avian influenza virus replication by targeting viral NP and modulating ISG15. Poultry Science. Abstract
submitted by kickingbird at 2 days ago from Poultry Science (via https://www.sciencedirect.com/science/article/pii/S003257912)
The H7N9 subtype of avian influenza virus (AIV) poses a significant and ongoing threat to public health. As a critical structural and functional component, the viral nucleoprotein (NP) is abundantly expressed ... Kieran Dee, etc.,al. [preprint]Subclade K influenza A (H3N2) viruses display partial immune escape with preserved cross-neutralisation in a UK population. https://doi.org/10.64898/2026.01.27.26344933. Abstract
submitted by kickingbird at 2 days ago from https://doi.org/10.64898/2026.01.27.26344933 (via https://www.medrxiv.org/content/10.64898/2026.01.27.26344933)
We examined whether the recent emergence of influenza A(H3N2) subclade K, associated with an unusually early influenza season in the Northern hemisphere, was accompanied by a reduction in human population ... Kong H, Yang J, Shi J, Cui P, Zeng X, Liu W, He X,. Protective Efficacy of a Hemagglutinin-Based mRNA Vaccine Against H5N1 Influenza Virus Challenge in Lactating Dairy Cows. Research (Wash D C). 2026 Jan 26;9:1104. Abstract
submitted by kickingbird at 3 days ago from Research (Wash D C). 2026 Jan 26;9:1104 (via https://spj.science.org/doi/10.34133/research.1104)
Highly pathogenic avian influenza H5N1 virus has spread to over 1,080 dairy farms across 18 states in the United States, resulting in 41 human infections and posing serious risks to both animal and public ... Ye, Y., Shuai, H., Song, Y. et al. Genomic features associated with sustained mammalian transmission of avian influenza A viruses. Nat Microbiol (2026). Abstract
submitted by kickingbird at 4 days ago from Nat Microbiol (2026) (via https://link.springer.com/article/10.1038/s41564-025-02257-4)
Comparably few lineages of influenza A virus (IAV) have evolved long-term sustained transmission in mammals. The reasons remain largely unknown, and the possibility of avian IAVs evolving sustained mammalian ... Zorian T Thornton, etc.,al. [preprint]antigen-prime: Simulating coupled genetic and antigenic evolution of influenza virus. https://doi.org/10.64898/2026.01.23.701420. Abstract
submitted by kickingbird at 5 days ago from https://doi.org/10.64898/2026.01.23.701420 (via https://www.biorxiv.org/content/10.64898/2026.01.23.701420v1)
Seasonal influenza virus undergoes rapid antigenic drift to escape population immunity. Computational methods can be used to organize viral genetic diversity into antigenically similar variants and estimate ... Belser, J.A., Brock, N., Sun, X. et al. Oseltamivir and baloxavir monotherapy and combination therapy efficacy against clade 2.3.4.4b A(H5N1) influenza virus infection in ferrets. Commun Biol (2026). Abstract
submitted by kickingbird at 5 days ago from Commun Biol (2026) (via https://link.springer.com/article/10.1038/s42003-026-09607-w)
Neuraminidase inhibitors (NAIs) and cap-dependent endonuclease inhibitors (CENIs) represent two classes of antiviral drugs recommended for early treatment of patients with seasonal influenza A virus (IAV) ... Arata Hidano, etc.,al. Epidemiology and Risk Modelling of Influenza A Virus Within and Between Pig Herds in Northern Lao PDR. Transboundary and Emerging Diseases. Abstract
submitted by kickingbird at 6 days ago from Transboundary and Emerging Diseases (via https://onlinelibrary.wiley.com/doi/10.1155/tbed/2407533)
Animal-origin influenza A virus (IAV) is a perennial candidate for causing the next pandemic. With high risk for interspecies IAV transmission but limited resources for surveillance, particularly in rural ... Yohei Watanabe, etc.,al. Intra-patient neuraminidase mutations in avian H5N1 influenza virus reduce sialidase activity to complement weaker hemagglutinin binding and facilitate human infection. PLOS Pathogens. Abstract
submitted by kickingbird at 7 days ago from PLOS Pathogens (via https://journals.plos.org/plospathogens/article?id=10.1371/j)
Clade 2.2 H5N1 influenza viruses have caused an unusually high number of human infections, providing a unique opportunity to investigate early molecular steps associated with host adaptation. Although ... Mana Esaki, etc.,al. Genetically distinct H5N2 high pathogenicity avian influenza virus isolated from a peregrine falcon on Amami-Oshima Island, Japan, harboring enhanced pathogenicity-associated amino acids in the PA pro. Virology. Abstract
submitted by kickingbird at 8 days ago from Virology (via https://www.sciencedirect.com/science/article/abs/pii/S00426)
We report the first confirmed case of high pathogenicity avian influenza virus (HPAIV) infection in a peregrine falcon (Falco peregrinus) on Amami-Oshima Island, a region known for its unique biodiversity. ... Brigleb PH, Sharp B, Lazure L, Livingston B, Patri. Immune history confers antibody- and T cell-dependent cross-protection against highly pathogenic avian influenza H5N1 viruses. J Virol 0:e02088-25. Abstract
submitted by kickingbird at 8 days ago from J Virol 0:e02088-25 (via https://journals.asm.org/doi/10.1128/jvi.02088-25)
The outbreak of highly pathogenic avian H5 influenza (HPAI) clade 2.3.4.4b in cattle has spread across the United States. Mice with pre-existing immunity to H1N1 virus or with a live-attenuated influenza ... Puente-Massaguer, E., Galdino Andrade, T., Scherm,. An H5N1 clade 2.3.4.4b virus vaccine that elicits cross-protective antibodies against conserved domains of H5 and N1 glycoproteins. Nat Commun (2026). Abstract
submitted by kickingbird at 8 days ago from Nat Commun (2026) (via https://link.springer.com/article/10.1038/s41467-026-68457-6)
The continuous evolution and global spread of highly pathogenic avian influenza (HPAI) H5N1 viruses, particularly clade 2.3.4.4b, pose major challenges for pandemic preparedness. This study evaluates a ... Nemeth, N.M., Andreasen, V.A., Weyna, A.A.W. et al. Disease susceptibility and biological vulnerability of black vultures to fatal clade 2.3.4.4b highly pathogenic avian influenza A(H5N1) virus infection. Sci Rep (2026). Abstract
submitted by kickingbird at 8 days ago from Sci Rep (2026) (via https://link.springer.com/article/10.1038/s41598-026-36912-5)
High numbers of black vultures (Coragyps atratus) have died from clade 2.3.4.4b highly pathogenic (HP) avian influenza A(H5N1) virus (IAV) since its initial detection in North America in November 2021. ... Zhai, S., Dou, Y., Cui, Z. et al. Emerging trends and hotspots in Oseltamivir resistance: insights from a bibliometric investigation. Naunyn-Schmiedeberg´s Arch Pharmacol (2026). Abstract
submitted by kickingbird at 8 days ago from Naunyn-Schmiedeberg´s Arch Pharmacol (2026) (via https://link.springer.com/article/10.1007/s00210-026-04977-8)
Influenza has long been a serious global public health problem, and the risk of drug resistance to Oseltamivir, as a first-line antiviral drug, cannot be ignored. Although some research findings have been ... Hew, Y.L., Isoda, N., Miura, T. et al. Evaluation of the Efficacy of Low-Concentration Gaseous Chlorine Dioxide in Inactivating Airborne H5 High Pathogenicity Avian Influenza Virus in Vivo Model. Food Environ Virol 18, 4 (2026). Abstract
submitted by kickingbird at 8 days ago from Food Environ Virol 18, 4 (2026) (via https://link.springer.com/article/10.1007/s12560-026-09677-3)
H5 high pathogenicity avian influenza virus (HPAIV) continues to spread globally, causing several high pathogenicity avian influenza (HPAI) outbreaks in poultry and significant economic losses. Biosecurity ... Joshua Mack, Amy Hurford. [preprint]Using an evolutionary epidemiological model of pandemics to estimate the infection fatality ratio for humans infected with avian influenza viruses. https://doi.org/10.64898/2026.01.21.26344526. Abstract
submitted by kickingbird at 8 days ago from https://doi.org/10.64898/2026.01.21.26344526 (via https://www.medrxiv.org/content/10.64898/2026.01.21.26344526)
The risk of highly pathogenic avian influenza infection to humans is challenging to estimate because many human avian influenza virus (AIV) infections are undetected as they may be asymptomatic, symptomatic ... 6604 items, 20/Page, Page[1/331][|<<] [|<] [1] [2] [3] [4] [5] [6] [7] [8] [9] [10] [>|] [>>|] |
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