Lasrado N, Wang L, Liu J, R?ssler A, Chaudhari J,. An intramuscular prime and mucosal boost vaccine regimen protects against lethal clade 2.3.4.4b H5N1 challenge in cynomolgus macaques. Sci Transl Med. 2025 Oct 15;17(820):eady2282. Abstract
submitted by kickingbird at Oct, 16, 2025 from Sci Transl Med. 2025 Oct 15;17(820):eady2282 (via https://www.science.org/doi/10.1126/scitranslmed.ady2282)
The H5N1 clade 2.3.4.4b avian influenza virus outbreak in poultry and dairy cattle is a potential pandemic threat for humans. A safe and effective H5N1 influenza vaccine will be needed if the virus acquires ... Yulia Sergeeva, etc.,al. Gold Nanoparticles with Adaptable Self-Assembled Monolayer Shells Allow Multivalent Inhibition and Sensing of Influenza Virus at Ultralow Concentrations. ACS Cent. Sci. 2025, 11, 9, 1659–1669. Abstract
submitted by kickingbird at Oct, 13, 2025 from ACS Cent. Sci. 2025, 11, 9, 1659–1669 (via https://pubs.acs.org/doi/10.1021/acscentsci.5c00602)
Multivalent inhibitors that mimic the polysaccharide array on cells represent a new paradigm in the development of antiviral agents and antibiotics. Covalent ligand anchoring limits the affinity and, in ... Martina Raschig, etc.,al. A Viral Neuraminidase-Specific Sensor for Taste-Based Detection of Influenza. ACS Cent. Sci. 2025. Abstract
submitted by kickingbird at Oct, 13, 2025 from ACS Cent. Sci. 2025 (via https://pubs.acs.org/doi/10.1021/acscentsci.5c01179)
Influenza has caused the deadliest pandemics in history, thereby prompting advances in our ability to ensure vigilance at all stages of future outbreaks. Quarantining patients early is crucial when it ... Julia Romanova, etc.,al. Protective efficacy of the UniFluVec influenza vaccine vector against the highly pathogenic influenza A/Indonesia/5/2005 (H5N1) strain in ferrets. Vaccine, Vol 65, 24 Oct 2025, 127795. Abstract
submitted by kickingbird at Oct, 11, 2025 from Vaccine, Vol 65, 24 Oct 2025, 127795 (via https://www.sciencedirect.com/science/article/pii/S0264410X2)
BackgroundThe emergence of new influenza strains with unpredictable antigenic properties poses a significant vaccination challenge. The increasing incidence of human H5 infections underscores the urgent ... Meiyan Xin, etc.,al. An H1N1 virus biosensor based on enzyme activity-gated PER-CRISPR/Cas12a cascade signal amplification. Enzyme and Microbial Technology. Abstract
submitted by kickingbird at Oct, 11, 2025 from Enzyme and Microbial Technology (via https://www.sciencedirect.com/science/article/abs/pii/S01410)
The rapid and accurate detection of the H1N1 influenza virus is a key link in epidemic prevention and control. This study innovatively constructed a cascade signal amplification biosensor based on DNA ... An SH, Heo GB, Kang YM, Lee YJ, Lee KN. Development of a multiplex and universal RT-PCR assay for hemagglutinin and neuraminidase subtyping of avian influenza virus. J Vet Sci. 2025 Sep;26(5):e59. Abstract
submitted by kickingbird at Oct, 5, 2025 from J Vet Sci. 2025 Sep;26(5):e59 (via https://vetsci.org/DOIx.php?id=10.4142/jvs.25066)
Importance: Avian influenza virus (AIV) is classified into subtypes by hemagglutinin (HA) and neuraminidase (NA) genes. Wild waterfowl harbor H1-H16 and N1-N9 subtypes. Large-scale AIV surveillance requires ... Amer Alagic. Quality Control Rapid Response in Pre-Pandemic Preparedness Showcasing a Synthetic H5N1 Genetic Template. Clinical Chemistry, Volume 71, Issue Supplement_1. Abstract
submitted by kickingbird at Oct, 3, 2025 from Clinical Chemistry, Volume 71, Issue Supplement_1 (via https://academic.oup.com/clinchem/article/71/Supplement_1/hv)
BackgroundThe SARS pandemic presented significant challenges globally, primarily due to the initial lack of well characterized patient samples, which impeded the cross-validation of assays and designs. ... Liam Brandt, Catherine Huang, Dana Ruminski Lowe,. Development and Performance Evaluation of a Molecular Reference Material for Influenza H5N1 Strain Screening. Clinical Chemistry, Volume 71, Issue Supplement_1. Abstract
submitted by kickingbird at Oct, 3, 2025 from Clinical Chemistry, Volume 71, Issue Supplement_1 (via https://academic.oup.com/clinchem/article/71/Supplement_1/hv)
BackgroundInfluenza A H5N1 is a highly pathogenic avian influenza virus strain that poses a significant threat to global public health due to its potential to cause severe illness and widespread outbreaks ... Wang T, Han R, Li J, Cheng X, Qi Z, Bing J, Zhai C. Novel Mini-Hemagglutinin Subunit Vaccine Induces Robust Mucosal and Systemic Immunity and Protection Against a Lethal Challenge With the H1N1 and H5N1 Influenza Viruses in Mice. J Med Virol. 2025 Oct;97(10):e70614. Abstract
submitted by kickingbird at Sep, 25, 2025 from J Med Virol. 2025 Oct;97(10):e70614 (via https://onlinelibrary.wiley.com/doi/10.1002/jmv.70614)
Conventional influenza vaccines target the globular head domains of hemagglutinins (HAs), which are highly plastic and provide strain-specific immunity. Therefore, a universal influenza vaccine with conserved ... Kathryn Kistler, Trevor Bedford. Seasonal influenza viruses show distinct adaptive dynamics during growth in chicken eggs. Molecular Biology and Evolution, 2025;, msaf227. Abstract
submitted by kickingbird at Sep, 22, 2025 from Molecular Biology and Evolution, 2025;, msaf227 (via https://academic.oup.com/mbe/advance-article/doi/10.1093/mol)
Human influenza viruses are grown in chicken eggs for vaccine production. Sequences of these egg-passaged viruses give us the opportunity to examine the evolution that occurs when these human viruses are ... Qiao Y, Tang M, Du M, Zhao C, Lv Y, Zhou J, Liu Y,. H5N1 influenza virus-like particles based on BEVS induce robust functional antibodies and immune responses. Virology. 2025 Aug 29;612:110672. Abstract
submitted by kickingbird at Sep, 9, 2025 from Virology. 2025 Aug 29;612:110672 (via https://www.sciencedirect.com/science/article/abs/pii/S00426)
Avian influenza virus infections pose a potential pandemic threat. The currently licensed vaccines have inherent limitations, emphasizing the urgent need for improved influenza vaccines. Here, we developed ... Zhang, Q., Cheng, J., Hou, J. et al. Synthetic biology-inspired development of live attenuated influenza vaccines. npj Vaccines 10, 204 (2025). Abstract
submitted by kickingbird at Sep, 4, 2025 from npj Vaccines 10, 204 (2025) (via https://link.springer.com/article/10.1038/s41541-025-01255-1)
Live attenuated influenza vaccines (LAIVs) provide robust, cross-protective immunity but have traditionally been developed empirically and are associated with safety concerns. Recent advances in rational ... Wang W, Ma Z, Lou Q, Li T, Huang Z, Yin W, Lou C,. Development Strategies for Influenza Vaccines Utilizing Phage RNA Polymerase and Capping Enzyme NP868R. Chem Bio Eng . 2025 Jun 9;2(8):475-484. Abstract
submitted by kickingbird at Sep, 4, 2025 from Chem Bio Eng . 2025 Jun 9;2(8):475-484 (via https://pubs.acs.org/doi/10.1021/cbe.5c00030)
Influenza remains a highly contagious respiratory disease with profound global health and economic implications. Although traditional vaccines, including inactivated influenza vaccines (IIVs), live attenuated ... Zhang A, Tan B, Wang J, Zhang S. Recombinant Tetrameric Neuraminidase Subunit Vaccine Provides Protection Against Swine Influenza A Virus Infection in Pigs. Vaccines (Basel). 2025 Jul 23;13(8):783. Abstract
submitted by kickingbird at Aug, 29, 2025 from Vaccines (Basel). 2025 Jul 23;13(8):783 (via https://www.mdpi.com/2076-393X/13/8/783)
Background/Objectives: Swine influenza A virus (swIAV), a prevalent respiratory pathogen in porcine populations, poses substantial economic losses to global livestock industries and represents a potential ... Bakhsh M, Senevirathne A, Riaz J, Kwon J, Aganja R. Bivalent Oral Vaccine Using Attenuated Salmonella Gallinarum Delivering HA and NA-M2e Confers Dual Protection Against H9N2 Avian Influenza and Fowl Typhoid in Chickens. Vaccines (Basel). 2025 Jul 25;13(8):790. Abstract
submitted by kickingbird at Aug, 29, 2025 from Vaccines (Basel). 2025 Jul 25;13(8):790 (via https://www.mdpi.com/2076-393X/13/8/790)
Background: Fowl typhoid (FT), a septicemic infection caused by Salmonella Gallinarum (SG), and H9N2 avian influenza are two economically important diseases that significantly affect the global poultry ... Zhang J, Feng Z, Shen Y, Shi W, Sun Y, Zhao J, Wu. End-of-Season Influenza Vaccine Effectiveness Against Laboratory-Confirmed Influenza in Outpatient Settings, Beijing, China: A Test-Negative Design. Vaccines (Basel). 2025 Jul 30;13(8):809. Abstract
submitted by kickingbird at Aug, 29, 2025 from Vaccines (Basel). 2025 Jul 30;13(8):809 (via https://www.mdpi.com/2076-393X/13/8/809)
his study aimed to estimate the end-of-season influenza vaccine effectiveness (VE) for the 2024/25 season in Beijing, China. Methods: We used a test-negative design (TND) to assess influenza VE among outpatients ... Sang Y, Nahashon SN, Webby RJ. Microbiome-Immune Interaction and Harnessing for Next-Generation Vaccines Against Highly Pathogenic Avian Influenza in Poultry. Vaccines (Basel). 2025 Aug 6;13(8):837. Abstract
submitted by kickingbird at Aug, 29, 2025 from Vaccines (Basel). 2025 Aug 6;13(8):837 (via https://www.mdpi.com/2076-393X/13/8/837)
Highly pathogenic avian influenza (HPAI) remains a persistent threat to global poultry production and public health. Current vaccine platforms show limited cross-clade efficacy and often fail to induce ... Wang L, Xie Q, Yu P, Zhang J, He C, Huang W, Wang. Research Progress of Universal Influenza Vaccine. Vaccines (Basel). 2025 Aug 15;13(8):863. Abstract
submitted by kickingbird at Aug, 29, 2025 from Vaccines (Basel). 2025 Aug 15;13(8):863 (via https://www.mdpi.com/2076-393X/13/8/863)
Influenza viruses continue to undergo antigenic drift and shift, resulting in the need to update existing vaccines annually. Therefore, the development of a universal influenza vaccine has become an urgent ... Yakovlev VA, Litvinova VR, Rudometova NB, Borgoyak. Immunogenic and Protective Properties of mRNA Vaccine Encoding Hemagglutinin of Avian Influenza A/H5N8 Virus, Delivered by Lipid Nanoparticles and Needle-Free Jet Injection. Vaccines (Basel). 2025 Aug 21;13(8):883. Abstract
submitted by kickingbird at Aug, 29, 2025 from Vaccines (Basel). 2025 Aug 21;13(8):883 (via https://www.mdpi.com/2076-393X/13/8/883)
Background/Objectives: The development of a vaccine against highly pathogenic avian influenza viruses subtype A/H5 is an urgent task due to concerns about its pandemic potential. Methods: In this study, ... Yujia Huang, etc.,al. [preprint]Streamlined CRISPR-based assays for detection and subtyping of avian influenza. https://doi.org/10.1101/2025.08.21.25334105. Abstract
submitted by kickingbird at Aug, 28, 2025 from https://doi.org/10.1101/2025.08.21.25334105 (via https://www.medrxiv.org/content/10.1101/2025.08.21.25334105v)
Avian influenza viruses (AIVs) are zoonotic pathogens that pose an increasing global threat due to their potential for human-to-human transmission, pandemic emergence and significant economic losses in ... 282 items, 20/Page, Page[2/15][|<<] [|<] [1] [2] [3] [4] [5] [6] [7] [8] [9] [10] [>|] [>>|] |
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