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2026-2-1 21:14:28
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Pardo-Roa, C., Nelson, M.I., Ariyama, N. et al. Cross-species and mammal-to-mammal transmission of clade 2.3.4.4b highly pathogenic avian influenza A/H5N1 with PB2 adaptations. Nat Commun 16, 2232 (2025).  Abstract  
submitted by kickingbird at Mar, 6, 2025 from Nat Commun 16, 2232 (2025) (via https://www.nature.com/articles/s41467-025-57338-z)
Highly pathogenic H5N1 avian influenza viruses (HPAIV) belonging to lineage 2.3.4.4b emerged in Chile in December 2022, leading to mass mortality events in wild birds, poultry, and marine mammals and one ...

Qianqian Li, etc.,al. [preprint]Dominant substitutions underlying the antigenic evolution of H5 influenza virus. https://doi.org/10.21203/rs.3.rs-6040842/v1.  Abstract  
submitted by kickingbird at Mar, 5, 2025 from https://doi.org/10.21203/rs.3.rs-6040842/v1 (via https://www.researchsquare.com/article/rs-6040842/v1)
Highly pathogenic avian influenza (HPAI) H5 viruses have recently been documented in mammals including humans, posing a major threat to global public health. To prevent a potential H5 pandemic, it is critical ...

Li S, Chu L, Zhang Y, Yu Y and Wang G. Genetic characterization of an H3N2 canine influenza virus strain in China in 2023-acquisition of novel human-like amino acid substitutions. Front. Vet. Sci. 12:1552115.  Abstract  
submitted by kickingbird at Mar, 4, 2025 from Front. Vet. Sci. 12:1552115 (via https://www.frontiersin.org/journals/veterinary-science/arti)
Around 2005, influenza A virus (IAV) once again crossed species barriers and established a stable lineage within canine populations. Currently, avian-origin H3N2 canine influenza virus (CIV) is the only ...

WPRO. WHO: Avian Influenza Weekly Update # 987: 28 February 2025. WHO/WPRO.  Abstract  
submitted by kickingbird at Mar, 3, 2025 from WHO/WPRO (via https://cdn.who.int/media/docs/default-source/wpro---documen)
Avian influenza subtype A(HxNy) normally spreads in birds but can also infect humans. Human infections are primarily acquired through direct contact with infected poultry or contaminated environments. ...

Mahmoud Bayoumi, etc.,al. [preprint]Identification of Amino Acid Residues Responsible for Differential Replication and Pathogenicity of Avian Influenza Virus H5N1 Isolated from Human and Cattle in Texas, US. https://doi.org/10.1101/2025.03.01.640810.  Abstract  
submitted by kickingbird at Mar, 3, 2025 from https://doi.org/10.1101/2025.03.01.640810 (via https://www.biorxiv.org/content/10.1101/2025.03.01.640810v1)
Highly pathogenic avian influenza viruses (HPAIV) pose a serious public health concern. In March 2024, a first-time outbreak of HPAIV H5N1 in dairy cattle herds was reported in the United States (US). ...

Hoang-Hai Nguyen, etc.,al. [preprint]WaveSeekerNet: Accurate Prediction of Influenza A Virus Subtypes and Host Source Using Attention-Based Deep Learning. https://doi.org/10.1101/2025.02.25.639900.  Abstract  
submitted by kickingbird at Mar, 2, 2025 from https://doi.org/10.1101/2025.02.25.639900 (via https://www.biorxiv.org/content/10.1101/2025.02.25.639900v1)
Background Influenza A virus (IAV) poses a significant threat to animal health globally, with its ability to overcome species barriers and cause pandemics. Rapid and accurate prediction of IAV subtypes ...

Hugo Castelan-Sanchez, Art Poon. [preprint]Phylogenetic discordance cannot identify genomic reassortment events: a case study with the avian influenza virus H5Nx. https://doi.org/10.1101/2025.02.24.639875.  Abstract  
submitted by kickingbird at Mar, 2, 2025 from https://doi.org/10.1101/2025.02.24.639875 (via https://www.biorxiv.org/content/10.1101/2025.02.24.639875v1)
Recombination plays a central role in the evolution of the RNA virus genome, as it allows the exchange of genetic material between different viral lineages. Reassortment is a form of recombination specific ...

Kj?r, L.J., Kirkeby, C.T., Boklund, A.E. et al. Prediction models show differences in highly pathogenic avian influenza outbreaks in Japan and South Korea compared to Europe. Sci Rep 15, 6783 (2025).  Abstract  
submitted by kickingbird at Mar, 2, 2025 from Sci Rep 15, 6783 (2025) (via https://link.springer.com/article/10.1038/s41598-025-91384-3)
Avian influenza poses substantial risks to animal welfare and public health. The recent surge in highly pathogenic avian influenza (HPAI) outbreaks has led to extensive poultry culling, highlighting the ...

Murray J, Nogales A, Martinez-Sobrido L, Martin DE. Evaluating Probenecid or Oseltamivir Inhibition of Influenza A Virus Replication Through Plaque Assay or Fluorescent Focus Assay Using Non-Structural Protein 1–H1N1 Venus Reporter Virus. Viruses. 2025; 17(3):335.  Abstract  
submitted by kickingbird at Mar, 2, 2025 from Viruses. 2025; 17(3):335 (via https://www.mdpi.com/1999-4915/17/3/335)
It is essential to understand the molecular mechanisms of influenza antiviral therapeutics to evaluate their efficacy. Virus plaque assays are commonly used to assess the antiviral effects of drugs on ...

Yu X, Su N, Luo J, Zhang D, Zhang H, Duan M, Shi N. Long noncoding RNA USP30-AS1 promotes influenza A virus replication by enhancing PHB1 function. Vet Microbiol. 2025 Feb 26;303:110444.  Abstract  
submitted by kickingbird at Mar, 2, 2025 from Vet Microbiol. 2025 Feb 26;303:110444 (via https://www.sciencedirect.com/science/article/abs/pii/S03781)
Long noncoding RNAs (lncRNAs) are important regulators of gene expression. Although evidence accumulated over the past decade shows that lncRNAs have key roles in the interaction between viruses and hosts, ...

Zhu Y, Cong Y, Sun Y, Sheng S, Liu C, Jiang J, Li. Molecular patterns of matrix protein 1 (M1): A strong predictor of adaptive evolution in H9N2 avian influenza viruses. Proc Natl Acad Sci U S A. 2025 Mar 4;122(9):e24239.  Abstract  
submitted by kickingbird at Mar, 1, 2025 from Proc Natl Acad Sci U S A. 2025 Mar 4;122(9):e24239 (via https://www.pnas.org/doi/10.1073/pnas.2423983122)
The H9N2 subtype of avian influenza virus (AIV) emerges as a significant member of the influenza A virus family. However, the varying degrees of epidemiological dominance among different lineages or clades ...

Frutos AM, Cleary S, Reeves EL, et al. Interim Estimates of 2024-2025 Seasonal Influenza Vaccine Effectiveness - Four Vaccine Effectiveness Networks, United States, October 2024-February 2025. MMWR Morb Mortal Wkly Rep 2025;74:83-90.  Abstract  
submitted by kickingbird at Feb, 28, 2025 from MMWR Morb Mortal Wkly Rep 2025;74:83-90 (via https://www.cdc.gov/mmwr/volumes/74/wr/mm7406a2.htm)
Annual influenza vaccination is recommended for all persons aged ≥6 months in the United States. Interim influenza vaccine effectiveness (VE) was calculated among patients with acute respiratory illness-associated ...

Falender R, Radniecki TS, Kelly C, et al. Avian Influenza A(H5) Subtype in Wastewater - Oregon, September 15, 2021-July 11, 2024. MMWR Morb Mortal Wkly Rep 2025;74:102-106.  Abstract  
submitted by kickingbird at Feb, 28, 2025 from MMWR Morb Mortal Wkly Rep 2025;74:102-106 (via https://www.cdc.gov/mmwr/volumes/74/wr/mm7406a5.htm)
Wastewater surveillance is an important tool in the surveillance of emerging pathogens and has been leveraged during the highly pathogenic avian influenza (HPAI) A(H5N1) virus outbreak in cattle and poultry ...

Kirill Vasilev, etc.,al. [preprint]Immunogenicity and protective efficacy of an intranasal neuraminidase-based influenza virus vaccine adjuvanted with bacterial cell membrane-derived adjuvants. https://doi.org/10.1101/2025.02.26.640278.  Abstract  
submitted by kickingbird at Feb, 27, 2025 from https://doi.org/10.1101/2025.02.26.640278 (via https://www.biorxiv.org/content/10.1101/2025.02.26.640278v1)
Influenza virus neuraminidase (NA) has emerged as a promising vaccine candidate due to its relatively stable antigenic structure and the ability of NA-specific antibodies to provide cross-protection within ...

Augustin Clessin, etc.,al. [preprint]Mass mortality events in the sub-Antarctic Indian Ocean caused by long-distance circumpolar spread of highly pathogenic avian influenza H5N1 clade 2.3.4.4b. https://doi.org/10.1101/2025.02.25.640068.  Abstract  
submitted by kickingbird at Feb, 27, 2025 from https://doi.org/10.1101/2025.02.25.640068 (via https://www.biorxiv.org/content/10.1101/2025.02.25.640068v1)
Since 2020, the outbreak of highly pathogenic avian influenza (HPAI) virus clade 2.3.4.4b has turned into the largest documented panzootic to date, reaching the sub-Antarctic region and Antarctica via ...

Hermann E, Krammer F. Clade 2.3.4.4b H5N1 neuraminidase has a long stalk, which is in contrast to most highly pathogenic H5N1 viruses circulating between 2002 and 2020. mBio. 2025 Feb 26:e0398924.  Abstract  
submitted by kickingbird at Feb, 27, 2025 from mBio. 2025 Feb 26:e0398924 (via https://journals.asm.org/doi/10.1128/mbio.03989-24)
Since 2020, H5N1 highly pathogenic avian influenza (HPAI) viruses of clade 2.3.4.4b have been rapidly spreading in wild birds but have also caused a large number of mammalian infections and more than 70 ...

McLaughlin A, Giacinti J, Sarma SN, Brown MGC, Ron. Examining avian influenza virus exposure in seabirds of the northwest Atlantic in 2022 and 2023 via antibodies in eggs. Conserv Physiol. 2025 Feb 24;13(1):coaf010.  Abstract  
submitted by kickingbird at Feb, 27, 2025 from Conserv Physiol. 2025 Feb 24;13(1):coaf010 (via https://academic.oup.com/conphys/article/13/1/coaf010/804256)
Seabirds are frequently infected by avian influenza virus (AIV), which prior to 2021 primarily consisted of low-pathogenic AIV with limited reports of disease during infection. However, since highly pathogenic ...

Korsun N, Trifonova I, Pavlova D, Uzunova Y, Ivano. Etiological Spectrum of Acute Respiratory Infections in Bulgaria During the 2023-2024 Season and Genetic Diversity of Circulating Influenza Viruses. Viruses. 2025 Feb 16;17(2):270.  Abstract  
submitted by kickingbird at Feb, 27, 2025 from Viruses. 2025 Feb 16;17(2):270 (via https://www.mdpi.com/1999-4915/17/2/270)
Influenza poses a serious threat to both individual and public health. This study aimed to investigate the virological and epidemiological characteristics of influenza infections and to explore the genetic ...

Azeem S, Yoon KJ. Diagnostic Assays for Avian Influenza Virus Surveillance and Monitoring in Poultry. Viruses. 2025 Feb 6;17(2):228.  Abstract  
submitted by kickingbird at Feb, 27, 2025 from Viruses. 2025 Feb 6;17(2):228 (via https://www.mdpi.com/1999-4915/17/2/228)
Diagnostic testing plays a key role in a surveillance program as diagnostic testing aims to accurately determine the infection or disease status of an individual animal. Diagnostic assays for AIV can be ...

Vázquez-Pérez JA, Wong-Arámbula C, Solís-Hernández. Mexico´s Laboratory-Confirmed Human Case of Infection with the Influenza A(H5N2) Virus. Viruses. 2025 Jan 31;17(2):205.  Abstract  
submitted by kickingbird at Feb, 27, 2025 from Viruses. 2025 Jan 31;17(2):205 (via https://www.mdpi.com/1999-4915/17/2/205)
In April 2024, the Instituto Nacional de Enfermedades Respiratorias of Mexico City identified a case of unsubtypeable Influenza A in a 58-year-old immunocompromised patient with renal failure due to diabetic ...

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