SUGUITAN AL JR, Matsuoka Y, Lau YF, Santos CP, et. The multi-basic cleavage site of the hemagglutinin of the highly pathogenic A/Vietnam/1203/2004 (H5N1) avian influenza virus acts as a virulence factor in a host-specific manner in mammals. J Virol. 2011. Abstract
submitted by kickingbird at Jan, 5, 2012 from J Virol. 2011 (via http://www.ncbi.nlm.nih.gov/pubmed/22205751)
Highly pathogenic avian influenza (HPAI) viruses of the H5 and H7 subtypes typically possess multiple basic amino acids around the cleavage site (MBS) of their hemagglutinin (HA) protein, a recognized ... VAN TT, Miller J, Warshauer DM, Reisdorf E, et al.. Pooling Nasopharyngeal/Throat Swab Specimens to Increase Testing Capacity for Influenza Viruses by PCR. J Clin Microbiol. 2011. Abstract
submitted by kickingbird at Jan, 5, 2012 from J Clin Microbiol. 2011 (via http://www.ncbi.nlm.nih.gov/pubmed/22205820)
Real-time PCR methodology can be applied to rapidly and accurately detect influenza viruses. During times of surge testing or enhanced pandemic surveillance, public health laboratories (PHLs) may experience ... LIU Q, Ma J, Liu H, Qi W, et al.. Emergence of novel reassortant H3N2 swine influenza viruses with the 2009 pandemic H1N1 genes in the United States. Arch Virol. 2011.. Abstract
submitted by kickingbird at Jan, 5, 2012 from Arch Virol. 2011. (via http://www.ncbi.nlm.nih.gov/pubmed/22198410)
Reassortant H1 swine influenza viruses (SIVs) carrying 2009 pandemic H1N1 virus (pH1N1) genes have been isolated from pigs worldwide. Seven novel reassortant H3N2 SIVs were identified from diseased pigs ... BANTIA S, Upshaw R, Babu YS. Characterization of the binding affinities of peramivir and oseltamivir carboxylate to the neuraminidase enzyme. Antiviral Res. 2011;91:288-91. Abstract
submitted by kickingbird at Jan, 5, 2012 from Antiviral Res. 2011;91:288-91 (via http://www.ncbi.nlm.nih.gov/pubmed/21722670)
With the continued threat of morbidity and mortality from influenza and the development of resistance to influenza antiviral drugs, there is increasing interest in new treatments, such as the investigational ... LEE SM, Gai WW, Cheung TK, Peiris JS, et al.. Antiviral effect of a selective COX-2 inhibitor on H5N1 infection in vitro. Antiviral Res. 2011;91:330-4.. Abstract
submitted by kickingbird at Jan, 5, 2012 from Antiviral Res. 2011;91:330-4. (via http://www.ncbi.nlm.nih.gov/pubmed/21798291)
A selective cyclooxygenase-2 (COX-2) inhibitor has been previously shown to suppress the hyper-induced pro-inflammatory responses in H5N1 infected primary human cells. Here, we demonstrate that COX-2 inhibitors ... Mariya V.SIVAY; Nikita Y.SILKO; Kirill A.SHARSHOV;. The role of wild goose(Anser) populations of Russia and theTibet Plateau in the spread of the avian influenza virus. Chinese Birds. Abstract
submitted by kickingbird at Jan, 2, 2012 from Chinese Birds (via http://www.cnki.net)
Wild birds of the orders Anseriformes and Charadriiformes represent a natural reservoir of low pathogenic avian influenza(LPAI) viruses(family Orthomyxoviridae).Wild geese(order Anseriformes)relating to ... Aeron C. Hurt, etc.,al. Community Transmission of Oseltamivir-Resistant A(H1N1)pandemic 2009 Influenza. N Engl J Med 2011; 365:2541-2542December 29, 2011. Abstract
submitted by kickingbird at Dec, 31, 2011 from N Engl J Med 2011; 365:2541-2542December 29, 2011 (via http://www.nejm.org/doi/full/10.1056/NEJMc1111078)
Oseltamivir-resistant prepandemic seasonal influenza A (H1N1) viruses with a H275Y neuraminidase substitution spread globally in 2008,1 reducing the effectiveness of oseltamivir.2 Although oseltamivir-resistant ... Schmolke M, Manicassamy B, Pena L, Sutton T, Hai R. Differential Contribution of PB1-F2 to the Virulence of Highly Pathogenic H5N1 Influenza A Virus in Mammalian and Avian Species. PLoS Pathog. 2011 Aug;7(8):e1002186. Epub 2011 Aug. Abstract
submitted by kickingbird at Dec, 27, 2011 from PLoS Pathog. 2011 Aug;7(8):e1002186. Epub 2011 Aug (via http://www.plospathogens.org/article/info%3Adoi%2F10.1371%2F)
Highly pathogenic avian influenza A viruses (HPAIV) of the H5N1 subtype occasionally transmit from birds to humans and can cause severe systemic infections in both hosts. PB1-F2 is an alternative translation ... UCHIDA Y, Watanabe C, Takemae N, Hayashi T, et al. Identification of host genes linked with the survivability of chickens infected with recombinant viruses possessing H5N1 surface antigens from a highly pathogenic avian influenza virus. J Virol. 2011. Abstract
submitted by kickingbird at Dec, 27, 2011 from J Virol. 2011 (via http://www.ncbi.nlm.nih.gov/pubmed/22190712)
Seventeen recombinant viruses were generated by a reverse genetic technique to elucidate the pathogenicity of highly pathogenic avian influenza viruses (HPAIVs) in chickens. The recombinant viruses generated ... CILLONIZ C, Pantin-Jackwood MJ, Ni C, Carter VS, e. Molecular signatures associated with Mx1-mediated resistance to highly pathogenic influenza virus infection: mechanisms of survival. J Virol. 2011. Abstract
submitted by kickingbird at Dec, 27, 2011 from J Virol. 2011 (via http://www.ncbi.nlm.nih.gov/pubmed/22190720)
Understanding the role of host factors during lethal influenza virus infection is critical to deciphering the events that will determine the fate of the host. One such factor is encoded by the Mx1 gene, ... TAUBER S, Ligertwood Y, Quigg-Nichol M, Dutia B, e. Behaviour of influenza A viruses differentially-expressing segment 2 gene products in vitro and in vivo. J Gen Virol. 2011. Abstract
submitted by kickingbird at Dec, 27, 2011 from J Gen Virol. 2011 (via http://www.ncbi.nlm.nih.gov/pubmed/22190016)
The influenza A virus genome comprises 8 segments of negative-sense RNA that code for up to 12 proteins. RNA segment 2 encodes three proteins, PB1, PB1-F2 and N40, that are translated from the same mRNA ... TARASOV SA, Zarubaev VV, Gorbunov EA, Sergeeva SA,. Activity of ultra-low doses of antibodies to gamma-interferon against lethal influenza A(H1N1)2009 virus infection in mice. Antiviral Res. 2011.. Abstract
submitted by kickingbird at Dec, 27, 2011 from Antiviral Res. 2011. (via http://www.ncbi.nlm.nih.gov/pubmed/22178245)
BACKGROUND:
The influenza A virus is a highly infective agent that causes acute pulmonary diseases. In serious cases, it causes pneumonia which is particularly fatal in patients with cardiopulmonary ... Vuong N. Bui,etc.,al. H4N8 subtype avian influenza virus isolated from shorebirds contains a unique PB1 gene and causes severe respiratory disease in mice. Dec 20 Virology. Abstract
submitted by kickingbird at Dec, 22, 2011 from Dec 20 Virology (via http://www.sciencedirect.com/science/article/pii/S0042682211)
H4N8 subtype avian influenza viruses were isolated from shorebirds in eastern Hokkaido. All the isolates shared > 99.7% nucleotide homology, and all the viral genes except for PB1 were highly related to ... WANG W, Suguitan AL Jr, Zengel J, Chen Z, et al.. Generation of recombinant pandemic H1N1 influenza virus with the HA cleavable by bromelain and identification of the residues influencing HA bromelain cleavage. Vaccine. 2011. Abstract
submitted by kickingbird at Dec, 21, 2011 from Vaccine. 2011 (via http://www.ncbi.nlm.nih.gov/pubmed/22172510)
The proteolytic enzyme bromelain has been traditionally used to cleave the hemagglutinin (HA) protein at the C-terminus of the HA2 region to release the HA proteins from influenza virions. The bromelain ... MA W, Belisle SE, Mosier D, Li X, et al.. 2009 pandemic H1N1 influenza virus causes disease and upregulation of genes related to inflammatory and immune responses, cell death, and lipid metabolism in pigs. J Virol. 2011;85:11626-37. Abstract
submitted by kickingbird at Dec, 21, 2011 from J Virol. 2011;85:11626-37 (via http://www.ncbi.nlm.nih.gov/pubmed/21900171)
There exists limited information about whether adaptation is needed for cross-species transmission of the 2009 pandemic H1N1 influenza virus (pH1N1). Here, we compare the pathogenesis of two pH1N1 viruses, ... LIN L, Li Y, Pyo HM, Lu X, et al.. Identification of RNA helicase A as a cellular factor that interacts with influenza A NS1 protein and its role in virus life cycle. J Virol. 2011. Abstract
submitted by kickingbird at Dec, 21, 2011 from J Virol. 2011 (via http://www.ncbi.nlm.nih.gov/pubmed/22171255)
Influenza A virus NS1 protein has multiple functions in the infected cell during the virus life cycle. Identification of novel cellular factors that interact with NS1 and understanding their functions ... ABED Y, Pizzorno A, Hamelin ME, Leung A, et al. The 2009 pandemic H1N1 D222G hemagglutinin mutation alters receptor specificity and increases virulence in mice but not in ferrets.. J Infect Dis. 2011;204:1008-16. Abstract
submitted by kickingbird at Dec, 21, 2011 from J Infect Dis. 2011;204:1008-16 (via http://www.ncbi.nlm.nih.gov/pubmed/21881115)
BACKGROUND:
The D222G (H1 numbering) hemagglutinin (HA) mutation within the receptor-binding site was detected with higher frequencies in severe cases of 2009 pandemic H1N1 (pH1N1) infections. We investigated ... MAINES TR, Belser JA, Gustin KM, van Hoeven N, et. Local Innate Immune Responses and Influenza Virus Transmission and Virulence in Ferrets.. J Infect Dis. 2011. Abstract
submitted by kickingbird at Dec, 21, 2011 from J Infect Dis. 2011 (via http://www.ncbi.nlm.nih.gov/pubmed/22158704)
Host innate immunity is the first line of defense against invading pathogens, including influenza viruses. Ferrets are well recognized as the best model of influenza virus pathogenesis and transmission, ... VANDERMEER ML, Thomas AR, Kamimoto L, Reingold A,. Association Between Use of Statins and Mortality Among Patients Hospitalized With Laboratory-Confirmed Influenza Virus Infections: A Multistate Study.. J Infect Dis. 2011.. Abstract
submitted by kickingbird at Dec, 21, 2011 from J Infect Dis. 2011. (via http://www.ncbi.nlm.nih.gov/pubmed/22170954)
Background.?Statins may have anti-inflammatory and immunomodulatory effects that could reduce the risk of mortality from influenza virus infections. Methods.?The Centers for Disease Control and Prevention's ... AL-GARAWI A, Husain M, Ilieva D, Humbles AA, et al. Shifting of Immune Responsiveness to House Dust Mite by Influenza A Infection:Genomic Insights.. J Immunol. 2011. Abstract
submitted by kickingbird at Dec, 21, 2011 from J Immunol. 2011 (via http://www.ncbi.nlm.nih.gov/pubmed/22174454)
Respiratory viral infections have been associated with an increased incidence of allergic asthma. However, the mechanisms by which respiratory infections facilitate allergic airway disease are incompletely ... 7557 items, 20/Page, Page[282/378][|<<] [|<] [281] [282] [283] [284] [285] [286] [287] [288] [289] [290] [>|] [>>|] |
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