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2024-3-29 2:56:30
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Huang SS, Banner D, Degousee N, Leon AJ, et al.. Differential pathological and immune responses in newly weaned ferrets are associated with a mild clinical outcome of pandemic 2009 H1N1 infection. J Virol 2012;86:13187-201.  Abstract  
submitted by kickingbird at Feb, 3, 2013 from J Virol 2012;86:13187-201 (via http://www.ncbi.nlm.nih.gov/m/pubmed/23055557/)
Young children are typically considered a high-risk group for disease associated with influenza virus infection. Interestingly, recent clinical reports suggested that young children were the smallest group ...

Chen L, Li F. Structural analysis of evolutionary origins of influenza hemagglutinin and other viral lectins. J Virol 2013.  Abstract  
submitted by kickingbird at Feb, 3, 2013 from J Virol 2013 (via http://www.ncbi.nlm.nih.gov/m/pubmed/23365425/)
Influenza and other viruses use host-cell-surface sugars as receptors. Here we show that the sugar-binding domains in influenza hemagglutinin and other viral lectins share the same structural fold as human ...

Ince WL, Mbaye A, Bennink JR, Yewdell JW, et al.. Reassortment Complements Spontaneous Mutation in Influenza A Virus NP and M1 genes to Accelerate Adaptation to a New Host. J Virol 2013.  Abstract  
submitted by kickingbird at Feb, 3, 2013 from J Virol 2013 (via http://www.ncbi.nlm.nih.gov/m/pubmed/23365443/)
Influenza A virus (IAV) infects a remarkably wide variety of avian and mammalian hosts. Evolution finely hones IAV genes to optimally infect and transmit in a particular host species. Sporadically, IAV ...

Beaulieu A, Gravel E, Cloutier A, Marois I, et al. Matriptase Proteolytically Activates Influenza Virus and Promotes Multicycle Replication in the Human Airway Epithelium. J Virol 2013.  Abstract  
submitted by kickingbird at Feb, 3, 2013 from J Virol 2013 (via http://www.ncbi.nlm.nih.gov/m/pubmed/23365447/)
Influenza viruses do not encode any proteases and must rely on host proteases for the proteolytic activation of their surface hemagglutinin protein in order to fuse with the infected host cell. Recent ...

Job ER, Deng YM, Barfod KK, Tate MD, et al.. Addition of Glycosylation to Influenza A Virus Hemagglutinin Modulates Antibody-Mediated Recognition of H1N1 2009 Pandemic Viruses. J Immunol 2013.  Abstract  
submitted by kickingbird at Feb, 3, 2013 from J Immunol 2013 (via http://www.ncbi.nlm.nih.gov/m/pubmed/23365085/)
Seasonal influenza A viruses (IAV) originate from pandemic IAV and have undergone changes in antigenic structure, including addition of glycans to the viral hemagglutinin (HA). Glycans on the head of HA ...

Lenzer J. Belief not science is behind flu jab promotion, new report says. BMJ 2012;345:e7856.  Abstract  
submitted by kickingbird at Feb, 3, 2013 from BMJ 2012;345:e7856 (via http://www.bmj.com/content/345/bmj.e7856?view=long&pmid=2316)
An independent meta-analysis of vaccines against influenza has found that claims of benefit have been significantly exaggerated. The report, released last month by the University of Minnesota’s Center ...

Yong-Hong Zhang, etc.,al. Interferon-induced transmembrane protein-3 genetic variant rs12252-C is associated with severe influenza in Chinese individuals. Nat. Commun. 4 : 1418 doi: 10.1038/ncomms2433 (2013).  Full Text  
submitted by kickingbird at Feb, 1, 2013 from Nat. Commun. 4 : 1418 doi: 10.1038/ncomms2433 (2013) (via http://www.nature.com/ncomms/journal/v4/n1/full/ncomms2433.h)
The SNP rs12252-C allele alters the function of interferon-induced transmembrane protein-3 increasing the disease severity of influenza virus infection in Caucasians, but the allele is rare. However, rs12252-C ...

Said A, Lange E, Beer M, Damiani A, et al. Recombinant equine herpes virus 1 (EHV-1) vaccine protects pigs against challenge with influenza A(H1N1)pmd09. Virus Res 2013 Jan 17. pii: S0168-1702(13)00005.  Abstract  
submitted by kickingbird at Jan, 30, 2013 from Virus Res 2013 Jan 17. pii: S0168-1702(13)00005 (via http://www.ncbi.nlm.nih.gov/m/pubmed/23333290/)
Swine influenza virus (SIV) is not only an important respiratory pathogen in pigs but also a threat to human health. The pandemic influenza A(H1N1)pdm09 virus likely originated in swine through reassortment ...

Lee YN, Lee DH, Park JK, Yuk SS, et al.. Experimental infection and natural contact exposure of ferrets with canine influenza virus (H3N2). J Gen Virol 2013;94..  Abstract  
submitted by kickingbird at Jan, 30, 2013 from J Gen Virol 2013;94. (via http://www.ncbi.nlm.nih.gov/m/pubmed/23329681/)
Epidemics of H3N2 canine influenza virus (CIV) among dogs in South Korea and southern China have raised concern over the potential for zoonotic transmission of these viruses. Here, we analysed the pathogenesis ...

Terrier O, Textoris J, Carron C, Marcel V, et al.. Host microRNA molecular signatures associated with human H1N1 and H3N2 influenza A viruses reveal an unanticipated antiviral activity for miR-146a. J Gen Virol 2013.  Abstract  
submitted by kickingbird at Jan, 30, 2013 from J Gen Virol 2013 (via http://www.ncbi.nlm.nih.gov/m/pubmed/23343627/)
While post-transcriptional regulation of gene expression by miRNAs have been shown to be involved in influenza virus replication cycle, only a few studies have further investigated this aspect in a human ...

Gao R, Du N, Liu D, Zhou J, et al.. Oseltamivir inhibits both viral entry and release but enhances apoptosis of cells infected with influenza A H1N1. Biochem Biophys Res Commun 2013 Jan 17. pii: S0006.  Abstract  
submitted by kickingbird at Jan, 30, 2013 from Biochem Biophys Res Commun 2013 Jan 17. pii: S0006 (via http://www.ncbi.nlm.nih.gov/m/pubmed/23333739/)
Oseltamivir (Tamiflu) has been shown to be effective as a treatment and chemoprophylaxis for influenza virus infections. However, the safety consideration of oseltamivir should not be overlooked because ...

Siboonnan N, Wiriyarat W, Boonarkart C, Chakritbud. A serine-to-asparagine mutation at position 314 of H5N1 avian influenza virus NP is a temperature-sensitive mutation that interferes with nuclear localization of NP. Arch Virol 2013..  Abstract  
submitted by kickingbird at Jan, 25, 2013 from Arch Virol 2013. (via http://www.ncbi.nlm.nih.gov/m/pubmed/23307364/)
We have generated a temperature-sensitive (ts) mutant from a human isolate of the H5N1 avian influenza virus by classical adaptation in cell culture. After 20 passages at low temperature, the virus showed ...

Jegaskanda S, Job ER, Kramski M, Laurie K, et al.. Cross-Reactive Influenza-Specific Antibody-Dependent Cellular Cytotoxicity Antibodies in the Absence of Neutralizing Antibodies.. J Immunol 2013..  Abstract  
submitted by kickingbird at Jan, 25, 2013 from J Immunol 2013. (via http://www.ncbi.nlm.nih.gov/m/pubmed/23319732/)
Abstract A better understanding of immunity to influenza virus is needed to generate cross-protective vaccines. Engagement of Ab-dependent cellular cytotoxicity (ADCC) Abs by NK cells leads to killing ...

Zhang AJ, To KK, Li C, Lau CC, et al.. Leptin mediates the pathogenesis of severe influenza A(H1N1)pdm09 associated with cytokine dysregulation is preventable by anti-leptin antibody in diet-induced obese mice.. J Infect Dis 2013..  Abstract  
submitted by kickingbird at Jan, 25, 2013 from J Infect Dis 2013. (via http://www.ncbi.nlm.nih.gov/m/pubmed/23325916/)
Abstract Background.?Obesity is associated with a high circulating leptin level and severe influenza A(H1N1)pdm09 infection. The mechanism for severe lung injury in obese patients and the specific treatment ...

Zimmermann U, Gavazzi G, Richard P, Eymin C, et al. Immunogenicity and safety of a booster dose of diphtheria, tetanus, acellular pertussis and inactivated poliomyelitis vaccine (Tdap-IPV; Repevax((R))) administered concomitantly versus non-concomitant. Vaccine 2013 Jan 10. pii: S0264-410X(13)00010.  Abstract  
submitted by kickingbird at Jan, 25, 2013 from Vaccine 2013 Jan 10. pii: S0264-410X(13)00010 (via http://www.ncbi.nlm.nih.gov/m/pubmed/23313654/)
Abstract BACKGROUND: Annual influenza vaccination provides an opportunity to administer a booster dose of diphtheria, tetanus, acellular pertussis and inactivated poliomyelitis vaccine (Tdap-IPV) to the ...

Chertow DS, Memoli MJ. Bacterial coinfection in influenza: a grand rounds review. JAMA 2013;309:275-82.  Abstract  
submitted by kickingbird at Jan, 25, 2013 from JAMA 2013;309:275-82 (via http://www.ncbi.nlm.nih.gov/m/pubmed/23321766/)
Abstract Bacterial coinfection complicated nearly all influenza deaths in the 1918 influenza pandemic and up to 34% of 2009 pandemic influenza A(H1N1) infections managed in intensive care units worldwide. ...

Haberg SE, Trogstad L, Gunnes N, Wilcox AJ, et al. Risk of Fetal Death after Pandemic Influenza Virus Infection or Vaccination.. N Engl J Med 2013.  Abstract  
submitted by kickingbird at Jan, 25, 2013 from N Engl J Med 2013 (via http://www.ncbi.nlm.nih.gov/m/pubmed/23323868/)
Abstract BACKGROUND: During the 2009 influenza A (H1N1) pandemic, pregnant women were at risk for severe influenza illness. This concern was complicated by questions about vaccine safety in pregnant ...

Rykkvin R, Kilander A, Dudman SG, Hungnes O.. Within-patient emergence of the influenza A(H1N1)pdm09 HA1 222G variant and clear association with severe disease, Norway. Euro Surveill. 2013;18(3):pii=20369.  Abstract  
submitted by kickingbird at Jan, 18, 2013 from Euro Surveill. 2013;18(3):pii=20369 (via http://www.eurosurveillance.org:80/ViewArticle.aspx?ArticleI)
The association between a particular mutation in the HA1 subunit of the influenza virus haemagglutinin, D222G, and severe and fatal disease in cases of influenza A(H1N1)pdm09 in Norway during the 2009 ...

CDC and other experts. Early Estimates of Seasonal Influenza Vaccine Effectiveness — United States, January 2013. MMWR Weekly.  Abstract  
submitted by kickingbird at Jan, 12, 2013 from MMWR Weekly (via http://www.cdc.gov/mmwr/preview/mmwrhtml/mm62e0111a1.htm?s_c)
In the United States, annual vaccination against seasonal influenza is recommended for all persons aged ≥6 months (1). Each season since 2004–05, CDC has estimated the effectiveness of seasonal influenza ...

Martin C.W. Chan, etc.,al. A ´pre-seasonal´ hospital outbreak of influenza pneumonia caused by the drift variant A/Victoria/361/2011-like H3N2 viruses, Hong Kong, 2011. Journal of Clinical Virology.  Abstract  
submitted by kickingbird at Jan, 12, 2013 from Journal of Clinical Virology (via http://www.sciencedirect.com/science/article/pii/S1386653212)
Abstract Background Beginning from late 2011 and early 2012, increasing circulation of antigenically drifted influenza A/Victoria/361/2011-like H3N2 viruses within genotype 3 of the A/Victoria/208/2009 ...

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