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2026-8-16 15:58:07
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Ross A. Edwards, etc.,al. [preprint]The Q226H Mutation in Avian H5N1 Hemagglutinin Mediates a Path towards Structural Adaptation in Humans. https://doi.org/10.64898/2026.05.21.726965.  Abstract  
submitted by kickingbird at May, 27, 2026 from https://doi.org/10.64898/2026.05.21.726965 (via https://www.biorxiv.org/content/10.64898/2026.05.21.726965v1)
The global outbreak of highly pathogenic avian influenza (HPAI) A(H5N1) among birds and the spillover to mammals increases the risk for humans. A recent case in British Columbia with a clade 2.3.4.4b H5 ...

Rang Wang, etc.,al. Genetic determinants of cell- and egg-preferred replication in H3N2 canine influenza virus. Veterinary Microbiology.  Abstract  
submitted by kickingbird at May, 27, 2026 from Veterinary Microbiology (via https://www.sciencedirect.com/science/article/abs/pii/S03781)
The H3N2 canine influenza virus (CIV), which originated from avian influenza viruses and has circulated in dogs for over two decades, remains poorly understood in terms of its host adaptation mechanisms ...

Heidi Liu, etc.,al. Strain-specific responses of avian influenza virus to disruption of solute carrier family 35 member A1 (SLC35A1) in chicken cells. Poultry Science.  Abstract  
submitted by kickingbird at May, 27, 2026 from Poultry Science (via https://www.sciencedirect.com/science/article/pii/S003257912)
Avian influenza virus (AIV) poses a persistent threat to poultry health and food security, with conventional control measures offering limited protection. A promising alternative is the use of gene editing ...

Vuokko H?rm?, etc.,al. Lessons from the 2024 avian influenza vaccination campaign in Finland: a qualitative inquiry. Vaccine.  Abstract  
submitted by kickingbird at May, 26, 2026 from Vaccine (via https://www.sciencedirect.com/science/article/pii/S0264410X2)
Highly pathogenicity avian influenza H5N1 (HPAI H5N1) viruses cause a continuous threat to wild avian populations. During recent years, spillover to both wild and domestic mammals has occurred with an ...

Gomaa MR, Yazbek J, et al. Spill-Over of Avian and Human Influenza a Viruses to Swine in Egypt and Lebanon. Zoonotic Diseases. 2026; 6(2):21.  Abstract  
submitted by kickingbird at May, 26, 2026 from Zoonotic Diseases. 2026; 6(2):21 (via https://www.mdpi.com/2813-0227/6/2/21)
Influenza A viruses circulate between birds, humans, and pigs, creating opportunities for the emergence of new strains with potential public health impact. In avian influenza (AI)-endemic countries such ...

Zhang Y, Bai X, Nie C, et al. Clade 2.3.4.4b H5N1 HPAIV from Migratory Birds in Beidaihe Wetland, North China. Viruses. 2026; 18(6):595.  Abstract  
submitted by kickingbird at May, 26, 2026 from Viruses. 2026; 18(6):595 (via https://www.mdpi.com/1999-4915/18/6/595)
During 2022–2024, a highly pathogenic avian influenza virus (HPAIV) H5N1 strain, designated A/Seagull/Hebei/qhd6/2024 (H5N1), was isolated from migratory birds in Beidaihe National Wetland Park, North ...

Vanstreels RET, Serafini PP, Giacinti J, Younger J. A public database to monitor the spread and impacts of high pathogenicity avian influenza viruses on albatrosses and petrels. Biodivers Data J. 2026 May 15;14:e186836.  Abstract  
submitted by kickingbird at May, 26, 2026 from Biodivers Data J. 2026 May 15;14:e186836 (via https://bdj.pensoft.net/article/186836/)
Background: High pathogenicity avian influenza (HPAI) viruses have rapidly emerged as a major global threat to wildlife, with severe consequences for seabird populations. Albatrosses and petrels (order ...

Brian Root, etc.,al. [preprint]Predicting Influenza Virus Host Tropism and Zoonotic Spillover Risk from Protein Sequences. https://doi.org/10.64898/2026.05.21.726772.  Abstract  
submitted by kickingbird at May, 26, 2026 from https://doi.org/10.64898/2026.05.21.726772 (via https://www.biorxiv.org/content/10.64898/2026.05.21.726772v1)
Novel infectious diseases, predominantly originating from non-human animals, pose a significant threat to global public health and economic stability. Avian influenza virus presents an especially significant ...

Pablo Puchades-Colera etc.,al. Methods for detecting highly pathogenic avian influenza H5N1 virus in dairy processing environments. Front. Microbiol..  Abstract  
submitted by kickingbird at May, 25, 2026 from Front. Microbiol. (via https://www.frontiersin.org/journals/microbiology/articles/1)
The spread of highly pathogenic avian influenza (HPAI) H5N1 into mammals, including U.S. dairy cattle, underscores the need for effective surveillance in milk and environmental samples. This study evaluated ...

Kieran Dee, etc.,al. [preprint]Understanding the emergence of the influenza A/H3N2 K subclade in its historical and evolutionary context. https://doi.org/10.64898/2026.05.21.726823.  Abstract  
submitted by kickingbird at May, 25, 2026 from https://doi.org/10.64898/2026.05.21.726823 (via https://www.biorxiv.org/content/10.64898/2026.05.21.726823v1)
The emergence in 2025/26 of the influenza A/H3N2 K substrain (H3N2/K) was the cause of significant public health concern. This genetically divergent virus was assessed to have a strongly decreased reactivity ...

Taehee Chang, Sangyi Lee, Jin Il Kim, Kyung-Duk Mi. [preprint]Spatiotemporal Dynamics of Highly Pathogenic Avian Influenza H5 Virus Introductions and Regional Spread in the Republic of Korea. https://doi.org/10.64898/2026.05.21.726857.  Abstract  
submitted by kickingbird at May, 25, 2026 from https://doi.org/10.64898/2026.05.21.726857 (via https://www.biorxiv.org/content/10.64898/2026.05.21.726857v1)
Highly pathogenic avian influenza (HPAI) viruses from clade 2.3.4.4 have caused recurrent outbreaks in poultry since 2014. In the Republic of Korea, clade 2.3.4.4b viruses have driven five epidemic waves, ...

Bojarzyn, C.R., Bie?, N., Behrens, M. et al. The activation of the metabolic oxaloacetate-pyruvate axis restores influenza A virus replication during impaired glycolysis. Virol J (2026).  Abstract  
submitted by kickingbird at May, 25, 2026 from Virol J (2026) (via https://link.springer.com/article/10.1186/s12985-026-03201-6)
Viruses strongly depend on the host cell for efficient replication and influenza A virus (IAV) amongst others also lead to remarkable changes of the host cell metabolism. The restriction of virus replication ...

Tommaso Felicetti, etc.,al. Streamlined Synthesis and Structure–Activity Relationship Analysis of 2-Amidothiophene-3-Carboxamides Targeting Influenza Polymerase PA-PB1 Heterodimerization. ChemMedChem.  Abstract  
submitted by kickingbird at May, 25, 2026 from ChemMedChem (via https://chemistry-europe.onlinelibrary.wiley.com/doi/10.1002)
Influenza viruses remain a major global health threat due to their rapid evolution and ability to evade current therapies. Among viral targets, the PA–PB1 interface of the RNA polymerase complex has emerged ...

WPRO. Avian Influenza Weekly Update # 1046: 22 May 2026. WHO.  Abstract  
submitted by kickingbird at May, 24, 2026 from WHO (via https://cdn.who.int/media/docs/default-source/wpro---documen)
Avian influenza subtype A(HxNy) normally spreads in birds but can also infect humans. Human infections are primarily acquired through direct contact with infected poultry or contaminated environments. ...

Lee, C., Tarbuck, N.N., Cochran, H.J. et al. Dairy cows infected with influenza A(H5N1) reveals low infectious dose and transmission barriers. Nat Commun (2026).  Abstract  
submitted by kickingbird at May, 24, 2026 from Nat Commun (2026) (via https://link.springer.com/article/10.1038/s41467-026-73490-6)
Highly pathogenic avian influenza A(H5N1) virus exhibits a strong tropism for the bovine mammary gland, challenging our understanding of influenza A virus host range and tissue specificity. We performed ...

Salaheldin AH, Atasoy MO, Lang J, Ahrens AK, Pohlm. Molecular Characterization of H5N1 Clade 2.3.4.4B Virus in Vaccinated Layer Chickens. Viruses. 2026; 18(6):589.  Abstract  
submitted by kickingbird at May, 23, 2026 from Viruses. 2026; 18(6):589 (via https://www.mdpi.com/1999-4915/18/6/589)
The global emergence of the avian influenza virus (AIV) H5N1 clade 2.3.4.4B since 2016 has caused substantial losses in wild bird and poultry populations, along with heightened risks of transmission to ...

Jinyan Shen, etc.,al. Genesis and biological features of H7 avian influenza viruses in migratory birds and implications for cross-species infection. Journal of Integrative Agriculture.  Abstract  
submitted by kickingbird at May, 23, 2026 from Journal of Integrative Agriculture (via https://www.sciencedirect.com/science/article/pii/S209531192)
H7 subtype avian influenza viruses (AIVs) pose a potential pandemic risk, as they can cause poultry outbreaks and spill over to mammals. H7 viruses harboured by migratory birds are recognized as progenitors ...

Lauren E Steele, etc.,al. Age-specific mortality patterns across influenza pandemics: evidence from all-cause mortality data across multiple populations. International Journal of Epidemiology.  Abstract  
submitted by kickingbird at May, 22, 2026 from International Journal of Epidemiology (via https://academic.oup.com/ije/article/55/3/dyag061/8679000)
BackgroundUnderstanding age-specific mortality patterns across historic influenza pandemics is crucial for future pandemic preparedness. Prior research shows that, while the 1918 pandemic caused unprecedented ...

Min Zhu, etc.,al. NS1-A53D enhances HA stability to coordinate viral entry with vRNP export and replication during adaptation of H1N1 canine influenza virus. Veterinary Microbiology.  Abstract  
submitted by kickingbird at May, 22, 2026 from Veterinary Microbiology (via https://www.sciencedirect.com/science/article/abs/pii/S03781)
Eurasian avian-like H1N1 influenza A viruses that have reassorted with the 2009 pandemic H1N1 virus pose a potential public health threat. We previously reported that synergistic mutations in HA and NS ...

Vargas-Maldonado N, etc.,al. Controlled human influenza infection reveals heterogeneous expulsion of infectious virus into air. Cell, 2026; 189, 2834-2844.e23.  Abstract  
submitted by kickingbird at May, 22, 2026 from Cell, 2026; 189, 2834-2844.e23 (via https://www.cell.com/cell/fulltext/S0092-8674(26)00232-1)
nfluenza virus is transmitted via respiratory expulsions, but detecting infectious virus in expulsions is challenging. Here, we describe quantification and genotyping of infectious virus in respiratory ...

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