Hu Y, et al. Immunogenicity and safety of a trivalent inactivated influenza vaccine produced in Shenzhen, China versus a comparator influenza vaccine: a phase IV randomized study. Hum Vaccin Immunother. 2019 Feb 19. Abstract
submitted by kickingbird at Feb, 21, 2019 from Hum Vaccin Immunother. 2019 Feb 19 (via https://www.ncbi.nlm.nih.gov/pubmed/30779689)
Seasonal influenza causes substantial morbidity and mortality in China, which largely results from limited vaccine accessibility and poor vaccination coverage. Since 2013, Sanofi Pasteur's facilities in ... Rüdiger D, Kupke SY, Laske T, Zmora P, Reichl U. Multiscale modeling of influenza A virus replication in cell cultures predicts infection dynamics for highly different infection conditions. PLoS Comput Biol. 2019 Feb 19;15(2):e1006819.. Abstract
submitted by kickingbird at Feb, 21, 2019 from PLoS Comput Biol. 2019 Feb 19;15(2):e1006819. (via https://journals.plos.org/ploscompbiol/article?id=10.1371/jo)
Influenza A viruses (IAV) are commonly used to infect animal cell cultures for research purposes and vaccine production. Their replication is influenced strongly by the multiplicity of infection (MOI), ... Ilyushina NA, Dickensheets H, Donnelly RP. A comparison of interferon gene expression induced by influenza A virus infection of human airway epithelial cells from two different donors. Virus Res. 2019 Feb 16. Abstract
submitted by kickingbird at Feb, 21, 2019 from Virus Res. 2019 Feb 16 (via https://www.ncbi.nlm.nih.gov/pubmed/30779949)
Influenza is an acute respiratory disease that can cause local annual epidemics and worldwide pandemics of different morbidity and mortality. Our understanding of host factors that modulate the frequency ... Ren L, et al. Influenza A virus (H1N1) triggers a hypoxic response by stabilizing hypoxia-inducible factor-1α via inhibition of proteasome. Virology. 2019 Feb 11;530:51-58. Abstract
submitted by kickingbird at Feb, 21, 2019 from Virology. 2019 Feb 11;530:51-58 (via https://www.ncbi.nlm.nih.gov/pubmed/30780125)
Virus reprogramming of host cellular function is a critical strategy for viral survival and replication. A better understanding of virus-host interaction may provide new potential avenues for the treatment ... Roy Chowdhury I, Yeddula SGR, Kim SH. Pathogenicity and Transmissibility of North American H7 Low Pathogenic Avian Influenza Viruses in Chickens and Turkeys. Viruses. 2019 Feb 16;11(2). Abstract
submitted by kickingbird at Feb, 21, 2019 from Viruses. 2019 Feb 16;11(2) (via https://www.ncbi.nlm.nih.gov/pubmed/30781528)
Low pathogenic avian influenza (LPAI) viruses can silently circulate in poultry and wild aquatic birds and potentially mutate into highly pathogenic avian influenza (HPAI) viruses. In the U.S., recent ... Zhang T, Zhao H, Wang J, Han GZ. Wild birds do not harbor higher diversity of influenza virus internal genes than poultry. Virology. 2019 Feb 7;530:59-64. Abstract
submitted by kickingbird at Feb, 20, 2019 from Virology. 2019 Feb 7;530:59-64 (via https://www.ncbi.nlm.nih.gov/pubmed/30776509)
Avian influenza A virus (AIV) has threatened global economy and public health. Wild birds have long been thought to serve as the natural reservoir of influenza virus, and thus it is expected that wild ... Hu Q, Gilley RP, Dube PH. House dust mite exposure attenuates influenza A infection in a mouse model of pulmonary allergic inflammation. Microb Pathog. 2019 Feb 15.. Abstract
submitted by kickingbird at Feb, 20, 2019 from Microb Pathog. 2019 Feb 15. (via https://www.ncbi.nlm.nih.gov/pubmed/30776411)
Environmental allergens elicit complex immune responses in the lungs that can promote the development of asthma or exacerbate preexisting asthma in susceptible individuals. House dust mites are one of ... Fu Y, et al. Infection Studies in Pigs and Porcine Airway Epithelial Cells Reveal an Evolution of A(H1N1)pdm09 Influenza A Viruses Toward Lower Virulence. J Infect Dis. 2019 Feb 18.. Abstract
submitted by kickingbird at Feb, 20, 2019 from J Infect Dis. 2019 Feb 18. (via https://www.ncbi.nlm.nih.gov/pubmed/30776304)
We analyzed the virulence of pandemic H1N1 2009 influenza A viruses in vivo and in vitro. Selected viruses isolated in 2009, 2010, 2014, and 2015 were assessed using an aerosol-mediated high-dose infection ... Oppenheim B, et al. Assessing global preparedness for the next pandemic: development and application of an Epidemic Preparedness Index. BMJ Glob Health. 2019 Jan 29;4(1):e001157.. Abstract
submitted by kickingbird at Feb, 20, 2019 from BMJ Glob Health. 2019 Jan 29;4(1):e001157. (via https://www.ncbi.nlm.nih.gov/pubmed/30775006)
Introduction: Robust metrics for national-level preparedness are critical for assessing global resilience to epidemic and pandemic outbreaks. However, existing preparedness assessments focus primarily ... Cao Y, et al. Global transcriptome analysis of H5N1 influenza virus-infected human cells. Hereditas. 2019 Feb 6;156:10. Abstract
submitted by kickingbird at Feb, 20, 2019 from Hereditas. 2019 Feb 6;156:10 (via https://www.ncbi.nlm.nih.gov/pubmed/30774581)
Background: Influenza A virus (IAV) belongs to the Orthomyxoviridae family. IAV causes a highly contagious respiratory disease in humans that exacts severe economic losses globally. The virus uses strategies ... Curthoys NM, et al. Influenza Hemagglutinin Modulates Phosphatidylinositol 4,5-bisphosphate Membrane Clustering. Biophys J. 2019 Jan 25.. Abstract
submitted by kickingbird at Feb, 20, 2019 from Biophys J. 2019 Jan 25. (via https://www.ncbi.nlm.nih.gov/pubmed/30773293)
The lipid phosphatidylinositol 4,5-bisphosphate (PIP2) forms nanoscopic clusters in cell plasma membranes; however, the processes determining PIP2 mobility and thus its spatial patterns are not fully understood. ... Naik RI, Vagi SJ, Uzicanin A, Dopson SA. Influenza-Related Communication and Community Mitigation Strategies: Results From the 2015 Pandemic Influenza Readiness Assessment. Health Promot Pract. 2019 Feb 17:. Abstract
submitted by kickingbird at Feb, 20, 2019 from Health Promot Pract. 2019 Feb 17: (via https://www.ncbi.nlm.nih.gov/pubmed/30773046)
Emergence of a novel infectious disease, such as pandemic influenza, is the one global crisis most likely to affect the greatest number of people worldwide. Because of the potentially severe and contagious ... Dumm RE, et al. Non-lytic clearance of influenza B virus from infected cells preserves epithelial barrier function. Nat Commun. 2019 Feb 15;10(1):779. Abstract
submitted by kickingbird at Feb, 19, 2019 from Nat Commun. 2019 Feb 15;10(1):779 (via https://www.ncbi.nlm.nih.gov/pubmed/30770807)
Influenza B virus (IBV) is an acute, respiratory RNA virus that has been assumed to induce the eventual death of all infected cells. We and others have shown however, that infection with apparently cytopathic ... Yeming Wang, et al. Comparative outcomes of adults hospitalized with seasonal influenza A or B virus infection: application of the seven-category ordinal scale. Open Forum Infectious Diseases 15 February 2019. Abstract
submitted by kickingbird at Feb, 19, 2019 from Open Forum Infectious Diseases 15 February 2019 (via https://academic.oup.com/ofid/advance-article/doi/10.1093/of)
ObjectiveTo investigate the difference of disease severity between influenza A and B among hospitalized adults using a novel ordinal scale and existing clinical outcome endpoints.MethodsA prospective, ... Han A, Czajkowski LM, et al. A Dose Finding Study of a Wild-Type Influenza A/H3N2 virus in a Healthy Volunteer Human Challenge Model. Clin Infect Dis. 2019 Feb 16. Abstract
submitted by kickingbird at Feb, 19, 2019 from Clin Infect Dis. 2019 Feb 16 (via https://www.ncbi.nlm.nih.gov/pubmed/30770534)
BACKGROUND: The development of vaccines and therapeutics have relied on healthy volunteer influenza challenge studies. A validated human infection model with wild-type A(H1N1)pdm09 was reported previously.OBJECTIVE: ... James J, et al. The cellular localization of avian influenza virus PB1-F2 protein alters the magnitude of IFN2 promoter and NFκB-dependent promoter antagonism in chicken cells. J Gen Virol. 2019 Jan 23.. Abstract
submitted by kickingbird at Feb, 18, 2019 from J Gen Virol. 2019 Jan 23. (via https://www.ncbi.nlm.nih.gov/pubmed/30672726)
The accessory protein, PB1-F2, of influenza A virus (IAV) functions in a chicken host to prolong infectious virus shedding and thus the transmission window. Here we show that this delay in virus clearance ... Koszalka P, et al. Baloxavir marboxil susceptibility of influenza viruses from the Asia-Pacific, 2012-2018. Antiviral Res. 2019 Feb 13.. Abstract
submitted by kickingbird at Feb, 17, 2019 from Antiviral Res. 2019 Feb 13. (via https://www.ncbi.nlm.nih.gov/pubmed/30771405)
Baloxavir Marboxil (BXM) is an influenza polymerase inhibitor antiviral that binds to the endonuclease region in the PA subunit of influenza A and B viruses. To establish the baseline susceptibility of ... Bolte H, et al. Packaging of the Influenza Virus Genome Is Governed by a Plastic Network of RNA- and Nucleoprotein-Mediated Interactions. J Virol. 2019 Feb 5;93(4). Abstract
submitted by kickingbird at Feb, 17, 2019 from J Virol. 2019 Feb 5;93(4) (via https://www.ncbi.nlm.nih.gov/pubmed/30463968)
The genome of influenza A virus is organized into eight ribonucleoproteins, each composed of a distinct RNA segment bound by the viral polymerase and oligomeric viral nucleoprotein. Packaging sequences ... White MC1, Tao H, Steel J, Lowen AC. H5N8 and H7N9 packaging signals constrain HA reassortment with a seasonal H3N2 influenza A virus. Proc Natl Acad Sci U S A. 2019 Feb 13. Abstract
submitted by kickingbird at Feb, 16, 2019 from Proc Natl Acad Sci U S A. 2019 Feb 13 (via https://www.ncbi.nlm.nih.gov/pubmed/30760600)
Influenza A virus (IAV) has a segmented genome, which (i) allows for exchange of gene segments in coinfected cells, termed reassortment, and (ii) necessitates a selective packaging mechanism to ensure ... Ito M, et al. Characterization of Mouse Monoclonal Antibodies Against the HA of A(H7N9) Influenza Virus. Viruses. 2019 Feb 11;11(2). Abstract
submitted by kickingbird at Feb, 16, 2019 from Viruses. 2019 Feb 11;11(2) (via https://www.ncbi.nlm.nih.gov/pubmed/30754701)
Many cases of human infection with the H7N9 virus have been detected in China since 2013. H7N9 viruses are maintained in chickens and are transmitted to humans at live bird markets. During circulation ... 7540 items, 20/Page, Page[169/377][|<<] [|<] [161] [162] [163] [164] [165] [166] [167] [168] [169] [170] [>|] [>>|] |
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