Tannig P, Peter AS, Lapuente D, Klessing S, Schmid. Genetic Co-Administration of Soluble PD-1 Ectodomains Modifies Immune Responses against Influenza A Virus Induced by DNA Vaccination. Vaccines (Basel). 2020 Oct 1;8(4):E570. Abstract
submitted by kickingbird at Oct, 8, 2020 from Vaccines (Basel). 2020 Oct 1;8(4):E570 (via https://www.mdpi.com/2076-393X/8/4/570)
Due to the low efficacy and the need for seasonal adaptation of currently licensed influenza A vaccines, the importance of alternative vaccination strategies is increasingly recognized. Considering that ...
Zhang C, Wang Y, Chen C, Long H, Bai J, Zeng J, Ca. A Mutation Network Method for Transmission Analysis of Human Influenza H3N2. Viruses. 2020 Oct 3;12(10):E1125. Abstract
submitted by kickingbird at Oct, 8, 2020 from Viruses. 2020 Oct 3;12(10):E1125 (via https://www.mdpi.com/1999-4915/12/10/1125)
Characterizing the spatial transmission pattern is critical for better surveillance and control of human influenza. Here, we propose a mutation network framework that utilizes network theory to study the ...
Hooshmand E, Moa A, Trent M, Kunasekaran M, Poulos. Epidemiology of 2017 influenza outbreaks in nine Australian Aged care facilities. Influenza Other Respir Viruses. 2020 Oct 7. doi: 1. Abstract
submitted by kickingbird at Oct, 8, 2020 from Influenza Other Respir Viruses. 2020 Oct 7. doi: 1 (via https://onlinelibrary.wiley.com/doi/10.1111/irv.12811)
Background: The 2017 A/H3N2 influenza season was the most severe season since the 2009 influenza pandemic. There were over 591 influenza outbreaks in institutions across the state of New South Wales (NSW) ...
Takahashi H, Fujimoto T, Horikoshi F, Uotani T, Ok. Determination of the potency of a cell-based seasonal quadrivalent influenza vaccine using a purified primary liquid standard. Biologicals. 2020 Oct 3:S1045-1056(20)30111-1. Abstract
submitted by kickingbird at Oct, 8, 2020 from Biologicals. 2020 Oct 3:S1045-1056(20)30111-1 (via https://www.sciencedirect.com/science/article/pii/S104510562)
In Japan, the practical application of completely cell-based seasonal influenza vaccines is under consideration. Considering the good correlation between the immunogenicity of egg-based influenza vaccines ...
Jiang H, Peng W, Qi J, Chai Y, Song H, Bi Y, Rijal. Structure-Based Modification of an Anti-neuraminidase Human Antibody Restores Protection Efficacy against the Drifted Influenza Virus. mBio. 2020 Oct 6;11(5):e02315-20. Abstract
submitted by kickingbird at Oct, 8, 2020 from mBio. 2020 Oct 6;11(5):e02315-20 (via https://mbio.asm.org/content/11/5/e02315-20)
Here, we investigate a monoclonal antibody, Z2B3, isolated from an H7N9-infected patient, that exhibited cross-reactivity to both N9 (group 2) and a broad range of seasonal and avian N1 (group 1) proteins ...
Hu J, Zhang L, Liu X. Role of Post-translational Modifications in Influenza A Virus Life Cycle and Host Innate Immune Response. Front Microbiol. 2020 Sep 4;11:517461. Abstract
submitted by kickingbird at Oct, 6, 2020 from Front Microbiol. 2020 Sep 4;11:517461 (via https://www.frontiersin.org/articles/10.3389/fmicb.2020.5174)
Throughout various stages of its life cycle, influenza A virus relies heavily on host cellular machinery, including the post-translational modifications (PTMs) system. During infection, influenza virus ...
Li Y, Chai W, Min J, Ye Z, Tong X, Qi D, Liu W, Lu. Neddylation of M1 negatively regulates the replication of influenza A virus. J Gen Virol. 2020 Oct 5. Abstract
submitted by kickingbird at Oct, 6, 2020 from J Gen Virol. 2020 Oct 5 (via https://www.microbiologyresearch.org/content/journal/jgv/10.)
Post-translational modification plays a critical role in viral replication. Previously we reported that neddylation of PB2 of influenza A virus (IAV) can inhibit viral replication. However, we found that ...
Kim HR, An S, Hwang J. An integrated system of air sampling and simultaneous enrichment for rapid biosensing of airborne coronavirus and influenza virus. Biosens Bioelectron. 2020 Sep 26;170:112656. Abstract
submitted by kickingbird at Oct, 5, 2020 from Biosens Bioelectron. 2020 Sep 26;170:112656 (via https://www.sciencedirect.com/science/article/pii/S095656632)
Point-of-care risk assessment (PCRA) for airborne viruses requires a system that can enrich low-concentration airborne viruses dispersed in field environments into a small volume of liquid. In this study, ...
Nissly RH, Zaman N, Ibrahim PAS, McDaniel K, Lim L. Influenza C and D viral load in cattle correlates with bovine respiratory disease (BRD): Emerging role of orthomyxoviruses in the pathogenesis of BRD. Virology. 2020 Sep 26;551:10-15. Abstract
submitted by kickingbird at Oct, 5, 2020 from Virology. 2020 Sep 26;551:10-15 (via https://www.sciencedirect.com/science/article/pii/S004268222)
Bovine respiratory disease (BRD) is the costliest disease affecting the cattle industry globally. Orthomyxoviruses, influenza C virus (ICV) and influenza D virus (IDV) have recently been implicated to ...
Tsuzuki S, Ishikane M, Matsunaga N, Morioka S, Yu. Interim 2019/2020 influenza vaccine effectiveness in Japan from October 2019 to January 2020. Jpn J Infect Dis. 2020 Sep 30. Abstract
submitted by kickingbird at Oct, 3, 2020 from Jpn J Infect Dis. 2020 Sep 30 (via https://www.jstage.jst.go.jp/article/yoken/advpub/0/advpub_J)
Herein we report the interim vaccine effectiveness (VE) of quadrivalent inactivated influenza vaccine for the 2019/2020 influenza season in Japan. We conducted a retrospective observational cohort study ...
Nelson MI, Perofsky A, McBride DS, Rambo-Martin BL. A heterogenous swine show circuit drives zoonotic transmission of influenza A viruses in the United States. J Virol. 2020 Sep 30:JVI.01453-20. Abstract
submitted by kickingbird at Oct, 3, 2020 from J Virol. 2020 Sep 30:JVI.01453-20 (via https://jvi.asm.org/content/early/2020/09/24/JVI.01453-20)
Influenza pandemics are associated with severe morbidity, mortality, and social and economic disruption. Every summer in the United States, youths attending agricultural fairs are exposed to genetically ...
Selzer L, Su Z, Pintilie GD, Chiu W, Kirkegaard K. Full-length three-dimensional structure of the influenza A virus M1 protein and its organization into a matrix layer. PLoS Biol. 2020 Sep 30;18(9):e3000827. Abstract
submitted by kickingbird at Oct, 3, 2020 from PLoS Biol. 2020 Sep 30;18(9):e3000827 (via https://pubmed.ncbi.nlm.nih.gov/32997652/)
Matrix proteins are encoded by many enveloped viruses, including influenza viruses, herpes viruses, and coronaviruses. Underneath the viral envelope of influenza virus, matrix protein 1 (M1) forms an oligomeric ...
Taniguchi K, Ikeda S, Hagiwara Y, Tsuzuki D, Klai. Epidemiology and burden of illness of seasonal influenza among the elderly in Japan: A systematic literature review and vaccine effectiveness meta-analysis. Influenza Other Respir Viruses. 2020 Sep 30. Abstract
submitted by kickingbird at Oct, 3, 2020 from Influenza Other Respir Viruses. 2020 Sep 30 (via https://onlinelibrary.wiley.com/doi/10.1111/irv.12814)
Background: Elderly populations are particularly vulnerable to influenza and often require extensive clinical support. In Japan, nationwide passive surveillance monitors seasonal influenza but does not ...
Soda K, Kashiwabara M, Miura K, Ung TTH, Nguyen HL. Characterization of H3 subtype avian influenza viruses isolated from poultry in Vietnam. Virus Genes. 2020 Sep 29. Abstract
submitted by kickingbird at Oct, 3, 2020 from Virus Genes. 2020 Sep 29 (via https://pubmed.ncbi.nlm.nih.gov/32996077/)
To date, avian influenza viruses (AIVs) have persisted in domestic poultry in wet markets in East Asian countries. We have performed ongoing virus surveillance in poultry populations in Vietnam since 2011, ...
Zhao L, Xia H, Huang J, Zheng Y, Liu C, Su J, Ping. Features of Nuclear Export Signals of NS2 Protein of Influenza D Virus. Viruses. 2020 Sep 29;12(10):E1100. Abstract
submitted by kickingbird at Oct, 3, 2020 from Viruses. 2020 Sep 29;12(10):E1100 (via https://www.mdpi.com/1999-4915/12/10/1100)
Emerging influenza D viruses (IDVs), the newest member in the genus Orthomyxovirus family, which can infect and transmit in multiple mammalian species as its relatives the influenza A viruses (IAVs). Additional ...
Tempia S, Moyes J, Cohen AL, Walaza S, McMorrow ML. Influenza economic burden among potential target risk groups for immunization in South Africa, 2013~2015. Vaccine. 2020 Sep 23:S0264-410X(20)31193-2. Abstract
submitted by kickingbird at Oct, 1, 2020 from Vaccine. 2020 Sep 23:S0264-410X(20)31193-2 (via https://pubmed.ncbi.nlm.nih.gov/32980198/)
Background: Data on influenza economic burden in risk groups for severe influenza are important to guide targeted influenza immunization, especially in resource-limited settings. However, this information ...
Madsen A, Dai YN, McMahon M, Schmitz AJ, Turner JS. Human Antibodies Targeting Influenza B Virus Neuraminidase Active Site Are Broadly Protective. Immunity. 2020 Sep 22:S1074-7613(20)30372-1. Abstract
submitted by kickingbird at Sep, 28, 2020 from Immunity. 2020 Sep 22:S1074-7613(20)30372-1 (via https://www.cell.com/immunity/fulltext/S1074-7613(20)30372-1)
nfluenza B virus (IBV) infections can cause severe disease in children and the elderly. Commonly used antivirals have lower clinical effectiveness against IBV compared to influenza A viruses (IAV). Neuraminidase ...
Mooij P, Mortier D, Stammes M, Fagrouch Z, Verscho. Aerosolized pH1N1 influenza infection induces less systemic and local immune activation in the lung than combined intrabronchial, nasal and oral exposure in cynomolgus macaques. J Gen Virol. 2020 Sep 25. Abstract
submitted by kickingbird at Sep, 28, 2020 from J Gen Virol. 2020 Sep 25 (via https://www.microbiologyresearch.org/content/journal/jgv/10.)
Non-human primates form an important animal model for the evaluation of immunogenicity and efficacy of novel 'universal' vaccine candidates against influenza virus. However, in most studies a combination ...
Xu C, Liu L, Ren B, Dong L, Zou S, Huang W, Wei H,. Incidence of influenza virus infections confirmed by serology in children and adult in a suburb community, northern China, 2018~2019 influenza season. Influenza Other Respir Viruses. 2020 Sep 25. Abstract
submitted by kickingbird at Sep, 28, 2020 from Influenza Other Respir Viruses. 2020 Sep 25 (via https://onlinelibrary.wiley.com/doi/10.1111/irv.12805)
Background: In mainland China, seasonal influenza disease burden at community level is unknown. The incidence rate of influenza virus infections in the community is difficult to determine due to the lack ...
Feldstein LR, Self WH, Ferdinands JM, Randolph AG,. Incorporating real-time influenza detection into the test-negative design for estimating influenza vaccine effectiveness: The real-time test-negative design (rtTND). Clin Infect Dis. 2020 Sep 25:ciaa1453.. Abstract
submitted by kickingbird at Sep, 26, 2020 from Clin Infect Dis. 2020 Sep 25:ciaa1453. (via https://academic.oup.com/cid/advance-article/doi/10.1093/cid)
With rapid and accurate molecular influenza testing now widely available in clinical settings, influenza vaccine effectiveness (VE) studies can prospectively select participants for enrollment based on ...
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