MOON HJ, Lee JS, Choi YK, Park JY, et al. Induction of type I interferon by high-molecular poly-gamma-glutamate protects B6.A2G-Mx1 mice against influenza A virus. Antiviral Res. 2012. Abstract
submitted by kickingbird at May, 25, 2012 from Antiviral Res. 2012 (via http://www.ncbi.nlm.nih.gov/pubmed/22401806)
In addition to development of vaccines and synthetic antiviral drugs, recent studies have advocated the use of natural substances that inhibit or prevent viral infections. High-molecular-weight poly-γ-glutamate ... HELDT FS, Frensing T, Reichl U. Modeling the intracellular dynamics of influenza virus replication to understand the control of viral RNA synthesis. J Virol. 2012.. Abstract
submitted by kickingbird at May, 25, 2012 from J Virol. 2012. (via http://www.ncbi.nlm.nih.gov/pubmed/22593159)
Influenza viruses transcribe and replicate their negative-sense RNA genome inside the nucleus of host cells via three viral RNA species. In the course of an infection, these RNAs show distinct dynamics ... PING J, Selman M, Tyler S, Forbes N, et al.. Low pathogenic avian influenza virus A/Turkey/Ontario/6213/1966(H5N1) is the progenitor of highly pathogenic A/Turkey/Ontario/7732/1966(H5N9). J Gen Virol. 2012.. Abstract
submitted by kickingbird at May, 25, 2012 from J Gen Virol. 2012. (via http://www.ncbi.nlm.nih.gov/pubmed/22592261)
The first confirmed outbreak of highly pathogenic avian influenza virus infections in North America was caused by A/turkey/Ontario/7732/1966(H5N9), however the phylogeny of this virus is largely unknown. ... VAN BORM S, Rosseel T, Vangeluwe D, Vandenbussche. Phylogeographic analysis of avian influenza viruses isolated from Charadriiformes in Belgium confirms intercontinental reassortment in gulls. Arch Virol. 2012.. Abstract
submitted by kickingbird at May, 25, 2012 from Arch Virol. 2012. (via http://www.ncbi.nlm.nih.gov/pubmed/22580556)
Nine influenza viruses isolated from gulls and shorebirds in Belgium (2008-2010), including H3N8, H5N2, H6N1, H11N9, H13N6, H13N8, and H16N3 subtypes, were targeted using random amplification and next-generation ... Chou YY, Vafabakhsh R, Doganay S, Gao Q, et al. One influenza virus particle packages eight unique viral RNAs as shown by FISH. Proc Natl Acad Sci U S A. 2012. Abstract
submitted by kickingbird at May, 8, 2012 from Proc Natl Acad Sci U S A. 2012 (via http://www.ncbi.nlm.nih.gov/pubmed/22547828)
Influenza A virus possesses a segmented genome of eight negative-sense, single-stranded RNAs. The eight segments have been shown to be represented in approximately equal molar ratios in a virus population; ... Zhou F, Zhou J, Ma L, Song S, et al. High-yield production of a stable Vero cell-based vaccine candidate against the highly pathogenic avian influenza virus H5N1.. Biochem Biophys Res Commun. 2012.. Abstract
submitted by kickingbird at May, 8, 2012 from Biochem Biophys Res Commun. 2012. (via http://www.ncbi.nlm.nih.gov/pubmed/22554519)
Highly pathogenic avian influenza (HPAI) viruses pose a global pandemic threat, for which rapid large-scale vaccine production technology is critical for prevention and control. Because chickens are highly ... Hui-Ling Yen, Joseph Sriyal Malik Peiris. Virology: Bird flu in mammals. Nature 2012 doi:10.1038/nature11192. Abstract
submitted by kickingbird at May, 3, 2012 from Nature 2012 doi:10.1038/nature11192 (via http://www.nature.com/nature/journal/vaop/ncurrent/full/natu)
An engineered influenza virus based on a haemagglutinin protein from H5N1 avian influenza, with just four mutations, can be transmitted between ferrets, emphasizing the potential for a human pandemic to ... Masaki Imai, etc.,al. Experimental adaptation of an influenza H5 HA confers respiratory droplet transmission to a reassortant H5 HA/H1N1 virus in ferrets. Nature 2012 doi:10.1038/nature10831. Full Text
submitted by kickingbird at May, 3, 2012 from Nature 2012 doi:10.1038/nature10831 (via http://www.nature.com/nature/journal/vaop/ncurrent/full/natu)
Highly pathogenic avian H5N1 influenza A viruses occasionally infect humans, but currently do not transmit efficiently among humans. The viral haemagglutinin (HA) protein is a known host-range determinant ... NIH. Statement on NSABB´s March 30, 2012 Recommendations to NIH on H5N1 Research. NIH. Abstract
submitted by kickingbird at May, 3, 2012 from NIH (via http://www.nih.gov/about/director/04142012_NSABB.htm)
April 14, 2012
On March 29-30, 2012, the National Science Advisory Board for Biosecurity (NSABB) was convened to examine two revised manuscripts regarding the transmissibility of the H5N1 avian flu virus ... Hongjie Yu, Simon Cauchemez, Christl A. Donnelly. Transmission Dynamics, Border Entry Screening, and School Holidays during the 2009 Influenza A (H1N1) Pandemic, China. Apr 18 Emerg Infect Dis. Abstract
submitted by kickingbird at Apr, 22, 2012 from Apr 18 Emerg Infect Dis (via http://wwwnc.cdc.gov/eid/article/18/5/11-0356_article.htm)
Pandemic influenza A (H1N1) 2009 virus spread rapidly around the world in 2009. We used multiple data sources from surveillance systems and specific investigations to characterize the transmission patterns ... Xiang Huo, Rongqiang Zu, Xian Qi, Yuanfang Qin, Li. Seroprevalence of avian influenza A (H5N1) virus among poultry workers in Jiangsu Province, China: an observational study. BMC Infectious Diseases 2012, 12:93. Abstract
submitted by kickingbird at Apr, 22, 2012 from BMC Infectious Diseases 2012, 12:93 (via http://www.biomedcentral.com/1471-2334/12/93/abstract)
Background
Since 2003 to 06 Jan 2012, the number of laboratory confirmed human cases of infection with avian influenza in China was 41 and 27 were fatal. However, the official estimate of the H5N1 case-fatality ... NORONHA JM, Liu M, Squires RB, Pickett BE, et al. Influenza Sequence Feature Variant Type (Flu-SFVT) analysis: evidence for a role of NS1 in influenza host range restriction. J Virol. 2012 Mar 7.. Abstract
submitted by kickingbird at Mar, 14, 2012 from J Virol. 2012 Mar 7. (via http://www.ncbi.nlm.nih.gov/pubmed/22398283)
Genetic drift of influenza virus genomic sequences occurs through the combined effects of sequence alterations introduced by a low fidelity polymerase and the varying selective pressures experienced as ... MAAMARY J, Pica N, Belicha-Villanueva A, Chou YY,. Attenuated influenza virus construct with enhanced hemagglutinin protein expression. J Virol. 2012. Abstract
submitted by kickingbird at Mar, 14, 2012 from J Virol. 2012 (via http://www.ncbi.nlm.nih.gov/pubmed/22398291)
Influenza A viruses encoding an altered viral NS1 protein have emerged as promising live attenuated vaccine platforms. A carboxy-terminal truncation in the NS1 protein compromises its interferon antagonism ... Belser JA, Gustin KM, Maines TR, Pantin-Jackwood M. Influenza Virus Respiratory Infection and Transmission Following Ocular Inoculation in Ferrets. PLoS Pathog 8(3): e1002569. doi:10.1371/journal.p. Abstract
submitted by kickingbird at Mar, 3, 2012 from PLoS Pathog 8(3): e1002569. doi:10.1371/journal.p (via http://www.plospathogens.org/article/info%3Adoi%2F10.1371%2F)
While influenza viruses are a common respiratory pathogen, sporadic reports of conjunctivitis following human infection demonstrates the ability of this virus to cause disease outside of the respiratory ... S. Tong,etc.,al. A distinct lineage of influenza A virus from bats. PNAS February 27, 2012. Abstract
submitted by kickingbird at Feb, 29, 2012 from PNAS February 27, 2012 (via http://www.pnas.org/content/early/2012/02/17/1116200109.abst)
Influenza A virus reservoirs in animals have provided novel genetic elements leading to the emergence of global pandemics in humans. Most influenza A viruses circulate in waterfowl, but those that infect ... MACDONALD LA, Aggarwal S, Bussey KA, Desmet EA, et. Molecular interactions and trafficking of influenza A virus polymerase proteins analyzed by specific monoclonal antibodies. Virology. 2012. Abstract
submitted by kickingbird at Feb, 19, 2012 from Virology. 2012 (via http://www.ncbi.nlm.nih.gov/pubmed/22325937)
The influenza polymerase complex composed of PA, PB1 and PB2, plays a key role in viral replication and pathogenicity. Newly synthesized components must be translocated to the nucleus, where replication ... J Gen Virol. 2012. An influenza reassortant with polymerase of pH1N1 and NS gene of H3N2 influenza A virus is attenuated in vivo. SHELTON H, Smith M, Hartgroves LC, Stilwell P, et. Abstract
submitted by kickingbird at Feb, 19, 2012 from SHELTON H, Smith M, Hartgroves LC, Stilwell P, et (via http://www.ncbi.nlm.nih.gov/pubmed/22323532)
Influenza viruses readily mutate by accumulating point mutations and also by reassortment in which they acquire whole gene segments from another virus in a co-infected host. The NS1 gene is a major virulence ... FERRARIS O, Escuret V, Bouscambert M, Casalegno JS. H1N1 influenza A virus neuraminidase modulates infectivity in mice. Antiviral Res. 2012. Abstract
submitted by kickingbird at Feb, 19, 2012 from Antiviral Res. 2012 (via http://www.ncbi.nlm.nih.gov/pubmed/22321413)
In the 2years since the onset of the H1N1 2009 pandemic virus (H1N1pdm09), sporadic cases of oseltamivir-resistant viruses have been reported. We investigated the impact of oseltamivir-resistant neuraminidase ... NGUYEN HT, Trujillo AA, Sheu TG, Levine M, et al.. Analysis of influenza viruses from patients clinically suspected of infection with an oseltamivir resistant virus during the 2009 pandemic in the United States. Antiviral Res. 2012. Abstract
submitted by kickingbird at Feb, 19, 2012 from Antiviral Res. 2012 (via http://www.ncbi.nlm.nih.gov/pubmed/22330888)
During the 2009 influenza pandemic, the Centers for Disease Control and Prevention provided antiviral susceptibility testing for patients infected with suspected drug-resistant viruses. Specimens from ... VEITS J, Weber S, Stech O, Breithaupt A, et al.. Avian influenza virus hemagglutinins H2, H4, H8, and H14 support a highly pathogenic phenotype. Proc Natl Acad Sci U S A. 2012. Abstract
submitted by kickingbird at Feb, 16, 2012 from Proc Natl Acad Sci U S A. 2012 (via http://www.pnas.org/content/109/7/2579.long)
High-pathogenic avian influenza viruses (HPAIVs) evolve from low-pathogenic precursors specifying the HA serotypes H5 or H7 by acquisition of a polybasic HA cleavage site. As the reason for this serotype ... 7480 items, 20/Page, Page[278/374][|<<] [|<] [271] [272] [273] [274] [275] [276] [277] [278] [279] [280] [>|] [>>|] |
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